DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and SPTBN4

DIOPT Version :10

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_066022.2 Gene:SPTBN4 / 57731 HGNCID:14896 Length:2564 Species:Homo sapiens


Alignment Length:2555 Identity:1021/2555 - (39%)
Similarity:1433/2555 - (56%) Gaps:290/2555 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWD-PSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIA 72
            ||: |.:|...|     :.....:::.|||.|||||||:|||:||||||||||||||.||.|.|.
Human    24 RWESPDRGWERE-----QPAASTAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIG 83

  Fly    73 DLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDG 137
            |||||:|||..|.:||||||||:||:||:|:||||.|||||||||||:||||||||:||||||||
Human    84 DLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDG 148

  Fly   138 NASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGL 202
            |..|.|||:||||||||||.|.||..||:||:|||||||||||||||||..||::||||||||||
Human   149 NHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGL 213

  Fly   203 AFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVV 267
            ||||:||:||||||.|.||:|:||.:||..||..||..||||:|||.|||.:|.|||||||||||
Human   214 AFNALIHRHRPDLVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVV 278

  Fly   268 TYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAG 332
            ::||||||:|...|:|||||||:...:|..|::..||...::||.||..|:..:..::|.|||:|
Human   279 SFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSG 343

  Fly   333 VQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEK 397
            ||.||..|:.|.|:|||.||.||||||||||::|||:||.|::.:.|:||..|.||:|||..|||
Human   344 VQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEK 408

  Fly   398 AEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEA 462
            ||||||.|||.|||||||||.||.|||.|.:|||:||:||||||||||||::|.|||||.|||||
Human   409 AEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEA 473

  Fly   463 IETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQ 527
            ||.||.|||||||.|..:...|.:|.|:|::|:..::|:|:|.|..|..|:.|||.|||.:|.||
Human   474 IEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQ 538

  Fly   528 QNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLS 592
            :.||||:|::|.|||::..|::.:.|:||:..:||||||.|:|.||....|||:.:  |:.....
Human   539 KVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEAL--NAAALRF 601

  Fly   593 DDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQI 657
            ...:.|:||||::|.:||..:....|||...|..||:.||.||.||....:..:.|:|.::||::
Human   602 SQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 666

  Fly   658 VSTDEVG---------------HDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHF 707
            :.....|               |||::...:|::||.|:.|:......||...:.|.||:..|..
Human   667 LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGA 731

  Fly   708 ---GADRI-----KDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIV 764
               |||.:     .:|......:|..|.:....|.:||:.|....|..||.|.:.:|:.|..|:.
Human   732 VGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLA 796

  Fly   765 SSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKAN-----VDKRLEAI 824
            ::.|.|.|||:.:.|.::|:.:..|::.:...:..|.:|..:  |..|..|.     :..|:...
Human   797 AAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLAT--LGGASGAGPLVVALQVRVVEA 859

  Fly   825 DNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFE 889
            :..:.|:||:|.||:|.|.|||::|::..|....|.||.||.:.|.:|.....::|||:::||||
Human   860 EQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924

  Fly   890 GFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGV 954
            ..|:|||:...||..||...::|:...||:|||:...|:|||..|:.:.|..|.:.:::.:...|
Human   925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLV 989

  Fly   955 QTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSI 1019
            :...:|..|..:.:.:|:|      ::|........||.||||::..|.|::.:.::|..||..:
Human   990 ENHVLEVAEVRAQVREKRR------AVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALL 1048

  Fly  1020 EDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVAS 1084
            .:..|.:|..:.:...::...|..|....:.....:..||.|.|||.|||.|..||.:.|.....
Human  1049 AERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGG 1113

  Fly  1085 ED--TPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNAL 1147
            .:  .|.||.||:.||.:|.:::||:|...|||..::...|.|.:.......|. :.|.|.|..|
Human  1114 SEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPG-LALDEWLPHL 1177

  Fly  1148 KDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHE 1212
            :.||.:|..:||.|:..|.|:...|||.||.||..|:|..||..||..:.|..:|..|..||:|.
Human  1178 ELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHR 1242

  Fly  1213 AFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKL 1277
            .||||||.:..|:...:|.|:.|:.:.:...::..:....:..:..:|:.||....:||.:|::|
Human  1243 DFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLEL 1307

  Fly  1278 HEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSK 1342
            ..||:|..||..|:.||...::|.:......:|.:|.|||||.||:|.|||.|.:.|:..|:|.:
Human  1308 QHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQ 1372

  Fly  1343 EKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGD 1407
            ||||....:..||.|:.:.:.:||..|:.|...||:|::...:.|:..::|..:..:|.|:...|
Human  1373 EKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD 1437

  Fly  1408 TANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKI 1472
            ...||.:||..::|.|.:::|:....|:|.|:..||..| ...|..| |.:..::.||.||..::
Human  1438 PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAAL-PLEPASK-ELVGERQNAVGERLVRL 1500

  Fly  1473 KAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEID 1537
            ..||.||::.|...||..|...|::||..|:.|:||:|...:.||.|..|....||||.|..||.
Human  1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565

  Fly  1538 NHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDA 1602
            .|.||:..:......|......:|:.....:..|...|..|::|.|.|::.|..:.:|:||:||.
Human  1566 AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDV 1630

  Fly  1603 QEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSG 1667
            .|.|:|:.||||.||.||:||||.|...|:|||..|||.||:|..:|.||....|..........
Human  1631 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDS 1695

  Fly  1668 DAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFD 1732
            :.::.:|||:|:||..||:|..|||..|.:...|:.|||:|.:||.||.::||||||.||||||:
Human  1696 EQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760

  Fly  1733 HVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIET 1797
            ||::|.|:|:|||.:|...|.||:|.||.:.|.||:.||:.:||:|||||.|||:|.:||||:.|
Human  1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGT 1825

  Fly  1798 RTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGR------DAGSVSTLQRKHYNFLQDLIT 1856
            |.|:|||||||||||.|.:::.|:|.||:.    .|.|      ...|.|::||....|..||..
Human  1826 RAQLLAASRELHKFFSDARELQGQIEEKRR----RLPRLTTPPEPRPSASSMQRTLRAFEHDLQL 1886

  Fly  1857 LYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMV 1921
            |.|||:|:||.:|:|:..|||:.|:.|.:||||||..|..|.:.|:..:..::.|.|..||.:.|
Human  1887 LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQV 1951

  Fly  1922 RILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYAS 1986
            |.|:.||:.:..|:..::||||||.||:|||.||.||.|::.|......|..||:.||......:
Human  1952 RDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016

  Fly  1987 ADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTID 2051
            .:|:.:|..|...:..:..:|:..||.||.:|||:|||::|.||:|||.||||.|.|.|||.::|
Human  2017 DEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVD 2081

  Fly  2052 EVENLIKKHEAFEKSAAAQEERFSALERLTTFE-------------------------------- 2084
            |||.||::||||.|:|||.|||||:|.||||.|                                
Human  2082 EVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAP 2146

  Fly  2085 ----------LKEMKR-----------------RQEL---------------------------- 2094
                      |:.:.|                 ||||                            
Human  2147 LLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211

  Fly  2095 ----------------------------AEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVDV 2131
                                        |||..|:|..|.||:...||.|.: :|..||::..:.
Human  2212 EDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAAR-RRRPERQESAEH 2275

  Fly  2132 GASHDDSAAKDTAVEFER--------------------------------VVEIQTERGGTPG-- 2162
            .|:|..:..:...:|..|                                :||...|:...||  
Human  2276 EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLP 2340

  Fly  2163 ------------------------------------------------AGEG------------- 2166
                                                            .|||             
Human  2341 AGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQG 2405

  Fly  2167 ---------------HEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPEL 2216
                           |||::.||.|.|: .:|:|||||..:|.....|.:.||||.||..|..  
Human  2406 GSAPAPPPPPTHTVQHEGFLLRKRELDA-NRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGS-- 2467

  Fly  2217 TFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVA 2281
            |..|||...|..|..|:||||.|||||.:::..:|:.|||||.|:.||:.|:.::.:.....|..
Human  2468 THGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVASSVAEHAEI 2532

  Fly  2282 ASRSQTLPATSQKDE--PKR 2299
            |...||||.||..||  |||
Human  2533 ARWGQTLPTTSSTDEGNPKR 2552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH_SPTB-like_rpt1 36..152 CDD:409095 92/115 (80%)
CH_SPTB_like_rpt2 169..273 CDD:409097 77/103 (75%)
Spectrin 298..408 CDD:395348 61/109 (56%)
SPEC 422..521 CDD:197544 59/98 (60%)
SPEC 525..740 CDD:238103 77/237 (32%)
SPEC 639..846 CDD:238103 59/234 (25%)
SPEC 848..1058 CDD:238103 58/209 (28%)
SPEC 955..1169 CDD:238103 62/215 (29%)
SPEC 1170..1380 CDD:238103 75/209 (36%)
SPEC 1386..1484 CDD:197544 29/97 (30%)
SPEC 1488..1699 CDD:238103 81/210 (39%)
SPEC 1594..1806 CDD:238103 110/211 (52%)
SPEC 1807..2015 CDD:238103 81/213 (38%)
Spectrin 2018..>2078 CDD:395348 40/59 (68%)
PH_beta_spectrin 2167..2274 CDD:269975 48/106 (45%)
SPTBN4NP_066022.2 Actin-binding 1..282 186/262 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 5/17 (29%)
CH_SF 20..163 CDD:469584 98/143 (69%)
CH_SPTBN4_rpt2 165..294 CDD:409171 93/128 (73%)
Spectrin 1. /evidence=ECO:0000255 311..418 59/106 (56%)
SPEC 430..644 CDD:238103 109/215 (51%)
Spectrin 2. /evidence=ECO:0000255 430..533 62/102 (61%)
Spectrin 3. /evidence=ECO:0000255 536..641 43/106 (41%)
Spectrin 4. /evidence=ECO:0000255 774..879 29/106 (27%)
SPEC 775..987 CDD:238103 69/213 (32%)
Spectrin 5. /evidence=ECO:0000255 884..982 37/97 (38%)
Spectrin 6. /evidence=ECO:0000255 1089..1196 38/107 (36%)
SPEC 1091..1195 CDD:197544 37/104 (36%)
SPEC 1201..1409 CDD:238103 75/207 (36%)
SPEC 1306..1514 CDD:238103 71/209 (34%)
Spectrin 7. /evidence=ECO:0000255 1306..1407 38/100 (38%)
Spectrin 8. /evidence=ECO:0000255 1412..1512 29/101 (29%)
Spectrin 9. /evidence=ECO:0000255 1515..1617 33/101 (33%)
SPEC 1516..1727 CDD:238103 81/210 (39%)
SPEC 1622..1834 CDD:238103 110/211 (52%)
Spectrin 10. /evidence=ECO:0000255 1623..1725 48/101 (48%)
Spectrin 11. /evidence=ECO:0000255 1728..1830 59/101 (58%)
Spectrin 1834..1933 CDD:395348 44/102 (43%)
Spectrin 12. /evidence=ECO:0000255 1835..1935 43/103 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1853..1872 4/22 (18%)
SPEC 1943..>2110 CDD:238103 80/166 (48%)
Spectrin 13. /evidence=ECO:0000255 1944..2046 37/101 (37%)
Spectrin 14. /evidence=ECO:0000255 2049..2123 45/73 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2208..2439 34/232 (15%)
PH_beta_spectrin 2421..2525 CDD:269975 48/106 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2533..2564 12/20 (60%)

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