DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and sptbn5

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_021323109.1 Gene:sptbn5 / 569585 ZFINID:ZDB-GENE-131121-26 Length:4138 Species:Danio rerio


Alignment Length:2461 Identity:702/2461 - (28%)
Similarity:1179/2461 - (47%) Gaps:329/2461 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 IDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLI 85
            :|..|.||           |.:.|.|:|.:|||||:|||:||...:....:.|::.::|.|.||:
Zfish     5 VDGEESDG-----------RFRELQEQRMTVQKKTYTKWMNSVFSKSGVVLTDVFTELRTGVHLV 58

  Fly    86 KLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTII 150
            :|||::|||:||.|::..:|:|||||...|:.||: .::.::.||..::|||:.:|.|||||.||
Zfish    59 RLLELISGEKLPTPSRRTLRVHCLENNSIAITFLK-SKIRVDLIGPENVVDGDRTLILGLIWIII 122

  Fly   151 LRFQIQDITIEEVDNKET---KSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHR 212
            |||||.:|.|.|.....:   :|||:|||:|||.|||||.||||::|:.||||||||||:||.||
Zfish   123 LRFQIGNINIVEAGGDASAARRSAKEALLIWCQRKTAGYTNVNVQDFSGSWRDGLAFNALIHAHR 187

  Fly   213 PDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLK 277
            |||..:.:|.:.:...:|.:||.:|||:.|:.:|||.|||.|.|||||||:|||..|||||||:|
Zfish   188 PDLFDYNRLRQDDPKRSLTHAFALAEDEFGIMQLLDVEDVMVPHPDEKSIMTYVSLYYHYFSKMK 252

  Fly   278 Q-ETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFS 341
            | :|:| |||.|:|.:..|.|.|...||:..||||:||:|.:..|.:|.|.|||..:|..:|.|.
Zfish   253 QGQTIQ-KRIAKIVDLLKELDDMKGLYESMVSDLLRWIKTKVVELNDRSFPNSLREMQHLVAAFK 316

  Fly   342 NYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELAL 406
            .|||||||||:.|:|.:|..||.|::|:|||||:.|.|.|||.:.||.:.|..||:|||:||..|
Zfish   317 KYRTIEKPPKYQERGAIEAHLFDLRTKLRANNQRDYIPPEGKTLGDIERNWTLLERAEHQRERVL 381

  Fly   407 REELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFG--FDLAAVEAAAKKHEAIETDIFA 469
            :..|:|.|:|||||.:|.|||::||::|.:..:|:.|.:.|  ..|...|.||::.||:..|:.|
Zfish   382 QSALMRLEQLEQLAQKFGRKATLRESYLEDTLQLIQQQDLGGLQRLEEAEIAARRLEALGADVLA 446

  Fly   470 YEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEML 534
            :|.|.:|:..:...:|.:.||...:::.|..::|..|..|.::|:.:|..:..:.......:::.
Zfish   447 HEPRFRALSEMAAVIERDNYHSKVQVIRRNVDIMNRWKDLKQVLQEQRAHVGDAANTFAVLRDIE 511

  Fly   535 YILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNS------------ 587
            .|..:::|::....:.|.||.|..|..||||..|::..|..|||.:..:..:|            
Zfish   512 LISMDLKELQAQADSSDMGKQLPDVVALLQKQDLIDTQIISLGETLNAISSSSALKVKHKGATKV 576

  Fly   588 QKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIK 652
            |:.|.|                   |...|..|:.|:..||..||...||::|:.|..:.|.||.
Zfish   577 QRELKD-------------------LNSHYNSLLGLSKNRRKALEGQLKLFEFFHDCEEVEAWIY 622

  Fly   653 EKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLK 717
            ||..::....:|.||:.:...:..|||||:||.|.:.....|...|.||....|...:.|:..::
Zfish   623 EKWVLLQAASLGRDLSQIQQAIQNHKALEAEIQSQESLCSGVVFRGQELCRGRHPNENDIQKWIR 687

  Fly   718 EILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKK 782
            .:..:|..|.:....|:.||..|....|.|||..:..:|:.|...::..||.|:|||:..:||::
Zfish   688 TLQKQWQQLKEQVTIRKNRLHAANVIKQYFADITEASSWLDDHKPLLIDEDYGKDEASSTALLQR 752

  Fly   783 HKDVADELKNYAEVIDALHKQAESL---------------------------------------- 807
            |:.|..|::.|:..:..|.:||:|.                                        
Zfish   753 HQRVEKEMEAYSSEVKRLGEQAKSAAQLAPLTTETQQTRMVHYSDSSDGEDEKEKKADKGGKAVS 817

  Fly   808 KLNEAEKANV-------------------------DKRL-------------------------- 821
            |:.:.|:|.:                         ||.|                          
Zfish   818 KILQQEQAMIRFKYRGPKLIWDRGEILTIISREKDDKLLLRDSRGNEQLVSSTYIRELPVSQEAP 882

  Fly   822 --------------------------------------------------EAIDNRYKELTELAK 836
                                                              .:::..:..|..||:
Zfish   883 PETTNGVAESPKRKVSRPRRTRSMRRGTAEISTSTLPDPHFQKDTIESTQNSLEKDFNRLYNLAQ 947

  Fly   837 LRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASR 901
            .:.:.|.|...|::..:..:..|.|:.:|..:|:|.:...:  ::|:::.::|.|..|:.:...:
Zfish   948 SKNKILEDTARLHRFYNACEEFESWMGDKENVLNTFSSNSN--NLEVVQAKYENFVTELASGRKQ 1010

  Fly   902 VAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETIS 966
            :..:.:...:||..:|....:|.:|...:.:.|..:::..:....:|.|:..|::|...|:|..:
Zfish  1011 LDDITKFGDELLKQQHSRKKDIQQRLGIVTRRWERIQKLKDEMAHELLSSADVKSFLQTCQEVQA 1075

  Fly   967 WIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIR 1031
            .::.:...| :|..:....:.:...:.|.:..:||:.|::.|:..|:..|...:|..|.|:..|.
Zfish  1076 QLQHRLAQL-DTPDVGSSPSALQAEEHRQAQAERDIEALERKIDYLKSVAKMKKDCSPAESAAIM 1139

  Fly  1032 ERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEK 1096
            |.:..:|.:..||.....:|...||||..|..|.::......|...||..:..|:|.:.:..|:.
Zfish  1140 EEVHALEDLLRQLKAQAIQRQRMLEEARRLQLFQKETRDLLMWAEATQEHLLEEETGSDVASAQA 1204

  Fly  1097 LLNQHQSIREEIDNYTEDYKNMMEYGERL---TSEGSTSDDPQYMFLRERLNALKDGWEELHQMW 1158
            ||.::..:::||:......|:|...|:.|   :.|....|      :::.|..|...|.:|.::|
Zfish  1205 LLKENLDLKQEIELQKAKLKDMERLGQSLDVASGEKGGKD------VQQTLTKLDHEWSQLDKLW 1263

  Fly  1159 ENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDD 1223
            .:|...|.|.|:.|..|.:|.:.|..:|..|..|...|...:::...:.|.|.|.....:||.:.
Zfish  1264 SSRNRRLEQGLEFQKLNMEADRIEATISGHEARLKVRDLGDSVDSVHSLLSRQEELEALLEALER 1328

  Fly  1224 KINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKL----------- 1277
            .|.........|:.|.:|.|.:|.:|::.|.           |..::||...||           
Zfish  1329 SIILFQDKCQELISKRNFAAKEIQQRSKVIQ-----------DHFKRLKESCKLRRLELLASKKY 1382

  Fly  1278 HEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSK 1342
            .|||:|.||:..|:.||:..::|||||....|..|..:|:|.|.|:.||..|:....::.:::..
Zfish  1383 QEFLRDAEEMLLWMDEKFEIAEDESYRDPTNILRKLKKHEAAEKEMQANAVRIDRLIETGEKMLA 1447

  Fly  1343 EKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGD 1407
            :.......|:.|.:|:.|::.:|:....|:|..|..|.::..:.:...|....|..:|:.:.:..
Zfish  1448 DDHYNTQSIQKKTQEVHKRWIELQRKMAERGDKLRQAGQQEQLMELLQDAKLKIEAIERMLQNAI 1512

  Fly  1408 TANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKT-AVLERFEK 1471
            ..:||.|...|:::.:.::.:....|.::..|..:.:.|.....:.:   .::|:| ..|:.|:.
Zfish  1513 RGHDLRSSRQLLKEHKQLEEEAQELAEKINSIVTRAKNLATNHFDSQ---RILKETDTYLKLFKS 1574

  Fly  1472 IKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEI 1536
            ::.||..|:..||...:.:.|..||:.|..||.|..|||::.:|..||.....|.:|::.|..|:
Zfish  1575 LEKPLDHRRSQLEADVDLYSFYHDVDLELNWISEHQPVADTTNYERSLVGAVSLLQKHKDLQAEV 1639

  Fly  1537 DNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFD 1601
            :.|...:..:.:.||.:......:.::.:.....|..||:||:::.:.|...|..:...:|...|
Zfish  1640 NAHSKYLQRVLDRGRAMARSNQWNGQEVQQRCEQLIAKWEELEESCKKRSGELNRAVTREQILLD 1704

  Fly  1602 AQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISS 1666
            ..|.|:.:||... ::..|.||.|::.::|:|:||.:|..:|..|..:            |::.|
Zfish  1705 CTELETLVSETSA-LVSTDYGKTELATRSLIKQHEGVEGQIEVLAAQV------------DELKS 1756

  Fly  1667 GDAVAVKQSQLDKL----------YAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVV 1721
            ....||:...|::|          .:.|:..|..|..||.|.|.|....||..:||:||..:..:
Zfish  1757 NVKQAVRVWGLEELNKPCNHIKSKLSELQHSATVREQRLRETLHLHEFKRETSELEEWIAQQTQI 1821

  Fly  1722 AGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNE 1786
            |.|.:||.|:::...|..||..|.:..| ||.||:.....:||.||::.|.:|..|.|.::.|.|
Zfish  1822 AASNDLGSDYENAMQLRGRFEVFLKQLE-VGKERMHTCEQLADKLIKSNHPESRFIRETQNLLRE 1885

  Fly  1787 SWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFL 1851
            ||.:|.:|.:.|.:.|..|.:.|||:.|..|.||:|.|:...:.:::.:|...|.:..|||...:
Zfish  1886 SWDELQDLSKDRKEKLRKSEKCHKFYKDLTDALGQIKERHKTIPEDIAKDLKGVQSQLRKHEALV 1950

  Fly  1852 QDLITLYSQVQQIQEESAKLQDAYAGDKAKE----ITNREQEVLHAWDNLQAMCDARKQKLADTG 1912
            .:|.....|:|::.:.:    ||..|..:.|    :...:|||:..|:.|:...:.|:::|....
Zfish  1951 HELAGTEQQLQELLDGT----DAILGMCSPELRVGLQELQQEVVENWERLRMRMEQREEELQSAK 2011

  Fly  1913 DLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKE 1977
            |.:.|.|..:...:|...::..|...|..|||:..:|.:..||.|.|||..||:.|...:|:|:.
Zfish  2012 DRYMFLNTAQDYSLWCSQVLSWMKAEESIRDVATCDLQLFQHQQLWAEIVAREETFAQAVSMGQG 2076

  Fly  1978 LLTRNHYASADIKDRLMTLSNSRNALLRRWE--ERW-ENLQLILEVYQFARDAAVAEAWLIAQEP 2039
            ||..:...:.:|:::|..|...|..|...|:  ::| ||..|   ...|.||....|....:||.
Zfish  2077 LLENDIPNAREIQEKLKALQEEREKLSDNWQLRQKWLENTYL---EQVFYRDTEYMEKITNSQEI 2138

  Fly  2040 YLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIK 2104
            .|.:|:||.|:|:||:|||:||||||...:||::..||              ||.||..:.:.:.
Zfish  2139 QLKNSDLGTTVDDVESLIKRHEAFEKLLHSQEDKMVAL--------------QESAERLKTEGLT 2189

  Fly  2105 EEQEA------KAASEAAEQAK-REAERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGGTPG 2162
            .|:.:      ||..|..|:.| ...:||:|::|...|         ..|.|.|           
Zfish  2190 REKNSNIKNKLKALQERRERIKDLSGKRREDLEVSKLH---------CIFSRDV----------- 2234

  Fly  2163 AGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMAAK----------AGRISFYKDQKGYKSNPELT 2217
             .|..|....|.::....:|...:....|:.|..|          .|.|.....|.|   |..:|
Zfish  2235 -SEAEEWITDRMNKIQDDSKMDMSNLQTKMKMLQKHQVFEAEILAHGNIIESVQQAG---NELVT 2295

  Fly  2218 FRGEPSYDLQNAAIEIASDYTKKKHVLRVK---LANGALFL--LQAHDDTEMSQWV 2268
            .....|.:::.....:.|.:...|..|.|:   |.:...||  ||..:..|:  |:
Zfish  2296 MHHPKSKEIRQTVSALISHWKALKQELAVRGKVLEDNRDFLEFLQKVEQVEV--WI 2349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 44/97 (45%)
CH 170..269 CDD:278723 61/98 (62%)
Spectrin 298..408 CDD:278843 56/109 (51%)
SPEC 422..521 CDD:197544 30/100 (30%)
SPEC 525..740 CDD:238103 59/226 (26%)
SPEC 639..846 CDD:238103 63/347 (18%)
SPEC 848..1058 CDD:238103 42/209 (20%)
SPEC 955..1169 CDD:238103 51/216 (24%)
SPEC 1170..1380 CDD:238103 57/220 (26%)
SPEC 1386..1484 CDD:197544 17/98 (17%)
SPEC 1488..1699 CDD:238103 56/220 (25%)
SPEC 1594..1806 CDD:238103 67/221 (30%)
SPEC 1807..2015 CDD:238103 60/214 (28%)
Spectrin 2018..>2078 CDD:278843 26/59 (44%)
PH 2167..2275 CDD:278594 24/117 (21%)
PH_beta_spectrin 2167..2274 CDD:269975 24/117 (21%)
sptbn5XP_021323109.1 SAC6 24..>387 CDD:227401 190/364 (52%)
SPEC 394..605 CDD:238103 60/229 (26%)
SPEC 606..>776 CDD:238103 53/169 (31%)
SPEC 958..1167 CDD:238103 43/211 (20%)
SPEC 1066..1272 CDD:238103 50/212 (24%)
SPEC 1275..1484 CDD:238103 57/219 (26%)
SPEC 1381..1588 CDD:238103 50/209 (24%)
SPEC 1591..1799 CDD:238103 56/220 (25%)
SPEC 1800..2010 CDD:238103 66/214 (31%)
SPEC 2014..2222 CDD:238103 72/224 (32%)
SPEC 2120..2331 CDD:238103 64/248 (26%)
SPEC 2230..2443 CDD:238103 28/137 (20%)
SPEC 2444..2655 CDD:238103
SPEC 2656..2866 CDD:238103
SPEC 2870..2969 CDD:197544
SPEC 2973..3184 CDD:238103
SPEC 3189..3390 CDD:238103
SPEC 3394..>3559 CDD:238103
Atrophin-1 <3557..3901 CDD:331285
PH-like 3919..4019 CDD:327399
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0517
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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