DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and LOC558044

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	NP_001093459.1	Gene:	LOC558044 / 558044	-ID:	-	Length:	2391	Species:	Danio rerio

Alignment Length:	2387	Identity:	1184/2387 - (49%)
Similarity:	1598/2387 - (66%)	Gaps:	107/2387 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALA---------------------------- 45
            |||.:.        |.|:|..|||:||||||||||||
Zfish    24 RWDIAA--------ETEWDNENSSARLFERSRIKALADMDFDPREPEPCLSPAAFVNQVQYSNIL 80

  Fly    46 --------EERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKG 102
                    :|||:||||||||||||||.||.|||.|||.|:|||:.||:||||||||:|||||||
Zfish    81 EGRFKQLQDEREAVQKKTFTKWVNSHLGRVTCRIGDLYTDLRDGRMLIRLLEVLSGEQLPKPTKG 145

  Fly   103 KMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKE 167
            :||||||||||||||||:||:|||||:|||||||||..|.||||||||||||||||::|..||||
Zfish   146 RMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKE 210

  Fly   168 TKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNN 232
            .||||||||||||||||||.||||.|||||||||||||||:||||.||:.|:.|.::||.:||.|
Zfish   211 KKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRSDLIDFDNLKRSNAHYNLQN 275

  Fly   233 AFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMEND 297
            ||:|||.:|||.||||.|||.|:.||||||||||.||||||||:|...|:|||||||:..|:|.|
Zfish   276 AFNVAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDYAIEAD 340

  Fly   298 KMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLL 362
            :::..||...|:||:|||.||.:|.:|:..|||:.||.||..|:.|||:||||||.|||||||||
Zfish   341 QLIEKYETLASELLQWIEQTIVTLNDRQLANSLSAVQNQLQAFNTYRTVEKPPKFTEKGNLEVLL 405

  Fly   363 FTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKA 427
            ||:||||||||||.|.|:|||:|||||||||||||||||||||||.|||||||||.|||||||||
Zfish   406 FTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEMLAARFDRKA 470

  Fly   428 SMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDV 492
            :|||||||||||||||||||.:|.|||||.:|||||||||.||.|||.||.||..|||:|.||:|
Zfish   471 AMRETWLSENQRLVSQDNFGVELGAVEAATRKHEAIETDIQAYGERVAAVEAVARELEAEGYHEV 535

  Fly   493 KRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLM 557
            :|:|.|:|||:|||.||.|||.|||.||.....||:..||:.||::.||::|..|.:.|.||||.
Zfish   536 RRVLARRDNVLRLWEYLKELLAARRERLMAHRDLQRLLQELSYIMEWMEDMKSRLQSQDSGKHLH 600

  Fly   558 GVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVR 622
            .||||||||:||||||:...||||.|...:::|.|:: :|||||||.::..:|..|..||.||.:
Zfish   601 DVEDLLQKHTLVEADISAQAERVKAVQATAKRFASNE-QSYKPCDPALVEEKVDLLGRAYGELGQ 664

  Fly   623 LAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSH 687
            ||.:||.||::||:||||.|:..:|..||:|:|||:|..:.|.||::...:||||:|...|:.:.
Zfish   665 LAADRRVRLDDSRRLWQFLWELGEEAAWIREQEQIISGGDYGKDLSSALHLLSKHEAFRDEMAAR 729

  Fly   688 DPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADD 752
            ...|.|....|..|:.|||.||..:.:|:|::..:|.||.:.::.|.|.|..:|.:.|...||:|
Zfish   730 YGPLGNSIAGGEALVKEGHVGAPEVTERIKDVRAQWSHLEEASQLREQSLNESVAFHQFQTDAND 794

  Fly   753 VDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANV 817
            ::.|:|:|||.|||::||.||.:.|:|.:|.::|.:|::::..:||:||:|...|....|....|
Zfish   795 MEAWILETLRQVSSQEVGHDEFSTQTLARKQREVEEEIQSHRSLIDSLHEQGSLLPEAYAHSPQV 859

  Fly   818 DKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVE 882
            :.||.||:.||:||..|:...:|.|..||:||::.|||...:.|:.||.:.|..|.....:||:|
Zfish   860 EGRLPAIEQRYEELEGLSSSWRQALDGALALYRMFSEASACQLWVGEKEQWLHNMEIPTKLEDLE 924

  Fly   883 IMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDD 947
            :::.||:..:.|||....|::.|||:|:|||..::.|.|:|.:.||.||..||..:..|..:...
Zfish   925 VIQQRFDTLEPEMNTLGGRISDVNQVAQQLLGSDNRNKDQIDQTQNQLNNRWSDFQSLANQRKQA 989

  Fly   948 LKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSL 1012
            |:||..:|.:::||.|..||:::|.:::..|.||..||.|||.|||:|:||:|||.|||.||..|
Zfish   990 LESALNIQNYHLECNEIKSWMKEKTKVIESTQSLGNDLAGVMALQRKLTGMERDLEAIQGKLDDL 1054

  Fly  1013 EREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTK 1077
            ..||..:..||||:.:.|:.::|:|:.:||:|...:|.|:..|.||..|..||||||.||.||::
Zfish  1055 RSEAKKLVSEHPEQEEEIKGQLAEIQEVWEELRATMKRREESLGEASKLQGFLRDLDDFQAWLSR 1119

  Fly  1078 TQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRE 1142
            |||.||||||||||.|||:||.||::|:.|:|||.|||:.|...|..:| :|.|  |.|:|||.:
Zfish  1120 TQTTVASEDTPTSLAEAERLLAQHEAIKNEVDNYKEDYEKMRATGAEVT-QGQT--DAQHMFLAQ 1181

  Fly  1143 RLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQ 1207
            ||.||..||.||.:|||:|..:|:|:.|.|...|||:|.|..|:.||:.||..:.|.:|:.||..
Zfish  1182 RLQALDTGWHELRRMWESRHCVLAQAFDFQTLLRDAKQAEGFLNSQEYVLSHTEMPSSLQGAEEA 1246

  Fly  1208 LKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLK 1272
            :|:||.|||||||:::|||.:::....||...:..||||.::.::|..|...|:|.|.:...|||
Zfish  1247 IKKHEDFLTTMEASEEKINGVVESGRRLVSDGNTYADKIQEKTDSIQERHQKNKQAANELLAKLK 1311

  Fly  1273 NQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSA 1337
            :..:|..||||.:||..|:.||..|:||.||..|:.:||||.:||||.||:|:||:.|.:.:|..
Zfish  1312 DNRELQHFLQDGQELTLWINEKMLTAQDMSYDEARNLHSKWQKHQAFMAELASNKDWLDKIDKEG 1376

  Fly  1338 QELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQ 1402
            |.|.|||||.:..:...|..|.||:.:||..|:.|...||||||..|..|:|..:||::.::..|
Zfish  1377 QVLVKEKPELEQTVSETLSGLQKQWVELENTTQAKAQCLFDANRAELFTQSCSALDSWLQNISSQ 1441

  Fly  1403 IVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLE 1467
            :.|.|...||||||||::|.|:::.||.|:.::|:.:  |::.|.....:..|..:..::..|.:
Zfish  1442 LQSDDFGKDLTSVNILLKKHQMLEHQMDVREKEVQSL--QSQALALAQEDSGIVEVDGEQRRVTD 1504

  Fly  1468 RFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSL 1532
            ||.:::.||.||::.|...|||.||.||:|||.||:.|::|:|.|.|:|..|.:|.:|.||||:|
Zfish  1505 RFSQLQDPLKERRQHLLASKEAHQFNRDLEDEILWVKERMPLATSTDHGKDLPSVQLLMKKNQTL 1569

  Fly  1533 ATEIDNHEPRINAICNNGRKLI--DEGHEDAKKFEAL---ISDLTQKWQELKDAIENRRKHLLES 1592
            ..||..|:|||:.|..:|..:.  .|...|.::..||   :::|.:.|..|....|.|...|.|:
Zfish  1570 QKEIQGHQPRIDDIQAHGTNMSPGKESEMDRERRAALDGRLAELRELWALLISETEQRNVRLAEA 1634

  Fly  1593 EKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVAR 1657
            .:.||::.||.|||:||.||||:||.|::.|||.||..::|||:.|||::||||.||.||...:|
Zfish  1635 NRAQQFYTDAAEAEAWMGEQELHMMSEEKAKDEQSALVMVKKHQILEQALEDYAQTIHQLANSSR 1699

  Fly  1658 QFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVA 1722
            .....:....:.:.::|:|:|||||||||||.|||.:|.|.|:|..|.||||||||||.:|||||
Zfish  1700 LMVNSEHPESERITLRQAQVDKLYAGLKDLAEERRGKLQERLRLTQLKREVDDLEQWIAEREVVA 1764

  Fly  1723 GSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNES 1787
            ||.|||||::|||:|.::|.||||||..:|.|||..||..||.||::||.::|::|||||.|||:
Zfish  1765 GSHELGQDYEHVTMLRDKFREFARDTSTIGQERVDAVNAQADELIESGHPENASVAEWKDGLNEA 1829

  Fly  1788 WQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSD-ELGRDAGSVSTLQRKHYNFL 1851
            |.||||||:|||||||||.|||:|..|.::.||.|.||:..::. |||||..:|....|:|..:.
Zfish  1830 WADLLELIDTRTQMLAASYELHRFHQDAREALGLIREKKETLAGAELGRDLNTVQHFLRQHTAYE 1894

  Fly  1852 QDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFR 1916
            .|:..|..||.|:|:::|:||.||||:||.:|...|:.|..||:.||:....|:..|.||.:.||
Zfish  1895 HDVQALSGQVTQVQDDAARLQKAYAGEKADDIHRHERAVTEAWEGLQSATQTRRLLLLDTVEKFR 1959

  Fly  1917 FFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTR 1981
            |.||||.||:|||.:..|:.:.:.|||||...|::.|||.:|:||:||.|:|.||..:|:.|:..
Zfish  1960 FLNMVRDLMLWMEGINLQIQSHDSPRDVSSAGLVIANHQDIKSEIETRADSFTACSEMGRTLINN 2024

  Fly  1982 NHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSEL 2046
            |||||.:|:::|..|...|..:.::|:|:.::||::|||.||.|||::||:||..|||.:.::||
Zfish  2025 NHYASDEIQEKLDQLQAKRTEINQKWQEKMDHLQIVLEVLQFGRDASMAESWLAGQEPLVRAAEL 2089

  Fly  2047 GHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKA 2111
            |..:||||:|||:||||||.||..|:|||.||:|||.|.:|::||:|..|.|.|.......|...
Zfish  2090 GSNVDEVESLIKRHEAFEKLAAGWEDRFSQLEKLTTLEEQEIQRRREEEERARRPPTPPPVEEVV 2154

  Fly  2112 ASEAAEQAKR----EAERRDDVDVGASHDDSAAKDTA--VEFERV--------VEIQTE------ 2156
            .||..:.|.|    :......|.|...:.|   :||:  .|.|.|        ::..:.
Zfish  2155 QSEINDSAARTSLDQTTLNQSVSVNGVYSD---QDTSQGSESESVNGPGRDSGLDSASRQDPSAT 2216

  Fly  2157 ---RGGTPGAGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTF 2218
               |||..|..|..||.:.||.|.:|..||::||||..||...:.|.:.||||.|...:.  :.:
Zfish  2217 LPGRGGAEGTTEAMEGILCRKQEMESHNKKSANRSWQNVYCVLRKGSLGFYKDNKSASNG--IPY 2279

  Fly  2219 RGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKA------QSDS 2277
            .||....|..|..|:|.||.|:|||.:::|.:|..:|.||.|:.|||.|:.::::      :|..
Zfish  2280 HGEVPISLGEAVCEVAHDYKKRKHVFKLRLGDGKEYLFQAKDEAEMSSWIRAIQSSMSSSERSPG 2344

  Fly  2278 TAVAASRSQTLPATS-----------------QKDEPKRRSFFTLKK 2307
            .:...||:.|:|..|                 ::|..||.|||..||
Zfish  2345 ASRGLSRAMTMPPMSPSSGEAGGVTMRNKDGKERDREKRFSFFGKKK 2391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	81/97 (84%)
		CH	170..269	CDD:278723	75/98 (77%)
		Spectrin	298..408	CDD:278843	77/109 (71%)
		SPEC	422..521	CDD:197544	74/98 (76%)
		SPEC	525..740	CDD:238103	96/214 (45%)
		SPEC	639..846	CDD:238103	78/206 (38%)
		SPEC	848..1058	CDD:238103	84/209 (40%)
		SPEC	955..1169	CDD:238103	110/213 (52%)
		SPEC	1170..1380	CDD:238103	92/209 (44%)
		SPEC	1386..1484	CDD:197544	31/97 (32%)
		SPEC	1488..1699	CDD:238103	98/215 (46%)
		SPEC	1594..1806	CDD:238103	126/211 (60%)
		SPEC	1807..2015	CDD:238103	88/208 (42%)
		Spectrin	2018..>2078	CDD:278843	37/59 (63%)
		PH	2167..2275	CDD:278594	42/113 (37%)
		PH_beta_spectrin	2167..2274	CDD:269975	42/112 (38%)
LOC558044	NP_001093459.1	CH	94..197	CDD:237981	86/102 (84%)
		CH	213..316	CDD:237981	79/102 (77%)
		Spectrin	341..451	CDD:278843	77/109 (71%)
		SPEC	465..563	CDD:197544	73/97 (75%)
		SPEC	568..782	CDD:238103	96/214 (45%)
		SPEC	681..888	CDD:238103	78/206 (38%)
		SPEC	785..994	CDD:238103	80/208 (38%)
		SPEC	997..1201	CDD:238103	107/206 (52%)
		SPEC	1209..1419	CDD:238103	92/209 (44%)
		SPEC	1420..1635	CDD:238103	79/216 (37%)
		SPEC	1636..1848	CDD:238103	126/211 (60%)
		SPEC	1849..2058	CDD:238103	88/208 (42%)
		SPEC	2065..>2123	CDD:197544	36/57 (63%)
		PH_beta_spectrin	2230..2333	CDD:269975	42/104 (40%)
		PH	2230..2333	CDD:278594	42/104 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3289
eggNOG	1	0.900	-	-		E2759_KOG0517
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2452	1.000	Inparanoid score	I29
OMA	1	1.010	-	-		QHG52262
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	1	1.000	-	-		FOG0000586
OrthoInspector	1	1.000	-	-		otm26043
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3302
SonicParanoid	1	1.000	-	-		X1255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770