DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and sptan1

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_021324499.1 Gene:sptan1 / 553383 ZFINID:ZDB-GENE-051113-60 Length:2501 Species:Danio rerio


Alignment Length:1894 Identity:531/1894 - (28%)
Similarity:870/1894 - (45%) Gaps:351/1894 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   606 IVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADE-ENWIKEKEQIVSTDEVGHDLTT 669
            |..|.||:.|.|.....|:|.||.:||:|.: :||:...||| |.||:||.||.| ||...|.:.
Zfish    15 IQERRQQVLDRYRRFKELSVVRRQKLEDSYR-FQFFRRDADELEKWIQEKLQIAS-DENYKDPSN 77

  Fly   670 VNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRR 734
            :...|.||:|.|:|:.::...:..:.:.|:.:|:||||.::.|:.||:|:...||.||..||.:.
Zfish    78 LQGKLQKHQAFEAEVQANAEAIIKLDETGNLMISEGHFASETIRTRLEELHRLWDLLLQKTKEKG 142

  Fly   735 QRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDA 799
            .||..|.:..|...:.:|..:|:.|...||:||::                              
Zfish   143 IRLLQAQKLVQYLRECEDALDWISDKEAIVTSEEL------------------------------ 177

  Fly   800 LHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKE 864
                                                                             
Zfish   178 ----------------------------------------------------------------- 177

  Fly   865 KTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNH 929
                      |:|:|.||:::.:||.|..::.|:..||..|||.|.:|....||.::.||::|..
Zfish   178 ----------GQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQAAGKLTQENHPEAELILKKQEE 232

  Fly   930 LNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRR 994
            :|..|..|:..|:.:...|..|..||.|..:..||||||::|::::. :|....||..|..|.|:
Zfish   233 VNSAWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMA-SDDFGRDLASVQALLRK 296

  Fly   995 LSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAG 1059
            ..|::|||||:..|:::|..||:.::..||:.|..|..:..::...|||:..:..||.::|.::.
Zfish   297 HEGLERDLAALNDKVNTLGGEADRLQQTHPQNATQIHLKRDELITNWEQIQTLATERHARLNDSY 361

  Fly  1060 DLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGER 1124
            .|.||..|.....:|:|:.:..:.:::....:..||.||::||..:.|||.:.:.:|:..|.|:.
Zfish   362 MLQRFTADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSTDEAGQA 426

  Fly  1125 LTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQE 1189
            |.:.|..:.:.    ::|:|..|.:....|.::||.|:....|.:|.|||.||..|.:..:|:||
Zfish   427 LLNTGHYASEE----VKEKLGILSEEKVSLLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487

  Fly  1190 HFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENIT 1254
            .||..:|...:|:..|..||:||.|..::.|.::||..|.:.|..|::.:|:..|.:..|.:.:.
Zfish   488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAKDDVATRRDALL 552

  Fly  1255 GRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAF 1319
            .||:...:||..:...|::...|.:|.:|.:||..|:.||..|:.||:|:....:..|..:||||
Zfish   553 SRRNALHERAQFRRAALEDSFHLQQFFRDSDELKSWINEKMKTATDEAYKDPSNLQGKVQKHQAF 617

  Fly  1320 EAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVL 1384
            |||::||:.|:...:||.|||...|......:..::.|::.|:..|...|:.||..|.:||::..
Zfish   618 EAELSANQSRIDALQKSGQELVDGKHYASSEVSTRMDEVSSQWKKLLEATELKGIKLREANQQQQ 682

  Fly  1385 VQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKT 1449
            ..:..:||:.::.::|..:.|.|...|||||..|.:|..:::..:|....:::.|..|....| .
Zfish   683 FNRNVEDIELWLYEVEGHLASDDFGKDLTSVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ-D 746

  Fly  1450 VPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPD 1514
            ......:.|..|:.|::.|:|.:|.|:..|::.|.......|..||||||:.||.||.|:|:|.:
Zfish   747 AGHFDADNIRKKQEALVARYEALKEPMAARKQKLSDSLRLQQLFRDVEDEETWIREKEPIASSTN 811

  Fly  1515 YGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELK 1579
            .|..|..|..|.||:|:|..||..|||||.|:...|..:|||||...:..:|.:.:|..:|..||
Zfish   812 RGKDLIGVQNLLKKHQALQAEISGHEPRIKAVTQKGEAMIDEGHFAGEDVKAKLQELHNRWDGLK 876

  Fly  1580 DAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVED 1644
            .....||:.|.:|.:.||||.||.||||||.|:|..:...|.||||.||:.|:||||.|...:..
Zfish   877 GKAAQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSPDYGKDEDSAEALLKKHEALMSDLSA 941

  Fly  1645 YANTIRQLGEVA----RQFSGDD-----------------------ISSGD-------------- 1668
            |.::|:.|.|.|    :|.:..|                       :..||              
Zfish   942 YGSSIQALKEEAQACRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006

  Fly  1669 ------------------------------------------------------AVAVKQSQLDK 1679
                                                                  :|:::..|:::
Zfish  1007 VEVNDRQGFVPAAYVKKLDPTQSSSRENLLDEQGSIGLRQDQIENQTAATKEVCSVSMRMKQVEE 1071

  Fly  1680 LYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEF 1744
            ||..|.:|..:|:..|.::.:.|||.||.::|:|||.::|....::|:|.|.:.|.:|.::|::|
Zfish  1072 LYGTLLELGEKRKDMLEKSCKKFMLFREANELQQWINEKESALTNEEVGSDLEQVEVLQKKFDDF 1136

  Fly  1745 ARDTEAVGGERVAKVNGIADNLIQAG------------------------HSDSATIAEWKD--- 1782
            .:|.:| ...|:..:|.:|..|...|                        .:||...:.||.   
Zfish  1137 QKDLKA-NESRLRDINKVASELESEGLMAEEAPVVQAQQVEVLGSAPGKDEADSKGASPWKSVRL 1200

  Fly  1783 ------------NLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGV-SDELG 1834
                        .||..|:.|.:|.|.|:.||.::.|:.:|..|..:....|.||...: :|..|
Zfish  1201 AVQTTANFNTIKELNNRWRSLQQLAEDRSNMLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG 1265

  Fly  1835 RDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQA 1899
            .|..||..|||||..|.:||..|..:|..:.|.:.:|..::. :...:|..:..|:..||.:|..
Zfish  1266 HDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-EAVDDIQEKCTELNTAWSSLVG 1329

  Fly  1900 MCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTR 1964
            ..|.||:||.::.||.||.:..|.||.|:..:...:::.|..:||:|.|.|:..||..:.|||.|
Zfish  1330 RADQRKEKLGNSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDAR 1394

  Fly  1965 EDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAV 2029
            ...|.|....|::||.|.||||.:||.:|..|...|..|.:.|.:|...|...||:..|.||...
Zfish  1395 AGTFLAFEQFGQQLLARGHYASPEIKQKLEALDRERADLEKAWVQRRMMLDQCLELQLFNRDCEQ 1459

  Fly  2030 AEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTT-------FELKE 2087
            ||.|:.|:|.:|.|.:.|.::|.||.||||||.|:|:...|||:.:||:....       :...|
Zfish  1460 AENWMAAREAFLASDDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQSFADQLISADHYAKPE 1524

  Fly  2088 M-KRRQELAEEAERQRIK--EEQEAKAASEAAEQAKREAERRDDVDVGASH------DDSAAKDT 2143
            : |||.|:.:...|.:.:  |::.....|:..:|..|:.   |:::...|.      |:|....|
Zfish  1525 IFKRRSEVLDRWLRLKAQMIEKRSKLGESQTLQQFSRDV---DEIEAWISEKLQTATDESYKDPT 1586

  Fly  2144 AVEFERVVE----------------------IQT-----ERGGTPGAGEGHEGYVTRKHE-WDST 2180
            .::..:::.                      |.|     :||...|:.:..:..:....| |...
Zfish  1587 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDTGNALIQRGACAGSEDAVKARLNALDEQWQFL 1651

  Fly  2181 TKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFR-GEPSYDLQNAAIE--IAS-DYTK-- 2239
            ..|::.:|                  ||..::|.:..|. |...:|...:.:|  :|| ||.|  
Zfish  1652 VNKSAEKS------------------QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1698

  Fly  2240 -------KKHVL----------RVKLANGALFLLQAHDDTEMSQWVTSLKAQSDST--------A 2279
                   |||.|          |:|..||....|.|.:..:.||    :|.:.|:.        :
Zfish  1699 ASVNNLLKKHQLLEADISAHEDRLKDLNGQADSLMASNAFDTSQ----VKDKRDAVNGRFGKIKS 1759

  Fly  2280 VAASRSQTL 2288
            :||.|...|
Zfish  1760 MAAGRRAKL 1768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723
CH 170..269 CDD:278723
Spectrin 298..408 CDD:278843
SPEC 422..521 CDD:197544
SPEC 525..740 CDD:238103 53/134 (40%)
SPEC 639..846 CDD:238103 49/207 (24%)
SPEC 848..1058 CDD:238103 63/209 (30%)
SPEC 955..1169 CDD:238103 63/213 (30%)
SPEC 1170..1380 CDD:238103 70/209 (33%)
SPEC 1386..1484 CDD:197544 24/97 (25%)
SPEC 1488..1699 CDD:238103 89/305 (29%)
SPEC 1594..1806 CDD:238103 81/345 (23%)
SPEC 1807..2015 CDD:238103 71/208 (34%)
Spectrin 2018..>2078 CDD:278843 28/59 (47%)
PH 2167..2275 CDD:278594 29/131 (22%)
PH_beta_spectrin 2167..2274 CDD:269975 29/130 (22%)
sptan1XP_021324499.1 Spectrin 44..147 CDD:306853 40/104 (38%)
SPEC 150..361 CDD:238103 71/316 (22%)
Spectrin 361..465 CDD:306853 27/107 (25%)
SPEC 468..678 CDD:238103 70/209 (33%)
SPEC 679..890 CDD:238103 69/211 (33%)
SPEC 891..1161 CDD:238103 67/270 (25%)
SH3_Alpha_Spectrin 971..1023 CDD:212742 2/51 (4%)
SPEC 1092..1342 CDD:238103 70/251 (28%)
SPEC 1237..1448 CDD:238103 72/211 (34%)
SPEC 1449..1666 CDD:238103 54/237 (23%)
Spectrin 1666..1770 CDD:306853 28/107 (26%)
SPEC 1773..1982 CDD:238103
SPEC 1879..2090 CDD:238103
SPEC 1986..2204 CDD:238103
SPEC 2104..2341 CDD:238103
EFh 2356..2424 CDD:238008
EFhand_Ca_insen 2431..2499 CDD:312305
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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