DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and SPTBN5

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_016877788.1 Gene:SPTBN5 / 51332 HGNCID:15680 Length:3734 Species:Homo sapiens


Alignment Length:2317 Identity:649/2317 - (28%)
Similarity:1132/2317 - (48%) Gaps:189/2317 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 FERSRIKALAEERESVQKKTFTKWVNS-HLC-RVNCRIADLYVDMRDGKHLIKLLEVLSGERLPK 98
            :|...|:.|......:|:||||||:|: ..| :...:|.:||.::.||.||::|||::|||.||.
Human    60 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPP 124

  Fly    99 PTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEV 163
            |::|::|:|.|||..:||.||| .:|.:..||..:||||:.:|.|||||.|||||||..|::::.
Human   125 PSRGRLRVHFLENSSRALAFLR-AKVPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKE 188

  Fly   164 D---NKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTN 225
            :   :....|.|:|||:|||.|||.|.|||:.:|:.||.|||.|||:||.|||||:.:..|....
Human   189 EFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPDR 253

  Fly   226 AIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQ-ETVQGKRIGKV 289
            .:|||..||.|||.:||:|:|||.|||....|||:||:|||..||||.|:|.| :||| :|:.|:
Human   254 PLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQ-RRLTKI 317

  Fly   290 VGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVE 354
            :....|.:.:...||...:|||:||......|..|:|.:||..::..||.|:.:||.||||:..:
Human   318 LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRLQQ 382

  Fly   355 KGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQL 419
            :|..|.|||.||:.::|.|::|:.|.||..::::::.|..||.||..|..||::.|::.::||.|
Human   383 RGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETL 447

  Fly   420 AARFDRKASMRETWLSENQRLVSQDNF-GFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDE 483
            |.||..||::||::|.:.::::.|... ...||.||||.::...:|..|...|.|.||:..:.|.
Human   448 ARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADI 512

  Fly   484 LESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLM 548
            |..|:||....:..|::.|...|..||:.|:.:|.::.....:....||:......:||:::...
Human   513 LRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPAR 577

  Fly   549 TDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQL 613
            :...|:.|..|.:|||:|.|:||.::..|..|..:.|.:.:.     :|......|::.::.:.|
Human   578 STACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAEL-----DSSLGTSVEVLQAKARTL 637

  Fly   614 EDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHK 678
            ......||.|...||:.||::.:..:|..:..:||.|:||..|.|....:|.||:.:...|.|||
Human   638 AQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 702

  Fly   679 ALESEITSHDPQLQNVAKVGSELI-----TEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLE 738
            |||:|:..|.....::.:.|.:|.     |:...|     :|.:.:...|..|......|..||:
Human   703 ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG-----ERAEAVQGGWQLLQTRVVGRGARLQ 762

  Fly   739 NAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKH-------KDVADELKNYAE- 795
            .|:...|.||||.:..:|:.:....:.....|:|:|..::||::|       :..|.||:...| 
Human   763 TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ 827

  Fly   796 ------------VIDALHKQAESLK----LNEA----------------------EKANVDKRLE 822
                        |..||....|||:    .:||                      :...:.:..:
Human   828 GRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQD 892

  Fly   823 AIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHR 887
            .:...|:.|..||:||:.||.:|::|:...|....::.|::::|.:|..:.|..|  .:|:|:.:
Human   893 HLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQAD--TLEVMQLK 955

  Fly   888 FEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTL----REKAEAKMDDL 948
            :|.|...:.......|.|:..|.||......||.:|..:|..|:|.|..|    ||||      :
Human   956 YENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA------V 1014

  Fly   949 KSAHGVQ--TFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRD----LAAIQA 1007
            :.||.|:  :|..||..|...:.|   :|.:.::|:             .|...|    |...|.
Human  1015 QLAHSVEVCSFLQECGPTQVQLRD---VLLQLEALQ-------------PGSSEDTCHALQLAQK 1063

  Fly  1008 KLSSLEREANSIED-----EHP--EEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFL 1065
            |...|||..:.::.     |.|  .|::.::.::..::.:.:|:.:.:.:|..:..|......||
Human  1064 KTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFL 1128

  Fly  1066 RDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGS 1130
            ::......|....|..:.|::....:..|::||.:||.:.|||..:.|..:.:....:.:    :
Human  1129 QESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM----A 1189

  Fly  1131 TSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKD 1195
            ..|.|....:...|..|....:||..:||.||..|.:.|:.|.|.|:........:..:.:|..|
Human  1190 ALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLD 1254

  Fly  1196 DTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDN 1260
            :...::.:|.:.|::|..|...:.....:...|....:.||:..|..|..:.::.::|..:....
Human  1255 NLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRL 1319

  Fly  1261 RQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAA 1325
            :.|:..:..:|...::|.|:.||:.||.:|::||...:..|...:.:.|.....||:|.|:|:.|
Human  1320 QGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLA 1384

  Fly  1326 NKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCD 1390
            .:..:...::..:||...:|..::.|:.:|:.|..:::.|.....|:|..|..|.::..:.:...
Human  1385 TRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQ 1449

  Fly  1391 DIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKI 1455
            |....:..||..:.|.:|..||.|...|.::.|.::::....|.::..:......:..:      
Human  1450 DAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS------ 1508

  Fly  1456 EPIVVKKTAV-LERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSL 1519
             |.::::|.. |.|.|.::..|..|...|:...|..|||.....|..|:.|.:|..:...|...|
Human  1509 -PAILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECL 1572

  Fly  1520 FNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIEN 1584
            .....|.:|::.|..|:..|:.::..:.::||.|...||..|:.......:|...|.||:.|.|.
Human  1573 NGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEA 1637

  Fly  1585 RRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTI 1649
            |.:.|.::...||||.|..|.|.|:.|:...:...|.|:||.:...|:.||:.|::.:..|.:::
Human  1638 RAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSM 1702

  Fly  1650 RQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQW 1714
            .:|.:.|:..:|.::.....|.  |.:|.:....|::||..|...|...|:|....||.:||:.|
Human  1703 EELDQTAQTLTGPEVPEQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGW 1765

  Fly  1715 I-TDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIA 1778
            : :.::...|.:.||:|.:|...|..:|.:|....| :|.:|||....:|::|::.|||....:.
Human  1766 LASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE-MGSQRVAACRLLAESLLERGHSAGPMVR 1829

  Fly  1779 EWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTL 1843
            :.:.:|..:|.:|.||.:.|...|..:....:...|..:||.::.||...:.:.:.||...:...
Human  1830 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQ 1894

  Fly  1844 QRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKL 1908
            .|.|....::|:....|:|::.|.:.::|....|.:|..:..|:|.|..||..||...:.|:.:|
Human  1895 LRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQL 1959

  Fly  1909 ADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACIS 1973
            .....|.||...||....|...:.:.:...|..::.|...|.::.||.|:||::.||..:.....
Human  1960 ERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQ 2024

  Fly  1974 LGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQE 2038
            ||::.|......:.::::.|..|.:.|:.:.:.|..:.|.||...:...|.|:....|..|.|||
Human  2025 LGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQE 2089

  Fly  2039 PYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSAL-ERLTTFELKEMKRRQELAEEAERQR 2102
            ..|.:|.||.:::|||.||:|||.|.|...||:::.:|| |||.|.....::.|..:..: .|.|
Human  2090 VSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQ-RRMR 2153

  Fly  2103 IKEEQEAK---------------AASEAAEQAKREAER-RDDVDVGASHD--DSAAKDTAVEFER 2149
            :||..|::               ||::|.:..:..|:: ::.|..|...|  ....|..|.|   
Human  2154 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE--- 2215

  Fly  2150 VVEIQTERGGTPGAGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMA---AKAGRISFYKDQKGYK 2211
             .|:|           .||..:|      |..||.      :..:|   .:||.:|  :..:|.:
Human  2216 -AEVQ-----------AHEEVMT------SVAKKG------EALLAQSHPRAGEVS--QRLQGLR 2254

  Fly  2212 SNPE-----LTFRGEPSYDLQN-----AAIEIASDYTKKKHV 2243
            .:.|     :..||:...|.:|     ..:::|..:.::|.|
Human  2255 KHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEV 2296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 49/99 (49%)
CH 170..269 CDD:278723 57/98 (58%)
Spectrin 298..408 CDD:278843 42/109 (39%)
SPEC 422..521 CDD:197544 32/99 (32%)
SPEC 525..740 CDD:238103 57/219 (26%)
SPEC 639..846 CDD:238103 63/257 (25%)
SPEC 848..1058 CDD:238103 51/226 (23%)
SPEC 955..1169 CDD:238103 46/226 (20%)
SPEC 1170..1380 CDD:238103 44/209 (21%)
SPEC 1386..1484 CDD:197544 18/98 (18%)
SPEC 1488..1699 CDD:238103 58/210 (28%)
SPEC 1594..1806 CDD:238103 61/212 (29%)
SPEC 1807..2015 CDD:238103 49/207 (24%)
Spectrin 2018..>2078 CDD:278843 25/60 (42%)
PH 2167..2275 CDD:278594 19/90 (21%)
PH_beta_spectrin 2167..2274 CDD:269975 19/90 (21%)
SPTBN5XP_016877788.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0517
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.720

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