DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and actn2

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001005053.1 Gene:actn2 / 448602 XenbaseID:XB-GENE-489122 Length:894 Species:Xenopus tropicalis


Alignment Length:1070 Identity:321/1070 - (30%)
Similarity:478/1070 - (44%) Gaps:279/1070 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 NEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGK 82
            |...||.||   .:....::|..:...|.|::  |:||||.|.||||.:....|.::..|.|:|.
 Frog    11 NYCYDEEEY---MNQEEEWDRDMLLDPAWEKQ--QRKTFTAWCNSHLRKAGTMIENIEEDFRNGL 70

  Fly    83 HLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIW 147
            .|:.||||:||||||||.:||||.|.:.||:|||.|:..:.|.|.:||:.:|||||..:.||:||
 Frog    71 KLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIW 135

  Fly   148 TIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHR 212
            ||||||.||||::||.      |||:.||||||.|||.|.|||::||.|||:|||...|:||:||
 Frog   136 TIILRFAIQDISVEET------SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHR 194

  Fly   213 PDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAED-VFVEHPDEKSIITYVVTYYHYFSKL 276
            |||:.:.||:|.:|:.|:|.|.||||..|.:.|:||||| |....|||::|:|||..:||.|:..
 Frog   195 PDLIDYSKLNKDDAVGNINLAMDVAEKYLDIPKMLDAEDIVSTAKPDERAIMTYVSCFYHAFAGA 259

  Fly   277 KQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFS 341
            :|......||.||:.:..||::|:.:||...|:||:||..||..|..|..|.::..:..:|..|.
 Frog   260 EQAETAANRICKVLAVNQENERMMEEYERLASELLEWIRRTIPWLENRTSEKTMQAMLKKLEDFR 324

  Fly   342 NYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELAL 406
            :||...|||:..||..||:...|||:|:|.:|:..:.|.||||:|||..||:|||:.|...|..|
 Frog   325 DYRRKHKPPRVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIANAWQRLEQGEKGYEEWL 389

  Fly   407 REELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNF-GFDLAAVEAAAKKHEAIETDIFAY 470
            ..||.|.|::|.||.:|.:|||:.|:|.:..::|:.|.:: ...|..|.|..:||||.|:::.|.
 Frog   390 LTELRRLERVEHLAEKFRQKASLHESWTAGKEQLLLQKDYETASLTEVRALLRKHEAFESELAAR 454

  Fly   471 EERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEM-- 533
            ::||:.:.|:..||....|:|..||..|...:...|..|..|.:.||..||.:.:|.:...::  
 Frog   455 QDRVEQIAAIAQELNELDYYDAARINERCQKICDQWDRLGTLTQKRREALERTEKLLETVDQLHL 519

  Fly   534 ----------------------LYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINIL 576
                                  ::|:.|:|||::|:...:.           .|.:|.|||    
 Frog   520 EFIKRAGPFNIWMEGAMEDLQDMFIVHNVEEIQKLITAHEQ-----------FKATLPEAD---- 569

  Fly   577 GERVKVV-VQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQF 640
            .||..:: :||                                                      
 Frog   570 SERQAILGIQN------------------------------------------------------ 580

  Fly   641 YWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEG 705
                        |.|:::.:..:                   :|:||:|.         ..||  
 Frog   581 ------------EVEKVIQSYNI-------------------KISSHNPY---------SSIT-- 603

  Fly   706 HFGADRIKDRLKEILNKWDHLLDLTKYRRQ-------RLENAVEYFQLFA-DADDVDNWMLDTLR 762
                      |.||..||:.:..|...|.|       |.:|.....:.|| .|:.:..|:...: 
 Frog   604 ----------LDEIRTKWEKVKQLVPIRDQTLQEELARQQNNERLRRQFAGQANVIGPWIQKQM- 657

  Fly   763 IVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAE----KANVDKRLEA 823
                |::||                    :..:....|..|..|||:.|..    |.|||| ||.
 Frog   658 ----EEIGR--------------------SCIDFTGTLEDQMNSLKMLEHNIVNYKHNVDK-LEG 697

  Fly   824 ----------IDNRYKELT--------ELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLD 870
                      .||::...:        ||......|.::.:....|..:|.|:.|          
 Frog   698 DHQMIQESLIFDNKHTNYSMEHIRVGWELMLTTVARTINEVETQILTRDAKGITQ---------- 752

  Fly   871 TMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWS 935
                    |.:.:.:..|..|||:.|.                .:||.:....|....:      
 Frog   753 --------EQINVFRSSFNHFDKKKNG----------------LMEHDDFRACLISMGY------ 787

  Fly   936 TLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDR 1000
            .|.|...|::..|....|:.|...:     |:|:...|...|||:.|..:...           |
 Frog   788 DLGEAEFARIMALVDPSGIGTISFQ-----SFIDFMTRETAETDTSEQVIAAF-----------R 836

  Fly  1001 DLAAIQAKL--SSLEREANSIEDEHPEEAK 1028
            .|||.:..:  ..|.||.      .||:|:
 Frog   837 ILAADKPYILPEELRREL------PPEQAQ 860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 51/97 (53%)
CH 170..269 CDD:278723 58/99 (59%)
Spectrin 298..408 CDD:278843 46/109 (42%)
SPEC 422..521 CDD:197544 32/99 (32%)
SPEC 525..740 CDD:238103 33/246 (13%)
SPEC 639..846 CDD:238103 43/236 (18%)
SPEC 848..1058 CDD:238103 36/183 (20%)
SPEC 955..1169 CDD:238103 18/76 (24%)
SPEC 1170..1380 CDD:238103
SPEC 1386..1484 CDD:197544
SPEC 1488..1699 CDD:238103
SPEC 1594..1806 CDD:238103
SPEC 1807..2015 CDD:238103
Spectrin 2018..>2078 CDD:278843
PH 2167..2275 CDD:278594
PH_beta_spectrin 2167..2274 CDD:269975
actn2NP_001005053.1 CH_ACTN_rpt1 35..139 CDD:409063 55/105 (52%)
CH_ACTN_rpt2 143..257 CDD:409065 66/119 (55%)
Spectrin 281..390 CDD:395348 45/108 (42%)
SPEC 402..629 CDD:238103 68/347 (20%)
Spectrin 637..739 CDD:395348 25/127 (20%)
FRQ1 750..860 CDD:227455 32/171 (19%)
EFhand_Ca_insen 824..890 CDD:400872 14/54 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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