DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and Dys

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:3016 Identity:595/3016 - (19%)
Similarity:1037/3016 - (34%) Gaps:1036/3016 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 LAEERESVQKKTFTKWVNSHLCRVNCR-IADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIH 107
            |.:||:.:||||||||:||||....|. :.||::|:|||..|:.||..|:...| ||.||:||:|
  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69

  Fly   108 CLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAK 172
            .:.|::|.:..:::..|.|.||.|.|||.|||.|.|||||.|.|.|..|.:    |.:..:...:
  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHL----VKSHSSNGVE 130

  Fly   173 DALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVA 237
            .:||.|.:..|.. |.:.:.:|::||.||.||..|:..|..:| ..:...:.:|:..|:.|||:|
  Fly   131 KSLLAWARQYTEP-HGLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDLA 193

  Fly   238 EDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLK-----QETVQGK----------RIG 287
            .....:.||||||||....||.|||..||:..||....::     ||..:|:          .|.
  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258

  Fly   288 KVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFEN--SLAGVQGQLAQFSNYRTIEKPP 350
            .:..:.::||:.  ....:|||....:|.  :|.||.:..:  .|:.......:.|.|::.    
  Fly   259 DLDEVPLDNDQT--SLGLYTSDSAGSMEQ--RSSGELKTHSMRPLSTATNASVEISGYQSA---- 315

  Fly   351 KFVEKGNLEVLLFTL------------------QSKMRANNQKPY-------------------- 377
                   ||.:|..|                  .:|::.:..:.:                    
  Fly   316 -------LEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSN 373

  Fly   378 ----TPKEGKMISD------------INKAWE--RLEKAEHERELALREELIRQEKLEQLAARFD 424
                :.|.|..:|.            :|:.||  ||...:.:.::.:|....:::|||||     
  Fly   374 LINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL----- 433

  Fly   425 RKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQA----VVAVCD--- 482
                 |:...|...|:....:.|..|...|....:.:.::.|:...:|.|.:    ||.|.|   
  Fly   434 -----RQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSG 493

  Fly   483 ---ELE------SERY-HDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQ--------LQQN 529
               :||      .||: |.||...|||:.:.: :..:...|.||...|::...        :.|.
  Fly   494 NFNDLEDRLSALGERWSHVVKWSDLRKEKLQQ-YKCISRWLDAREQDLKLMESRDVTDVGGITQR 557

  Fly   530 FQEMLYILDNMEEIKQLLMT------------DDYGKHLM----GVEDLL--------------- 563
            ..|:.|...::.|:::.|:.            ||.|:.::    ..||.|               
  Fly   558 INELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIE 622

  Fly   564 -------------------------------------------------QKHSLVEAD-INILGE 578
                                                             :|..|..|| .|.|..
  Fly   623 TKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALEN 687

  Fly   579 RV------------------------------KVVVQNSQK--FLSDDPESYKPCDPE------- 604
            .:                              ::..:||::  .|.:..:.|:.|:.|       
  Fly   688 HIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLL 752

  Fly   605 IIVSRVQQLEDAYAELVRLAVERRSRLEESRKLW--QFYWDT--------ADEENWIKEKEQIVS 659
            :..:.::|||..||   .|:.:..|:..||..|.  :.|:::        ||..:|.|:.....|
  Fly   753 LEETHIKQLEQRYA---NLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSAS 814

  Fly   660 TDEVGHDLTTVNLM---LSKHKALESEITS----------------HD----------------- 688
            .:|:...|:.:..:   :|:.|....|:..                ||                 
  Fly   815 GNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESL 879

  Fly   689 ----PQLQN-VAKVGSELI---------TEGHF-------------GADRIKDRL--KEILNKWD 724
                .|:|: |.||.::.:         .:.||             ..|.|...|  :|:...|:
  Fly   880 SRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWN 944

  Fly   725 HLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDV-GRDEANVQSLLKKHKDVAD 788
            .|.:....|..:...|:|....||..   .|.::..||..:...: |.|.|:.|.|.|...||. 
  Fly   945 RLPEQLNERVIKQTTAIENLNHFAAE---YNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVI- 1005

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQR---LLDALSLYK 850
            ..:|::|:   |.|:||     .|:|.::..::.|::..|.::.::.:.:|::   |...:.|.:
  Fly  1006 SARNFSEI---LIKEAE-----PAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQ 1062

  Fly   851 L-MSEADGVEQWIKEKTKMLDTMTPGKDIEDV----EIM--KHRFEGFDKEMNANASRVAVVNQL 908
            | :.|.|   ||:.:    |::.||...|.|:    |:.  |.||:...:......::...:|:.
  Fly  1063 LRLKETD---QWLTD----LESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNER 1120

  Fly   909 ARQLLHVEHPNSDEILERQ------------NHLNQEWSTLREKAEAK---MDDLKSAHGVQTFY 958
            ..:||    ...||:.::.            ..:|..|:.:.|...||   ::.:.:..|     
  Fly  1121 GGELL----LQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLG----- 1176

  Fly   959 IECRETISWIEDKKRILTET---DSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIE 1020
                      |.||.:::||   |.||..:       |.......|...|..:|..||....|  
  Fly  1177 ----------EFKKFMVSETGYLDKLENKI-------RNTPENAADAEEIMEELDDLENVLRS-- 1222

  Fly  1021 DEHPEE------------------AKIIRERIAQIELIWEQLTQMLKERDSKLEE-AGDLHRFLR 1066
              |.||                  |..||..|.:....|.||.|..|:|...||: ..:..:..:
  Fly  1223 --HSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEK 1285

  Fly  1067 DLDHFQTWLTKT--------QTDVASEDTPTSLPEAEKLLNQ-------HQSIREEIDNYTEDYK 1116
            .:..|:.|||:.        ..||...|.|   .|.::|.::       .:.|.|.||.:|.:.|
  Fly  1286 CIVQFEKWLTRVDDILSDHLDNDVTIVDQP---EEFQRLAHEFVANEKNFKEISELIDEHTRNGK 1347

  Fly  1117 -----------NMME-------------------YGERL-------------------TSEGSTS 1132
                       |:||                   |..||                   .|.|..:
  Fly  1348 VGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNT 1412

  Fly  1133 DDPQYM------------------------------------FLRERLNALK------------- 1148
            ...||.                                    .|.:|::|||             
  Fly  1413 VQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQS 1477

  Fly  1149 ------------------DGWEELHQMWENRQ-------VLL----------------SQSLDQ- 1171
                              |..:.|.:.:|:.|       :||                ::|.|| 
  Fly  1478 KATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQS 1542

  Fly  1172 -----------------QLFNRD--ARQTEV-------------LLSQQEHFLSKDDTPVN--LE 1202
                             :|.:.|  .|.||:             .|...||.|.:.:.|.|  :|
  Fly  1543 CMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIE 1607

  Fly  1203 QAENQ--------LKRHEAFLTTMEA-------NDDKINTLLQVADTLVEK-------------- 1238
            :.:.|        ||......||:.|       |||  ..::.|:||:.::              
  Fly  1608 KLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDD--TEIVVVSDTVRQRRARTPQSGESPSSA 1670

  Fly  1239 DHFDADKIGKRAENITGRRDD--------------------------NRQRALD----------- 1266
            ....::...|..||..|...|                          |.|:..:           
  Fly  1671 HTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKR 1735

  Fly  1267 -----------------QHEKLK--------NQVKLHEFLQDLEELAEWVQEKYATSQ------- 1299
                             |::|:.        .|.::.:.:..||.:..:|.|...|.|       
  Fly  1736 KAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSED 1800

  Fly  1300 -DESYR---SAKTIHSKWTRHQAFEA---EIAANKERLFEAEK-----SAQELS----------- 1341
             |.|.|   ..|.:....::|...|.   :::.|.|...|.|:     ||:..|           
  Fly  1801 SDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRI 1865

  Fly  1342 --------------------KEKPEFKD------VIEPK-LKELAKQFDDLEVHT---------- 1369
                                :|:|:..|      |.:|| .::|..:.|.||..:          
  Fly  1866 SFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPD 1930

  Fly  1370 KEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVS-GDTANDLT----SVNILMQKQQVIQTQM 1429
            ||.|   |||  |.||....:||..:..::...|.| .||:..:|    :.|..:.|  |:::..
  Fly  1931 KESG---FDA--EPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSK--VLESLS 1988

  Fly  1430 AVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCR 1494
            :       .:|.....|:..:.||:.:.:..:    :..|:|....::.:.|..:.|.|.   |.
  Fly  1989 S-------PVDDSNVTLKSPISEEQPQNLDDR----VREFDKQAKQMIYKLKLTKAKIEQ---CH 2039

  Fly  1495 DVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHE 1559
            :.|.|    |.:|.:|  ||       ...|..:..||..|....:..|:.:....:.::.|...
  Fly  2040 ESEAE----DLRLLIA--PD-------AATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFR 2091

  Fly  1560 -------------------DAKKFEALISD-------LTQKWQELKDA--IENRRKHLLESEKVQ 1596
                               |:...|.|::.       |.:|..:||.:  :|.|.:.:.|.....
  Fly  2092 EVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDL 2156

  Fly  1597 QYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSG 1661
            |....|....:.|.:....||.|    .|.:..||:...:::|.|:.:..|..|    ::.....
  Fly  2157 QVIVSAIGKNAQMPKVTPLMMNE----IEKTKNNLIAHADSIELSLTELRNGPR----ISNGKER 2213

  Fly  1662 DDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWIT-DREVVAGSQ 1725
            .|.||...::.: |:.:...:|...|||.             ..:.|..:..|:| ::.::....
  Fly  2214 PDASSAATMSCR-SEYNNEPSGTGALAGS-------------FDKSVLQISDWLTWEQNMIKIQS 2264

  Fly  1726 ELGQDFDHVTLLSER--------------FNEFARDTEAVGG--------ERVAKVNGIADNLIQ 1768
            .|..|.|.|.|..|:              .||.....|.:.|        |:..|...:|.:.  
  Fly  2265 VLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHC-- 2327

  Fly  1769 AGHSDSATIAEWK-----DNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828
                 ||.:...:     ..|.|.|.      ||...:|..:.:|.....|.:....:.||.:..
  Fly  2328 -----SADLDYMRCCLKVTRLREHWD------ETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKW 2381

  Fly  1829 VS--DELGRDAGSVSTL-------QRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEIT 1884
            ::  ::.....|:::|.       |::..:|..:|...........|.:.||...|..|....|.
  Fly  2382 LARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIK 2446

  Fly  1885 NREQEVLHAWDNLQA-MCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVE 1948
            ...:.:...:.||.: :.:..||..|....|..|...:...:.::.:.......:|.  |:....
  Fly  2447 KMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAES--DIERNP 2509

  Fly  1949 LLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALL--RRWEE-- 2009
            |:.   :.|::||:|....:......|::||.              :|::..:|::  ||.:|  
  Fly  2510 LMF---KDLQSEIETHRVVYDRLDGTGRKLLG--------------SLTSQEDAVMLQRRLDEMN 2557

  Fly  2010 -RWENLQ-------------------LILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVE 2054
             ||.||:                   |:|.:.:...       |:|.::..|.:..||....:..
  Fly  2558 QRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTE-------WVIRKDTELSTLGLGPVRGDAV 2615

  Fly  2055 NLIKK---HEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAA 2116
            :|.|:   |:||.:.  .:::|......||:       .||.:|.||            |.|   
  Fly  2616 SLQKQLDDHKAFRRQ--LEDKRPIVESNLTS-------GRQYIANEA------------AVS--- 2656

  Fly  2117 EQAKREAERRDDVDVGASHDDSAAKDTAVEFERVV--EIQTERGGTPGAGEGHEGYVTRKHEWDS 2179
                      |..|..|:||..:...:|.|..|.:  .|:.|.|             ....:|::
  Fly  2657 ----------DTSDTEANHDSDSRYMSAEEQSRELTRSIRREVG-------------KLSEQWNN 2698

  Fly  2180 TTKKASNRSW----DKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKK 2240
            ...::.|  |    |: ||....   .|.|..:...|...|..:.:.|: |..:::..|::..::
  Fly  2699 LIDRSDN--WKHRLDE-YMTKMR---QFQKILEDLSSRVALAEQTKTSW-LPPSSVGEANEQMQQ 2756

  Fly  2241 KHVLRVKLANGALFLLQAHDDTEMSQ 2266
            ...||.|:...:..|    ||....|
  Fly  2757 LQRLRDKMTTASALL----DDCNEQQ 2778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 50/98 (51%)
CH 170..269 CDD:278723 36/98 (37%)
Spectrin 298..408 CDD:278843 23/167 (14%)
SPEC 422..521 CDD:197544 26/115 (23%)
SPEC 525..740 CDD:238103 60/417 (14%)
SPEC 639..846 CDD:238103 54/283 (19%)
SPEC 848..1058 CDD:238103 56/253 (22%)
SPEC 955..1169 CDD:238103 67/389 (17%)
SPEC 1170..1380 CDD:238103 70/402 (17%)
SPEC 1386..1484 CDD:197544 17/102 (17%)
SPEC 1488..1699 CDD:238103 46/238 (19%)
SPEC 1594..1806 CDD:238103 45/239 (19%)
SPEC 1807..2015 CDD:238103 40/222 (18%)
Spectrin 2018..>2078 CDD:278843 12/62 (19%)
PH 2167..2275 CDD:278594 20/104 (19%)
PH_beta_spectrin 2167..2274 CDD:269975 20/104 (19%)
DysNP_001036722.1 CH 13..111 CDD:278723 50/98 (51%)
CH 129..225 CDD:278723 36/97 (37%)
SPEC 312..525 CDD:238103 43/233 (18%)
SbcC <325..957 CDD:223496 102/645 (16%)
Smc <816..1591 CDD:224117 150/826 (18%)
SPEC 1174..1365 CDD:238103 50/219 (23%)
SPEC 1289..1485 CDD:295325 31/198 (16%)
SPEC 2369..2576 CDD:238103 39/225 (17%)
SPEC 2477..2714 CDD:238103 58/312 (19%)
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439902
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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