Protein Alignment beta-Spec and Dys

DIOPT Version :10

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Alignment Length: 3016
• Identity: 595/3016 - (19%)
• Similarity: 1037/3016 - (34%)
• Gaps: 1036/3016 - (34%)

  Fly    44 LAEERESVQKKTFTKWVNSHLCRVNCR-IADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIH 107
            |.:||:.:||||||||:||||....|. :.||::|:|||..|:.||..|:...| ||.||:||:|
  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69

  Fly   108 CLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAK 172
            .:.|::|.:..:::..|.|.||.|.|||.|||.|.|||||.|.|.|..|.:    |.:..:...:
  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHL----VKSHSSNGVE 130

  Fly   173 DALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVA 237
            .:||.|.:..|.. |.:.:.:|::||.||.||..|:..|..:| ..:...:.:|:..|:.|||:|
  Fly   131 KSLLAWARQYTEP-HGLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDLA 193

  Fly   238 EDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLK-----QETVQGK----------RIG 287
            .....:.||||||||....||.|||..||:..||....::     ||..:|:          .|.
  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258

  Fly   288 KVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFEN--SLAGVQGQLAQFSNYRTIEKPP 350
            .:..:.::||:.  ....:|||....:|.  :|.||.:..:  .|:.......:.|.|::.
  Fly   259 DLDEVPLDNDQT--SLGLYTSDSAGSMEQ--RSSGELKTHSMRPLSTATNASVEISGYQSA---- 315

  Fly   351 KFVEKGNLEVLLFTL------------------QSKMRANNQKPY-------------------- 377
                   ||.:|..|                  .:|::.:..:.:
  Fly   316 -------LEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSN 373

  Fly   378 ----TPKEGKMISD------------INKAWE--RLEKAEHERELALREELIRQEKLEQLAARFD 424
                :.|.|..:|.            :|:.||  ||...:.:.::.:|....:::|||||
  Fly   374 LINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL----- 433

  Fly   425 RKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQA----VVAVCD--- 482
                 |:...|...|:....:.|..|...|....:.:.::.|:...:|.|.:    ||.|.|
  Fly   434 -----RQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSG 493

  Fly   483 ---ELE------SERY-HDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQ--------LQQN 529
               :||      .||: |.||...|||:.:.: :..:...|.||...|::...        :.|.
  Fly   494 NFNDLEDRLSALGERWSHVVKWSDLRKEKLQQ-YKCISRWLDAREQDLKLMESRDVTDVGGITQR 557

  Fly   530 FQEMLYILDNMEEIKQLLMT------------DDYGKHLM----GVEDLL--------------- 563
            ..|:.|...::.|:::.|:.            ||.|:.::    ..||.|
  Fly   558 INELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIE 622

  Fly   564 -------------------------------------------------QKHSLVEAD-INILGE 578
                                                             :|..|..|| .|.|..
  Fly   623 TKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALEN 687

  Fly   579 RV------------------------------KVVVQNSQK--FLSDDPESYKPCDPE------- 604
            .:                              ::..:||::  .|.:..:.|:.|:.|
  Fly   688 HIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLL 752

  Fly   605 IIVSRVQQLEDAYAELVRLAVERRSRLEESRKLW--QFYWDT--------ADEENWIKEKEQIVS 659
            :..:.::|||..||   .|:.:..|:..||..|.  :.|:::        ||..:|.|:.....|
  Fly   753 LEETHIKQLEQRYA---NLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSAS 814

  Fly   660 TDEVGHDLTTVNLM---LSKHKALESEITS----------------HD----------------- 688
            .:|:...|:.:..:   :|:.|....|:..                ||
  Fly   815 GNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESL 879

  Fly   689 ----PQLQN-VAKVGSELI---------TEGHF-------------GADRIKDRL--KEILNKWD 724
                .|:|: |.||.::.:         .:.||             ..|.|...|  :|:...|:
  Fly   880 SRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWN 944

  Fly   725 HLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDV-GRDEANVQSLLKKHKDVAD 788
            .|.:....|..:...|:|....||..   .|.::..||..:...: |.|.|:.|.|.|...||.
  Fly   945 RLPEQLNERVIKQTTAIENLNHFAAE---YNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVI- 1005

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQR---LLDALSLYK 850
            ..:|::|:   |.|:||     .|:|.::..::.|::..|.::.::.:.:|::   |...:.|.:
  Fly  1006 SARNFSEI---LIKEAE-----PAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQ 1062

  Fly   851 L-MSEADGVEQWIKEKTKMLDTMTPGKDIEDV----EIM--KHRFEGFDKEMNANASRVAVVNQL 908
            | :.|.|   ||:.:    |::.||...|.|:    |:.  |.||:...:......::...:|:.
  Fly  1063 LRLKETD---QWLTD----LESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNER 1120

  Fly   909 ARQLLHVEHPNSDEILERQ------------NHLNQEWSTLREKAEAK---MDDLKSAHGVQTFY 958
            ..:||    ...||:.::.            ..:|..|:.:.|...||   ::.:.:..|
  Fly  1121 GGELL----LQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLG----- 1176

  Fly   959 IECRETISWIEDKKRILTET---DSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIE 1020
                      |.||.:::||   |.||..:       |.......|...|..:|..||....|
  Fly  1177 ----------EFKKFMVSETGYLDKLENKI-------RNTPENAADAEEIMEELDDLENVLRS-- 1222

  Fly  1021 DEHPEE------------------AKIIRERIAQIELIWEQLTQMLKERDSKLEE-AGDLHRFLR 1066
              |.||                  |..||..|.:....|.||.|..|:|...||: ..:..:..:
  Fly  1223 --HSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEK 1285

  Fly  1067 DLDHFQTWLTKT--------QTDVASEDTPTSLPEAEKLLNQ-------HQSIREEIDNYTEDYK 1116
            .:..|:.|||:.        ..||...|.|   .|.::|.::       .:.|.|.||.:|.:.|
  Fly  1286 CIVQFEKWLTRVDDILSDHLDNDVTIVDQP---EEFQRLAHEFVANEKNFKEISELIDEHTRNGK 1347

  Fly  1117 -----------NMME-------------------YGERL-------------------TSEGSTS 1132
                       |:||                   |..||                   .|.|..:
  Fly  1348 VGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNT 1412

  Fly  1133 DDPQYM------------------------------------FLRERLNALK------------- 1148
            ...||.                                    .|.:|::|||
  Fly  1413 VQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQS 1477

  Fly  1149 ------------------DGWEELHQMWENRQ-------VLL----------------SQSLDQ- 1171
                              |..:.|.:.:|:.|       :||                ::|.||
  Fly  1478 KATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQS 1542

  Fly  1172 -----------------QLFNRD--ARQTEV-------------LLSQQEHFLSKDDTPVN--LE 1202
                             :|.:.|  .|.||:             .|...||.|.:.:.|.|  :|
  Fly  1543 CMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIE 1607

  Fly  1203 QAENQ--------LKRHEAFLTTMEA-------NDDKINTLLQVADTLVEK-------------- 1238
            :.:.|        ||......||:.|       |||  ..::.|:||:.::
  Fly  1608 KLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDD--TEIVVVSDTVRQRRARTPQSGESPSSA 1670

  Fly  1239 DHFDADKIGKRAENITGRRDD--------------------------NRQRALD----------- 1266
            ....::...|..||..|...|                          |.|:..:
  Fly  1671 HTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKR 1735

  Fly  1267 -----------------QHEKLK--------NQVKLHEFLQDLEELAEWVQEKYATSQ------- 1299
                             |::|:.        .|.::.:.:..||.:..:|.|...|.|
  Fly  1736 KAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSED 1800

  Fly  1300 -DESYR---SAKTIHSKWTRHQAFEA---EIAANKERLFEAEK-----SAQELS----------- 1341
             |.|.|   ..|.:....::|...|.   :::.|.|...|.|:     ||:..|
  Fly  1801 SDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRI 1865

  Fly  1342 --------------------KEKPEFKD------VIEPK-LKELAKQFDDLEVHT---------- 1369
                                :|:|:..|      |.:|| .::|..:.|.||..:
  Fly  1866 SFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPD 1930

  Fly  1370 KEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVS-GDTANDLT----SVNILMQKQQVIQTQM 1429
            ||.|   |||  |.||....:||..:..::...|.| .||:..:|    :.|..:.|  |:::..
  Fly  1931 KESG---FDA--EPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSK--VLESLS 1988

  Fly  1430 AVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCR 1494
            :       .:|.....|:..:.||:.:.:..:    :..|:|....::.:.|..:.|.|.   |.
  Fly  1989 S-------PVDDSNVTLKSPISEEQPQNLDDR----VREFDKQAKQMIYKLKLTKAKIEQ---CH 2039

  Fly  1495 DVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHE 1559
            :.|.|    |.:|.:|  ||       ...|..:..||..|....:..|:.:....:.::.|...
  Fly  2040 ESEAE----DLRLLIA--PD-------AATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFR 2091

  Fly  1560 -------------------DAKKFEALISD-------LTQKWQELKDA--IENRRKHLLESEKVQ 1596
                               |:...|.|::.       |.:|..:||.:  :|.|.:.:.|.....
  Fly  2092 EVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDL 2156

  Fly  1597 QYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSG 1661
            |....|....:.|.:....||.|    .|.:..||:...:::|.|:.:..|..|    ::.....
  Fly  2157 QVIVSAIGKNAQMPKVTPLMMNE----IEKTKNNLIAHADSIELSLTELRNGPR----ISNGKER 2213

  Fly  1662 DDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWIT-DREVVAGSQ 1725
            .|.||...::.: |:.:...:|...|||.             ..:.|..:..|:| ::.::....
  Fly  2214 PDASSAATMSCR-SEYNNEPSGTGALAGS-------------FDKSVLQISDWLTWEQNMIKIQS 2264

  Fly  1726 ELGQDFDHVTLLSER--------------FNEFARDTEAVGG--------ERVAKVNGIADNLIQ 1768
            .|..|.|.|.|..|:              .||.....|.:.|        |:..|...:|.:.
  Fly  2265 VLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHC-- 2327

  Fly  1769 AGHSDSATIAEWK-----DNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828
                 ||.:...:     ..|.|.|.      ||...:|..:.:|.....|.:....:.||.:..
  Fly  2328 -----SADLDYMRCCLKVTRLREHWD------ETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKW 2381

  Fly  1829 VS--DELGRDAGSVSTL-------QRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEIT 1884
            ::  ::.....|:::|.       |::..:|..:|...........|.:.||...|..|....|.
  Fly  2382 LARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIK 2446

  Fly  1885 NREQEVLHAWDNLQA-MCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVE 1948
            ...:.:...:.||.: :.:..||..|....|..|...:...:.::.:.......:|.  |:....
  Fly  2447 KMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAES--DIERNP 2509

  Fly  1949 LLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALL--RRWEE-- 2009
            |:.   :.|::||:|....:......|::||.              :|::..:|::  ||.:|
  Fly  2510 LMF---KDLQSEIETHRVVYDRLDGTGRKLLG--------------SLTSQEDAVMLQRRLDEMN 2557

  Fly  2010 -RWENLQ-------------------LILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVE 2054
             ||.||:                   |:|.:.:...       |:|.::..|.:..||....:..
  Fly  2558 QRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTE-------WVIRKDTELSTLGLGPVRGDAV 2615

  Fly  2055 NLIKK---HEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAA 2116
            :|.|:   |:||.:.  .:::|......||:       .||.:|.||            |.|
  Fly  2616 SLQKQLDDHKAFRRQ--LEDKRPIVESNLTS-------GRQYIANEA------------AVS--- 2656

  Fly  2117 EQAKREAERRDDVDVGASHDDSAAKDTAVEFERVV--EIQTERGGTPGAGEGHEGYVTRKHEWDS 2179
                      |..|..|:||..:...:|.|..|.:  .|:.|.|             ....:|::
  Fly  2657 ----------DTSDTEANHDSDSRYMSAEEQSRELTRSIRREVG-------------KLSEQWNN 2698

  Fly  2180 TTKKASNRSW----DKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKK 2240
            ...::.|  |    |: ||....   .|.|..:...|...|..:.:.|: |..:::..|::..::
  Fly  2699 LIDRSDN--WKHRLDE-YMTKMR---QFQKILEDLSSRVALAEQTKTSW-LPPSSVGEANEQMQQ 2756

  Fly  2241 KHVLRVKLANGALFLLQAHDDTEMSQ 2266
            ...||.|:...:..|    ||....|
  Fly  2757 LQRLRDKMTTASALL----DDCNEQQ 2778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	54/108 (50%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	38/103 (37%)
		Spectrin	298..408	CDD:395348	23/167 (14%)
		SPEC	422..521	CDD:197544	26/115 (23%)
		SPEC	525..740	CDD:238103	60/417 (14%)
		SPEC	639..846	CDD:238103	54/283 (19%)
		SPEC	848..1058	CDD:238103	56/253 (22%)
		SPEC	955..1169	CDD:238103	67/389 (17%)
		SPEC	1170..1380	CDD:238103	70/402 (17%)
		SPEC	1386..1484	CDD:197544	17/102 (17%)
		SPEC	1488..1699	CDD:238103	46/238 (19%)
		SPEC	1594..1806	CDD:238103	45/239 (19%)
		SPEC	1807..2015	CDD:238103	40/222 (18%)
		Spectrin	2018..>2078	CDD:395348	12/62 (19%)
		PH_beta_spectrin	2167..2274	CDD:269975	20/104 (19%)
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	53/106 (50%)
		CH_SF	129..229	CDD:469584	38/101 (38%)
		SPEC	312..525	CDD:238103	43/233 (18%)
		PRK03918	<716..1238	CDD:235175	114/573 (20%)
		SMC_prok_B	<995..1279	CDD:274008	73/329 (22%)
		SPEC	1174..1365	CDD:238103	50/219 (23%)
		SPEC	1289..1485	CDD:413338	31/198 (16%)
		SPEC	2369..2576	CDD:238103	39/225 (17%)
		SPEC	2477..2714	CDD:238103	58/312 (19%)
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074