DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and kst

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster


Alignment Length:2577 Identity:792/2577 - (30%)
Similarity:1267/2577 - (49%) Gaps:372/2577 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SIVRWDPSQGPGNEYI--------DEYEYDG--------------GNSSSR----LFERSRIKAL 44
            |::|.:.|:.....||        .:||..|              .|.:.|    .||..|||.|
  Fly     5 SVLRSNFSRNEYRRYISYERQSLASQYEPGGYSALQTPTPSNRNSANMTQRDGIIKFENERIKTL 69

  Fly    45 AEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCL 109
            .|||..:||||||||:||.|.:....:.||:.|:.||..|:||||::|.|:|.||..|:||:|.:
  Fly    70 QEERLHIQKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLGKPNSGRMRVHKI 134

  Fly   110 ENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITI---EEVDNKETKSA 171
            |||:|:|.|| ..:|.||:||:.||||||..|.||||||||||||||:|.|   ||.::.|.:||
  Fly   135 ENVNKSLAFL-HTKVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDEENESSEKRSA 198

  Fly   172 KDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKL--SKTNAIHNLNNAF 234
            |||||||||.||.||..||:.:||.|||.||.|||:||.|||||.::..:  ||.:.:.|||:||
  Fly   199 KDALLLWCQRKTHGYPGVNITDFTNSWRSGLGFNALIHSHRPDLFEYSTIVNSKNSNLDNLNHAF 263

  Fly   235 DVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKM 299
            |.|.::||:..||||||:....||||||:|||.:|||.|:::|.|...||||..:||..|:.|:.
  Fly   264 DTAANELGIPSLLDAEDIDSARPDEKSILTYVASYYHTFARMKNEQKSGKRIANIVGQLMDADRK 328

  Fly   300 VHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFT 364
            ...||..|::||.||......|.:|:..|||.|:|.:|..|..|||||||||:.|:..:|.|.||
  Fly   329 KMQYEGLTTNLLSWIRQKTLELEQRDLPNSLEGIQRELLAFKEYRTIEKPPKYKERSEIEALYFT 393

  Fly   365 LQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASM 429
            :.:.::|.||.||.|::|::::||.|||:.||.|||.||:|||:||:||||||||..:|::|:.:
  Fly   394 INTLLKALNQPPYNPQDGQLVNDIEKAWQILEYAEHHREVALRDELLRQEKLEQLNYKFEKKSVL 458

  Fly   430 RETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKR 494
            ||.:|.|..:::|...:   |..|:|..||||||..||.|..||...:.|:.:||:.|.||..:|
  Fly   459 REGYLKEMIQVLSDPRY---LRQVDATLKKHEAISADILARVERFNDLTAMAEELDRENYHGKER 520

  Fly   495 ILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGV 559
            :..|:..||..|..|||||..:|:.|.....|....:|:....:.:.|::|...::|.|.||:||
  Fly   521 VRRREQEVMAKWRQLLELLENQRLNLSQMSNLMNLLREIASTTEAVRELQQQFASEDVGPHLLGV 585

  Fly   560 EDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLA 624
            |:|||.|||.|..:|..||.:|...:.:..:.|.:.:     |..::..|:..||:||:||:|.:
  Fly   586 EELLQAHSLQELQVNTYGETLKRFNRQALPYKSSEHK-----DAALLAQRLADLEEAYSELLRRS 645

  Fly   625 VERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDP 689
            ..||:||||:|....|..|..:||:|:.:|::|..|.....||..|..:..||||||.||.|..|
  Fly   646 AARRARLEEARNFHHFMEDYDNEESWLVDKQRICKTGITAKDLRAVLSLQQKHKALEDEIKSRKP 710

  Fly   690 QLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVD 754
            :...::..|..||.|.|..:..|:.|:..:...|..|..|.:.||::||:|.|.:|.:.||::.:
  Fly   711 KSGQMSTAGKRLIGEQHPRSSEIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDANEAE 775

  Fly   755 NWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESL------------ 807
            :|:.:.:.:|:|.|.|.||.:.|:||::|:|:..||..|:..|..|::||:.|            
  Fly   776 SWLNEKIALVNSRDYGNDEPSAQALLQRHRDLQGELNAYSGDILNLNQQADKLIKAGICTLELSA 840

  Fly   808 ----------------------------------------------------------------- 807
                                                                             
  Fly   841 AEPELPEVEQEEWVNETRLVPKEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQGMKMDKGEV 905

  Fly   808 -----KLNE----------------------------------AEKA------------------ 815
                 |.|:                                  |||.                  
  Fly   906 MLLKSKTNDDWWCVRKDNGVEGFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKTILVRQVVPV 970

  Fly   816 ----------------------------NVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLM 852
                                        :|:||.:.|:..|.||.|:|:.|...|.|::.|:...
  Fly   971 KRIKPVSVAPKPLVQRRTSTQSINENADSVEKRQQRINQTYDELQEMAQKRHALLEDSIHLFGFY 1035

  Fly   853 SEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEH 917
            .|.|..|:|:|||.:|:.:    .:.|.|:..|.:||.|..:::|.:.||..::..........|
  Fly  1036 RECDDFEKWMKEKERMIKS----DEGEGVDNAKRKFEKFITDLSAASKRVEEIDGAVDTFRRQGH 1096

  Fly   918 PNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLE 982
            ...|:|:.||..::|.|..|......:...|:.|..|:.|...|.|...|:.: |.:..:|..:.
  Fly  1097 SQLDKIIARQRQIHQIWQRLNNAKAQREKSLEGASSVELFNRTCDEAKVWMSE-KMLQLDTAVIT 1160

  Fly   983 MDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQM 1047
            .||..|..||||...::|:||.::.|::.:....||:::.:|.|...:..|..:::.:|:|:.|.
  Fly  1161 PDLRTVQALQRRHQNLERELAPVEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQDMWQQVQQR 1225

  Fly  1048 LKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYT 1112
            ..:..:::|.......|.........|:...:..:.::::...:..|..||.:|..:.::|..:.
  Fly  1226 GSDLRNRIESEVGQQVFNNSAKVLLAWIDSVKDQLNADESARDVETANNLLKKHNDLGDDIRAHD 1290

  Fly  1113 EDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRD 1177
            .::..:::.|::| |:|. .:..:.:.:.|||.|.:|.   :|:.|..:|..|.|.:|.|:|||:
  Fly  1291 TEFVEVIQLGKQL-SDGK-PNMAETVAVIERLKAEQDA---IHRGWAEKQKWLLQCVDLQMFNRE 1350

  Fly  1178 ARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFD 1242
            |.:.:......|.||..::...:|::.|..||||..|..::.|.|..:......||.|:..||:|
  Fly  1351 ADKIDATTKSHEAFLEYNNLGASLDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYD 1415

  Fly  1243 ADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAK 1307
            :..||.|...:.|:|...:.||.::...|:.....|:|..:.::|..|:|:|...:.||:||...
  Fly  1416 SKYIGDRRNQVLGKRKAVKDRAFERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENYRDLS 1480

  Fly  1308 TIHSKWTRHQAFEAEIAANKERLFEAEKSAQEL---SKEKPEFKDVIEPKLKELAKQFDDLEVHT 1369
            .:..|..:|||||.|:.||:.:|....|..|.|   ....||    :|.::.:|.|::.||...:
  Fly  1481 NLPRKLQKHQAFERELRANEGQLRNVTKDGQALVQAGNRVPE----VESRVADLNKRWKDLLTLS 1541

  Fly  1370 KEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKAR 1434
            ::||..|..|..:....::.:|....:.:|:..:.|||..|||.|...|:.|||::::::.:..:
  Fly  1542 EDKGRKLEQAASQREHNRSLEDAKKKVDELDSALRSGDVGNDLRSCKDLINKQQILESEITIWDQ 1606

  Fly  1435 QVEE------------------IDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQK 1481
            :|.|                  |:..|:.||                   :||:.::.|...|:.
  Fly  1607 KVAELVSTGDDMAHGGHFNAQNIEAGTKELQ-------------------QRFKDLRDPTQRRRA 1652

  Fly  1482 ALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAI 1546
            .||:.....:|..:::.|..||:|.||.|.|.:.|.:|.....|.||::.|..||..|:|.||..
  Fly  1653 KLEESLNYHKFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLHKKHKKLEAEIKGHQPMINKA 1717

  Fly  1547 CNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSE 1611
            ...|:.||.:.|.:.::.|:|...|.|.||:|:.....|.:.|..|.|.|||.|||.|.|||:.|
  Fly  1718 LVAGQSLISQQHPEREQVESLCQQLEQAWQDLERHCGERSRKLDMSLKAQQYLFDAGEIESWLGE 1782

  Fly  1612 QELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQ 1676
            :...:...:.|:|..||..|:.||:.:|..::.|:..:.::|.........:......:|.||..
  Fly  1783 RNNVLRSTEYGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSCAAMVAANHPDSKVLAAKQQL 1847

  Fly  1677 LDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERF 1741
            ::|:...|..||.:|:.||.|:|.......|.|::||||.::|..|.|::.||||:|:.||..:|
  Fly  1848 IEKMLKSLHKLASQRQGRLMESLYKHEYFLESDEVEQWIREQEQAASSEDYGQDFEHLQLLQNKF 1912

  Fly  1742 NEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASR 1806
            ::.....| ||.:||.:...:|..||.:....:..:.:.::.|..||::||:|:..|.|.|.|:.
  Fly  1913 DDLKHRVE-VGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTSWENLLQLLNQREQKLHAAG 1976

  Fly  1807 ELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKL 1871
            |:|:|..|..:.|.||.:|...:|.|||||..|...|.|||..|..||:.|.:|:|.:.|:|.:|
  Fly  1977 EIHRFHRDVAEALFRIQDKNAALSQELGRDLNSALALLRKHEGFENDLVALEAQLQVLVEDSVRL 2041

  Fly  1872 QDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMN 1936
            |..|..: |..|..::.:|:.||::|:....||..:||.:.||..|...||.::.|..:|...:.
  Fly  2042 QAKYPSN-ASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFLTDVRDIVSWSSNLRAALQ 2105

  Fly  1937 TSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRN 2001
            ..|...|.:|...|...|.::..||:.|||.|.....|...::...|||:||::::...:.:.|.
  Fly  2106 AEEHVSDAAGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGHYAAADVEEKCAAMLDERQ 2170

  Fly  2002 ALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKS 2066
            .|...|.::...|:..::::.|.|||...:....:|:..|.||:.|.|:::|:|.|:||:.||:.
  Fly  2171 KLHAAWNKKKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALSSSDFGQTVEDVQNKIRKHDEFERL 2235

  Fly  2067 AAAQEERFSALE---------------RLTTFELKEMKRRQELAEEAERQRIKEEQE---AKAAS 2113
            ...|||:.|.|:               .:.|.....:.|||::.:....:|.|.|..   ||...
  Fly  2236 IQTQEEKVSLLQEHGRKLIEQRHYDSANIQTILQGVLARRQKVKDLCAVRRYKLEDALLYAKFVR 2300

  Fly  2114 EAAEQAK---REAERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGHEGYVTRKH 2175
            :.|| ||   .|.:::.:.|             |..:..|..:                      
  Fly  2301 DCAE-AKYWINEKQKKLEAD-------------AASYAEVTNL---------------------- 2329

  Fly  2176 EWDSTTKKASNRSWDKVYMAAKAGRISFYKD------QKGYKSNP------------------EL 2216
              |...||.......:..:||..|||...:|      .|.::|:|                  ||
  Fly  2330 --DEKIKKLQKHQAFQAEVAANQGRIQEIQDTGVILLSKQHESSPEIKRAIEIVLEAWQGLLAEL 2392

  Fly  2217 TFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHD------------------DTE 2263
            ..||....:.|: ::|..|...|.:..:|.|     ..::||.|                  |::
  Fly  2393 EQRGRGLEEAQD-SLEFNSQLDKIEAWIRDK-----EMMVQASDTGRDLEHCNALMRKLDDVDSD 2451

  Fly  2264 M---SQWVTSLKAQSDSTAVAASRSQTLPATSQKDEPKRRSF 2302
            |   .|.|..:...:|.....|.    :||.:|..:.:|:.|
  Fly  2452 MRVDDQRVKHINQLADKLINQAQ----VPADTQSVDKRRKDF 2489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 54/97 (56%)
CH 170..269 CDD:278723 60/100 (60%)
Spectrin 298..408 CDD:278843 51/109 (47%)
SPEC 422..521 CDD:197544 38/98 (39%)
SPEC 525..740 CDD:238103 74/214 (35%)
SPEC 639..846 CDD:238103 77/368 (21%)
SPEC 848..1058 CDD:238103 55/209 (26%)
SPEC 955..1169 CDD:238103 47/213 (22%)
SPEC 1170..1380 CDD:238103 65/212 (31%)
SPEC 1386..1484 CDD:197544 23/115 (20%)
SPEC 1488..1699 CDD:238103 68/210 (32%)
SPEC 1594..1806 CDD:238103 69/211 (33%)
SPEC 1807..2015 CDD:238103 67/207 (32%)
Spectrin 2018..>2078 CDD:278843 21/59 (36%)
PH 2167..2275 CDD:278594 29/152 (19%)
PH_beta_spectrin 2167..2274 CDD:269975 29/151 (19%)
kstNP_001097492.2 CH 76..178 CDD:237981 59/102 (58%)
CH 197..303 CDD:237981 63/105 (60%)
SPEC 450..640 CDD:238103 68/197 (35%)
SPEC 658..832 CDD:238103 60/173 (35%)
SH3 885..935 CDD:214620 2/49 (4%)
SPEC 1030..1236 CDD:238103 55/210 (26%)
SPEC 1134..1341 CDD:238103 46/212 (22%)
SPEC 1343..1551 CDD:238103 65/211 (31%)
SPEC 1449..1658 CDD:238103 59/231 (26%)
SPEC 1555..1764 CDD:238103 59/227 (26%)
SPEC 1765..1975 CDD:238103 68/210 (32%)
SPEC 1873..2080 CDD:238103 75/208 (36%)
SPEC 1979..2185 CDD:238103 67/206 (33%)
SPEC 2188..2402 CDD:238103 55/251 (22%)
SPEC 2407..2618 CDD:238103 19/92 (21%)
SPEC 2514..2725 CDD:238103
SPEC 2726..2934 CDD:238103
SPEC 2935..3145 CDD:238103
SPEC 3042..3251 CDD:238103
SPEC 3149..3357 CDD:238103
SPEC 3359..3567 CDD:238103
SPEC 3465..3680 CDD:238103
PH 3799..3902 CDD:278594
PH_beta_spectrin 3801..3904 CDD:269975
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439904
Domainoid 1 1.000 106 1.000 Domainoid score I1672
eggNOG 1 0.900 - - E2759_KOG0517
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1400at33392
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 1 1.000 - - otm47215
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
87.650

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