DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and alpha-Spec

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster


Alignment Length:1747 Identity:495/1747 - (28%)
Similarity:862/1747 - (49%) Gaps:219/1747 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   712 IKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLF-ADADDVDNWMLDTLRIVSSEDVGRDEAN 775
            |::|.:::|::::.....|:.:|::||:: ..||.| .|||::::|:.:.|: .:||:..||..|
  Fly    18 IQERREQVLSRYNDFKIETRQKREKLEDS-RRFQYFKRDADELESWIHEKLQ-AASEESYRDPTN 80

  Fly   776 VQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQ 840
            :|:.::||:....|:..::..|.:|....:.: :|:...|:     |:|..|..||.:|.:|...
  Fly    81 LQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEM-INQQHFAS-----ESIQVRLDELHKLWELLLS 139

  Fly   841 RLLD-------ALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNAN 898
            ||.:       ||.|.:.:.:.:.|..|||:|...:.....|:|:|.||:::.:|:.|.|:|.:.
  Fly   140 RLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQ 204

  Fly   899 ASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRE 963
            ..||..|||||.:|:...||..|.|.:|:..||:.|..|::.|..:.:.|..||.:|.|..:..|
  Fly   205 EYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADE 269

  Fly   964 TISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAK 1028
            |::||.:|..:|: :|....||..|..|||:..|::|||||::.|:|:|..||..:...|.:.:.
  Fly   270 TVAWIAEKDVVLS-SDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSD 333

  Fly  1029 IIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPE 1093
            .||::.|:|...|:.||...:||..||:|:..|||||.|.....:|:...:..:::::....:..
  Fly   334 QIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAG 398

  Fly  1094 AEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMF--LRERLNALKDGWEELHQ 1156
            ||.||.:||..:.|||...:.:|...|.|::|.      :...|..  ::|:|.||::....|..
  Fly   399 AEALLERHQEHKGEIDAREDSFKLTTESGQKLL------EREHYAAAEIQEKLAALENDKSSLLS 457

  Fly  1157 MWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEAN 1221
            :||:|::|..|.:|.|||.||..|.:..:::||.||:.:|...:|:..|..:|:||.|..::.|.
  Fly   458 LWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQ 522

  Fly  1222 DDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEE 1286
            ::||..|...|..|::..|:.||.:.:|.:.:..||...::::..:.:.|::..:..:|.:|.:|
  Fly   523 EEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDE 587

  Fly  1287 LAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVI 1351
            ...|:.||...:.|:||.....::.|..:||.||.|:.|||.|:.:......||.:::....|.|
  Fly   588 TKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQI 652

  Fly  1352 EPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVN 1416
            ..:::|:...::.|...:.:||..|.:|.::....:|.:||:.:::::|.|::|.|...|||||.
  Fly   653 NTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQ 717

  Fly  1417 ILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEP-------IVVKKTAVLERFEKIKA 1474
            .|.:|..:::..:.....::|.|        |....:.||.       |..|:..:..|:..:.|
  Fly   718 NLQKKHALLEADVMAHQDRIESI--------KVAANKFIESGHFDADNIRNKEGNLSARYAALAA 774

  Fly  1475 PLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNH 1539
            |:.||::.|....:..|..||:|||..||.||.|:|.|.:.|..|..|..|.||:|::..||:||
  Fly   775 PMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNH 839

  Fly  1540 EPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQE 1604
            |.|:..:.::|..::.:....:......:..|.::|..||:....|::.|.:|.:..|||.||.|
  Fly   840 EARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANE 904

  Fly  1605 AESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVAR----------QF 1659
            |||||.|:|......|.||||.|::.|:||||.|...:|.:.|||:.|.|.|:          ..
  Fly   905 AESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDI 969

  Fly  1660 SGDD-----------------ISSGD--------------------------------------- 1668
            :|.:                 :..||                                       
  Fly   970 TGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSAS 1034

  Fly  1669 --------AVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAG-S 1724
                    ::|.:|:|::..|..|..||.||:.:|||.::.::|.||..||.|||.|:|..|. :
  Fly  1035 QQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIA 1099

  Fly  1725 QELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSA-TIAEWKDNLNESW 1788
            ..:|:|.:.|.:|.::|::|..|.:| ...|:|.:|.||..|...|.:::| .|.....:|||.|
  Fly  1100 DVVGEDLEEVEVLQKKFDDFNDDLKA-NEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKW 1163

  Fly  1789 QDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGV-SDELGRDAGSVSTLQRKHYNFLQ 1852
            .:|..|...:...|.::.|:.:|..|..:....|.||.:.: :|:||:|..||.||||||....:
  Fly  1164 NNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVER 1228

  Fly  1853 DLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRF 1917
            ||..|..:::|:.|.:.:|..::. |.|::...:::|:...||.:.....|||:||.|:.||.||
  Fly  1229 DLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRF 1292

  Fly  1918 FNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKA----------------------- 1959
            .:..|.|:.|:..::..:.:.|...||:|.|.|:..||:.:|                       
  Fly  1293 LSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIAS 1357

  Fly  1960 ---------EIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQ 2015
                     |||.|...|||....|.|||..|||||.:||:::..|:.:|..|.:.|.||...|:
  Fly  1358 PSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLE 1422

  Fly  2016 LILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERL 2080
            ..|::..:.||..:||:|:.|:|.:|.:.:..:....||.||||||.|:|:....|::.:||:.:
  Fly  1423 QNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTV 1487

  Fly  2081 T---------TFELKEMKRRQEL-----AEEA---ERQRIKEEQEAKAASEAAE----------Q 2118
            .         ...|.:.||:|.|     .:|.   :|.|:.:||..:..|..|:          |
  Fly  1488 ADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQ 1552

  Fly  2119 AKREAERRDDVDVGASHDDSAA--KDTAVEFERVVEIQTERGGTPGAGE--GHEGYVTRK----- 2174
            ...|...:|..::.:.|....|  .:.|...:|:..:....|......:  |.|..|.::     
  Fly  1553 LATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIA 1617

  Fly  2175 HEWDSTTKKASNRSW-------DKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPS-YDLQNAAI 2231
            .:|:..|.|.:.:|.       .:.|:||       .||...:....|.....|.| .||  |::
  Fly  1618 DQWEYLTHKTTEKSLKLKEANKQRTYIAA-------VKDLDFWLGEVESLLTTEDSGKDL--ASV 1673

  Fly  2232 EIASDYTKKKHVLRVKLANGALFLLQAHDD--TEMSQWVTSL--KAQSDSTAVAASR 2284
            :   :..||..::...:.        ||:|  .:|:....||  ..|.|:..:...|
  Fly  1674 Q---NLMKKHQLVEADIV--------AHEDRIKDMNNQADSLVESGQFDTAGIQEKR 1719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723
CH 170..269 CDD:278723
Spectrin 298..408 CDD:278843
SPEC 422..521 CDD:197544
SPEC 525..740 CDD:238103 7/27 (26%)
SPEC 639..846 CDD:238103 37/141 (26%)
SPEC 848..1058 CDD:238103 74/209 (35%)
SPEC 955..1169 CDD:238103 70/215 (33%)
SPEC 1170..1380 CDD:238103 59/209 (28%)
SPEC 1386..1484 CDD:197544 26/104 (25%)
SPEC 1488..1699 CDD:238103 81/284 (29%)
SPEC 1594..1806 CDD:238103 82/287 (29%)
SPEC 1807..2015 CDD:238103 75/240 (31%)
Spectrin 2018..>2078 CDD:278843 21/59 (36%)
PH 2167..2275 CDD:278594 25/124 (20%)
PH_beta_spectrin 2167..2274 CDD:269975 25/123 (20%)
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 2/51 (4%)
SPEC 1074..1287 CDD:238103 70/214 (33%)
SPEC 1182..1425 CDD:238103 76/243 (31%)
SPEC 1426..1638 CDD:238103 48/211 (23%)
SPEC 1533..1744 CDD:238103 39/207 (19%)
SPEC 1646..1850 CDD:238103 20/94 (21%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 66/216 (31%)
SPEC 154..364 CDD:238103 75/210 (36%)
SPEC 261..470 CDD:238103 70/215 (33%)
SPEC 471..680 CDD:238103 59/208 (28%)
SPEC 682..893 CDD:238103 60/218 (28%)
Spectrin 893..>961 CDD:395348 32/67 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439905
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1400at33392
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - P PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.850

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