DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and actn4

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_021337009.1 Gene:actn4 / 322221 ZFINID:ZDB-GENE-030131-940 Length:923 Species:Danio rerio


Alignment Length:817 Identity:292/817 - (35%)
Similarity:444/817 - (54%) Gaps:77/817 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 ESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVD 113
            |..|:||||.|.||||.:...:|.::..|.|||..|:.||||:||||||||.:||||:|.:.||:
Zfish    39 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVN 103

  Fly   114 KALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLW 178
            |||.|:..:.|.|.:||:.:||||||.:.||:||||||||.||||::||.      |||:.||||
Zfish   104 KALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEET------SAKEGLLLW 162

  Fly   179 CQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGL 243
            ||.|||.|.||||:||..||:|||||||:||:|||:|:.::||.|.:.:.||||||:|||..|.:
Zfish   163 CQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIDYDKLRKDDPVTNLNNAFEVAERYLDI 227

  Fly   244 AKLLDAEDVF-VEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFT 307
            .|:|||||:. ...||||:|:|||..:||.||..::......||.||:.:..||:.::.|||...
Zfish   228 PKMLDAEDIVGTLRPDEKAIMTYVSCFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLA 292

  Fly   308 SDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRAN 372
            ||||:||..||..|..|..|.::|.:|.:|..|.:||.:.||||..||..||:...|||:|:|.:
Zfish   293 SDLLEWIRRTIPWLENRAPEKTMAEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLS 357

  Fly   373 NQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSEN 437
            |:..:.|.||:|:||||.||.:||.||...|..|..|:.|.|:|:.||.:|.:||::.|.|....
Zfish   358 NRPAFMPSEGRMVSDINGAWHKLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEGWTDGK 422

  Fly   438 QRLVSQDNF-GFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDN 501
            :.:::|.:: ...|:.::|..|||||.|:|:.|:::||:.:.|:..||....|:|...:..|...
Zfish   423 EAMLTQKDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQK 487

  Fly   502 VMRLWTYLLELLRARRMRLEISLQLQQNFQEM------------------------LYILDNMEE 542
            :...|..|..|.:.||..||.:.:..::..|:                        ::|:.|::|
Zfish   488 ICEQWDALGSLTQNRRESLERTEKQLESIDELYLEYAKRAAPFNNWMEGAMEDLQDMFIVHNIDE 552

  Fly   543 IKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEII- 606
            |:.|:...:..|..:  .:..::...::|   |..|..|:...|..|...::|  |....|:.| 
Zfish   553 IQGLITAHEQFKSTL--PEANKEREAIQA---IQAEVQKIANYNGIKLAGNNP--YTTITPQSID 610

  Fly   607 --VSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEEN----WIKEK-EQI--VSTDE 662
              ..:||||.....:.::..:.|:...:..|:  ||    |::.|    ||:.| |:|  :|.:.
Zfish   611 KKWEKVQQLVPQRDQALQEELTRQQSNDHLRR--QF----ANQANMIGPWIQNKMEEIGRISIEM 669

  Fly   663 VGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILN-KWDHL 726
            .|    |:...|:.....|..|..:.|.:..: :...:||.|.....::......|.|. .|:.|
Zfish   670 NG----TLEDQLTHLSQYEQSIIEYKPNIDQL-EGDHQLIQEALIFDNKYTAYTMEHLRVGWEQL 729

  Fly   727 LDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEAN-VQS------LLKKHK 784
            |.........:||.|    |..||..:....|...| .|.....:|.:. :||      |:....
Zfish   730 LTTIARTINEIENQV----LTRDAKGISQEQLHEYR-TSFNHFDKDHSGLLQSEEFKACLISLGY 789

  Fly   785 DVADELKNYAEVIDALHKQAESL----KLNEAEKANV 817
            ||.::.:....::|:...:|..:    .|.:||.|.:
Zfish   790 DVENDKQKRTGIMDSDDFRALLISTGNSLGDAEFARI 826

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 53/97 (55%)
CH 170..269 CDD:278723 61/99 (62%)
Spectrin 298..408 CDD:278843 50/109 (46%)
SPEC 422..521 CDD:197544 29/99 (29%)
SPEC 525..740 CDD:238103 48/249 (19%)
SPEC 639..846 CDD:238103 45/198 (23%)
SPEC 848..1058 CDD:238103
SPEC 955..1169 CDD:238103
SPEC 1170..1380 CDD:238103
SPEC 1386..1484 CDD:197544
SPEC 1488..1699 CDD:238103
SPEC 1594..1806 CDD:238103
SPEC 1807..2015 CDD:238103
Spectrin 2018..>2078 CDD:278843
PH 2167..2275 CDD:278594
PH_beta_spectrin 2167..2274 CDD:269975
actn4XP_021337009.1 SAC6 38..>402 CDD:227401 190/368 (52%)
SPEC 404..631 CDD:238103 54/233 (23%)
Spectrin 639..742 CDD:306853 25/113 (22%)
EFh_PEF 749..>880 CDD:330173 16/79 (20%)
EFhand_Ca_insen 853..919 CDD:312305
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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