Protein Alignment beta-Spec and Sptb

DIOPT Version :10

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_001420901.1
• Gene: Sptb / 314251
• RGDID: 1303243
• Length: 2329
• Species: Rattus norvegicus
• Alignment Length: 2341
• Identity: 1111/2341 - (47%)
• Similarity: 1540/2341 - (65%)
• Gaps: 75/2341 - (3%)

  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            |||   .|.:      |.|..:||:||||||||||||:|||.||||||||||||||.||:|||:|
  Rat    22 RWD---APDD------ELDNDSSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRISD 77

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||.|:|||:.|||||||||||.||:|||||||||||||||||||||:||||||||:|||||||||
  Rat    78 LYKDLRDGRMLIKLLEVLSGEMLPRPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGN 142

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.||||||||||||||||.::..:.:||:|||||||||||||||||..|||.|||:||:||||
  Rat   143 HRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPQVNVTNFTSSWKDGLA 207

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            |||:||||||||:.|:||..:||.|||.:||||||.:||:..|||.||||.|:|||||||||||.
  Rat   208 FNALIHKHRPDLIDFDKLKDSNARHNLEHAFDVAERQLGIIPLLDPEDVFTENPDEKSIITYVVA 272

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            :||||||:|...|:|||:|||:..|:|.:||:..|....||||.|||.||..|..|:|.|||:||
  Rat   273 FYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSRKFANSLSGV 337

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..||.|||:||||||.|||||||||||:||:|||||||.|||.:||::||||:|||.||:|
  Rat   338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEA 402

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            |::||||||.||||||||||||.||||||:||||||:||||||:|||||:||||||||.||||||
  Rat   403 EYQRELALRSELIRQEKLEQLARRFDRKAAMRETWLNENQRLVTQDNFGYDLAAVEAAKKKHEAI 467

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            |||..||||||:|:..:..|||.|.|||.|||..||:|::|||:||.||||:||.|||.:|.||:
  Rat   468 ETDTAAYEERVKALEDLAQELEKENYHDQKRISARKNNILRLWSYLQELLRSRRQRLEATLALQK 532

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSD 593
            .||:||:.:|.|:|||..:::.::||||:.||||||||.|:||||.|.|::||.:...:.:|  .
  Rat   533 LFQDMLHSIDWMDEIKAHILSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKTITAATLQF--T 595

  Fly   594 DPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIV 658
            :.:.|:||||::|..||..||..::||..:|..|:::||:|::||:|:|:..:.|:||||||||.
  Rat   596 EGKGYQPCDPQVIQDRVSHLEQCFSELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660

  Fly   659 STDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723
            |:.:.|.|||:|.::..||||.|.|:...|..|:.:.:...:::.:..||..:|:.|:||:..:|
  Rat   661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLKQIFQEAEDMVAQKQFGHPQIETRVKEVSAQW 725

  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD 788
            |||.:|..:|::.|::|..:||...||||:..|:.|..|::|.||||:||...::|.||||:..:
  Rat   726 DHLKELAAFRKKDLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKEFLE 790

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMS 853
            ||:....|::.|..||:.......:..:|..||:|:...|:::...|:||..:|.:||.||.:..
  Rat   791 ELEESRGVMEHLENQAQGFPEEFRDSPDVTNRLQALRKLYQQVMAQAELRGHKLQEALDLYTVFG 855

  Fly   854 EADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP 918
            |:|..|.|:.||.|.||.|.....:||:|:::|||:..|:||....:::..||..|..|:...||
  Rat   856 ESDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDILDQEMKTLMAQIDGVNLAANNLVESGHP 920

  Fly   919 NSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEM 983
            .|.|:.:.|:.||:.|...:.....:.:.:.||..|..:.::|.||..||.||.:::..|..|..
  Rat   921 RSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETSKWIVDKTKVVESTKDLGQ 985

  Fly   984 DLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048
            ||.||:.:||:|||::||:.||:.::|:||||:..:.:.||::.:.|.:|.|.:|.:|:.|...|
  Rat   986 DLAGVIAIQRKLSGLERDVLAIRDRVSALERESQYLMESHPDQKEDIGQRQADVEKMWKGLQDAL 1050

  Fly  1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113
            :.::..|.||..|..||:|||.|:.||:..|..|||||.|.||||||:||.||.:|:||||.:.:
  Rat  1051 QGQELSLGEASKLQAFLQDLDDFKAWLSMAQKAVASEDMPESLPEAEQLLQQHAAIKEEIDAHKD 1115

  Fly  1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDA 1178
            ||..:...||::. ||.|  ||.|..|.:||..|...|:.|.:|||:|...|:|.|..|.|.:||
  Rat  1116 DYHRVKASGEKVI-EGQT--DPDYQLLGQRLEGLDTDWDALWRMWESRGNTLTQCLGFQEFQKDA 1177

  Fly  1179 RQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDA 1243
            :|.|.:||.||:.|:..:.|.:|..||..:::.|.||.:||.|.||:.:.:...:.||.:.:..:
  Rat  1178 KQAEAILSNQEYTLAHLEPPDSLAAAEAGIRKFEDFLVSMENNRDKVLSPVDSGNMLVSEGNLYS 1242

  Fly  1244 DKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKT 1308
            :||.::.:.|..|...|.::|.:....||:.::|..|||:.:||..|:.:|..||.|.||..|:.
  Rat  1243 NKIKEKVQLIEDRHMKNNEKAQEVTALLKDNLELQNFLQNCKELTLWINDKLLTSPDISYDEARN 1307

  Fly  1309 IHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKG 1373
            :|:||.:||||.||:|:::..|.......::|..|||:|.||:..:|:.|.|.:|:|:..||.|.
  Rat  1308 LHNKWMKHQAFMAELASHQGWLENIVAEGRQLMAEKPQFTDVVSERLEALHKLWDELQTTTKAKT 1372

  Fly  1374 AMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEE 1438
            ..|..|....|..||..|:..:|:.:|.|:.|.|...|||:||.::.|.:.::.|:.::..::||
  Rat  1373 EQLSAARSSDLRLQTHADLSKWISAMEDQLRSDDLGKDLTTVNRMLVKLKRVEEQVNLRKEELEE 1437

  Fly  1439 IDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWI 1503
            :..:...|.....:..:        ::.:||..:..||..|:|.||..|...|..||:|||.||:
  Rat  1438 LFAEAPPLGAEAGDTDM--------SIEKRFLDLLEPLGRRKKQLELSKAKLQISRDLEDETLWV 1494

  Fly  1504 DEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALI 1568
            :|:||:|.|.|||.:|..|.:..||||:|..||..|.||:..:.:.|::|:.....|.:..|..:
  Rat  1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHAPRVEDVLHRGQELVKAAEIDCQDIEERL 1559

  Fly  1569 SDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMK 1633
            ..|...|..|::|...|.:.|.|:.:.|||:.||.|||:|:||||||:..::..|||..|..::|
  Rat  1560 GHLQSSWDTLREAAAGRLQRLREAHEAQQYYLDAGEAEAWISEQELYVFSDEPPKDEEGAIVMLK 1624

  Fly  1634 KHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEA 1698
            :|...:::||:|...|:||...|:.........|:.:...|.|:||.||||||:|.|||.:|...
  Rat  1625 RHLRQQRTVEEYGRNIKQLAGRAQSLLSAGHPEGEQIIRLQGQVDKQYAGLKDMAEERRRKLENM 1689

  Fly  1699 LQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIA 1763
            ..||.|.||.||||||||::|:||.|||:||||||||:|.::|.:|||:|.|:|.|||..||.|.
  Rat  1690 YHLFQLKREADDLEQWITEKEMVASSQEMGQDFDHVTMLRDKFRDFARETGAIGQERVDNVNSII 1754

  Fly  1764 DNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828
            :.||.||||::||||||||.||:.|.||||||:||.|:||||.:||::|:...::||.|.||...
  Rat  1755 ERLIDAGHSEAATIAEWKDGLNDMWADLLELIDTRMQLLAASYDLHRYFYTGTEILGLIDEKHRE 1819

  Fly  1829 VSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHA 1893
            :.:::|.||.:..:..|.|..|.::|..|..||||.|:.:.:||.||||:||..|.::||||..|
  Rat  1820 LPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAA 1884

  Fly  1894 WDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLK 1958
            |..|...|..|:.:|.||.|.||||:|||.|:.|||.::||:.|.|:|||||.||||:..||.:|
  Rat  1885 WQALLDACAGRRAQLVDTADKFRFFSMVRDLLSWMESIIRQIETQERPRDVSSVELLLKYHQGIK 1949

  Fly  1959 AEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQF 2023
            |||:||..||..|:.||:.||.|.|.||.:|:::|..:.:.|..:..:||.|.:.|.::|||.||
  Rat  1950 AEINTRAKNFSTCLELGESLLQRQHQASDEIREKLQQVISRRQEMNDKWEARSDRLHMLLEVCQF 2014

  Fly  2024 ARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEM 2088
            :|||:|||||||||||||.|.:.|||:|.||.|||:|||||||.|:..|||:|||:.||.||||.
  Rat  2015 SRDASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKER 2079

  Fly  2089 KRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVD-------------VGASHDDSAA 2140
            :......||...|    |:|.:.|.||.:......||....:             :...|.|...
  Rat  2080 QTPDRPTEEPGPQ----EEEGETAGEAPQVHHAATERTSPGEERGPWPQDLQPPPLPGHHKDEQE 2140

  Fly  2141 KDTAVE------FERVVEIQTERGGTPGA-----GEGH----EGYVTRKHEWDSTTKKASNRSWD 2190
            |....|      ..:|::.....|..|..     ..||    |||:.|||:.:...||||||||:
  Rat  2141 KSVGDERPATEPLFKVLDTPLSEGDEPTTLPAQRDLGHTVQMEGYLGRKHDLEGPNKKASNRSWN 2205

  Fly  2191 KVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFL 2255
            .:|...:..:::||||.|.....  :.:.||....|::|..|||.:|.|||||.:::|:||:.:|
  Rat  2206 NLYCVLRNSQLTFYKDAKNLALG--VPYHGEEPLALRHAICEIAVNYKKKKHVFKLRLSNGSEWL 2268

  Fly  2256 LQAHDDTEMSQWVTSLKAQSDSTAVAASRS-----QTLPATS---------QKDEPKRRSFFTLK 2306
            ....|:.||..|:     |..|||:..|:|     |:||..|         :||:.||.|||..|
  Rat  2269 FHGKDEEEMLLWL-----QGMSTAINESQSIRVKAQSLPLPSLAGPDASVGKKDKEKRFSFFPKK 2328

  Fly  2307 K 2307
            |
  Rat  2329 K 2329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	99/115 (86%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	77/103 (75%)
		Spectrin	298..408	CDD:395348	75/109 (69%)
		SPEC	422..521	CDD:197544	72/98 (73%)
		SPEC	525..740	CDD:238103	90/214 (42%)
		SPEC	639..846	CDD:238103	75/206 (36%)
		SPEC	848..1058	CDD:238103	73/209 (35%)
		SPEC	955..1169	CDD:238103	92/213 (43%)
		SPEC	1170..1380	CDD:238103	74/209 (35%)
		SPEC	1386..1484	CDD:197544	24/97 (25%)
		SPEC	1488..1699	CDD:238103	83/210 (40%)
		SPEC	1594..1806	CDD:238103	114/211 (54%)
		SPEC	1807..2015	CDD:238103	92/207 (44%)
		Spectrin	2018..>2078	CDD:395348	43/59 (73%)
		PH_beta_spectrin	2167..2274	CDD:269975	42/110 (38%)
Sptb	NP_001420901.1	CH_SPTB-like_rpt1	40..156	CDD:409095	99/115 (86%)
		CH_SPTB_rpt2	170..281	CDD:409168	83/110 (75%)
		Spectrin	302..411	CDD:395348	74/108 (69%)
		Spectrin	422..526	CDD:395348	76/103 (74%)
		SPEC	530..742	CDD:238103	90/213 (42%)
		SPEC	641..848	CDD:238103	75/206 (36%)
		SPEC	745..954	CDD:238103	72/208 (35%)
		SPEC	962..1168	CDD:238103	92/208 (44%)
		SPEC	1170..1379	CDD:238103	74/208 (36%)
		SPEC	1385..1475	CDD:197544	24/97 (25%)
		SPEC	1485..1690	CDD:238103	82/204 (40%)
		SPEC	1691..1901	CDD:238103	111/209 (53%)
		SPEC	1798..2005	CDD:238103	92/206 (45%)
		SPEC	2013..>2086	CDD:197544	48/72 (67%)
		PH_beta_spectrin	2182..2287	CDD:269975	43/111 (39%)