DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and Sptbn4

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_008757363.1 Gene:Sptbn4 / 308458 RGDID:1304682 Length:2609 Species:Rattus norvegicus


Alignment Length:2553 Identity:1025/2553 - (40%)
Similarity:1435/2553 - (56%) Gaps:290/2553 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWD-PSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIA 72
            ||: |.:|     .|.......|:::.|||.|||||||:|||:||||||||||||||.||.|.|.
  Rat    73 RWESPDRG-----WDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIG 132

  Fly    73 DLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDG 137
            |||.|:|||..|.:||||||||:||:||:|:||||.|||||||||||:||||||||:||||||||
  Rat   133 DLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDG 197

  Fly   138 NASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGL 202
            |..|.|||:||||||||||.|.||..||:||:|||||||||||||||||..||::||||||||||
  Rat   198 NHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGL 262

  Fly   203 AFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVV 267
            ||||:||:||||||...||:|:||.:||..||..||..||||:|||.|||.:|.|||||||||||
  Rat   263 AFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVV 327

  Fly   268 TYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAG 332
            ::||||||:|...|:|||||||:...:|.||::..||...::||.||..|:..:..::|.|||:|
  Rat   328 SFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSG 392

  Fly   333 VQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEK 397
            ||.||..|:.|.|:|||.||.||||||||||::|||:||:|::.:.|:||..|.||:|||..|||
  Rat   393 VQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEK 457

  Fly   398 AEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEA 462
            ||||||.|||.|||||||||.||.|||.|.:|||:||:||||||||||||::|.|||||.|||||
  Rat   458 AEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEA 522

  Fly   463 IETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQ 527
            ||.||.|||||||.|..:...|.:|.|:|.:|:..::|:|:|.|..|..|:.|||.|||.:|.||
  Rat   523 IEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQ 587

  Fly   528 QNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLS 592
            :.||||:|::|.|||::..|::.:.|:||:..:||||||.|:|.||....|||:.:  |:.....
  Rat   588 KVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEAL--NAAALRF 650

  Fly   593 DDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQI 657
            ...:.|:||||::|.:||..:....:||...|..||:.||.||.||....:..:.|:|.::||::
  Rat   651 SQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 715

  Fly   658 V-STDEVG---------HDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHF---GA 709
            : :|...|         |||::...:|::||.|:.|:......||...:.|.||...|..   ||
  Rat   716 LEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGA 780

  Fly   710 D-----RIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDV 769
            :     .:.:|......:|..|.:....|.:||:.|....|..||.|.:.:|:.|..|:.::.|.
  Rat   781 EPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDF 845

  Fly   770 GRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKAN-----VDKRLEAIDNRYK 829
            |.|||:.:.|.::|:.:..|::.:...:..|.:|..:  |..|..|.     :..|:...:..:.
  Rat   846 GHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLAT--LGGASGAGPLVVALQVRVVEAEQLFA 908

  Fly   830 ELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKE 894
            |:||:|.||:|.|.|||::|::..|....|.||.||.:.|..|.....::|||:::||||..|:|
  Rat   909 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQE 973

  Fly   895 MNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYI 959
            ||:...||..|||..::|:...||:|||:...|:|||..|:.:.|..|.:.:::.:...|:...:
  Rat   974 MNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVL 1038

  Fly   960 ECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHP 1024
            |..|..:.:.:|:|      ::|........||.||||::..|.|::.:.::|..||..:.:..|
  Rat  1039 EVAEVRAQVREKRR------AVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFP 1097

  Fly  1025 EEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASED--T 1087
            .:|..:.:...::...|..|....:.....:..||.|.|||||||.|..||.:.|....:.:  .
  Rat  1098 AQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPL 1162

  Fly  1088 PTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWE 1152
            |.||.||:.||.:|.:::||:|...|||..::...|.|.:.......|. :.|.|.|..|:.||.
  Rat  1163 PRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASDGAELGPG-LALDEWLPHLEVGWH 1226

  Fly  1153 ELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTT 1217
            :|..:||.|:..|.|:...|||.||..|...:|..||..||..:.|..:|..|..:|||..||||
  Rat  1227 KLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTT 1291

  Fly  1218 MEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQ 1282
            ||.|..|:...:|.|:.|:.:.:...::..:....:..:..:|:.||....:||.:|:.|..||:
  Rat  1292 MELNQQKMQVAVQAAEGLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLR 1356

  Fly  1283 DLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEF 1347
            |..||..|:.||...::|.:...:..:|.:|.|||||.||:|.|||.|.:.|:..|:|.:||||.
  Rat  1357 DCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPEL 1421

  Fly  1348 KDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDL 1412
            ...:..||.|:.:.:.:||..|:.|...||:|::...:.|:..::|..:..:|.|:...|...||
  Rat  1422 AASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGDL 1486

  Fly  1413 TSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVV--KKTAVLERFEKIKAP 1475
            .:||..::|.|.:::|:....|:|.|:..||..|    |.|:....:|  :::||.||..::..|
  Rat  1487 ATVNSQLKKLQSMESQVEEWCREVGELQAQTAAL----PLEQASKELVGERQSAVGERLVRLLEP 1547

  Fly  1476 LLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHE 1540
            |.||::.|...||..|...|::||..|:.|:||:|...:.|..|..|....||||.|..||..|.
  Rat  1548 LQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMLTERGTGLQAVQQHIKKNQGLRREIQAHG 1612

  Fly  1541 PRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEA 1605
            ||:..:......|......:|:........|...|..|::|.|.|::.|..:.:|:||:||..|.
  Rat  1613 PRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREATERRQQTLDAAFQVEQYYFDVAEV 1677

  Fly  1606 ESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAV 1670
            |:|:.||||.||.||:||||.|...|:|||..|||.||:|..:|.||....|..........:.:
  Rat  1678 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI 1742

  Fly  1671 AVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVT 1735
            :.:|||:|:||..||:|..|||..|.:...|:.|||:||:||.||.::||||||.||||||:||:
  Rat  1743 SRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHVS 1807

  Fly  1736 LLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQ 1800
            :|.|:|:|||.:|...|.||:|.||.:.|.||:.||:.:||:|||||.|||:|.:||||:.||.|
  Rat  1808 VLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 1872

  Fly  1801 MLAASRELHKFFHDCKDVLGRILEKQHGVSDELGR------DAGSVSTLQRKHYNFLQDLITLYS 1859
            :|||||||||||.|.:::.|:|.||:.    .|.|      ...|.|::||....|..||..|.|
  Rat  1873 LLAASRELHKFFSDARELQGQIEEKRR----RLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVS 1933

  Fly  1860 QVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRIL 1924
            ||:|:||.:|:|:..|||:.|:.|.:||||||..|..|.|.|:..:..::.|.|..||.:..|.|
  Rat  1934 QVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARDL 1998

  Fly  1925 MIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADI 1989
            :.||:.:..|:..::||||||.||:|||.||.||.|::.|.....||..||:.||......:.:|
  Rat  1999 LSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTACQELGRSLLLNKSAMADEI 2063

  Fly  1990 KDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVE 2054
            :.:|..|.:.:..:..:|:..||.||.:|||:|||::|.||:|||.||||.|.|.|||.::||||
  Rat  2064 QAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVE 2128

  Fly  2055 NLIKKHEAFEKSAAAQEERFSALERLTTFE-LK-------------------------------- 2086
            .||::||||.|:|||.|||||:|.||||.| ||                                
  Rat  2129 QLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLR 2193

  Fly  2087 --------------------------------EMK------------------------------ 2089
                                            |:|                              
  Rat  2194 PGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALDT 2258

  Fly  2090 -----------------RRQELAEEAE---RQRIKEEQEAKAASEAAEQAKREAERRDDVDVGAS 2134
                             .|||||:.||   |:|..|.||:....|.|.: :|..||::..|....
  Rat  2259 TDTPGTPAVTEQVRPRPERQELADRAEELPRRRRSERQESTDQPEEAAR-RRRPERQESADHEGP 2322

  Fly  2135 H-----------------------DDSAAKDTAVEFERV---------VEIQTERGGTPG----- 2162
            |                       .:|:.::|....|.|         ||...|:...||     
  Rat  2323 HSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGLPAAV 2387

  Fly  2163 ----------------------------------------------AGEG--------------- 2166
                                                          .|||               
  Rat  2388 PSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGS 2452

  Fly  2167 -------------HEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTF 2218
                         |||::.||.|.|: .:|:|||||..:|.....|.:.||||.||..|..  |.
  Rat  2453 APAPPPPPTHTVQHEGFLLRKRELDA-NRKSSNRSWVNLYCVLSKGELGFYKDSKGPASGG--TH 2514

  Fly  2219 RGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAAS 2283
            .|||...|..|..|:||||.|||||.:::..:|:.|||||.|:.||:.|:.::.......|..|.
  Rat  2515 GGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIAR 2579

  Fly  2284 RSQTLPATSQKDE--PKR 2299
            ..||||.||..||  |||
  Rat  2580 WGQTLPTTSSTDEGNPKR 2597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 76/97 (78%)
CH 170..269 CDD:278723 74/98 (76%)
Spectrin 298..408 CDD:278843 61/109 (56%)
SPEC 422..521 CDD:197544 59/98 (60%)
SPEC 525..740 CDD:238103 76/232 (33%)
SPEC 639..846 CDD:238103 59/229 (26%)
SPEC 848..1058 CDD:238103 59/209 (28%)
SPEC 955..1169 CDD:238103 63/215 (29%)
SPEC 1170..1380 CDD:238103 74/209 (35%)
SPEC 1386..1484 CDD:197544 29/99 (29%)
SPEC 1488..1699 CDD:238103 80/210 (38%)
SPEC 1594..1806 CDD:238103 111/211 (53%)
SPEC 1807..2015 CDD:238103 82/213 (38%)
Spectrin 2018..>2078 CDD:278843 40/59 (68%)
PH 2167..2275 CDD:278594 48/107 (45%)
PH_beta_spectrin 2167..2274 CDD:269975 48/106 (45%)
Sptbn4XP_008757363.1 CH 111..214 CDD:237981 81/102 (79%)
CH 230..333 CDD:237981 76/102 (75%)
SPEC 361..584 CDD:238103 133/222 (60%)
SPEC 479..693 CDD:238103 108/215 (50%)
SPEC 819..1031 CDD:238103 70/213 (33%)
SPEC 1135..1239 CDD:197544 38/104 (37%)
SPEC 1245..1453 CDD:238103 74/207 (36%)
SPEC 1351..1558 CDD:238103 71/210 (34%)
SPEC 1560..1771 CDD:238103 80/210 (38%)
SPEC 1666..1878 CDD:238103 111/211 (53%)
Spectrin 1878..1977 CDD:278843 45/102 (44%)
SPEC 1987..>2154 CDD:238103 80/166 (48%)
PH 2464..2566 CDD:278594 48/104 (46%)
PH_beta_spectrin 2466..2570 CDD:269975 48/106 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 183 1.000 Domainoid score I3341
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52262
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.930

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