DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and Sptbn5

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_038962422.1 Gene:Sptbn5 / 296090 RGDID:1311047 Length:3602 Species:Rattus norvegicus


Alignment Length:2372 Identity:625/2372 - (26%)
Similarity:1109/2372 - (46%) Gaps:209/2372 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 FERSRIKALAEERESVQKKTFTKWVNS--HLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPK 98
            :|...::.|..:...:|:|||..|:|:  .|.||..||.:||.::.||.||::|||::|||.||.
  Rat    61 YEIGHVRKLQAQHTHMQEKTFINWINNIFRLGRVGIRIQNLYTELADGAHLLRLLELISGEALPA 125

  Fly    99 PTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEV 163
            |:.|::|:|.|||...||.||| .:|.:..||..:||||:.||.|||:|.|||||||..|:::..
  Rat   126 PSPGRLRVHFLENNSHALAFLR-AKVPVPFIGPENIVDGDQSLILGLLWVIILRFQISHISLDRE 189

  Fly   164 D---NKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTN 225
            :   :....|||:|||:|||.:||.|.||::.:|:.||.|||||||::|.|||||:.:..||...
  Rat   190 EFGASAALLSAKEALLVWCQRQTASYSNVDITDFSRSWSDGLAFNALLHAHRPDLLDYGSLSLDR 254

  Fly   226 AIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVV 290
            .::||:.||.|||.:||:|:|||||||...||||:||:|||..||||||:|:|.....:|:.||:
  Rat   255 PLYNLSFAFRVAEQQLGIAQLLDAEDVAARHPDERSIMTYVSQYYHYFSRLQQGQTARRRLAKVL 319

  Fly   291 GIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEK 355
            ....|.:.:...||...:|||.|||.....|..::|.:||..::..|:.|:::|..||||:..::
  Rat   320 LQLQETEVLQAQYEQLAADLLCWIEEKQMQLEAQDFPDSLPAMRQLLSAFASFRAQEKPPRLQQQ 384

  Fly   356 GNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLA 420
            |..|.|||.||:.:||.|::|:.|:||...:::.:.|..||:.|..|..|::::|::.|:|:.||
  Rat   385 GASETLLFQLQTTLRAQNRRPFLPREGLGPAELAQCWAELERVEASRSQAMQQKLLQLERLDTLA 449

  Fly   421 ARFDRKASMRETWLSENQRLVSQDNFGF-DLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDEL 484
            .||..|||.||::|::.::::.|..... |.|.||||.::...:|..:...|.|.||:..:.|.|
  Rat   450 RRFQCKASHRESFLNDAEQMLEQARASLTDPATVEAATQRLNMLEAGLLPQEGRFQALGEMADIL 514

  Fly   485 ESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMT 549
            :.|.||....:..|:..:...|..||:.|:..|..|..:..:....||:....|.:.|::.|..:
  Rat   515 QQEEYHSWADVACRQKEITGRWRRLLQCLQEERKCLAGTQAVLSLLQEVEAATDQLGELQGLAGS 579

  Fly   550 DDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLE 614
            ......|..|..|||.|.|:||.::.....|..:|..:.:.     :|.:....:.:.::...|:
  Rat   580 TACEPQLAEVVLLLQSHDLLEAQVSAHRTHVNRLVHQTAQL-----DSSQGTSVQTLQTKALALD 639

  Fly   615 DAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKA 679
            :.:..||.|...||:.||::.:..||.....:||.|::|..|:|.....|.|||.:...|.||||
  Rat   640 ELHHSLVSLVRTRRTLLEQTLQRAQFLHSCEEEEAWLQEHRQLVEKAAPGRDLTQIANALQKHKA 704

  Fly   680 LESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYF 744
            ||:|:..|.....::.:.|..|..:.........:|.:.:...|..|......||.||:.|:...
  Rat   705 LETELHRHQAVCIDLMQRGRNLSVKEPLTQPDPLERAEAVQGIWQLLWTGAARRRTRLQTALLVG 769

  Fly   745 QLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD----------ELKNYAEVIDA 799
            |.|:|..:..:|:|...:.:.|...|:|:::.::||::|..:..          ||::.|....|
  Rat   770 QYFSDLAEAASWLLQRQKQLESASYGKDQSDSEALLQQHLRLEQGLCAFAVDLRELEDQARAAAA 834

  Fly   800 LHKQAESLKLNE------------------------AEKANVDKRLEA---------IDNRYKEL 831
            |..|.......|                        |.:|..|...::         :...|:.|
  Rat   835 LVSQMVHTGTREGPRHVPPTPNVLSALGLPGEDPRTAPQAEYDFHFDSNAILQAQADLRQNYENL 899

  Fly   832 TELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMN 896
            ..||||.:.||.:.::|:...|....::.|::.:|.:..|:.|..|  ::|:.:.::|.....:.
  Rat   900 RALAKLHRARLEETVTLFSFYSSCRELQSWLEAQTALFQTLQPQGD--NLEVTQLKYENVLMTLA 962

  Fly   897 ANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIEC 961
            ............|.||......:..:|.::|..|...|..|....|.|:..|..|..|.:...|.
  Rat   963 TGKGHWEEAISTAEQLKQRCPGHISKIQQQQEELKHRWQQLEALKEEKLLQLTRAMEVCSLLQES 1027

  Fly   962 RETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSG-MDRDLAAIQAKLSSLEREANSIEDEHPE 1025
            ..|      :.::|:....||       .|..|.|| ..|.|...|.|:..||::.:..:....|
  Rat  1028 EPT------RAQLLSVISRLE-------ALGTRSSGDSHRTLQQTQQKVLVLEKKISYCQKATIE 1079

  Fly  1026 EAKIIRERIAQIELIWEQ---LTQMLKERDSKLEEAGDLHR-------FLRDLDHFQTWLTKTQT 1080
               ::....|:..|:|||   |..:||:...::.:...:..       .|::......|....|.
  Rat  1080 ---LMESGPAEGRLLWEQVLMLQSLLKQAQGQVAQQVQVQTKDRVQRGILQESQKLLLWAEGIQA 1141

  Fly  1081 DVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLN 1145
            .:.|::....:..|::||.:|.::|||...:.|..:.:...|:.:...||    ||:..:...|.
  Rat  1142 QLCSKEQLEDVASAQQLLRKHGALREETCLWKERLQQLEAQGQLVAVSGS----PQFQEVASALR 1202

  Fly  1146 ALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKR 1210
            .|....::|..:||.||..|...|:.|.|.::........:..|..|..|:...::.:|::.|::
  Rat  1203 LLGQHSQQLKALWEQRQQKLWAGLELQRFGQEVDSFTATCASHEASLQLDNLGEDIREAQSLLQQ 1267

  Fly  1211 HEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQV 1275
            |:.......:...:..||....:.|:........:|.:...:...:....::|:..:..:|...:
  Rat  1268 HQGLGWLHSSLGSRAETLWARGEKLLLNHPTAVHRIRELLHSAQAQWARVQERSDQRRGQLLASL 1332

  Fly  1276 KLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQEL 1340
            :|.|:.|..|.|..|::||:....||..::...| .:|  |:..::|:.|:.:.:.:.:::.:||
  Rat  1333 QLQEWKQAAEGLMLWMEEKWPRVADEGPQTGSNI-LQW--HKITKSELLASHKYMEDLQQTGKEL 1394

  Fly  1341 SKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVS 1405
            ....|..::.|:.:|:.|..::::|...|.|:|..|....::..:.:...|:...:..||..:.|
  Rat  1395 LHSNPYAQEDIQDRLQSLNHKWEELSHKTAEQGDRLPQTRQQGQLLELLQDVRGMMEHLEGALQS 1459

  Fly  1406 GDTANDLTSVNILMQ-------KQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKT 1463
            .:|..||.|...|..       |.|.:.::||....|...:     :...|:.||        ..
  Rat  1460 TETGQDLCSSRRLQTQHRQLEGKSQALASKMAALISQTHNV-----FTSWTILEE--------SQ 1511

  Fly  1464 AVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDY-GNSLFNVHVLKK 1527
            ...:||:.:::.|..||:.|:...|..:|......|..|:.|.:| :.||.| .....:...|::
  Rat  1512 KCQQRFKSLQSKLATRQQQLQASVELHKFNLLSNLELTWVAEHMP-STSPIYPAQCWHDAQSLQR 1575

  Fly  1528 KNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLES 1592
            |::.|..|:..|...::.:.:.|:.|...||..|:........|...|.||:.|.|.|...|.::
  Rat  1576 KHKVLQAEVKGHVGHMHRVLSTGQSLAASGHPQAQHILEQCQKLEGHWAELEQACEGRAHCLQQA 1640

  Fly  1593 EKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVAR 1657
            ...|:|..:..|.|:|:.|:...:...|.|.:|.:...|::||:.|.|.:.....::..|.:..:
  Rat  1641 VIFQRYLLNVSEMETWVEEKLPLVSSRDYGSNEEATFGLIRKHQMLRQEIALCWGSMEDLEQRFQ 1705

  Fly  1658 QFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDR-EVV 1721
            ..:|.: :|...|.|:    :||.| |:.||.:|...|...|:|....||.:||:.|:..| :||
  Rat  1706 TLAGFE-ASERLVVVR----EKLQA-LQKLADDRGQELEGTLRLHEFMREAEDLQSWLDSRKQVV 1764

  Fly  1722 AGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNE 1786
            .|....|:|.:||..|...|.:|....| .|.:||.....:|::|::.|||.:....:.:.:|..
  Rat  1765 RGEHGFGEDHEHVLQLCTEFTKFQHQVE-TGAQRVETCRQLAESLLELGHSAAHKSHQRQQDLQA 1828

  Fly  1787 SWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFL 1851
            :|.:|.:|.:.:..:|:.:....:...|..::|.:|.||...:.:::.:|...|....::|....
  Rat  1829 AWCELWQLTQAQGLLLSDAETTLRVHRDLLEILSQIQEKATNLPNDVAQDLHGVEKQLQRHEGLE 1893

  Fly  1852 QDLITLYSQVQQIQEESAKLQ----DAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTG 1912
            ::|..:..|:|::.:....:|    .|.|     .:..::|.|..||:.||...:.||.:|....
  Rat  1894 RELAGMEQQLQELLKAGGNVQKLCPQALA-----TVQQKQQAVTQAWEALQLRMEQRKAQLEQAY 1953

  Fly  1913 DLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKE 1977
            .|.||...||....|:..:..::...:...:.|.:.|.:..||.|.||:..||:.......:|::
  Rat  1954 LLVRFHTAVRDYTSWVASVHLELQMEDDSWEPSSILLRLRAHQWLWAELKAREELQEQGTKMGQQ 2018

  Fly  1978 --LLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPY 2040
              |:.|   ....::|.|.||...|:.:.:.|..:.|.||..|:..:..|........|.|||.:
  Rat  2019 ALLVAR---TPTKVQDGLQTLQEKRDQVFQAWALKQERLQATLQEQRLLRQGDHLVKLLTAQEAF 2080

  Fly  2041 LLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSAL-ERLTTFELKEMKRRQELAEEAERQRIK 2104
            |.:|.||.:::|||.||:|...|:|..|.|:::.||| |:|   ::....:.|.|....:.:|.:
  Rat  2081 LKASGLGSSVEEVEQLIRKLVIFQKVLALQDKKESALCEQL---KMIPSPKGQNLVYHVQERRAQ 2142

  Fly  2105 EEQEAKAASEAAEQA------KREAERRDD------VDVGASHDDSAAKDTAVEFER----VVEI 2153
            .::.|::..:|...:      .|.|.:.:|      ..:.|.......||......:    ..|:
  Rat  2143 VKELAESRGQALRTSLMIGNFTRTATQVEDWIQERLQQLRACSPLGNLKDYLKHLRKHQAFRAEV 2207

  Fly  2154 QTERGGTPGAGEGHEGYVTRKHE------------WDSTTKKASNRSWDKVYMAAKAGRISFYKD 2206
            |..........:..||.:::.|.            ||         .|:|:..|           
  Rat  2208 QAHEQIVTSVAKQGEGLLSQSHPQAREVSQRLEALWD---------LWEKLRQA----------- 2252

  Fly  2207 QKGYKSNPELTFRGEPSYD-------LQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEM 2264
                     :|.:|:...|       ||:|  ::|..:.::|.    ::.:|....|......::
  Rat  2253 ---------VTLQGQALEDRCNFLEFLQSA--DLAETWIQEKE----RMVDGCDVGLNLEHCLQL 2302

  Fly  2265 SQWVTSLKAQSDSTAVAASRSQTLPATSQKDE 2296
            .:.|..|:...|.|.:...::.:|...:|..|
  Rat  2303 CRQVCKLQVTVDDTRIRRIKNLSLQLKNQGPE 2334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 50/99 (51%)
CH 170..269 CDD:278723 58/98 (59%)
Spectrin 298..408 CDD:278843 39/109 (36%)
SPEC 422..521 CDD:197544 31/99 (31%)
SPEC 525..740 CDD:238103 55/214 (26%)
SPEC 639..846 CDD:238103 60/249 (24%)
SPEC 848..1058 CDD:238103 46/213 (22%)
SPEC 955..1169 CDD:238103 49/224 (22%)
SPEC 1170..1380 CDD:238103 40/209 (19%)
SPEC 1386..1484 CDD:197544 22/104 (21%)
SPEC 1488..1699 CDD:238103 54/211 (26%)
SPEC 1594..1806 CDD:238103 59/212 (28%)
SPEC 1807..2015 CDD:238103 48/213 (23%)
Spectrin 2018..>2078 CDD:278843 23/60 (38%)
PH 2167..2275 CDD:278594 20/126 (16%)
PH_beta_spectrin 2167..2274 CDD:269975 20/125 (16%)
Sptbn5XP_038962422.1 CH_SPTBN5_rpt1 57..181 CDD:409096 57/120 (48%)
CH_SF 196..304 CDD:412120 63/107 (59%)
SPEC 331..548 CDD:413338 74/216 (34%)
SPEC 448..660 CDD:238103 59/216 (27%)
SPEC 664..>831 CDD:238103 45/166 (27%)
SPEC 770..1018 CDD:238103 49/249 (20%)
SPEC 1126..1222 CDD:197544 24/99 (24%)
SPEC 1227..1432 CDD:238103 40/207 (19%)
SPEC 1333..1534 CDD:238103 49/216 (23%)
SPEC 1536..1738 CDD:238103 53/208 (25%)
SPEC 1742..1953 CDD:238103 54/216 (25%)
SPEC 1852..2058 CDD:238103 50/213 (23%)
SPEC 2059..2262 CDD:238103 47/234 (20%)
SPEC 2163..2368 CDD:238103 33/207 (16%)
SPEC 2371..2566 CDD:238103
SPEC 2472..2681 CDD:238103
SPEC 2684..2894 CDD:238103
SPEC 2895..3106 CDD:238103
SPEC 3001..3213 CDD:238103
Spectrin 3213..3320 CDD:395348
SPEC 3325..>3488 CDD:238103
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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