DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and Sptbn2

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	XP_008758314.1	Gene:	Sptbn2 / 29211	RGDID:	3751	Length:	2395	Species:	Rattus norvegicus

Alignment Length:	2401	Identity:	1140/2401 - (47%)
Similarity:	1562/2401 - (65%)	Gaps:	139/2401 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SQGPGN------EYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRI 71
            ||.||.      .:|:..:|     :|.|  ..|.|.|.:|||:||||||||||||||.||.||:
  Rat    28 SQNPGGILLSPAAFINPAQY-----ASVL--EGRFKQLQDEREAVQKKTFTKWVNSHLARVTCRV 85

  Fly    72 ADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVD 136
            .|||.|:|||::|::||||||||.|||||||:||||||||||||||||:||:|||||:|||||||
  Rat    86 GDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVD 150

  Fly   137 GNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDG 201
            ||..|.|||:||||||||||||::|..||||.||||||||||||||||||.||||.|||||||||
  Rat   151 GNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDG 215

  Fly   202 LAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYV 266
            ||||||:|||||||:.||.|.|.||.:||.|||::||.:|||.||||.|||.|:.||||||||||
  Rat   216 LAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYV 280

  Fly   267 VTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLA 331
            .||||||||:|...|:|||||||:..|||.:.:|..||:..|:||:|||.||.:|.:|:..|||:
  Rat   281 ATYYHYFSKMKALAVEGKRIGKVLDHAMEAEHLVEKYESLASELLQWIEQTIVTLNDRQLANSLS 345

  Fly   332 GVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLE 396
            |||.||..|::|||:||||||.|||||||||||:|||:||||||.|||:||::||||||||||||
  Rat   346 GVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLE 410

  Fly   397 KAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHE 461
            |||||||||||.|||||||||||||||||||:|||||||||||||||||||.:|||||||.:|||
  Rat   411 KAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHE 475

  Fly   462 AIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQL 526
            ||||||.||..|||||.||..||.:|.|||:|||..|::||.|||.:|.|::.|||.||.::|:|
  Rat   476 AIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLEL 540

  Fly   527 QQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFL 591
            |:.||::||::|.|.|:|..|.:.|.||||.|||||||.|.||||||.:..|||:.|..::.:|
  Rat   541 QKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRF- 604

  Fly   592 SDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQ 656
            .|..:.|:||||:::..||..||.:|..|..||..||:||||||:||:|.|:..:.|.|::|::.
  Rat   605 CDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQH 669

  Fly   657 IVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILN 721
            ::::.|.|.|||.|..:|:||.||..|::.....|:...:.|.:|:.|||.||::...|..|:..
  Rat   670 LLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQA 734

  Fly   722 KWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDV 786
            :|:.|..|.:.|.|||..|...:|..|||:|::.|::|.||:|||.:||.||.:.|:|.::|:.:
  Rat   735 QWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRAL 799

  Fly   787 ADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKL 851
            .:|::.:...:|||.:||.:|....:....|..|:..::..|:||...|..|.:.|..||:.|.:
  Rat   800 EEEIRAHRPTLDALREQAAALPPALSHTPEVQGRVPTLEQHYEELQARAGERARALEAALAFYTM 864

  Fly   852 MSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVE 916
            :|||.....|::||.:.|:.:...:.:||:|:::.|||..:.||||.|:||..|:.:|.|||...
  Rat   865 LSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKAS 929

  Fly   917 HPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSL 981
            .|..|.|:..|..|||.|...|..|:.|...|.||..:|.:::||.||.:|:.:|.:::..|..|
  Rat   930 PPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDL 994

  Fly   982 EMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQ 1046
            ..||.||:.|||:|:|.:|||.||.|::..|.:|||::...||.:|..|..|:.:::..||.|..
  Rat   995 GNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRA 1059

  Fly  1047 MLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNY 1111
            .::.|:..|.||..|..|||.||.||.||.:|||.||||:.|.:|||||.||.||.::|.|::..
  Rat  1060 TMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERA 1124

  Fly  1112 TEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNR 1176
            ..:|..:...||.:|.:.:   |||.:|||:||.||..|||||.:|||:||..|:|:...|.|.|
  Rat  1125 QSEYSRLRTLGEEVTRDQA---DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLR 1186

  Fly  1177 DARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHF 1241
            ||||.|.:||.||:.||..:.|..|:.|:..:|:.|.|::||:||.::|..||:....||.|.:.
  Rat  1187 DARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNI 1251

  Fly  1242 DADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSA 1306
            .|:||.::|::|..|...|::.......:|::..:...||||.:||..|:.||..|:||.||..|
  Rat  1252 HAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYDEA 1316

  Fly  1307 KTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKE 1371
            :.:|:||.:||||.||:||||:.|.:.:|..:||:.||||.|.::..||::|.:::|:||..|:.
  Rat  1317 RNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQA 1381

  Fly  1372 KGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQV 1436
            |...||||||..|..|:|..::|::..|:.|:.|.|...||||||||::|||:::.:|||:.::|
  Rat  1382 KARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEV 1446

  Fly  1437 EEIDKQTEYLQKTVPEEKIEPIVVKKT--AVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDE 1499
            |.|..|.    |.:.:|......|::|  ||.|:|..:..|:.:|.:.|:..:|..||.||||||
  Rat  1447 EAIQAQA----KALAQEDQSAGEVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDE 1507

  Fly  1500 KLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKL--IDEGHEDAK 1562
            .||:.|:||:|:|.::|..|.:|.:|.||||:|..||..|||||..:....|.|  ...|.|
  Rat  1508 ILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTLGTAAAGPE--- 1569

  Fly  1563 KFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEIS 1627
                 :::|.:.|:.|...:|.|.|.|.|:.:.||::.||.|||:||.||||:||.:::.|||:|
  Rat  1570 -----LAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELS 1629

  Fly  1628 AQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERR 1692
            ||..:|||:.|||::.|||.||:||...::.....:......:.::|:|:||||||||:||||||
  Rat  1630 AQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERR 1694

  Fly  1693 ARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVA 1757
            .||.|.|:|..|.||:|||||||.:|||||.|.|||||::|||:|.::|.||:|||..:|.|||.
  Rat  1695 ERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVD 1759

  Fly  1758 KVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRI 1822
            ..|.:|:.||..||:..||:|||||:|||:|.|||||::||.|:|||:.||.:|.|..:..|.|:
  Rat  1760 SANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARV 1824

  Fly  1823 LEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNRE 1887
            ..||..:.|..|||..:...|||:|..:..|:..|.:||||:|::..:||.|||||||:||....
  Rat  1825 QHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGLRLQKAYAGDKAEEIGRHM 1889

  Fly  1888 QEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMN 1952
            |.|..||..||....||:|.|.||.|.||||..||.||:||:.:..||:..|:|||||..:|::.
  Rat  1890 QAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIK 1954

  Fly  1953 NHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLI 2017
            |.|.:||||:.|.|.|.|||.:|:|||.|||||:.:|.::|..|.:.|.....:|:|:.:.|||:
  Rat  1955 NQQGIKAEIEARADRFSACIDMGQELLARNHYAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLV 2019

  Fly  2018 LEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTT 2082
            |||..|.|||.:|||||.:|||.:.|:|||.|:||||:|||:||||:|||.|.||||||||:||.
  Rat  2020 LEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTA 2084

  Fly  2083 FELK--EMKRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDV---------------- 2129
            .|.:  |.||::|     |.:|.|:...::..:...|.:..:.:|..|.
  Rat  2085 LEERENEQKRKRE-----EEERRKQPPTSEPMASQPEGSLVDGQRVLDTAWDGTQSKLPPSTQAP 2144

  Fly  2130 DVGASHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGH--------------------------- 2167
            .:.....|:.:....:|.:|:.:.....|  ||:|.|.
  Rat  2145 SINGVCTDTESSQPLLEQQRLEQSNVPEG--PGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSS 2207

  Fly  2168 ---------------------EGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYK 2211
                                 ||.:.||.|.::..|||:||||..||...:.|.:.||||.:.
  Rat  2208 ESAHVATLPARGAELSAQEQMEGTLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARA-- 2270

  Fly  2212 SNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSD 2276
            ::..:.:.||....|..|...:|.||.|:|||.::.|.:|..:|.||.|:.|||.|:..:.| :.
  Rat  2271 ASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNA-AI 2334

  Fly  2277 STAVAAS----------------RSQTLPATSQ--------------KDEPKRRSFFTLKK 2307
            :||.:||                |:.|:|..||              ::..||.|||...|
  Rat  2335 ATASSASGEPEEPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKKNK 2395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	78/97 (80%)
		CH	170..269	CDD:278723	77/98 (79%)
		Spectrin	298..408	CDD:278843	78/109 (72%)
		SPEC	422..521	CDD:197544	71/98 (72%)
		SPEC	525..740	CDD:238103	93/214 (43%)
		SPEC	639..846	CDD:238103	69/206 (33%)
		SPEC	848..1058	CDD:238103	78/209 (37%)
		SPEC	955..1169	CDD:238103	95/213 (45%)
		SPEC	1170..1380	CDD:238103	86/209 (41%)
		SPEC	1386..1484	CDD:197544	35/99 (35%)
		SPEC	1488..1699	CDD:238103	97/212 (46%)
		SPEC	1594..1806	CDD:238103	118/211 (56%)
		SPEC	1807..2015	CDD:238103	93/207 (45%)
		Spectrin	2018..>2078	CDD:278843	41/59 (69%)
		PH	2167..2275	CDD:278594	41/155 (26%)
		PH_beta_spectrin	2167..2274	CDD:269975	40/154 (26%)
Sptbn2	XP_008758314.1	CH	68..166	CDD:214479	78/97 (80%)
		CH	184..287	CDD:237981	81/102 (79%)
		Spectrin	312..421	CDD:278843	77/108 (71%)
		Spectrin	436..529	CDD:278843	67/92 (73%)
		SPEC	541..753	CDD:238103	92/212 (43%)
		SPEC	756..965	CDD:238103	75/208 (36%)
		SPEC	968..1179	CDD:238103	95/213 (45%)
		SPEC	1181..1390	CDD:238103	86/208 (41%)
		SPEC	1391..1595	CDD:238103	82/215 (38%)
		SPEC	1596..1808	CDD:238103	118/211 (56%)
		SPEC	1809..2017	CDD:238103	93/207 (45%)
		SPEC	2025..>2082	CDD:197544	40/56 (71%)
		PH_beta_spectrin	2228..2331	CDD:269975	40/104 (38%)
		PH	2249..2331	CDD:278594	30/83 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3140
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2478	1.000	Inparanoid score	I28
OMA	1	1.010	-	-		QHG52262
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	1	1.000	-	-		FOG0000586
OrthoInspector	1	1.000	-	-		otm45312
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980