DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and Spta1

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001011908.3 Gene:Spta1 / 289257 RGDID:1305194 Length:2415 Species:Rattus norvegicus


Alignment Length:1747 Identity:450/1747 - (25%)
Similarity:795/1747 - (45%) Gaps:226/1747 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   709 ADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDE 773
            |:.|:.|.:|:|:::....:....|.|:||.:..|.....||||::.|:::.|.|  ::|...:.
  Rat    20 AEEIQHRRQEVLDQYQRFKERVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEI--TKDKTYEP 82

  Fly   774 ANVQSLLKKHKDVADELKNYAEVIDALH-----KQAESLKLNEAEKANVDKRLEAIDNRYKELTE 833
            .|:|...:||:....|::..:.|:..|.     :.||....:||.|.:    |:.:.:.:..|.|
  Rat    83 TNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTH----LKELRHLWDLLLE 143

  Fly   834 LAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNAN 898
            |.:.:...||.||..|:...|.:.:.:|:|||..::..:..|.|.|..|::..:||.|.:|:.|.
  Rat   144 LTQEKSDILLRALKFYQYCQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTAR 208

  Fly   899 ASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRE 963
            ..:|..|||.|.:....:||...||..:|:.:|..|..|...|..:.:.|.:|..:|.|..:..|
  Rat   209 KGKVDRVNQYANECAQEQHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNE 273

  Fly   964 TISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAK 1028
            .|.|:|:|:.:||..| ...||.....|......::|:||.:..|:..|..:|:.:...|..:|.
  Rat   274 AIQWMEEKEPLLTSED-YGKDLVSSEALFHSHKRLERNLAVMDDKVKELCAKADKLMVSHSADAP 337

  Fly  1029 IIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPE 1093
            .|::....:...||.:..:...|.:||:.:...||||.|.|....|:.:....:.:::.||.:..
  Rat   338 QIQQMKMDLVSNWELIRALATNRYAKLKASYGYHRFLSDYDELTGWMEEKTALINADELPTDVAS 402

  Fly  1094 AEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMW 1158
            .|.||.:||..:.|||:|.:.::.....|:.|......:.|.    :||::..|...|..|.::|
  Rat   403 GEALLARHQQHKHEIDSYDDRFQTAEATGQDLLDGNHEASDE----IREKMTILAHDWAALRELW 463

  Fly  1159 ENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDD 1223
            ...|....||||..||.||:.|.:..:|:||.||..:|...::...|..|::|:.|.....|.::
  Rat   464 NKCQHQYRQSLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEE 528

  Fly  1224 KINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELA 1288
            ||.||.:.|..|::.||:|::.|....:.:..|||..|:||..:.:.|.:...|.:..||.::|.
  Rat   529 KIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLK 593

  Fly  1289 EWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEP 1353
            .|:.:|...:.||.|:..:.:.|:..:.|.||.|:|||:..|...|::.|::.:......|.:..
  Rat   594 TWINKKKKLADDEDYKDVQNLKSRVQKQQDFEEELAANEIMLNNLERTGQDMIENDHYASDAVAA 658

  Fly  1354 KLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNIL 1418
            ::.|:|..:.:|...|.:||..|::||:.:..:...:|:..::.::|:|:.|.|....|..|..|
  Rat   659 RMSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVERQVASEDYGKGLADVQNL 723

  Fly  1419 MQKQQVIQTQMAVKARQVEEIDKQTEYLQ--KTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQK 1481
            ::|..::::  ||.||| :::|..|:...  :.:.....|.|..::.::|.|||.:|.||..|:|
  Rat   724 LRKHGLLES--AVLARQ-DQVDTLTDMAAHFEEIGHPDSENICARQESLLSRFEALKEPLATRKK 785

  Fly  1482 ALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAI 1546
            .|....:..|.|||.|||:.||.|..|.|.|...|..|.....|..:::.:..:|.:|||||..|
  Rat   786 KLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQTI 850

  Fly  1547 CNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSE 1611
            ...|.|:::|||..::...:.:..|.:..:.|:.....|...|..:.::|||..|..|||:|:.|
  Rat   851 TERGNKMVEEGHFASEDIASRVESLNKNMESLRARAIRRENDLKANVQLQQYLADLHEAEAWIKE 915

  Fly  1612 QELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVA-----RQFSGDDISSGDA-- 1669
            :|..:..::.|.||.:|..|:||||.....:..:.|:|:.||:.|     :|.:..|.:..:|  
  Rat   916 KEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFGNSIKALGDQAEACQQQQAAPVDEAGREARV 980

  Fly  1670 -------------VAVK------------------------------------------------ 1673
                         |::|                                                
  Rat   981 IALYDFEARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFVPAVYVRKLAHDELPGFPQQRR 1045

  Fly  1674 ---------QSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQ 1729
                     |.|::.||..|.|.|.|||.||.:....|:|:.|..|:.:||.:::    ::..|.
  Rat  1046 EEPVNIPQLQEQIETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----TENTGV 1106

  Fly  1730 DFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLI-------QAGHSDSATIAEWKDNLNES 1787
            :.|.|..|.::|:||.||.:: ...|:..:|.:||.|:       :..|.        :..||..
  Rat  1107 ELDDVWELQKKFDEFQRDLKS-NEPRLKDINKVADELLFEDLLTPEGSHI--------RQELNTR 1162

  Fly  1788 WQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGV-SDELGRDAGSVSTLQRKHYNFL 1851
            |..|..|.:.:.|:|:::..:..|..:..||..:|.:|...: :.:.|.|..||..|||:|..|.
  Rat  1163 WSSLKRLADEQYQLLSSAHAVEMFLREADDVKEQIDKKCQALNAADPGSDLLSVQALQRQHEVFE 1227

  Fly  1852 QDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFR 1916
            :|:|.|..:|..:.|.:.:|.:::. |..:::..:..|:..|||.||.:...||:.|.:....|.
  Rat  1228 RDIIPLGEKVTTLGETAERLCESHP-DATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFL 1291

  Fly  1917 FFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTR 1981
            |.:....|..|::.:...:::.|...|::|.|:|:..||....:|...:..|.|....|:||:.|
  Rat  1292 FLSKASDLENWIKAIGGVISSPELAEDLTGTEILLERHQEHYDDIKREDPTFQALEDFGRELIDR 1356

  Fly  1982 NHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSEL 2046
            .|..|.:|:..|..:...|:.|.:.||.|.:.|...||:..|.......|:|::|:|..|.|.:.
  Rat  1357 GHRNSHEIETTLQDIKLKRDDLEKNWENRKKMLDQCLELQLFRGKCEQVESWMVARENSLRSDDR 1421

  Fly  2047 GHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFEL-KEMKRRQELAEEAERQRIKEEQEAK 2110
            .| ::.::.|:||.:..:|:.||||.:.:.||...|..: .:...::|:|  |..||:.:..:..
  Rat  1422 DH-LNSLQALMKKRDDLDKAIAAQEGKIADLENHATRLMDNDHYAKEEIA--ARLQRVLDRWKDL 1483

  Fly  2111 AASEAAEQAK-----------REAERRDDVDVGASH------DDSAAKDTAVEFERVVEIQTERG 2158
            .....||..|           |:.|   |::...|.      |:|....|.:: .:.::.|....
  Rat  1484 KTQLLAELGKLGDYADLKQFYRDLE---DLEEWISEMLPVACDESYKDPTNIQ-RKYLKHQAFEN 1544

  Fly  2159 GTPGAGEGHEGYVT------------------------RKHEWDSTTKKASNRSWDKVYMAAKAG 2199
            ...|..|..||.:.                        .|..||...::.:::. .|:..|::..
  Rat  1545 EVNGRAEQVEGVINLGKSLIERRVCDGDEENMQEQLDKLKENWDYLLERTTDKG-QKLNEASRQQ 1608

  Fly  2200 RIS-------FY----------KDQ------------KGYKSNPELTFRGEPSYDLQNAAIEIAS 2235
            |.:       |:          |||            |......|:..|.:|..||...|.|:.|
  Rat  1609 RFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNGLAKELIS 1673

  Fly  2236 DYTKKKHVLRVKLANG-----------------------ALF-LLQAHDDTEMSQWV 2268
            ..|.....:..|: ||                       ||| ..|..||.|  .|:
  Rat  1674 SGTFNIEQIEEKM-NGVNERFKNVQSLAAAHHEKLKETYALFQFFQDLDDEE--AWI 1727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723
CH 170..269 CDD:278723
Spectrin 298..408 CDD:278843
SPEC 422..521 CDD:197544
SPEC 525..740 CDD:238103 9/30 (30%)
SPEC 639..846 CDD:238103 36/141 (26%)
SPEC 848..1058 CDD:238103 58/209 (28%)
SPEC 955..1169 CDD:238103 56/213 (26%)
SPEC 1170..1380 CDD:238103 62/209 (30%)
SPEC 1386..1484 CDD:197544 27/99 (27%)
SPEC 1488..1699 CDD:238103 73/287 (25%)
SPEC 1594..1806 CDD:238103 69/295 (23%)
SPEC 1807..2015 CDD:238103 57/208 (27%)
Spectrin 2018..>2078 CDD:278843 18/59 (31%)
PH 2167..2275 CDD:278594 33/179 (18%)
PH_beta_spectrin 2167..2274 CDD:269975 33/179 (18%)
Spta1NP_001011908.3 SPEC 53..261 CDD:238103 59/213 (28%)
SPEC 263..474 CDD:238103 56/215 (26%)
SPEC 475..685 CDD:238103 62/209 (30%)
SPEC 686..893 CDD:238103 59/209 (28%)
SPEC 900..>956 CDD:197544 21/55 (38%)
SH3 980..1031 CDD:418401 2/50 (4%)
Spectrin 1080..1177 CDD:395348 27/109 (25%)
SPEC 1184..1393 CDD:238103 58/209 (28%)
SPEC 1394..1604 CDD:238103 44/217 (20%)
SPEC 1606..1817 CDD:238103 26/125 (21%)
SPEC 1713..1924 CDD:238103 7/17 (41%)
SPEC 1926..2144 CDD:238103
SPEC 2040..2256 CDD:238103
FRQ1 2265..>2379 CDD:227455
EFhand_Ca_insen 2346..2414 CDD:400872
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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