DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and Utrn

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_006227699.1 Gene:Utrn / 25600 RGDID:3947 Length:3424 Species:Rattus norvegicus


Alignment Length:2875 Identity:598/2875 - (20%)
Similarity:1067/2875 - (37%) Gaps:865/2875 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 EERESVQKKTFTKWVNSHLCR-----VNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMR 105
            :|...|||||||||:|:...:     :|    |::.|::||:.|:.|||.|:|..||| .:|..|
  Rat    32 DEHNDVQKKTFTKWINARFSKSGKPPIN----DMFSDLKDGRKLLDLLEGLTGTSLPK-ERGSTR 91

  Fly   106 IHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKS 170
            :|.|.||::.||.|.:..|.|.|||..||||||..|.|||:|:|||.:|::|:..:.:.:.:..:
  Rat    92 VHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNPKLTLGLLWSIILHWQVKDVMKDIMSDLQQTN 156

  Fly   171 AKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFD 235
            ::..||.|.:..|..|..|||.||||||.|||||||::|:|:|||..::::.|.:....|.:||.
  Rat   157 SEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDRVVKMSPTERLEHAFS 221

  Fly   236 VAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYF----------------SKLKQETVQGK 284
            .|...||:.||||.|||.|:.||:||||.|:.:.:...                .|.|:| .:|:
  Rat   222 KAHTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKE-CEGE 285

  Fly   285 RI---------------GKVVGIAMENDKMVHDYENFTSDLLKWI---ETTIQSLGEREFENSLA 331
            .|               .:......|.|..:..|:....::|.|:   |.|.|     |.::...
  Rat   286 EINIQSAVLTEEGQSPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ-----EQDDISD 345

  Fly   332 GVQGQLAQFSNYRTI--------EKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDI 388
            .|:....||:.:.|.        ......::.||..:...||..:.....|:..|.        :
  Rat   346 DVEDVKEQFATHETFMMELTAHQSSVGSVLQAGNQLMTQGTLSDEEEFEIQEQMTL--------L 402

  Fly   389 NKAWERLEKAEHERELALREEL--IRQEKLEQLAARFDRKASMRETWLS-ENQRLVSQDNF--GF 448
            |..||.|.....||:..|.:.|  :::::|:||:.           ||: ..:|:...::.  |.
  Rat   403 NARWEALRVESMERQSRLHDALMELQKKQLQQLSG-----------WLTLTEERIQKMESLPVGD 456

  Fly   449 DLAAVEAAAKKHEAIETDIFAYEERVQA---VVAVCDELESERYHDVKRILLRKDNVMRL---WT 507
            ||.:::...::|:::::|:.|.:.:|.:   :|.:.||...|     ....:.:|.:.:|   ||
  Rat   457 DLPSLQNLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGE-----SATAVLEDQLQKLGERWT 516

  Fly   508 YLLELLRARRMRL-EISLQLQQNFQEMLYI---LDNMEEIKQLLMTDDY-GKHLMGV-------- 559
            .:......|..|| ||::..|:..:|...:   |...||....:.|.:: .:..:||        
  Rat   517 AVCRWTEERWNRLQEINILWQELLEEQCLLEAWLTEKEEALNKVQTGNFKDQKELGVSVRRLAIL 581

  Fly   560 -EDLLQKHSLVEADINILGERVKVVVQN---SQKFLSDDPESYKPCDPEIIVSRVQQLED----- 615
             ||:..|...:: .::.:|:.|..::.|   |:|..||..|..:..|     |.||:|||     
  Rat   582 KEDMEMKRQTLD-QLSEIGQDVGQLLSNPKASEKMNSDSEELTQRWD-----SLVQRLEDSSNQV 640

  Fly   616 --AYAELVRLAVERRSRLE--------------------------------ESRKLWQFYWDTAD 646
              |.|:|....:.::..||                                |::|  :|...:|:
  Rat   641 TQAVAKLGMSQIPQKDLLETVHVREQGMIKKPKQELPPPPPPKKRQIHVDVEAKK--KFDATSAE 703

  Fly   647 EENWIKEKEQIVSTDEV-----GHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITE-- 704
            .::||...:..:...|:     ..:.:.|.   .|.|.||.|.....|||..:.:.| :::.|  
  Rat   704 LQSWILRSKAALQNTEMNEYKKSQETSGVR---KKWKGLEKEQKEKIPQLDELNQTG-QILQEQM 764

  Fly   705 GHFG--ADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQL-------FADADDV------- 753
            |..|  |:.|.|.|:.:|.:|       |...|:||:.....||       |...|.:       
  Rat   765 GKEGLLAEEINDVLERVLLEW-------KMISQQLEDLGRKIQLQEDINAYFRQLDALEKTIRAK 822

  Fly   754 DNWMLD----------------------------------------TLRIVSS---------EDV 769
            :.|:.|                                        .||...|         :|:
  Rat   823 EEWLRDASFSESPQRSLPSLKDSCQRELTDLLGLHPRIEILCASCSALRSQPSVPGFVQQGFDDL 887

  Fly   770 GRDEANVQSLLKKH-KDVADELKN-----YAEVIDALHK---------QAESLKLNE---AEKAN 816
            .|....||..|::: :.:.:|||:     |.:.::.|.|         ||....||:   .|:|.
  Rat   888 RRHYQAVQKALEEYQQQLENELKSQPEPAYLDTLNTLKKMLSESEKAAQASLSALNDPSAVEQAL 952

  Fly   817 VDKRL--EAIDNRYKELTELAK----LRKQRLLDALSLYKL-MSEADGVEQWIKEKTKMLDTMTP 874
            .:|:.  |.::|:...|.:|::    |.|..|.|....|:. ..:|.|  :|.|.|||:      
  Rat   953 QEKKALDETLENQKPTLHKLSEETKALEKNMLPDVGKTYRQEFDDAQG--KWNKVKTKV------ 1009

  Fly   875 GKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLRE 939
            .:|:..:|.:..|...|    .|::..:.......:..|..|.....:....|..|:| .:|...
  Rat  1010 SRDLRSLEEIIPRLRDF----KADSEVIEKWTNGVKDFLMKEQAAQGDTTALQRQLDQ-CTTFAN 1069

  Fly   940 KAEAKMDDLKSAHGVQTFYIECRET--ISWIEDK---KRILTETDSLEMDL--TGVMTLQRRLSG 997
            :.|.....||:...::|....|..|  .:|::.:   .:...|..|.|:|:  :.:...|.:...
  Rat  1070 EIETIESSLKNLRDIETSLQRCPVTGVKTWVQTRLADYQSQLEKFSQEIDIQKSRLSDSQEKAMN 1134

  Fly   998 MDRDLAAIQAKLSSLERE--ANSIEDEHPEE----------------AKIIRERIAQ--IELIWE 1042
            :.:|||.:|..::..|.:  ....|.:.|||                .|.:|.:|.:  |:|:..
  Rat  1135 LKKDLAEMQEWMAQAEEDYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDSIKLVAA 1199

  Fly  1043 QLTQMLKERDSKLEEA------------GDLH----------RFLRDLDHFQTWLTKTQTDVASE 1085
            ::....:|..|:..|.            |..|          ..|..||...:||...:..:.|.
  Rat  1200 RVPSGGQELTSEFNEVLESYQLLCNRIRGKCHTLEEVWSCWVELLHYLDLETSWLNTLEERMQST 1264

  Fly  1086 DTPTSLPE-AEKLLNQHQS----IREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLN 1145
            :   :||| ||.:.:..:|    :|...||.|:    :.|.|:.|. :|...||    .:.|:|.
  Rat  1265 E---ALPERAEAVHDALESLESVLRHPADNRTQ----IRELGQTLI-DGGILDD----IISEKLE 1317

  Fly  1146 ALKDGWEELHQMWENRQVLLSQ--------------------SLDQQL------------FNRDA 1178
            |....:|||..:.|::|:.|.:                    .||:||            ..::|
  Rat  1318 AFNSRYEELSHLAESKQISLEKQLQVLRETDHMLQVLKESLGELDKQLTTYLTDRIDAFQLPQEA 1382

  Fly  1179 RQTEVLLSQQE---HFLSKD-------------------------------------DTPVNLEQ 1203
            ::.:..:|..|   ..|.|:                                     ..|.|.||
  Rat  1383 QKIQAEISAHELTLEELKKNVRPQPPTSPEGRTTRGGSQMDLLQRKLREVSTKFQLFQKPANFEQ 1447

  Fly  1204 AENQLKR----HEAFLTTMEAND----------DK--------------INTLLQVADTLVEKDH 1240
            .....||    .:|.|..:...|          ||              :.|:::....:|:|..
  Rat  1448 RMLDCKRVLDGVKAELHVLSVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQ 1512

  Fly  1241 FDADK---------------IGKRAENITGRRDDNRQRALDQHEKLKNQVK-LHEFLQDLEELAE 1289
            .|..|               :|  |:...|::|  .:||.....|||.:.. |.|:|...|  ||
  Rat  1513 TDNPKGMDEQLTSLKVLYNDLG--AQVTEGKQD--LERASQLSRKLKKEAAILSEWLSTTE--AE 1571

  Fly  1290 WVQEKYATSQ------DESYRSAKTI--------------------------------------- 1309
            .||:  :||:      |.....||.|                                       
  Rat  1572 LVQK--STSEGVIGDLDTEISWAKNILKDLERRKVDLNAITESSAALQHLVVGSESVLEDTLCVL 1634

  Fly  1310 HSKWTR--------------HQ----AFEAEIAANKERLFEAEKSAQELSKEKPEFK-------- 1348
            ::.|:|              ||    .|:..:|.....|::||....|:.| ||..|        
  Rat  1635 NAGWSRVRTWTEDWRNTLLNHQNQLEVFDGHVAHISTWLYQAEALLDEIEK-KPASKQEEIVKRL 1698

  Fly  1349 ------------------------------DVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREV 1383
                                          :::||||.||:|.|:.:..|. ....||...:...
  Rat  1699 LSELSDASIQVENVREQAIVLVNARGSSSRELVEPKLAELSKNFEKVSQHI-NSAQMLIGQDPAG 1762

  Fly  1384 LVQQT--CDDIDSYITDLEK--QIVSG--DTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQ 1442
            .|:..  ..|::|..:|:|.  ::|..  |.:||               .:|..:..|:||:.::
  Rat  1763 TVEAVGPFSDLESLESDIENMLKVVEKHLDPSND---------------EKMDEERAQIEEVLQR 1812

  Fly  1443 TEY-LQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAF------QFCRDVEDEK 1500
            .|: |.:.:.:.|.|.|.::...:..|:.||||  :.::|.:.......      .:..::....
  Rat  1813 GEHLLHEPMEDSKKEKIRLQLLLLHTRYNKIKA--IPQRKTIPLSSGIMSSALPADYLVEINKIL 1875

  Fly  1501 LWIDE-----KLPVANSPDYGNSLFNVHVLKKKNQSLATEIDN--------HEPRINAICNNGRK 1552
            |.:|:     .:|..|:..|.:..|....||:    :..::|.        ||.:.:.|      
  Rat  1876 LTLDDIELSLNIPELNTTVYEDFSFQEDSLKR----IKDQLDRLGEQLAAVHEKQPDVI------ 1930

  Fly  1553 LIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLES-EKVQQYFFDAQEAESWMSEQELYM 1616
             ::....:|.:...::|.|..||..:.....:||.....: |:.:|:..|..:...|:||.|..:
  Rat  1931 -LEASGPEAIQIRDMLSQLNAKWDRVNRLYSDRRGSFARAVEEWKQFHCDLDDLTQWLSEAEDLL 1994

  Fly  1617 M----------VEDRGKDEISAQNLMKKHE----NLEQSVEDYANTIRQLGEVARQFSGDDISSG 1667
            :          :|.....::..::.:..|:    ::.|..||....:|         ..|.....
  Rat  1995 VGTCAPDGSLDLEKARTHQLELEDGLSSHQPCLIDVNQKGEDIVQRLR---------PSDASFLK 2050

  Fly  1668 DAVAVKQSQLDKLYAGLKDLAGERRARL-NEALQLFMLSREVDDLEQWITDREVVAGSQELGQDF 1731
            |.:|....:...|.|.:|||    :.|| .|:.|:....:.:|::..|:|..|.....:......
  Rat  2051 DKLASLNQRWSALVAEVKDL----QPRLKGESKQVSGYRKRLDEVVCWLTKVENAVQKRSTPDPE 2111

  Fly  1732 DHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESW----QDLL 1792
            ::...|::...|.....|.:.....|::..::|..:.....|:  ::|...|:|..|    :::.
  Rat  2112 ENPWELTDLAQEMDAQAENIKWLNRAELEMLSDKNLSLCERDN--LSESLRNVNTMWTKICREVP 2174

  Fly  1793 ELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITL 1857
            .|::||||                                   |..|..          |..|..
  Rat  2175 SLLKTRTQ-----------------------------------DPCSAP----------QTRIAA 2194

  Fly  1858 YSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVR 1922
            :..||::...|:          |.:...|..|:     ::.|..|....:|||            
  Rat  2195 HPNVQKVALVSS----------ASDAPLRGPEI-----SVPADLDKTITELAD------------ 2232

  Fly  1923 ILMIWMEDLVRQMNTSE--KPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYA 1985
                |:. |:.||..|.  ...||..:...::..:..||:::.|........:|.:.|  :|..:
  Rat  2233 ----WLV-LIDQMLKSNIVTVGDVKEINKTVSRMKITKADLEQRHPQLDFVFTLAQNL--KNKAS 2290

  Fly  1986 SADIKDRLMTLSNSRNALLRRWEE---RWENLQLILEVYQFARDAAVAEA--WLIAQEPYLLSSE 2045
            |:|:          |.|:..:.|:   :||:.|..:|:.:...:..|.::  |...:|       
  Rat  2291 SSDL----------RTAITEKLEKLKTQWESTQHGVELRRQQLEDMVVDSLQWDDHRE------- 2338

  Fly  2046 LGHTIDEVENLIKKHEA-FEKSAAAQEERFS-----------------------------ALERL 2080
                  |.|.|::|||| |.....|:.:..|                             .||..
  Rat  2339 ------ETEELMRKHEARFYMLQQARRDPLSKQVSDNQLLLQELGSGDGVIMAFDNVLQKLLEEY 2397

  Fly  2081 TTFELKEMKRRQELAEEA---ERQRIKEEQEAKAASEAAEQAKR-----------EAERRDDVDV 2131
            ::.:.:.::...|..:.:   .:|.|.:.|.|..|.....|..|           |||...:|..
  Rat  2398 SSDDTRNVEETTEYLKTSWINLKQSIADRQSALEAELRTVQTSRRDLENFVKWLQEAETTANVLA 2462

  Fly  2132 GASHDDSAAKDTAVE---FERVVEIQTE---------------RGGTPGAGEGHEGYVTR----- 2173
            .||..::|.:|:.:.   .:::::||.|               :......|...|..:.:     
  Rat  2463 DASQRENALQDSVLARQLRQQMLDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDD 2527

  Fly  2174 -KHEW-DSTTKKASNRS--------WDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQN 2228
             ...| |...|.||.|:        |::  :.|....:..:.:.|..:...::...|:.      
  Rat  2528 MNQRWNDLKAKSASIRAHLEASAEKWNR--LLASLEELIKWLNMKDEELKKQMPIGGDV------ 2584

  Fly  2229 AAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKA--------QSDSTAVAASRS 2285
            .|:::..|:.|   |||.:|......:|.|.|...:......::|        ||.:......|:
  Rat  2585 PALQLQYDHCK---VLRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNPQSKTELTPEERA 2646

  Fly  2286 QTLPATSQKDEPKRR 2300
            |.:....:|...:.|
  Rat  2647 QKIAKAMRKQSSEVR 2661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 49/102 (48%)
CH 170..269 CDD:278723 48/98 (49%)
Spectrin 298..408 CDD:278843 24/120 (20%)
SPEC 422..521 CDD:197544 21/108 (19%)
SPEC 525..740 CDD:238103 61/278 (22%)
SPEC 639..846 CDD:238103 63/302 (21%)
SPEC 848..1058 CDD:238103 47/237 (20%)
SPEC 955..1169 CDD:238103 59/287 (21%)
SPEC 1170..1380 CDD:238103 72/406 (18%)
SPEC 1386..1484 CDD:197544 23/104 (22%)
SPEC 1488..1699 CDD:238103 43/245 (18%)
SPEC 1594..1806 CDD:238103 43/230 (19%)
SPEC 1807..2015 CDD:238103 35/212 (17%)
Spectrin 2018..>2078 CDD:278843 14/91 (15%)
PH 2167..2275 CDD:278594 22/130 (17%)
PH_beta_spectrin 2167..2274 CDD:269975 22/129 (17%)
UtrnXP_006227699.1 CH 37..140 CDD:237981 52/107 (49%)
CH 156..260 CDD:237981 48/103 (47%)
SPEC 315..533 CDD:238103 50/246 (20%)
SPEC 548..>651 CDD:295325 27/108 (25%)
SPEC 696..909 CDD:238103 42/223 (19%)
SPEC 808..1020 CDD:238103 43/219 (20%)
SPEC 917..1128 CDD:295325 48/223 (22%)
SPEC 1137..1341 CDD:238103 50/215 (23%)
SPEC 1240..1451 CDD:238103 44/222 (20%)
SPEC 1552..1750 CDD:295325 40/203 (20%)
SPEC 1972..2174 CDD:238103 38/216 (18%)
SPEC 2222..2434 CDD:238103 47/253 (19%)
SPEC 2442..2682 CDD:238103 40/231 (17%)
SPEC 2684..>2800 CDD:238103
WW 2809..2837 CDD:238122
EF-hand_2 2838..2956 CDD:286194
EF-hand_3 2960..3051 CDD:286195
ZZ_dystrophin 3060..3108 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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