DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and Sptbn2

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	NP_067262.1	Gene:	Sptbn2 / 20743	MGIID:	1313261	Length:	2388	Species:	Mus musculus

Alignment Length:	2396	Identity:	1141/2396 - (47%)
Similarity:	1569/2396 - (65%)	Gaps:	129/2396 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            |||         :.:.::|..:||:||||||||||||:|||:||||||||||||||.||.||:.|
Mouse    25 RWD---------LPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGD 80

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||.|:|||::|::||||||||.|||||||:||||||||||||||||:||:|||||:|||||||||
Mouse    81 LYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGN 145

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.|||:||||||||||||::|..||||.||||||||||||||||||.||||.|||||||||||
Mouse   146 HRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLA 210

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            ||||:|||||||:.||.|.|.||.:||.|||::||.:|||.||||.|||.|:.||||||||||.|
Mouse   211 FNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVAT 275

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            |||||||:|...|:|||||||:..|||.:.:|..||:..|:||:|||.||.:|.:|:..|||:||
Mouse   276 YYHYFSKMKALAVEGKRIGKVLDHAMEAEHLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGV 340

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..|::|||:||||||.|||||||||||:|||:||||||.|||:||::||||||||||||||
Mouse   341 QNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            |||||||||.|||||||||||||||||||:|||||||||||||||||||.:|||||||.:|||||
Mouse   406 EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAI 470

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            ||||.||..|||||.||..||.:|.|||:|||..|::||.|||.:|.:::.|||.||.::|:||:
Mouse   471 ETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLRQMVAARRERLLLNLELQK 535

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSD 593
            .||::||::|.|.|:|..|.:.|.||||.|||||||.|.||||||.:..|||:.|..::.:| .|
Mouse   536 VFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRF-CD 599

  Fly   594 DPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIV 658
            ..:.|:||||:::..||..||.:|..|..||..||:||||||:||:|.|:..:.|.|::|::.::
Mouse   600 PGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLL 664

  Fly   659 STDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723
            ::.:.|.|||.|..:|:||.||..|::.....|:...:.|.:|:.|||.||::...|..|:..:|
Mouse   665 ASADTGRDLTGVLRLLNKHAALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQW 729

  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD 788
            :.|..|.:.|.|:|..|...:|..|||:|::.|::|.||:|||.:||.||.:.|:|.::|:.:.:
Mouse   730 ERLEALAEERAQQLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEE 794

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMS 853
            |::.:...:|||.:||.:|....:....|..|:..::..|:||...|..|.:.|..||:.|.::|
Mouse   795 EIRAHRPTLDALREQAAALPPALSHTPEVQGRVPTLEQHYEELQARAGERARALEAALAFYTMLS 859

  Fly   854 EADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP 918
            ||.....|::||.:.|:.:...:.:||:|:::.|||..:.||||.|:||..||.:|.|||....|
Mouse   860 EAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVNDIAEQLLKASPP 924

  Fly   919 NSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEM 983
            ..|.|:..|..|||.|...|..|:.|...|.||..:|.:::||.||.:|:.:|.:::..|..|..
Mouse   925 GKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGN 989

  Fly   984 DLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048
            ||.||:.|||:|:|.:|||.||.|::..|.:|||::...||.:|..|..|:.:::..||.|...:
Mouse   990 DLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQAGWEDLRATM 1054

  Fly  1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113
            :.|:..|.||..|..|||.||.||.||.:|||.||||:.|.:|||||.||.||.::|.|::....
Mouse  1055 RRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQS 1119

  Fly  1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDA 1178
            :|..:...||.:|.:.:   |||.:|||:||.||..|||||.:|||:||..|:|:...|.|.|||
Mouse  1120 EYSRLRTLGEEVTRDQA---DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDA 1181

  Fly  1179 RQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDA 1243
            ||.|.:||.||:.||..:.|..|:.|:..:|:.|.|::||:||.::|..||:....||.|.:..|
Mouse  1182 RQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHA 1246

  Fly  1244 DKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKT 1308
            :||.::|::|..|...|::.......:|::..:...||||.:||..|:.||..|:||.||..|:.
Mouse  1247 EKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELRLWIDEKMLTAQDVSYDEARN 1311

  Fly  1309 IHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKG 1373
            :|:||.:||||.||:||||:.|.:.:|..:||:.||||.|.|:..||::|.:::|:||..|:.|.
Mouse  1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKVVVSEKLEDLHRRWDELETTTQAKA 1376

  Fly  1374 AMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEE 1438
            ..||||||..|..|:|..::|::..|:.|:.|.|...||||||||::|||:::.:|||:.::||.
Mouse  1377 RSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEA 1441

  Fly  1439 IDKQTEYLQKTVPEEKIEPIVVKKT--AVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKL 1501
            |..|.:.|    .:|......|::|  ||.|:|..:..|:.||.:.|...:|..||.||||||.|
Mouse  1442 IQAQAQAL----AQEDQSAGEVERTSRAVEEKFRALCQPMKERCRRLHASREQHQFHRDVEDEIL 1502

  Fly  1502 WIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKL--IDEGHEDAKKF 1564
            |:.|:||:|:|.::|..|.:|.:|.||||:|..||..|||||..:....|.|  ...|.|
Mouse  1503 WVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTLGTAAAGPE----- 1562

  Fly  1565 EALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQ 1629
               :::|.:.|:.|...:|.|.|.|.|:.:.||::.||.|||:||.||||:||.:::.|||:|||
Mouse  1563 ---LAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ 1624

  Fly  1630 NLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRAR 1694
            ..:|||:.|||::.|||.||:||...::.....:......:.::|:|:|||||.||:||||||.|
Mouse  1625 AEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYASLKELAGERRER 1689

  Fly  1695 LNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKV 1759
            |.|.|:|..|.||:|||||||.:|||||.|.|||||::|||:|.::|.||::||..:|.|||...
Mouse  1690 LQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSKDTSTIGQERVDSA 1754

  Fly  1760 NGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILE 1824
            |.:|:.||..||:..||:|||||:|||:|.|||||::||.|:|||:.||.:|.|..:..|.|:..
Mouse  1755 NALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQH 1819

  Fly  1825 KQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQE 1889
            ||..:.|..|||..:...|||:|..:..|:..|.:||||:|::..:||.|||||||:||....|.
Mouse  1820 KQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGQRLQKAYAGDKAEEIGRHMQA 1884

  Fly  1890 VLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNH 1954
            |..||..||....||:|.|.||.|.||||..||.||:||:.:..||:..|:|||||..:|::.|.
Mouse  1885 VAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQ 1949

  Fly  1955 QSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILE 2019
            |.:||||:.|.|.|.:||.:|:|||.|:|||:.:|.::|..|.:.|.....:|:|:.:.|||:||
Mouse  1950 QGIKAEIEARADRFSSCIDMGQELLARSHYAAEEISEKLSQLQSRRQETADKWQEKMDWLQLVLE 2014

  Fly  2020 VYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFE 2084
            |..|.|||.:|||||.:|||.:.|:|||.|:||||:|||:||||:|||.|.||||||||:||..|
Mouse  2015 VLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALE 2079

  Fly  2085 LKEMKRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDV----------------DVGA 2133
            .:|.:|:::..||   :|.|:...::..:...|.:..:.:|..|.                .|..
Mouse  2080 ERENERKRKREEE---ERRKQPPTSEPMASQPEGSLVDGQRVPDTAWDGTQSKLPPSTQAPSVNG 2141

  Fly  2134 SHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGH------------------------------- 2167
            ...|:.:....:|.:|:.:.....|  ||:|.|.
Mouse  2142 VCTDTDSSQPLLEQQRLEQSNVPEG--PGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSEAAH 2204

  Fly  2168 -----------------EGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPE 2215
                             ||.:.||.|.::..|||:||||..||...:.|.:.||||.:.  ::..
Mouse  2205 GATLPTRGPELSAQEQMEGMLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARA--ASAG 2267

  Fly  2216 LTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWV----------TS 2270
            :.:.||....|..|...:|.||.|:|||.::.|.:|..:|.||.|:.|||.|:          :|
Mouse  2268 VPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASS 2332

  Fly  2271 LKAQSDSTAVAA-----SRSQTLPATSQ--------------KDEPKRRSFFTLKK 2307
            ...:|:...|.:     :|:.|:|..||              ::..||.|||...|
Mouse  2333 APGESEEPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKKNK 2388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	78/97 (80%)
		CH	170..269	CDD:278723	77/98 (79%)
		Spectrin	298..408	CDD:278843	78/109 (72%)
		SPEC	422..521	CDD:197544	70/98 (71%)
		SPEC	525..740	CDD:238103	91/214 (43%)
		SPEC	639..846	CDD:238103	67/206 (33%)
		SPEC	848..1058	CDD:238103	79/209 (38%)
		SPEC	955..1169	CDD:238103	95/213 (45%)
		SPEC	1170..1380	CDD:238103	87/209 (42%)
		SPEC	1386..1484	CDD:197544	36/99 (36%)
		SPEC	1488..1699	CDD:238103	96/212 (45%)
		SPEC	1594..1806	CDD:238103	116/211 (55%)
		SPEC	1807..2015	CDD:238103	91/207 (44%)
		Spectrin	2018..>2078	CDD:278843	41/59 (69%)
		PH	2167..2275	CDD:278594	41/165 (25%)
		PH_beta_spectrin	2167..2274	CDD:269975	41/164 (25%)
Sptbn2	NP_067262.1	SAC6	51..>441	CDD:227401	299/389 (77%)
		Spectrin	429..522	CDD:334073	66/92 (72%)
		SPEC	534..746	CDD:238103	90/212 (42%)
		SPEC	749..958	CDD:238103	76/208 (37%)
		SPEC	961..1172	CDD:238103	95/213 (45%)
		SPEC	1174..1383	CDD:238103	87/208 (42%)
		SPEC	1384..1588	CDD:238103	83/215 (39%)
		SPEC	1589..1801	CDD:238103	116/211 (55%)
		SPEC	1802..2010	CDD:238103	91/207 (44%)
		SPEC	2018..>2075	CDD:197544	40/56 (71%)
		PH_beta_spectrin	2221..2326	CDD:269975	40/106 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3229
eggNOG	1	0.900	-	-		E2759_KOG0517
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2474	1.000	Inparanoid score	I31
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52262
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	1	1.000	-	-		FOG0000586
OrthoInspector	1	1.000	-	-		otm43240
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3302
SonicParanoid	1	1.000	-	-		X1255
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870