DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and sma-1

DIOPT Version :10

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_741632.2 Gene:sma-1 / 179629 WormBaseID:WBGene00004855 Length:4166 Species:Caenorhabditis elegans


Alignment Length:2420 Identity:732/2420 - (30%)
Similarity:1203/2420 - (49%) Gaps:225/2420 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 EYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLE 89
            :.|..|:.:..||||||:.|.:||..:||||||||.||.|.|.:..|.||:.|:.||..|:||||
 Worm   129 DQDEFNNETLYFERSRIRTLQDERVHIQKKTFTKWCNSFLNRASLEIVDLFEDVGDGIMLMKLLE 193

  Fly    90 VLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQ 154
            ::||::|.||.:|:||:..:||::|.|.||:::::.|||||:.||:|.|..|.||||||||||||
 Worm   194 IISGDKLGKPNRGRMRVQKVENLNKVLDFLKKKKIQLENIGAEDILDRNERLILGLIWTIILRFQ 258

  Fly   155 IQDITIEEVDNK-ETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQF 218
            |..|.||:.:.: |.|.||||||||||.|||||.||.:.|||||||:||||||:||.||||||.|
 Worm   259 IDTIVIEDEEERGERKHAKDALLLWCQRKTAGYPNVRIENFTTSWRNGLAFNALIHSHRPDLVDF 323

  Fly   219 EKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQG 283
            .:|:....:.|||:||||||.||.:|:|||||||.|..||||||||||..|||:|:|.|.|....
 Worm   324 NRLNPNEHVDNLNHAFDVAEKKLEIARLLDAEDVDVTRPDEKSIITYVSLYYHHFAKQKTEMTGA 388

  Fly   284 KRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEK 348
            :||..:||..|.::.|..|||:..|:||.||..||::|..|.|.|||.|::.:.|:|:.:||.||
 Worm   389 RRIANIVGKLMVSETMEDDYEHIASELLNWIRVTIKTLESRRFPNSLNGMREEHAKFNQFRTSEK 453

  Fly   349 PPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQ 413
            |||:.|||.||.|.||:|:|.:|.::|.|.|.:|..:.||..||.:|:.||:||::|:..||.||
 Worm   454 PPKYKEKGELEALFFTIQTKRKAMSRKQYQPPQGLFMHDIESAWAQLDYAENERQVAIIAELQRQ 518

  Fly   414 EKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVV 478
            |||||||.||.:||.:|::||...|.::.:...|...:.||...||.:||.|||.|.|:|.:.:.
 Worm   519 EKLEQLAQRFHKKAKLRDSWLRSVQVVLEEMEHGRSASQVEKTLKKQQAISTDILAREDRFKMLT 583

  Fly   479 AVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEI 543
            |:|:||.:|:||:..::...:..::..||.||.||..|:..|.....|....:::..:.:.:..:
 Worm   584 AMCNELCTEKYHESDKVRGMEREIIDRWTQLLTLLEQRKRALMSLNDLMSLLRDIDTLSNELYSL 648

  Fly   544 KQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVS 608
            :..:...|.||||:||||||.||.|::|.||..|..:..:.|::..::....|.:     :::..
 Worm   649 EPAVRNRDVGKHLIGVEDLLGKHDLLDAQINAHGSLLSKLSQSANNYIRHKEEQF-----DVLQR 708

  Fly   609 RVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLM 673
            ::.::...|..||.|...||..||.:|.|:||..|..:|..|:.|||::.:|.....|::.|...
 Worm   709 KLDEVTAQYNTLVELCRSRRLGLERARSLFQFVQDHEEEMAWLAEKEKLCTTALNSGDISAVPQT 773

  Fly   674 LSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHL---LDLTKYRRQ 735
            ...:|.:|.|:.:|..:.:.:...|..|:..|....| |:.||.::.::|:.|   :|.......
 Worm   774 TLLYKNVEMEMQTHWARSKGMIAGGERLVQNGQSKED-IQRRLTQMNHRWERLRVAVDALGNWLS 837

  Fly   736 RLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVI--- 797
            ...:|.:|||   ||::.::|:.:.:.:|.|:|:||||...:|||::|..:.:|::.|...|   
 Worm   838 EARHAQQYFQ---DANEAESWIREKMPLVKSDDLGRDEGAAESLLQRHARLEEEIRAYKSDISRL 899

  Fly   798 ---------DALHKQAESLKLNEAEKANVDK---------------------------------- 819
                     .|.|....|..:.|.|:.||.:                                  
 Worm   900 EEMQSQLANSAFHTATTSQSVQETEEVNVPQVEMSYNYEGNGMRVSKGEVLALLEKSTPEWWRAL 964

  Fly   820 -----------------------------------------------RLEAIDNRYKELTELAKL 837
                                                           |...|.|.|:||..||.:
 Worm   965 KRDGTEGYVPANYCKIVPGETVTVTQTTQKTTTTLEGNETKSSVVADRQHKISNDYRELKRLADV 1029

  Fly   838 RKQRLLDALSLYKLMSEADGVEQWIKE-KTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNAN-AS 900
            |::.|.|.:.|.:...|.|..|:|.|| :..:.|..:|    |.|...:.:|:..:.:|..| .:
 Worm  1030 RRRLLSDNIKLLRFYRECDEFERWAKEIEVSLADEPSP----EHVAAFRRKFDKLEADMKTNGGT 1090

  Fly   901 RVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETI 965
            ::..:|.:|..|:...|..|.:|..||:.:|..|..|....:.:...|::...|..|...|....
 Worm  1091 QLKHINDIANDLISEGHGQSRKIEVRQHKINAMWDNLERLRKQRGVRLEATERVADFDTTCESAR 1155

  Fly   966 SWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKII 1030
            .|      :|::.:.|:.:...|.:||    .::|||..::.|:::||:.|.:::.:|||||..|
 Worm  1156 EW------MLSKFEQLDRNPNDVKSLQ----NLERDLKPLEDKIAALEKLAAAVKKDHPEEAAAI 1210

  Fly  1031 RERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAE 1095
            ..:||::..:...|.:..:|:....|:......|...|.....|:.||:..:..:..|..:.|||
 Worm  1211 ERKIAELRALHADLLRRAQEKMLLAEQTQGKEMFESALRDMIGWIEKTRKVMMEDVHPVDVAEAE 1275

  Fly  1096 KLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWEN 1160
            :||.:|..:.|:|.:...:.:...|.|.||...     :|:...:.|:|..|......|..::..
 Worm  1276 ELLKKHYELGEQIKDKKYEVEYCQELGRRLLER-----NPRMSKVEEQLQNLVSEMASLRDLYRR 1335

  Fly  1161 RQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKI 1225
            |..:|.|.||.|||||::.:.:......|.||..|:...::|..||.||||......::|.:.::
 Worm  1336 RDTILKQQLDLQLFNRESERIDAATKGHEAFLEFDNLGDSVESVENLLKRHRDLEAKLDAQEARL 1400

  Fly  1226 NTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEW 1290
            ....:.||.:::..|.|:..|.:|..::..||:..|:.|..:.::|:..::..|..::.:|:..|
 Worm  1401 EAFSRTADDMIKAQHADSAYIEQRRRDVLARREAVRRAAAQRKKQLEASLEYQEMRREADEVVGW 1465

  Fly  1291 VQE--KYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEP 1353
            :.|  |...|.|:|..:...|..:..:|:||||||.||:.|:.:.......|..:|......:|.
 Worm  1466 MYEKAKLVMSGDDSALAPSAIPHRLLKHEAFEAEIIANEPRIQQINSEGDGLVSKKHYESPNVEK 1530

  Fly  1354 KLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNIL 1418
            .::::..|:.||:.....||..|..|..:..:.:..:|..:.:.:::..:.|.|...||.||..|
 Worm  1531 IVRQVNAQWGDLKKQVWNKGLRLRQAADQKGLDRILEDAHAKLDEMQTALNSKDQGLDLRSVKDL 1595

  Fly  1419 MQKQQVIQTQMAVKARQVEEIDKQ-----------TEYLQKTVPEEKIEPIVVKKTAVLERFEKI 1472
            :||..|::.:|.:...::.:|:.:           .:.:..||.:            :|:|:..:
 Worm  1596 LQKHAVLEQEMGLYGNKLSDIENRGKKMAVDGHYDADRIHSTVGQ------------LLQRYAAM 1648

  Fly  1473 KAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEID 1537
            |.|...|:..|::.:...|...||:.|..||.||.|:|:|.|.|.:|.....:.||.:.|..|::
 Worm  1649 KGPAQRRKGDLDESRLWHQLVFDVDCELQWIAEKKPIASSQDCGRTLTEALNMVKKQEQLEAEVN 1713

  Fly  1538 NHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDA 1602
            .|..:|:.:.....:||...|..:.:.:|..|:|...|.|||..:..||..:....|.|||.|||
 Worm  1714 QHGGQIDKVLLQAGELIKRHHSASSQIKAKSSELETAWSELKKLLRLRRAVVDWGVKEQQYLFDA 1778

  Fly  1603 QEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSG 1667
            .|.||||:|:...:..||.|.||.:|:.|:.||..|.:.:..|...:.:|.....:....:....
 Worm  1779 AEVESWMNEKRNALASEDYGNDEDAARKLLSKHRALCEDMTTYRQWLEKLEVKCVELVESNRPHV 1843

  Fly  1668 DAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFD 1732
            :....:|.:|.:.:..|..||.:||..|.:|:.|:...||..||.|.|.:...||.|:|..:|::
 Worm  1844 ERFQKRQDELVREFDALSKLAEDRRNALEDAVCLYEYMRESADLGQSIEENLRVAMSEEFAEDYE 1908

  Fly  1733 HVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIET 1797
            |:..|..:|:||.:..:. |.||.......|:.:::.....:..:.:.::.|..:|..|.|.||.
 Worm  1909 HLKELQSKFDEFKQKVKN-GSERFTSCETAANAILRRNPPFARDVVKKQEALRTAWNTLCEYIEA 1972

  Fly  1798 RTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQ 1862
            |...||.:.|||:|..|..:....:.:|...:..:||||...|.:|.:.|....:::.....::.
 Worm  1973 RDSKLAVAEELHRFHRDVDEFEQWMADKMANMPRDLGRDVKHVHSLWQHHEALDKEIHNSQPRLA 2037

  Fly  1863 QIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIW 1927
            ::.||:.:|:..|.|..|::|..|:|.:...|:.|:...|.||..|....||..|...||.|:.|
 Worm  2038 KLVEEAERLKKTYPGGNAEQIGGRQQTLEQEWEELKNATDDRKDMLRAAFDLHTFNGKVRDLLAW 2102

  Fly  1928 MEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDR 1992
            .:..:..:.:.....|:...|.|...|..|..|:|.||..|...::.|::::|..||||.:||::
 Worm  2103 TDLTISDIQSDLHINDLQQAEWLQTEHSRLSHEMDAREPEFARLVNDGEKMITAQHYASEEIKNK 2167

  Fly  1993 LMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLI 2057
            ...|.::...|...|..|...|...::.:.|.|:|....|.:.::...|.|..:|.::.:||:..
 Worm  2168 THLLKSALERLRSEWALRNGFLSQAVQWHAFQREAKQIIASIGSKRTTLRSLAVGGSVADVESQT 2232

  Fly  2058 KKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAAEQAKRE 2122
            |:.:.|||:.:..:||.:.|:. |..||  ||.|...::.....:....:|.|...:..|  .|.
 Worm  2233 KRLDTFEKALSTLDERTATLDH-TANEL--MKARHMESKNISMWQSNVHEELKLLRQDIE--ARH 2292

  Fly  2123 AERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGHEGYVTRKHEWDSTTKKASNR 2187
            |..:|...: ||.|...|:                         .|.::..|   .:..:||.:.
 Worm  2293 AMLKDAFAL-ASFDSDVAQ-------------------------IEAWIDEK---TNGVRKAQDL 2328

  Fly  2188 SWDKVYMAAKAGRISFYK-------------DQ--------KGYKSNPELTFR-GEPSYDL---- 2226
            |.:.:.:..|..|:..::             ||        |....||::..| .|.||..    
 Worm  2329 SSESISIDEKMKRLQTHQALEAEVTANKPVVDQILQRGNQLKNLHRNPKIANRCDELSYKWNQLS 2393

  Fly  2227 -----QNAAIEIASDYTKKKHVLRVKLA--NGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASR 2284
                 |:.|:|.|.|..:.|.::...||  |....|:...|..:..:....|..:.|.|     |
 Worm  2394 GACADQSLALEEARDLLRFKQLVENVLAWINEKEVLVSTADMGKDMEHCRLLLERLDGT-----R 2453

  Fly  2285 SQTLPATSQKDEPKR 2299
            |.::......||..|
 Worm  2454 SDSIVDEQTLDEINR 2468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH_SPTB-like_rpt1 36..152 CDD:409095 64/115 (56%)
CH_SPTB_like_rpt2 169..273 CDD:409097 74/103 (72%)
Spectrin 298..408 CDD:395348 52/109 (48%)
SPEC 422..521 CDD:197544 35/98 (36%)
SPEC 525..740 CDD:238103 56/217 (26%)
SPEC 639..846 CDD:238103 64/302 (21%)
SPEC 848..1058 CDD:238103 53/211 (25%)
SPEC 955..1169 CDD:238103 52/213 (24%)
SPEC 1170..1380 CDD:238103 57/211 (27%)
SPEC 1386..1484 CDD:197544 20/108 (19%)
SPEC 1488..1699 CDD:238103 65/210 (31%)
SPEC 1594..1806 CDD:238103 64/211 (30%)
SPEC 1807..2015 CDD:238103 57/207 (28%)
Spectrin 2018..>2078 CDD:395348 15/59 (25%)
PH_beta_spectrin 2167..2274 CDD:269975 28/139 (20%)
sma-1NP_741632.2 SAC6 155..642 CDD:227401 247/486 (51%)
CH_beta_spectrin_rpt2 274..378 CDD:409043 74/103 (72%)
SPEC 634..732 CDD:197544 26/102 (25%)
SPEC 737..916 CDD:238103 49/182 (27%)
SH3 928..979 CDD:214620 1/50 (2%)
SPEC 1039..1237 CDD:238103 52/211 (25%)
SPEC 1242..1450 CDD:238103 56/212 (26%)
SPEC 1453..1553 CDD:197544 27/99 (27%)
SPEC 1562..1762 CDD:238103 51/211 (24%)
SPEC 1664..1874 CDD:238103 65/209 (31%)
SPEC 1770..1980 CDD:238103 64/210 (30%)
SPEC 1982..2192 CDD:238103 58/209 (28%)
SPEC 2194..2407 CDD:238103 51/246 (21%)
SPEC 2408..2618 CDD:238103 15/66 (23%)
SPEC 2620..2830 CDD:238103
SPEC 2832..3041 CDD:238103
SPEC 3044..3253 CDD:238103
SPEC 3255..3466 CDD:238103
SPEC 3361..3574 CDD:238103
SPEC 3472..3689 CDD:238103
PH_beta_spectrin 3780..3883 CDD:269975
Blue background indicates that the domain is not in the aligned region.

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