Protein Alignment beta-Spec and unc-70

DIOPT Version :10

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_001256073.1
• Gene: unc-70 / 179077
• WormBaseID: WBGene00006803
• Length: 2326
• Species: Caenorhabditis elegans
• Alignment Length: 2276
• Identity: 1293/2276 - (56%)
• Similarity: 1687/2276 - (74%)
• Gaps: 55/2276 - (2%)

  Fly    40 RIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKM 104
            |.:.|.:|||.||||||||||||||.||:|::.|||:||||||.|::||.|||||||||||.|||
 Worm    99 RFRGLRDERELVQKKTFTKWVNSHLVRVSCKVQDLYMDMRDGKMLLRLLAVLSGERLPKPTPGKM 163

  Fly   105 RIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETK 169
            ||||||||:|.|||||.|.|||||:|||||||||:.|.|||||||||||||||||.|:.||.||:
 Worm   164 RIHCLENVEKGLQFLRNQHVHLENLGSHDIVDGNSRLTLGLIWTIILRFQIQDITFEDADNHETR 228

  Fly   170 SAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAF 234
            |||:|||||||||||||.||||:||:|||||||||||:|||||||||.::.|.|:||::||.:||
 Worm   229 SAKEALLLWCQMKTAGYPNVNVKNFSTSWRDGLAFNALIHKHRPDLVDYDNLQKSNALYNLQSAF 293

  Fly   235 DVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKM 299
            |.||::|||||.||||||.|:.|||||||||||||||||:||||:.:||||||||:...||||||
 Worm   294 DTAENQLGLAKFLDAEDVNVDQPDEKSIITYVVTYYHYFNKLKQDNIQGKRIGKVINELMENDKM 358

  Fly   300 VHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFT 364
            ::.||..:||||:||...||.|.||.|||:|.|||.||.:|::|||.||||||.|||.|||||||
 Worm   359 INRYETLSSDLLEWINAKIQLLNERHFENNLEGVQRQLTEFNDYRTQEKPPKFDEKGELEVLLFT 423

  Fly   365 LQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASM 429
            |||.||||||:|:.|:|||:|:|||:||:.||||||||||.|:||||||||||||||||:|||.|
 Worm   424 LQSAMRANNQRPFVPREGKLIADINRAWQSLEKAEHERELVLKEELIRQEKLEQLAARFNRKAEM 488

  Fly   430 RETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKR 494
            |||||:||||||||||||.||::||||.|||||||||||||||||||||||..|||:|.|||..:
 Worm   489 RETWLTENQRLVSQDNFGNDLSSVEAATKKHEAIETDIFAYEERVQAVVAVAGELEAENYHDQAK 553

  Fly   495 ILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGV 559
            |..||:||::||.||.:||.|||:|||:|:.:|:.|.:||..||.|::||..|:::|.|.|||.|
 Worm   554 INERKENVLQLWNYLFQLLLARRVRLELSMAIQKIFHDMLLTLDLMDDIKSRLLSEDLGAHLMDV 618

  Fly   560 EDLLQKHSLVEADINILGERVKVVVQNSQKFLS-DDPE--SYKPCDPEIIVSRVQQLEDAYAELV 621
            |||||||:|:|:||||:||||...:..:|:|.: |.|:  .|||.:|..|..|...|:..|.||:
 Worm   619 EDLLQKHALLESDINIIGERVNNSIAQAQRFRNPDGPDGSGYKPVEPGTIDERSDVLQKRYKELL 683

  Fly   622 RLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITS 686
            .||.||:.|||::::|.||:||.|:.|:.|||:||::|:.:.|.|:.||:.:|:|||..|:.:..
 Worm   684 DLAAERKRRLEDNKRLCQFWWDVAELEHGIKEQEQVLSSTDTGRDIVTVSHLLAKHKNAENNLRD 748

  Fly   687 HDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADAD 751
            .:..|..:...|.||..|...|:|.|..||.||.:..:.|.:|:..|::||...|||:|.|.|||
 Worm   749 LEKYLDRLDVSGKELQDESIPGSDNIPPRLAEIRDYINKLKELSASRKERLAGGVEYYQFFTDAD 813

  Fly   752 DVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKAN 816
            |||.::.||||::||||||:||..||.|||||.||.|||:|:.:.|..||.:||||.....|..:
 Worm   814 DVDRYLYDTLRVMSSEDVGKDEGTVQLLLKKHDDVHDELQNFDQHIKVLHAKAESLPQEAREHPD 878

  Fly   817 VDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDV 881
            :.:||:....:..||..|::||||||:||||||||.|:||.||.||.||.|:|.|:.||:|||:|
 Worm   879 IRQRLDTTLKQKAELENLSQLRKQRLIDALSLYKLYSDADSVESWIDEKGKLLATLVPGRDIEEV 943

  Fly   882 EIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMD 946
            |||||||:..:::|....::|..||.||||||:|||||||:||.|||.||..|:.||:..:.|.:
 Worm   944 EIMKHRFDTLEQDMKNQEAKVTNVNDLARQLLNVEHPNSDDILHRQNKLNARWAQLRDMVDQKRN 1008

  Fly   947 DLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSS 1011
            :|:.||.::||.|:|:||::|||||.|:|.::|:|..||:|||.||||||.|:|||.||||||.|
 Worm  1009 ELERAHRLETFRIDCQETVTWIEDKTRVLEDSDALTNDLSGVMKLQRRLSMMERDLGAIQAKLDS 1073

  Fly  1012 LEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLT 1076
            |.:||:.||.|.|:||:.|||.|.:|..:|:.|.:.::|.::||:|||||.||||||||||.|||
 Worm  1074 LHKEADDIERERPQEAQAIREDIKRIHQVWDILNKKVREHEAKLDEAGDLQRFLRDLDHFQAWLT 1138

  Fly  1077 KTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLR 1141
            .||..||||:.|.||.|||:|||||.:||||||.|.||||.|...|:|:|.:   ..||||||||
 Worm  1139 ATQRQVASEEEPQSLAEAEQLLNQHAAIREEIDGYAEDYKKMRAMGDRVTQD---QTDPQYMFLR 1200

  Fly  1142 ERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAEN 1206
            :||..|::|||||.:||:|||.||||.|:.|:|.|||:|.||:|||||::|:|||.|.:||||||
 Worm  1201 QRLAGLQEGWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEVMLSQQENYLAKDDIPQSLEQAEN 1265

  Fly  1207 QLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKL 1271
            |||||:.|:|||:|||:||..:....|.|.:..|:.||||.|:|.||..||..||::|.:..:||
 Worm  1266 QLKRHQDFITTMDANDEKIRAVGMFGDQLCQDGHYAADKIHKKARNIDERRGANREKAQEVLKKL 1330

  Fly  1272 KNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKS 1336
            |:.:.|.:||.|.:||.||::||...:|||:||.||||.||:.|||||::|:|||||||.:.:.:
 Worm  1331 KDALSLQQFLSDCDELREWIEEKMIRAQDETYRDAKTITSKFVRHQAFQSELAANKERLDQLKHA 1395

  Fly  1337 AQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEK 1401
            |..|..:|||:...|:|:::|||.|:|:||..|:|||..||||||:.|..|:..|:..:.|.||.
 Worm  1396 AINLGDDKPEYHGTIDPQIEELATQWDELEKTTEEKGQKLFDANRQQLYVQSIADMKEWATQLEN 1460

  Fly  1402 QIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVL 1466
            ::...|...|||:||:.||||.:|:|:|..||:.::::.:....|::..|:| :|.|...:.||.
 Worm  1461 EMTREDQPGDLTTVNVAMQKQHLIETEMIKKAQHIDQLMEMEPQLEELHPDE-LENIKAHRLAVQ 1524

  Fly  1467 ERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQS 1531
            |:.::::|||.:|:||||:||.||||.|||:||||||.|:|.:|.:.:.|.||.:.|.|:|..|.
 Worm  1525 EQLQRLQAPLDDRRKALERKKAAFQFGRDVDDEKLWISERLVLAKAQNLGESLPDCHRLQKNLQL 1589

  Fly  1532 LATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQ 1596
            |:.|||||||.||.|||||::||||||.:...||..|.:|...|||||:|:::|:..|.||||..
 Worm  1590 LSNEIDNHEPWINQICNNGQELIDEGHANGPAFEKKIQELRSAWQELKEAVKDRKGDLGESEKAH 1654

  Fly  1597 QYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSG 1661
            |:.:|..|||:||||||||||.::|||||.|.:|.:||||.|:..::.:|:|||.|...|.:|..
 Worm  1655 QFLYDCGEAEAWMSEQELYMMQDERGKDEFSTKNQIKKHERLQSDIDKFADTIRALATKAHKFVE 1719

  Fly  1662 DDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQE 1726
            :.....:.:.|:|:|::||||||:||:.|||.||.|.|:|:.|.||:|||.|||.|:||||||||
 Worm  1720 EKSPLTEQIQVRQAQIEKLYAGLQDLSKERRKRLEETLELYALHREIDDLLQWIADKEVVAGSQE 1784

  Fly  1727 LGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDL 1791
            .|||::||.:|.|||.:||||||.:|.||||..|...|.||..||:|:.|||.|||:|||:|::|
 Worm  1785 NGQDYEHVQMLQERFQQFARDTENIGSERVANANDGCDTLIGHGHTDAPTIALWKDSLNEAWENL 1849

  Fly  1792 LELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLIT 1856
            |||::||.|:|.|||.||||:|||:|.|.||:||.|.:.|:||||:.||..|.|||.|:|:|:..
 Worm  1850 LELMDTRAQILEASRLLHKFYHDCRDCLSRIMEKTHAMPDDLGRDSSSVGALSRKHQNYLKDIAA 1914

  Fly  1857 LYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMV 1921
            :..||.||:.::|:|:|.||||||.:|.:||.||:.||.:|:.:||||..:|.||.|||:|.|||
 Worm  1915 IGEQVAQIERDAAELRDGYAGDKALDIGSRESEVVKAWRHLRGLCDARTSRLMDTSDLFKFMNMV 1979

  Fly  1922 RILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYAS 1986
            |.|::||:::.|:||:.|:|:||||||||||||||||||||.||:||.||||||::||.|.||||
 Worm  1980 RDLLLWMDEVKREMNSQERPKDVSGVELLMNNHQSLKAEIDAREENFNACISLGRDLLNRKHYAS 2044

  Fly  1987 ADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTID 2051
            ::|:.:|:.|:..|..::||||:|||.||||||||||||||||||:||.||||||:|.|.|..::
 Worm  2045 SEIEKKLIKLTTERAEMMRRWEDRWEYLQLILEVYQFARDAAVAESWLFAQEPYLISKEYGRNLE 2109

  Fly  2052 EVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAA 2116
            |...||||||||||||.||||||.|||:||||||||.:.|:|
 Worm  2110 ETIKLIKKHEAFEKSAFAQEERFLALEKLTTFELKETQHREE----------------------- 2151

  Fly  2117 EQAKREAERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGG-TPGA--GEGHEGYVTRKHEWD 2178
            |.|||.         |.:|..|.::.|..       .:|..|. ..||  ||..||.:.|||.::
 Worm  2152 ETAKRR---------GPAHIGSPSRSTPA-------AETSFGAQDDGAKQGEAFEGTLIRKHTYE 2200

  Fly  2179 STTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHV 2243
            |..:||:||||:|:|...:...:|||||.|    :.:.:..|||...|...::.:||||.|||:|
 Worm  2201 SLDRKAANRSWEKLYAVLRQNELSFYKDPK----HRDESVHGEPPMALPGCSVNVASDYQKKKNV 2261

  Fly  2244 LRVKLANGALFLLQAHDDTEMSQWVTSLK-AQSDSTAVAASRSQTLPATSQKDEPKRRSFFTLKK 2307
            |.::|..||.:|.|...:.:|.:|:|.|: |...:....|||||||||.....: |:..||:..|
 Worm  2262 LSLRLPIGAEYLFQCGSEEDMQRWLTELQVATGQAQLEEASRSQTLPAEGSATK-KKGGFFSRGK 2325

  Fly  2308 K 2308
            |
 Worm  2326 K 2326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	86/111 (77%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	80/103 (78%)
		Spectrin	298..408	CDD:395348	75/109 (69%)
		SPEC	422..521	CDD:197544	74/98 (76%)
		SPEC	525..740	CDD:238103	93/217 (43%)
		SPEC	639..846	CDD:238103	94/206 (46%)
		SPEC	848..1058	CDD:238103	116/209 (56%)
		SPEC	955..1169	CDD:238103	131/213 (62%)
		SPEC	1170..1380	CDD:238103	112/209 (54%)
		SPEC	1386..1484	CDD:197544	34/97 (35%)
		SPEC	1488..1699	CDD:238103	111/210 (53%)
		SPEC	1594..1806	CDD:238103	118/211 (56%)
		SPEC	1807..2015	CDD:238103	120/207 (58%)
		Spectrin	2018..>2078	CDD:395348	45/59 (76%)
		PH_beta_spectrin	2167..2274	CDD:269975	42/107 (39%)
unc-70	NP_001256073.1	CH_SPTB-like_rpt1	99..211	CDD:409095	86/111 (77%)
		CH_SPTB_like_rpt2	228..332	CDD:409097	80/103 (78%)
		SPEC	368..580	CDD:238103	158/211 (75%)
		SPEC	481..695	CDD:238103	130/213 (61%)
		SPEC	698..908	CDD:238103	95/209 (45%)
		SPEC	804..1014	CDD:238103	116/209 (56%)
		SPEC	910..1120	CDD:238103	116/209 (56%)
		SPEC	1122..1334	CDD:238103	130/214 (61%)
		SPEC	1230..1439	CDD:238103	112/208 (54%)
		SPEC	1440..1650	CDD:238103	96/210 (46%)
		SPEC	1652..1864	CDD:238103	118/211 (56%)
		SPEC	1865..2073	CDD:238103	120/207 (58%)
		SPEC	2079..>2157	CDD:197544	57/100 (57%)
		PH_beta_spectrin	2189..2290	CDD:269975	41/104 (39%)