Protein Alignment beta-Spec and fln-1

DIOPT Version :10

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_001294364.1
• Gene: fln-1 / 176855
• WormBaseID: WBGene00022048
• Length: 2259
• Species: Caenorhabditis elegans
• Alignment Length: 2113
• Identity: 423/2113 - (20%)
• Similarity: 710/2113 - (33%)
• Gaps: 696/2113 - (32%)

  Fly    47 ERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPK-PTKGKMRIHCLE 110
            |.:.:|:.|||:||.:||.:....|..|..|..||..||.|.:|||.:.:.| ..|...|...||
 Worm    23 EWKIIQQNTFTRWVKNHLQKAGETIESLETDFSDGLKLIALAQVLSHKNVGKFNKKVAFRSQKLE 87

  Fly   111 NVDKALQFLR-EQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEV----DNKETKS 170
            ||..||.|.: |:.:.:.||.|..|||.|..|.|||:||:||.:.|....|:|.    |||| ::
 Worm    88 NVSLALNFFQNEENIKIINIDSTHIVDHNKKLILGLVWTLILHYSISMGWIQEKREDGDNKE-ET 151

  Fly   171 AKDALLLWC--QMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPD-LVQFEKLSKTNAIHNLNN 232
            .|..||.|.  ::..:|   :.:.|||:.|.||:|..|:::...|. |..:|..|..:|:.|...
 Worm   152 PKQKLLNWIRNRLPVSG---MPISNFTSDWNDGVALGALVNSMAPGALEDWENWSPNDALENTEK 213

  Fly   233 AFDVAEDKLGLAKLLDAEDVFVEHP--DEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAME 295
            |...|:|.|.:|.|:...::.  ||  ||.|::||:    ..|...|...::.|
 Worm   214 AMKSAQDLLKVAPLIAPAEMI--HPEIDEMSVMTYL----SQFPATKPIIMKPK----------- 261

  Fly   296 NDKMVHDYENFTSDLLKWIETTIQSLGE-------REFENSLAGVQGQLAQFSNYRTIEKPPKFV 353
                              ::.||.:|.:       |||:..|:            |...||...:
 Worm   262 ------------------VQATISNLDKILQVNDPREFDLKLS------------RDGFKPKVSI 296

  Fly   354 --EKG-NLEVLLFTLQSKMRANNQKPYTP-KEGKMISDINKAWERLEKAEHERELALREELIRQE 414
              |.| ::.:.|..::.|..|...| :|| |.|.:..|:........:.:...|.::..:::...
 Worm   297 RDEDGQDIHLSLKKVEDKENAYKVK-FTPTKIGFIHVDVAANDVHTFETQTIPEASVICQVVPIA 360

  Fly   415 KLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVA 479
            :|                 |..|:.....|:..|  |.|:|.....|||..|....|.|:..:..
 Worm   361 RL-----------------LDYNKTAKVGDDVKF--AVVDAIEGPVEAIVVDPTGKEHRMVILDG 406

  Fly   480 VCDELESERY-------HDV----KRILL---------RKDNVMRLWTYLLELLRARRMRLEISL 524
            ......|..|       |.|    |::.|         :..|..::|        .|.:..|
 Worm   407 TSPGEHSFEYKIPCIGLHSVNVFHKKLPLTGSPFPLRGKPKNSFKVW--------GRGIAPE--- 460

  Fly   525 QLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINIL------GERVKVV 583
            .:::|                    |..|.|   ||.|..:.::..|:|::.      |..:.|.
 Worm   461 GIRKN--------------------DVVGVH---VESLDPEENIANANISLEVLKPSDGSHLPVS 502

  Fly   584 VQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVE--RRSRL----EESRKLWQFYW 642
            |..:.:..|.|.| |.|          :|..|....||::|.|  ...::    |.|.|:..|
 Worm   503 VGYNDESQSMDFE-YSP----------KQAPDDLEVLVKVAGEVIESHKIHVAPESSSKIRAF-- 554

  Fly   643 DTADEENWIKEKEQIVSTDEVGH--DLTTVNLMLSK------HKALESEITSHDPQLQNVAKVGS 699
             .|..|..|..:..:...:..|.  ||:......||      .:...|.|.|:.|.:..|.|||
 Worm   555 -GAGLEGGIVNEPCVFDVEMNGESKDLSFAVEGPSKAEIGCQERPDGSAILSYTPTVAGVYKVG- 617

  Fly   700 ELITEG-HF------------------------GAD-------------RIKDRL--------KE 718
             ::.:| |.                        |.|             |:..||        .|
 Worm   618 -VLADGKHIQDSPFVLRVTEPIEGLKPSATRVTGIDESKVYNVGEKIPFRVDTRLCGVDLVPKVE 681

  Fly   719 ILNKWDHLLDLTKYRRQRLENAVEYFQLFADA---DDVDNWMLDTLRIVSSEDVGRDEANVQSLL 780
            ||   |..|:...|..:.:...:..:.|..||   ..:|         ||...|....|.....:
 Worm   682 IL---DPELNPISYGAREITPGLFEYTLIPDAPIKHKID---------VSVAGVSVPGAPFSVKV 734

  Fly   781 KKHKDVADELKNYAEVID--ALHKQ--------------AESLKLNEAEKANVDKRLEAIDNRYK 829
            |:..| |.:||.:...:|  ...|:              |..:.|.:.:..|||  |:.:||:
 Worm   735 KEPTD-ASKLKIFGPGVDGPVYSKEPTRFTIDATQAGPGAVEVALRDDQGENVD--LDVLDNQ-- 794

  Fly   830 ELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKE 894
                          |.....|..::..|..|        |:.:..|::|..:||        :.:
 Worm   795 --------------DGSFTVKYTAQRPGAYQ--------LNVVFAGEEISPIEI--------NVK 829

  Fly   895 MNANASRVAVVNQLARQLLHVEH-----------PNS------DEIL-ERQN---HLNQE--WST 936
            .|.:.|.:.|.......||...|           |.|      ||:. :|.|   .:|.:  :||
 Worm   830 PNVDVSGIRVEGLENENLLIGSHLRPTINIGKLEPKSKGLQLIDEVNGKRYNVPMKINPDGTYST 894

  Fly   937 ---LREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETD---------SLEMDLTGVM 989
               |.|..|.|:..|.....|:...:|             ::..||         .||..:.|
 Worm   895 DTPLMEVGEHKLQLLFDEIPVKEAVVE-------------VIKGTDVNKCKAYGPGLEQAVVG-- 944

  Fly   990 TLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSK 1054
                       :.|..:..|......|.|:|...|.:|                        :|:
 Worm   945 -----------EKAVFELDLDGAGEGALSMEMRGPAKA------------------------ESR 974

  Fly  1055 LEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMM 1119
            :::.|:               .|...:..:: .|.....|.|.....|  :|.:..  ..:|.::
 Worm   975 IQDRGN---------------GKCSVEYVAK-APGDYEMAIKFGKDEQ--KEHVKG--SPFKAVV 1019

  Fly  1120 EYGE---RLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLD---QQLFNRDA 1178
            :|.:   ::|..|  .|.|.|. |.:.:|.:.|               .|::.|   :.....|.
 Worm  1020 DYKKDPSQITISG--LDQPNYR-LNQPINFVID---------------TSKTKDLPVKATVPSDF 1066

  Fly  1179 RQTEVLLSQ-----QEHFL-----SKDDTPVNLEQAENQLKRHEAFLTTME---------ANDDK 1224
            .|.:.::|:     :.|.:     .|.:..:.:|...:.||..|..:..:.         .:|.|
 Worm  1067 AQLQPVVSRSPSNPRHHNVRFVPSGKPNVSIPIEIIYDGLKIDEKLVKVLPEVEPQLIKILHDKK 1131

  Fly  1225 INTLLQVADTL-------VEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQ 1282
            .::|.....|.       |..|..|...:.|....:.|  .|.::|.  .|.:...|..:::...
 Worm  1132 KDSLTTTPITTNASHEGHVPFDVRDCGNVKKIESRVFG--PDGKERL--NHVRSTEQNGIYDVSF 1192

  Fly  1283 DLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKP-- 1345
            ..:...|:....|...|:.:.|..........:....:.||..:.|   .||.|...|:...|
 Worm  1193 PTDMAGEYCVVFYINGQEVAARVPVMAEKIGRKEDVIKEEIVFHPE---IAEHSPTVLTYNHPID 1254

  Fly  1346 EFKDVIEPKLKELAKQFDDLEV-HTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTA 1409
            ..|....|.::.||.:.|.:.: |.:|    |.|....|     .|.|....|.|
 Worm  1255 AKKKKAHPAIQVLAAKPDAVRLEHIQE----LVDNGHRV-----ADRIVFTATKL---------- 1300

  Fly  1410 NDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKA 1474
                                            .|..|......|.::.:..:....|| :|:|:|
 Worm  1301 --------------------------------GTNTLDVFYGGEHVDHVEYEAIGKLE-YERIQA 1332

  Fly  1475 PLLERQKALEKKKEAFQFCRDVED-EKLWIDEKLPVAN----SPDYGNSLFNVHVLKK--KNQSL 1532
               ||.|.:.:|::      ||:. ||.:.||......    :|..|.........||  ..|.|
 Worm  1333 ---ERAKVVVEKED------DVDKYEKQYKDEPSSAPADPRVAPTNGKEPTTAQESKKNGNQQKL 1388

  Fly  1533 A--TEIDNHEP-------RINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKH 1588
            |  .||: |:|       :.|        :.|.|:: .|..||::...||| :|:.:.|:|....
 Worm  1389 APSAEIE-HKPLEKYFTFQFN--------VRDLGYQ-PKDLEAIVMPPTQK-KEVAEIIDNLDGT 1442

  Fly  1589 LL--ESEKVQ-------------------QYFFDAQEAESWMS---------------------- 1610
            :|  .:.||.                   :::.||. .:.|.:
 Worm  1443 ILVKYTPKVHGSHELSILQNGAQLQGTPIKFYVDAY-GDGWATVYGPGLQNAVVGEPATFTVCAK 1506

  Fly  1611 ---EQELYMMVEDRGKDEISAQNLMKKHENLE-----------------------QSVEDYANTI 1649
               .:||.:.:|...|.:|      |.|:|.:                       ::|:|....:
 Worm  1507 GSQAKELSVSIEGPAKSQI------KIHDNKDGTCSAAWVPPVPGEYKVHVKLGGKAVKDSPFRV 1565

  Fly  1650 RQLGEVARQFSGDDISSGD----AVAVKQSQLDKLYAGLKDLAGERR---------ARLNEAL-- 1699
            ..:||..::   ..:|.|.    |:.:.|.:|..:.|.:|...|...         .||..:.
 Worm  1566 LVMGEGQKR---SHLSVGSTSEVALPITQQELKGISASIKSPGGIEEPCFVRLLDGGRLGVSFTP 1627

  Fly  1700 -----QLFMLSRE------------VDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARD 1747
                 .|..:.|:            ||..:.....:..|:||.:.    ..:||   :.||...|
 Worm  1628 REAGEHLITVKRDGKLVPKAPFKIKVDKTQVGDASKVEVSGSGKA----KGITL---QANELLVD 1685

  Fly  1748 TEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFF 1812
            |...|      ..|::.: :|.......|..|.|..       |::::.|.|:....:..:....
 Worm  1686 TSKAG------YGGLSVS-VQGPSKAELTCKEVKSG-------LIKVLYTPTEPGVYAIAIKFAD 1736

  Fly  1813 HDCKD----------VLGRILE------KQHGV 1829
            |..||          ..||:::      :|||:
 Worm  1737 HHVKDSPLTVQCTGKSAGRVIQTIQKDVEQHGI 1769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	45/106 (42%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	32/108 (30%)
		Spectrin	298..408	CDD:395348	22/120 (18%)
		SPEC	422..521	CDD:197544	22/118 (19%)
		SPEC	525..740	CDD:238103	56/280 (20%)
		SPEC	639..846	CDD:238103	54/279 (19%)
		SPEC	848..1058	CDD:238103	43/244 (18%)
		SPEC	955..1169	CDD:238103	32/225 (14%)
		SPEC	1170..1380	CDD:238103	44/241 (18%)
		SPEC	1386..1484	CDD:197544	15/97 (15%)
		SPEC	1488..1699	CDD:238103	57/308 (19%)
		SPEC	1594..1806	CDD:238103	49/310 (16%)
		SPEC	1807..2015	CDD:238103	8/39 (21%)
		Spectrin	2018..>2078	CDD:395348
		PH_beta_spectrin	2167..2274	CDD:269975
fln-1	NP_001294364.1	CH_dFLNA-like_rpt1	13..136	CDD:409160	47/112 (42%)
		CH_FLN_rpt2	151..255	CDD:409079	33/112 (29%)
		IG_FLMN	261..358	CDD:214720	23/138 (17%)
		IG_FLMN	367..446	CDD:214720	17/80 (21%)
		IG_FLMN	549..637	CDD:214720	20/92 (22%)
		IG_FLMN	643..737	CDD:214720	20/105 (19%)
		IG_FLMN	740..830	CDD:214720	22/123 (18%)
		IG_FLMN	930..1020	CDD:214720	19/146 (13%)
		IG_FLMN	<1406..1476	CDD:214720	15/79 (19%)
		IG_FLMN	1484..1567	CDD:214720	10/88 (11%)
		Filamin	1561..1650	CDD:395505	14/91 (15%)
		IG_FLMN	1661..1750	CDD:214720	21/109 (19%)
		Filamin	<1789..1842	CDD:395505
		IG_FLMN	1854..1944	CDD:214720
		IG_FLMN	1959..2039	CDD:214720
		IG_FLMN	2045..2133	CDD:214720
		IG_FLMN	2170..2258	CDD:214720