DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and DMD

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_006724531.1 Gene:DMD / 1756 HGNCID:2928 Length:3703 Species:Homo sapiens


Alignment Length:2758 Identity:595/2758 - (21%)
Similarity:1045/2758 - (37%) Gaps:750/2758 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 ERESVQKKTFTKWVNSHLCRVNCR-IADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLE 110
            |||.|||||||||||:...:...: |.:|:.|::||:.|:.|||.|:|::||| .||..|:|.|.
Human    12 EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPK-EKGSTRVHALN 75

  Fly   111 NVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDAL 175
            ||:|||:.|:...|.|.||||.||||||..|.|||||.|||.:|::::....:...:..:::..|
Human    76 NVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKIL 140

  Fly   176 LLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEK-LSKTNAIHNLNNAFDVAED 239
            |.|.:..|..|..|||.||||||.||||.||:||.|||||..:.. :.:.:|...|.:||::|..
Human   141 LSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARY 205

  Fly   240 KLGLAKLLDAEDVFVEHPDEKSIITYVVTYY---------------------------------- 270
            :||:.||||.|||...:||:|||:.|:.:.:                                  
Human   206 QLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH 270

  Fly   271 --HYFSKLKQETVQG------------------------------------------KRIGKVVG 291
              ||..::.....||                                          |..|..: 
Human   271 QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSL- 334

  Fly   292 IAMENDKMVHDYENFTSDLLKWI---ETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFV 353
              ||::..:..|:....::|.|:   |.|:|:.|  |..|.:..|:.|......| .::......
Human   335 --MESEVNLDRYQTALEEVLSWLLSAEDTLQAQG--EISNDVEVVKDQFHTHEGY-MMDLTAHQG 394

  Fly   354 EKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISD-----------INKAWERLEKAEHERELALR 407
            ..||    :..|.||:...         ||:..|           :|..||.|..|..|::..|.
Human   395 RVGN----ILQLGSKLIGT---------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446

  Fly   408 EEL--IRQEKLEQLAARFDRKASMRETWLS---ENQRLVSQDNFGFDLAAVEAAAKKHEAIETDI 467
            ..|  ::.:||::|           ..||:   |..|.:.::..|.||..::...::|:.::.|:
Human   447 RVLMDLQNQKLKEL-----------NDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDL 500

  Fly   468 FAYEERVQA---VVAVCDELESER-----YHDVKRILLRKDNVMRLWT----YLLE--LLRARRM 518
            ...:.||.:   :|.|.||...:.     ...:|.:..|..|:.| ||    .||:  ||:.:|:
Human   501 EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICR-WTEDRWVLLQDILLKWQRL 564

  Fly   519 RLEISL------------------------QLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGV 559
            ..|..|                        ::..:.|::..:..::|:.||.:     ||.....
Human   565 TEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSM-----GKLYSLK 624

  Fly   560 EDLLQ--KHSLV----EADI--------NILGERVKVVVQNSQKFLSDDPESYKPCDPE---IIV 607
            :|||.  |:..|    ||.:        |::.:..|...|.||...:..|...:....|   .:.
Human   625 QDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 689

  Fly   608 SRVQQL-EDAYAEL----------VRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTD 661
            :|.|.| :.|..||          :.:..|.|.||:.         |..:..:||...|.::.:.
Human   690 TREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV---------DITELHSWITRSEAVLQSP 745

  Fly   662 EVGHDLTTVNLMLSKHK--ALESEITSHDPQLQNVAK----VGSELITEGHFGADRIKDRLKEIL 720
            |........|....|.|  |:|.|......:||:.::    :..:::.|| ..||.||...:::.
Human   746 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEG-VNADSIKQASEQLN 809

  Fly   721 NKWDHLLDLTKYRRQRLE---NAVEYF----QLFADADDVDNWMLDTLRI---VSSEDVGRDEAN 775
            ::|.....|...|...||   |.:.::    ||.......:||    |:|   ..||...     
Human   810 SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENW----LKIQPTTPSEPTA----- 865

  Fly   776 VQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRK- 839
            ::|.||..||..:.|.:....|:.|..|:.:||........:|....|..|.:|::....:.|: 
Human   866 IKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 930

  Fly   840 --QRLLDALSLYKLMSEADGVEQWIKE-KTKMLDTMTPGKDIEDVEIMKHRFEGFD--------- 892
              |.:.|.|...:.......:..|::: :||:   ..|...:.|.|||:.|.....         
Human   931 ELQTIFDTLPPMRYQETMSAIRTWVQQSETKL---SIPQLSVTDYEIMEQRLGELQALQSSLQEQ 992

  Fly   893 -----------KEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMD 946
                       |||:..|.     ::::|:.    ....:||..|...|:.:.....:|.|.:|:
Human   993 QSGLYYLSTTVKEMSKKAP-----SEISRKY----QSEFEEIEGRWKKLSSQLVEHCQKLEEQMN 1048

  Fly   947 DL-KSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLS 1010
            .| |..:.:||......|...:::::...|.:::.|:..|.     |.||  :..|:..||..|:
Human  1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK-----QCRL--LVSDIQTIQPSLN 1106

  Fly  1011 SLEREANSIEDE-HPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFL---RDLDHF 1071
            |:......|::| .||.|..:...:.::...|:.:.|.:..|...|:  |.|.:.:   :||...
Human  1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK--GGLEKTVSLQKDLSEM 1169

  Fly  1072 QTWLTKTQTDVASED----TPTSLPEA-----------------EKLLNQ-------------HQ 1102
            ..|:|:.:.:....|    ||..|.:|                 .|||.:             .:
Human  1170 HEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1234

  Fly  1103 SIREEIDNYTEDY---------------------------------------------------- 1115
            ::::|::..|.:|                                                    
Human  1235 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGA 1299

  Fly  1116 ----------KNMMEYGE----------RLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWEN 1160
                      :|:|.:.|          :..::|...|:    .:.|.|......|.|||:....
Human  1300 EEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDE----LINEELETFNSRWRELHEEAVR 1360

  Fly  1161 RQVLLSQSLDQQLFNRDARQTEV---LLSQQEHFLSKD------------DTPVNLEQAENQLKR 1210
            ||.||.||:      :.|::||.   |:.:...|:.|.            ..|...::.::.|..
Human  1361 RQKLLEQSI------QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1419

  Fly  1211 HEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGR-----RDDNRQRALDQHEK 1270
            ||..|..|:    |.|...:.|..::.:    .|...|:.::::.:     :..|.::.|.:.:.
Human  1420 HEISLEEMK----KHNQGKEAAQRVLSQ----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKM 1476

  Fly  1271 LKNQVKLHEFLQDLEELAEWVQEKYATSQ----DESYRSAKTIHSKWTRHQAFEAEIAANKERLF 1331
            :.::||:|  |..||  .:.|:::...||    ...|:|...:.|        |.|:.....|  
Human  1477 ILDEVKMH--LPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKS--------EVEMVIKTGR-- 1527

  Fly  1332 EAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREV--------LVQQT 1388
               :..|:...|.|          |||.::...|::|..|.||.:.:..:::        .:::.
Human  1528 ---QIVQKKQTENP----------KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1579

  Fly  1389 CDDIDSYI--TDLE---KQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYL-- 1446
            .:.:..::  ||:|   :..|.|..:|              :.:::|......:||:||..:|  
Human  1580 MNVLTEWLAATDMELTKRSAVEGMPSN--------------LDSEVAWGKATQKEIEKQKVHLKS 1630

  Fly  1447 --------------QKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVE 1497
                          ::|:.|:|:..:.....||..|.|:....|||.||.:|      .|.::|:
Human  1631 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME------TFDQNVD 1689

  Fly  1498 DEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQS------LATEIDNHEPRINAICNNGRKLI-D 1555
            ....||.:          .::|.:....||..|.      |..|:::..|::::..:....|: :
Human  1690 HITKWIIQ----------ADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN 1744

  Fly  1556 EGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQ------EAESWMSEQEL 1614
            .|....|..|..||:|..::..:...|:. .|..:..::::|:..|.|      |||   .:|.:
Human  1745 RGDHCRKLVEPQISELNHRFAAISHRIKT-GKASIPLKELEQFNSDIQKLLEPLEAE---IQQGV 1805

  Fly  1615 YMMVEDRGKD-----EISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQ 1674
            .:..||..||     |.:.:.|:::.:||:|.:.|         |..|          :.:.:||
Human  1806 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD---------ERKR----------EEIKIKQ 1851

  Fly  1675 SQLDKLYAGLKDLAGERRAR-LNEALQLFMLSREVDDLEQWI---------------------TD 1717
            ..|...:..||||..:||.: |..:.|.:...|:.|||.:.:                     .|
Human  1852 QLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID 1916

  Fly  1718 REVVAGSQEL--------GQDFDHVTL--------LSERFNEFARDTEAVGGERVAKVNGIADNL 1766
            ||:....:||        |...|...:        ||:|:.|.............|:::.:.:..
Human  1917 RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1981

  Fly  1767 IQAGHSD-----SATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQ 1826
            :.....|     |...:.:...:....|.|||:    .|:|.|.....|.|.|    |.:..|..
Human  1982 MMVMTEDMPLEISYVPSTYLTEITHVSQALLEV----EQLLNAPDLCAKDFED----LFKQEESL 2038

  Fly  1827 HGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVL 1891
            ..:.|.|.:.:|.:..:..|....||....:         |..|||:|.:            ::.
Human  2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATPV---------ERVKLQEALS------------QLD 2082

  Fly  1892 HAWDNLQAMCDARKQKLADTGDLFRFFNM-VRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQ 1955
            ..|:.:..|...|:.:...:.:.:|.|:. ::|...|:.:..:.:..::.|.:.        .|.
Human  2083 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--------EHA 2139

  Fly  1956 SLKAEIDTREDNFG-------ACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEE---- 2009
            ..|..:...:|..|       ...:.|:|::.::....|.|      |.....:|..||:|    
Human  2140 KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI------LQEKLGSLNLRWQEVCKQ 2198

  Fly  2010 ------RWENLQLILEVYQFARDAAVAEAWL-----IAQEPYLLSSE--LGHTIDEVENLIKK-- 2059
                  |.|..:.||.  :|.||......||     ||..|.....|  |...:::|:.|:::  
Human  2199 LSDRKKRLEEQKNILS--EFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELP 2261

  Fly  2060 -HEAFEK-----------SAAAQEERFSALE-RLTTFELKEMKRRQELAE---EAERQRIKE-EQ 2107
             .:...|           ||....|....|| :|....|:.:|..:.|.|   |.|.| ||: .|
Human  2262 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ-IKDLGQ 2325

  Fly  2108 EAKAASEAAEQAK----------------REAERRDDVDVGASHDDSAAKDTAVE--FERVVEIQ 2154
            ..|...:..||..                .:..:....||..:.....||...||  ..:...:.
Human  2326 LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLY 2390

  Fly  2155 TERGGTPGAGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFR 2219
            .|:..|..        |.||.|..|:..||.||...:  :.||...::           |.||..
Human  2391 KEKPATQP--------VKRKLEDLSSEWKAVNRLLQE--LRAKQPDLA-----------PGLTTI 2434

  Fly  2220 G-EPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDD-----TEMSQWVTSLKAQSDST 2278
            | .|:   |...:......||:..:.::::.:..:..:.|..|     ||::.|::.|.....|.
Human  2435 GASPT---QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2496

  Fly  2279 AVAASRSQTL-------PATSQKDEPKR 2299
            .|.....:.:       .||.|..|.:|
Human  2497 RVMVGDLEDINEMIIKQKATMQDLEQRR 2524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 54/98 (55%)
CH 170..269 CDD:278723 47/99 (47%)
Spectrin 298..408 CDD:278843 27/123 (22%)
SPEC 422..521 CDD:197544 26/115 (23%)
SPEC 525..740 CDD:238103 54/251 (22%)
SPEC 639..846 CDD:238103 51/225 (23%)
SPEC 848..1058 CDD:238103 46/232 (20%)
SPEC 955..1169 CDD:238103 56/323 (17%)
SPEC 1170..1380 CDD:238103 45/233 (19%)
SPEC 1386..1484 CDD:197544 24/118 (20%)
SPEC 1488..1699 CDD:238103 49/229 (21%)
SPEC 1594..1806 CDD:238103 55/265 (21%)
SPEC 1807..2015 CDD:238103 39/225 (17%)
Spectrin 2018..>2078 CDD:278843 17/80 (21%)
PH 2167..2275 CDD:278594 25/113 (22%)
PH_beta_spectrin 2167..2274 CDD:269975 25/112 (22%)
DMDXP_006724531.1 CH 16..119 CDD:237981 57/103 (55%)
CH 135..240 CDD:237981 47/104 (45%)
SPEC 341..558 CDD:238103 54/244 (22%)
SPEC 560..827 CDD:295325 55/281 (20%)
SPEC 727..933 CDD:238103 49/215 (23%)
SPEC 943..1152 CDD:238103 45/227 (20%)
SPEC 1049..1263 CDD:238103 42/222 (19%)
SPEC 1162..1369 CDD:238103 31/210 (15%)
SPEC 1268..1474 CDD:238103 36/223 (16%)
SPEC 1467..1676 CDD:295325 47/249 (19%)
Spectrin 1679..1776 CDD:278843 21/113 (19%)
COG1340 1704..1974 CDD:224259 61/292 (21%)
SPEC 1780..1968 CDD:238103 45/209 (22%)
SPEC 1878..2102 CDD:295325 45/252 (18%)
SPEC 2105..2320 CDD:238103 48/231 (21%)
SPEC 2321..2579 CDD:295325 45/228 (20%)
SPEC 2472..2688 CDD:238103 12/53 (23%)
SPEC 2690..2933 CDD:238103
Apolipoprotein 2894..3040 CDD:279749
Spectrin 2934..3040 CDD:278843
WW 3059..3088 CDD:238122
EF-hand_2 3089..3207 CDD:286194
EF-hand_3 3211..3302 CDD:286195
ZZ_dystrophin 3311..3359 CDD:239074
MCM3AP_GANP <3488..3681 CDD:293374
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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