Protein Alignment beta-Spec and anc-1

DIOPT Version :10

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_491353.2
• Gene: anc-1 / 172034
• WormBaseID: WBGene00000140
• Length: 8545
• Species: Caenorhabditis elegans
• Alignment Length: 3252
• Identity: 607/3252 - (18%)
• Similarity: 1112/3252 - (34%)
• Gaps: 1164/3252 - (35%)

  Fly    47 ERESVQKKTFTKWVNSHLCRVNC--RIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKM--RIH 107
            |.|..||.|||:|:|.||...:.  ||.||:.|:|||..|..|:|||:||.| ...||::  |:|
 Worm    20 EDEKAQKNTFTRWINFHLEEHSSSGRIEDLFEDIRDGVLLCHLIEVLTGEAL-AVHKGRVSKRVH 83

  Fly   108 CLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQD--------------- 157
            .:.|:..||..||.:.:.|.|..:.||.|||..:.|||||.|||.|||:.
 Worm    84 HIANLTTALTVLRRRGLELINNNAADIADGNPRIVLGLIWQIILHFQIETNMILLREWGWAATGT 148

  Fly   158 ------------IT--------------IEEVDNKET---------------------------- 168
                        :|              :..:...:|
 Worm   149 EEPTSSAQPEVVVTAPSPTPSSKKSHSKVSSLSGSKTSLASGEKAPSSPLRQRIASFLTPTKKAP 213

  Fly   169 --------KSAKDALLLWCQMKTAG-YHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKT 224
                    :|.:...|.|...:... .....|.|....||||:.|.|::.:.|||::...:::..
 Worm   214 KLTAQPVKQSVEQVFLRWINAEIGDLVGGRRVENMDKQWRDGILFCALVSRWRPDVISMREVTNA 278

  Fly   225 NAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYF---------------- 273
            |...||..||::|...||:.:||..||:.:|.||::|:||||..:...|
 Worm   279 NPRDNLELAFNLAHQHLGVRRLLAVEDMMIEKPDKRSVITYVSQFVRMFGERSPMQGREQHEIFL 343

  Fly   274 --------------------SKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKW--IET 316
                                |::::|.::.:.:...:.:.    |:.:|.|.......||  |..
 Worm   344 AWLEATYLLCTRHELNSQECSRIRREFIEHRPLFNTIIVT----KVNYDVEELVEIEKKWDCIRE 404

  Fly   317 TIQSL---GEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYT 378
            |::..   .||:.....|.:...:|                 |...:|...|.  :.|.:.|...
 Worm   405 TLEKYARRSERDLPEPFASIATWIA-----------------GAEHILSRPLD--LDATDAKKTV 450

  Fly   379 PKEGKMISDINKAWERLEKAEHERELALRE-----ELIRQEKLEQLAARF--------------- 423
            ....|:||:..|..|.|.|.:.:.|.|::.     ..:..|..|.|.|||
 Worm   451 TMLQKLISEHQKYMEDLPKRQEDFEEAVKHGGLGGRPVAPEFSEPLRARFAQIEEENEPRISTLR 515

  Fly   424 ---------------DRKASMRET---------WLSENQRL--------------------VSQD 444
                           |.|..:..|         |:.|..:|                    .:..
 Worm   516 ILTTHYILLQYLQHIDEKIILWRTADSVTLLLRWIKEYTQLNAENPQAKCASYINKITLTMANDQ 580

  Fly   445 NFGFDLAAV-----EAAA---KKHEAI--------------ETDIFAYEERVQ------------ 475
            |...|..|:     |..|   |:.|::              ||.:...||.::
 Worm   581 NSKLDKEAILNTSNEKTAETLKRFESLWIELKLLKVEWVEWETHVSQLEEIIEERRRNGVPPTPE 645

  Fly   476 ------AVVAVCDEL-----ESERYHDVKRILLRKDNVMRL------------------------ 505
                  .:.|..|:|     .|.|..:.:|:.:...:..:|
 Worm   646 DEQALAVITAGADQLAPKLGASARLSNNQRLDVLTHSFKKLTKTTIKIGGRLVVELEPSTSEQAS 710

  Fly   506 -----WTYLLELLRAR---------------RMRLEISLQLQQNFQEMLYILDNMEEI------- 543
                 |....|||:..               |.:||...:..:|.::.|..|:.:.||
 Worm   711 KISYSWQASDELLKVEMQLRDRIQRDADSSDREQLEYRAETFRNIRDKLIELERLNEIYDNHSRD 775

  Fly   544 -----KQLLMTDDYGKHLMGVE--------DLLQKHSLVEADINILGERVKVVVQNSQKFLSDDP 595
                 .:.|:..|.|..:.|::        | |..::.|..:.|      :|.|..::..||:|.
 Worm   776 QVDTPNRNLIRHDMGTIIYGLQAGQYANFVD-LSCYAFVYDEYN------QVPVNLTENVLSEDY 833

  Fly   596 ESYKPCDPEIIVSRVQQLEDAYAELVRLAVE--------RRSRLEESRKLWQFYWDTADEENW-- 650
            ........:.|::|.:..||...|.:|...|        :.:.:||.|..|..  ..::.|:|
 Worm   834 VREIVNRKKAILTRRENNEDEIRESIRDMEECDRIIEGWQSTEIEELRAEWNI--KLSEFESWHE 896

  Fly   651 --------------------------IKEK-----------------EQIVST------------ 660
                                      :||:                 ||:.:|
 Worm   897 MMQQVEVLSQTIQTRLDVTVIQTIWILKERSYDIKHSELGGTLRESLEQLATTSETSVNRHLQNL 961

  Fly   661 ---------------DEVGHD-------------LTTVNLMLSKH-------------KALESEI 684
                           :|||.:             :.|::::.:|.             |.|.|:.
 Worm   962 ELSNEQDCPDAIEFLEEVGRESVSKLSAAVDDRYIYTLHVLRTKMELFRRLQNFCDAVKILRSQN 1026

  Fly   685 TS-HDPQLQNVAKVGSELIT-----------------------EGHF---GADRIKDRLKEILNK 722
            |. :..::..:.:|.||:.|                       .|.|   ..||:.::|..:::.
 Worm  1027 TKWNGIKISQIDQVQSEIDTLIVRLDEEWTQDANQLRAELASIHGSFFQLEFDRLNEKLNMLIHD 1091

  Fly   723 WDHLLDLTKYRRQRLENAVEYF--------QLFADADDVDNWMLDTLRIVSSEDV-GRD------ 772
            .|.|.:|..:||..|..|.|..        |....:|..|:.:..|..:..:.|: |.:
 Worm  1092 KDKLRELMVHRRHYLTAANELITDSKTDLAQRATSSDHPDDILRATDEVTKALDIKGEELRRLGE 1156

  Fly   773 --EANVQSLL------------------------------------------------------- 780
              |.|:..|:
 Worm  1157 LAEMNITDLVVVALILSFRRRQLGSEGEPEVEELRRALREIIARPITEPRDVSPDAIVADILRMK 1221

  Fly   781 ---KKHKDVADELK----------NYAEVIDALHKQAE-----------------SLKLNEAE-- 813
               |:.:...||::          ::|.:|:...::|:                 |.:.:|.|
 Worm  1222 DEKKRDEKTIDEIQATTLTDEQRASFAPLIEDYRRRADRHRIVFEHLVMIYLDWLSRQFDELEDE 1286

  Fly   814 --------KANVDKRLEAID-NRYKELTELAKLRKQ------RLLDALSLYKLMSEADGVE---- 859
                    :|:..:|:.:.: |::|  |:||.:.:|      :.|.| .|..|..:.|.:|
 Worm  1287 IGMTIQTSRADDLRRMNSTEWNKWK--TDLANIERQVGPDTKKALSA-ELADLHRKRDSMEARIN 1348

  Fly   860 QWIKEKTKMLDTMTPGKD-----IEDVEIMKHRFEGFDKEMN---ANASRVAVVNQ-LARQLLHV 915
            :::....|:...:|..:.     .||:|..:.:||  |.|.:   .:...||:..| |..:|..:
 Worm  1349 KYLTHSAKINAKLTQFEKWLNAIEEDIEQTERQFE--DPERSYRFGSLHEVALAKQRLVAKLERL 1411

  Fly   916 EHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFY---------IECRETISWIEDK 971
            ...|.:|:|    .|.:.:.|:..    |:...::|.|:....         .:.:.::|.|...
 Worm  1412 NVANKEEVL----RLCERYHTIMH----KLTPFQTAVGLPLHVSTNLDRNGPFQSQISVSSIASS 1468

  Fly   972 KRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAI---QAKLSSLEREANSIEDEH---PEEAKII 1030
            :  |...:|       ||:|...:..:..|:|.:   :||::.|.::.:.|||.:   |:....:
 Worm  1469 E--LERPES-------VMSLTSSIGVIPADVAELSPFEAKINKLLQKLHIIEDSYLKGPKPIDTV 1524

  Fly  1031 RERIAQIELIWEQLTQMLKE-RDSKLEEA---GDLHRFLRDLDHFQTWLTKTQTDVASEDTPTS- 1090
            ||.:.|:|....:..::|:: ..|.:|:|   |..|||:..|:::...|...:.::..::..|:
 Worm  1525 REDVKQLEKYRNRGAEILQQLSTSNIEDAEKEGLKHRFVLMLNNYDDILRSIENEIRDDNELTAK 1589

  Fly  1091 -------LPEAEKLLNQHQSIREEIDNYTE--------DYKNMM-----EYGERLTSEGSTSDDP 1135
                   |..||:.|  ..|..|::|...|        |...:|     :|.|....:.|....|
 Worm  1590 NQEILAELSNAEQTL--QNSPLEDLDISAELDRLQMQLDLVKVMCNKPRKYVECELIDSSREGSP 1652

  Fly  1136 QYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRD-ARQTEV---LLSQQEHFLSKDD 1196
            |     ||....|    ::..|..|....:...::::|...| :|..:|   |::.:|:....|.
 Worm  1653 Q-----ERRRRKK----KVMVMVSNTITTIIHVVEERLEASDISRNPDVQQKLVAVKENLRELDT 1708

  Fly  1197 T-----------PVNLEQAEN--QLKR----------------------HEAFLTTMEANDDK-- 1224
            |           |:..|...:  ::||                      .:|..:.:...||:
 Worm  1709 TTVTPHPPSIMSPLGTENRNDLEEVKRLAAEIDRAIDTASSMYEDAPTDEDALKSAIHLLDDQKV 1773

  Fly  1225 -INTLLQVADTLVEKDHFD-------ADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFL 1281
             :|.|..|.:.:.||:..|       |..:|::..|:....::..:..|..    .|.||..:.|
 Worm  1774 TLNHLHVVLEGIPEKNEQDRTDAIDIASSVGEKLGNLKSAVEEVYEEVLAS----TNPVKEDQPL 1834

  Fly  1282 QDLEELAEWVQEKYATSQDESYR-----SAKTIHSKWTRHQAFEAEIAANKE----------RLF 1331
            |.::|:.....|:.....||..|     |.:.|..|.......:.|:.::::          :|.
 Worm  1835 QHIQEVQTTPAEQSNWDTDEFSRQPPVLSDERIELKTDPSAIDKFEVRSDEDPVPKIIDLFGQLQ 1899

  Fly  1332 EAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDL-EVHT--------KEKGAMLFDANR-EVLVQ 1386
            .|...|..|:.|..:..|.::....:|.||...: ::|.        .:|.|::...:: :..:.
 Worm  1900 TAVNEASPLACEGTDDVDALQVASDKLTKQDRTIRKIHAILDTIDDPVQKPAIIESLDKIKDQIN 1964

  Fly  1387 QTCDDIDSYITDLEKQ-----IVSGDTANDLTSVNILMQK------QQVIQTQMAVKARQ-VEEI 1439
            ...|:|:..|.:|...     :....|...|..:...:::      .::..|:..:.||| :..:
 Worm  1965 NARDNINRQIDNLNYNQTPVVVPKESTKTPLNEIEDAVRQASTVVSDELCNTEKLLSARQTLANV 2029

  Fly  1440 DKQTEYLQKTV---PE--EKIEPIVVKKTAVLERFEKIKAPLLE-------RQKALEKKKEAFQF 1492
            ..|.:.::..|   ||  |.:.||:.:.|.:::..||..|..:|       ||..:::.::....
 Worm  2030 KPQVDSVEANVWSNPETIETVTPILEEYTTLVDNIEKKLANEIEVPTNDPSRQDLVQQLQDVILE 2094

  Fly  1493 CRDV----------EDEKLWID-------------EKLPVANSPDYG---NSLFNVHVLKKKNQS 1531
            |.:|          |:.||.::             |||....|||..   ::|.|||  ::.|.:
 Worm  2095 CEEVVVNCDNIEKLEESKLKLEKARPLLDQIGDNVEKLSREQSPDTSDAIDALSNVH--QQYNAT 2157

  Fly  1532 LAT------EIDNHEPRINAICNNGRKLIDEGH---------------------------EDAKK 1563
            :.:      |:.|.|...:|    ..:||.|.|                           ..|:.
 Worm  2158 IMSIDDKIDELKNPEEDTSA----ADQLISELHVISEMPAVTIDLSMLNAIEEGLSTLPAHQAEN 2218

  Fly  1564 FEALISDLTQKWQELKDAIENRRKHL----------------------------LESEKVQQYFF 1600
            .:|.|.:|.|| :|:.|..|.....|                            .:||:::....
 Worm  2219 VQAKIDELRQK-KEVADQTEQILSDLNAFGDMPAITLDLDLLKSVEDGIAVLPVEDSERIKAKIV 2282

  Fly  1601 -------DAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTI--------- 1649
                   ||.:||:.:  ||| .::.|.   .||..:|     |:.|.:||..|::
 Worm  2283 DLRKKKEDADQAEALL--QEL-SVISDM---PISTLDL-----NMLQGIEDNLNSLPAEESDEIR 2336

  Fly  1650 RQLGEVARQFSGDDISSGDAVAVKQ----------SQLD-KLYAGLKD----LAGERRARLNEAL 1699
            .:|.|:.|:....|    .|.|:.|          |.|| .:..|::|    |..|...::.|.:
 Worm  2337 EKLNELRRRKQESD----QAEALLQELSVISDMPISTLDLNMLQGVEDNLNSLPTEEADKIREKI 2397

  Fly  1700 QLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVT------------------------LLSER 1740
            ......::..||.:        |..|||...:|..|                        .:.|:
 Worm  2398 NDLRRRKQESDLAE--------ALLQELSVIYDMPTSTIDLNMLQGIEDNLNSLPAEESDKIREK 2454

  Fly  1741 FNEFARD------TEAVGGE------------RVAKVNGIADNLIQAGHSDSATIAEWKDNLNES 1787
            .|:..|.      .||:..|            .:..:.||.|||......:|..|.|..::|...
 Worm  2455 INDLRRRKQESDLAEALLQELSVIYDMPTSTIDLNMLQGIEDNLNSLPAEESDKIREKINDLRRR 2519

  Fly  1788 WQD------LLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRK 1846
            .|:      ||:.:...:.|.|::.::: .....:|.|..:|      |::..:...::.:|::|
 Worm  2520 KQESDQAEALLQELSVVSDMPASTIDIN-MLQSIEDGLSTLL------SEDRSKIQQAIDSLRKK 2577

  Fly  1847 HYNFLQDL-------ITLYSQVQQIQ---EESAKLQDAYA----------GDKAKEITNREQEVL 1891
            ..:  .||       :::.|::..:.   ||..||::..:          .||..|:...:....
 Worm  2578 KSD--SDLAQHALEALSVQSKLPSVSINLEELKKLEETLSTVPVEDSKVIRDKIAELKTEKALAD 2640

  Fly  1892 HAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQM----------------NTSEK 1940
            ||.:.|..:.......::..|.         .::..:||.:.||                ...|:
 Worm  2641 HAENYLVELKKIEDMPISAVGS---------DVLATIEDQILQMPVQYQPSVKETLDKLKQAKEE 2696

  Fly  1941 PRDVSGV--EL-------LMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIK------ 1990
            ...::||  ||       ..:....|.|:||.:.:      ||.|:.:...|....|||
 Worm  2697 DDKLAGVYDELEKIAKLPARDYDNKLLAKIDEKLN------SLPKDQIAETHRKVEDIKVTKADI 2755

  Fly  1991 ------------------------DRLMTL-SNSRNAL------LR-----RWEERWENLQLILE 2019
                                    ::|.|: |:|.:.|      ||     ..:|..:.|..:.|
 Worm  2756 VAQIDVLDKLPAKDIDEHLLNSIEEKLPTIPSDSSDQLQIAIGKLRDRKQANIDEGKKILNELAE 2820

  Fly  2020 VYQFARDAAVAEAW-LIAQEPYLLSSELGHTI-DEVENLIKK---HEAFEKSAAA--------QE 2071
            :.:...|:....|. |:|.|.....||:...| .|::.|.:|   ||....:|.:        .|
 Worm  2821 IQKMPADSLNEHALNLLATESDKFGSEISDKIMQEIDVLREKQNNHEVARLNAESVLQQLDKISE 2885

  Fly  2072 ERFSAL--ERLTTF-----------------ELKEMKRRQELAEEAERQRIKEEQEAKAASEAAE 2117
            |...:|  |||..|                 ::.|:::..:.|.:.|:..:||:..||..:....
 Worm  2886 EPHLSLTEERLAPFLQNIDTVPACFVDKIRNKINEVQKLHDEAVQDEKDELKEKLVAKVQNIGKT 2950

  Fly  2118 QAKREAERRDDVDVGASHDDSAAKDTAVE-FE------RVVEI-QTERGGTPGAGEGHEGYVTRK 2174
            ..       |||:|....:.....:.::| ||      ::.|: :.:|.|.......|:..|..:
 Worm  2951 SI-------DDVNVSDFEEIEREINGSLEAFEAEPLLAKIQELREAKRVGDEARSAAHDQIVALE 3008

  Fly  2175 HEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTK 2239
            .|.:..|.|.|.:                 |.:|..|.:|            |....|:::...:
 Worm  3009 KEAEDVTAKESAK-----------------KKKKDKKKSP------------QEMIDELSAKVVE 3044

  Fly  2240 KKHVL-----RVKLANGALFLLQAHDDTEMSQWVTSLKA--QSDSTAVAASRSQTLPATSQKDEP 2297
            .|.::     ..|..|     |.|.|..:..|.|::|:|  :...|.|:..:.:.....:..|..
 Worm  3045 AKALIPKIEEAAKNEN-----LPADDKPKAEQLVSNLEAFVKDVETQVSEKQDELDKLNNANDAI 3104

  Fly  2298 KR 2299
            ||
 Worm  3105 KR 3106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	50/108 (46%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	34/104 (33%)
		Spectrin	298..408	CDD:395348	25/114 (22%)
		SPEC	422..521	CDD:197544	31/246 (13%)
		SPEC	525..740	CDD:238103	60/367 (16%)
		SPEC	639..846	CDD:238103	60/450 (13%)
		SPEC	848..1058	CDD:238103	49/238 (21%)
		SPEC	955..1169	CDD:238103	51/253 (20%)
		SPEC	1170..1380	CDD:238103	51/282 (18%)
		SPEC	1386..1484	CDD:197544	24/121 (20%)
		SPEC	1488..1699	CDD:238103	67/328 (20%)
		SPEC	1594..1806	CDD:238103	59/290 (20%)
		SPEC	1807..2015	CDD:238103	48/294 (16%)
		Spectrin	2018..>2078	CDD:395348	18/74 (24%)
		PH_beta_spectrin	2167..2274	CDD:269975	22/113 (19%)
anc-1	NP_491353.2	CH_SF	20..132	CDD:469584	53/112 (47%)
		CH_SF	221..328	CDD:469584	34/106 (32%)
		PRK03918	2090..2716	CDD:235175	124/673 (18%)
		PTZ00121	<2883..3913	CDD:173412	51/265 (19%)
		PTZ00121	<3859..4867	CDD:173412
		PTZ00121	<4813..5770	CDD:173412
		PTZ00121	<5716..6673	CDD:173412
		PTZ00121	<6619..7576	CDD:173412
		PTZ00121	<7522..8211	CDD:173412
		KASH	<8507..8545	CDD:463142