DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and Actn2

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	NP_150371.4	Gene:	Actn2 / 11472	MGIID:	109192	Length:	894	Species:	Mus musculus

Alignment Length:	905	Identity:	293/905 - (32%)
Similarity:	448/905 - (49%)	Gaps:	164/905 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRD 80
            ||.:|  .|.||......:..|..|...|....|..|:||||.|.||||.:...:|.::..|.|:
Mouse     6 PGVQY--NYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRN 68

  Fly    81 GKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGL 145
            |..|:.||||:||||||||.:||||.|.:.||:|||.::..:.|.|.:||:.:|||||..:.||:
Mouse    69 GLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGM 133

  Fly   146 IWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHK 210
            ||||||||.||||::||.      |||:.||||||.|||.|.|||::||.|||:|||...|:||:
Mouse   134 IWTIILRFAIQDISVEET------SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHR 192

  Fly   211 HRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVF-VEHPDEKSIITYVVTYYHYFS 274
            |||||:.:.||:|.:.|.|:|.|.::||..|.:.|:|||||:. ...|||::|:|||..:||.|:
Mouse   193 HRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA 257

  Fly   275 KLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQ 339
            ..:|......||.||:.:..||::::.:||...|:||:||..||..|..|..|.::..:|.:|..
Mouse   258 GAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED 322

  Fly   340 FSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHEREL 404
            |.:||...||||..||..||:...|||:|:|.:|:..:.|.||||:|||..||:|||:||...|.
Mouse   323 FRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEE 387

  Fly   405 ALREELIRQEKLEQLAARFDRKASMRETW-LSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIF 468
            .|..|:.|.|:||.||.:|.:|||..||| ..:.|.|:.:|.....|..|.|..:||||.|:|:.
Mouse   388 WLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLA 452

  Fly   469 AYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEM 533
            |:::||:.:.|:..||....|||...:..|...:...|..|..|.:.||..||.:.:|.:...::
Mouse   453 AHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQL 517

  Fly   534 LYILDNMEEIKQLLMTDDYGKHLM-GVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPES 597
                 ::|..|:....:::.:..| .::|:...||:         |.::.::...::|.:..||:
Mouse   518 -----HLEFAKRAAPFNNWMEGAMEDLQDMFIVHSI---------EEIQSLITAHEQFKATLPEA 568

  Fly   598 YKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDE 662
                             |...:.: ||::                         .|.|:::.:..
Mouse   569 -----------------DGERQSI-LAIQ-------------------------NEVEKVIQSYS 590

  Fly   663 VGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLL 727
            :                   .|:|.:|.         ..:|            :.|:.||||.:.
Mouse   591 I-------------------RISSSNPY---------STVT------------MDELRNKWDKVK 615

  Fly   728 DLTKYRRQRL------ENAVEYF--QLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHK 784
            .|...|.|.|      ::|.|..  |..|.|:.:..|:.:.:     |::.|....:...|   :
Mouse   616 QLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKM-----EEIARSSIQITGAL---E 672

  Fly   785 DVADELKNYA-EVIDALHKQAESLKLNEAEKANVDKRL--EAI--DNRYKELT--------ELAK 836
            |..::||.|. .:|:  :|       |..:|...|.:|  ||:  ||::...|        ||..
Mouse   673 DQMNQLKQYEHNIIN--YK-------NNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728

  Fly   837 LRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMN 896
            ....|.::.:....|..:|.|:.|                  |.:...:..|..||:..|
Mouse   729 TTIARTINEVETQILTRDAKGITQ------------------EQMNEFRASFNHFDRRKN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	50/97 (52%)
		CH	170..269	CDD:278723	55/99 (56%)
		Spectrin	298..408	CDD:278843	48/109 (44%)
		SPEC	422..521	CDD:197544	34/99 (34%)
		SPEC	525..740	CDD:238103	29/221 (13%)
		SPEC	639..846	CDD:238103	42/227 (19%)
		SPEC	848..1058	CDD:238103	9/49 (18%)
		SPEC	955..1169	CDD:238103
		SPEC	1170..1380	CDD:238103
		SPEC	1386..1484	CDD:197544
		SPEC	1488..1699	CDD:238103
		SPEC	1594..1806	CDD:238103
		SPEC	1807..2015	CDD:238103
		Spectrin	2018..>2078	CDD:278843
		PH	2167..2275	CDD:278594
		PH_beta_spectrin	2167..2274	CDD:269975
Actn2	NP_150371.4	Actin-binding	1..254		127/255 (50%)
		CH_ACTN_rpt1	35..139	CDD:409063	53/103 (51%)
		CH_ACTN_rpt2	143..257	CDD:409065	63/119 (53%)
		Spectrin 1	281..391		48/109 (44%)
		Spectrin	281..391	CDD:395348	48/109 (44%)
		Spectrin 2	401..506		37/104 (36%)
		SPEC	402..629	CDD:238103	67/323 (21%)
		Spectrin 3	516..627		28/207 (14%)
		Spectrin 4	637..740		25/119 (21%)
		Spectrin	637..739	CDD:395348	25/118 (21%)
		PTZ00184	747..>851	CDD:185504	8/42 (19%)
		EFhand_Ca_insen	824..890	CDD:400872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920