Protein Alignment beta-Spec and Actn1

DIOPT Version :9

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_001366004.1
• Gene: Actn1 / 109711
• MGIID: 2137706
• Length: 914
• Species: Mus musculus
• Alignment Length: 1035
• Identity: 325/1035 - (31%)
• Similarity: 480/1035 - (46%)
• Gaps: 225/1035 - (21%)

  Fly    49 ESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVD 113
            |..|:||||.|.||||.:...:|.::..|.|||..|:.||||:|||||.||.:||||:|.:.||:
Mouse    30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVN 94

  Fly   114 KALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLW 178
            |||.|:..:.|.|.:||:.:|||||..:.||:||||||||.||||::||.      |||:.||||
Mouse    95 KALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEET------SAKEGLLLW 153

  Fly   179 CQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGL 243
            ||.|||.|.|||::||..||:|||.|.|:||:|||:|:.:.||.|.:.:.|||.||||||..|.:
Mouse   154 CQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDI 218

  Fly   244 AKLLDAEDVF-VEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFT 307
            .|:|||||:. ...||||:|:|||.::||.||..::......||.||:.:..||::::.|||...
Mouse   219 PKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLA 283

  Fly   308 SDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRAN 372
            ||||:||..||..|..|..||::..:|.:|..|.:||.:.||||..||..||:...|||:|:|.:
Mouse   284 SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLS 348

  Fly   373 NQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSEN 437
            |:..:.|.||:|:||||.||..||:||...|..|..|:.|.|:|:.||.:|.:|||:.|.|....
Mouse   349 NRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGK 413

  Fly   438 QRLVSQDNF-GFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDN 501
            :.::.|.:: ...|:.::|..|||||.|:|:.|:::||:.:.|:..||....|:|...:..|...
Mouse   414 EAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQK 478

  Fly   502 VMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKH-------LMGV 559
            :...|..|..|.:.||..||.:.:|             :|.|.||.:  :|.|.       :.|.
Mouse   479 ICDQWDNLGALTQKRREALERTEKL-------------LETIDQLYL--EYAKRAAPFNNWMEGA 528

  Fly   560 EDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLA 624
            .:.||...:|.....|.|             |:...|.:|...|:             |:..|||
Mouse   529 MEDLQDTFIVHTIEEIQG-------------LTTAHEQFKATLPD-------------ADKERLA 567

  Fly   625 VERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDP 689
            :                   ....|   |..:||.|..|             :.|..:..|:..|
Mouse   568 I-------------------LGIHN---EVSKIVQTYHV-------------NMAGTNPYTTITP 597

  Fly   690 QLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRL--ENAVEYF------QL 746
            |                           ||..||||:..|...|.|.|  |:|.:..      |.
Mouse   598 Q---------------------------EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQF 635

  Fly   747 FADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELK----------NYAEVIDALH 801
            .|.|:.:..|:...:     |::||..      ::.|..:.|:|.          ||...||.|
Mouse   636 GAQANVIGPWIQTKM-----EEIGRIS------IEMHGTLEDQLSHLRQYEKSIVNYKPKIDQL- 688

  Fly   802 KQAESLKLNEA---EKANVDKRLEAIDNRYKE-LTELAKLRKQRLLDALSLYKLMSEADGVEQWI 862
             :.:...:.||   :..:.:..:|.|...::: ||.:|     |.::.:....|..:|.|:.|
Mouse   689 -ECDHQLIQEALIFDNKHTNYNMEHIRVGWEQLLTTIA-----RTINEVENQILTRDAKGISQ-- 745

  Fly   863 KEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQ 927
                            |.:...:..|..||::                   |......:|.....
Mouse   746 ----------------EQMNEFRASFNHFDRD-------------------HSGTLGPEEFKACL 775

  Fly   928 NHLNQEWSTLREKAEAKM--DDLKS---AHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTG 987
            ..|..:.....:|....|  ||.::   :.|......|....:| |.|..|:            |
Mouse   776 ISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMS-IVDPNRL------------G 827

  Fly   988 VMTLQRRLSGMDRDLA------AIQAKLSSLEREANSI-EDE-----HPEEAKIIRERIA 1035
            |:|.|..:..|.|:.|      .:.|....|..:.|.| |||     .|::|:....|:|
Mouse   828 VVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMA 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	51/97 (53%)
		CH	170..269	CDD:278723	58/99 (59%)
		Spectrin	298..408	CDD:278843	50/109 (46%)
		SPEC	422..521	CDD:197544	30/99 (30%)
		SPEC	525..740	CDD:238103	42/223 (19%)
		SPEC	639..846	CDD:238103	45/228 (20%)
		SPEC	848..1058	CDD:238103	39/205 (19%)
		SPEC	955..1169	CDD:238103	23/93 (25%)
		SPEC	1170..1380	CDD:238103
		SPEC	1386..1484	CDD:197544
		SPEC	1488..1699	CDD:238103
		SPEC	1594..1806	CDD:238103
		SPEC	1807..2015	CDD:238103
		Spectrin	2018..>2078	CDD:278843
		PH	2167..2275	CDD:278594
		PH_beta_spectrin	2167..2274	CDD:269975
Actn1	NP_001366004.1	CH_ACTN_rpt1	28..132	CDD:409063	54/101 (53%)
		CH_ACTN_rpt2	136..250	CDD:409065	66/119 (55%)
		SPEC	277..498	CDD:238103	86/220 (39%)
		SPEC	395..622	CDD:238103	75/329 (23%)
		Spectrin	634..733	CDD:395348	23/116 (20%)
		EFh	750..839	CDD:238008	20/120 (17%)
		EFhand_Ca_insen	844..910	CDD:400872	11/44 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920