DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and sptb

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_002936942.2 Gene:sptb / 100489265 XenbaseID:XB-GENE-492725 Length:2342 Species:Xenopus tropicalis


Alignment Length:2351 Identity:1115/2351 - (47%)
Similarity:1556/2351 - (66%) Gaps:81/2351 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            ||:..         |.:.|..|||:|:||||||||||:|||:||||||||||||||..|:|||:|
 Frog    21 RWETV---------EDDLDNDNSSARMFERSRIKALADEREAVQKKTFTKWVNSHLAFVSCRISD 76

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||:|:|||:.|||||||||||:||:.|||:|||||||||||||.||:||||||||||.||||:||
 Frog    77 LYLDLRDGRMLIKLLEVLSGEQLPRRTKGRMRIHCLENVDKALHFLKEQRVHLENIGPHDIVNGN 141

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.||||||||||||||||.| |:...||:|||||||||||||||||.||||.|||:|||||||
 Frog   142 HRLVLGLIWTIILRFQIQDIII-EMKGSETRSAKDALLLWCQMKTAGYPNVNVTNFTSSWRDGLA 205

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            |||:||||||||..||::.|:||.|||.:|||.|:.|||:.:|||.|||..|:|||||||||||.
 Frog   206 FNALIHKHRPDLFDFERMKKSNAKHNLEHAFDTADHKLGITQLLDPEDVLTENPDEKSIITYVVA 270

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            :||||||:|...|:|||||||:..|:|.|||:::||:.|||||.|||.||.:|..|.|.|||.||
 Frog   271 FYHYFSKMKALAVEGKRIGKVLDNAIETDKMIYEYESLTSDLLTWIEQTILALINRTFANSLTGV 335

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..||.|||.||||||.|||.|||||||:||:||.|.||.|.|::||::||||:||.|||||
 Frog   336 QQQLQAFSAYRTTEKPPKFQEKGYLEVLLFTIQSRMRENKQKVYVPQDGKLVSDINRAWGRLEKA 400

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            ||:||.|||.||||||||||||.||||||:|||||:||||.|::||||||||.:||||.||||||
 Frog   401 EHDRETALRNELIRQEKLEQLAKRFDRKAAMRETWISENQHLIAQDNFGFDLPSVEAAKKKHEAI 465

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            ||||:|||||:||:|.|..|||:|||||::||..||||::|||.||||:|::||.||.::::||.
 Frog   466 ETDIYAYEERIQALVNVAKELENERYHDIRRISARKDNIVRLWQYLLEILKSRRNRLNMTVELQT 530

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSD 593
            .|||||:|::.|:|||..|::.||||||:.||.|||||||.||||....::||...|.:.||:..
 Frog   531 LFQEMLHIVNWMDEIKGGLLSQDYGKHLLEVEYLLQKHSLTEADIAAQADKVKSFSQAALKFVGG 595

  Fly   594 DPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIV 658
            |  .|:||||::|..|||.||..|.|||.||.:||..|::||.||:|:.|..:...||:|||||.
 Frog   596 D--GYQPCDPQVIKDRVQHLELCYQELVSLAAQRRHNLQQSRCLWKFFGDIEEVARWIREKEQIY 658

  Fly   659 STDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723
            ::.:.|.|||:::::..||:|.|.|:...:..||:..|.|.::|...|:.:.:||::::.|..:|
 Frog   659 TSMDFGKDLTSISILQRKHRAFEDELKGLETNLQHTLKDGEQMIANKHYASPKIKEQIENIKVQW 723

  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD 788
            ..|.||..:|.:.|.:...:||...||||:...|.||.|::.|:|||.||.:.:.|:||.||:.|
 Frog   724 AQLKDLAAFRLKILCDTENFFQFQVDADDLAARMQDTYRMMQSDDVGHDEYSTKILVKKQKDLLD 788

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMS 853
            ::....:|::.|.:..:...........:|.||:.:...:.:|..||.||.|:|.||||.|.::.
 Frog   789 DIMINRKVLEGLSEVVQRFPEEFKTSPEIDSRLQKLRALFSDLASLADLRSQKLQDALSFYTVLG 853

  Fly   854 EADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP 918
            :.|..|.|:.||.|.|:.|...:.:||:.:::|||...|:||.|..|::..||..|..|:...||
 Frog   854 DIDACEMWMNEKEKWLEKMEIPESLEDMGVVQHRFNTLDQEMGALGSQIQDVNTAANALIESGHP 918

  Fly   919 NSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEM 983
            :..::.|..:|:|..|:..:|....|...:.||.|:..:.:||.||.:||.:|.:::.....|..
 Frog   919 SRKKVKEDLDHMNSRWTVFQEMVSQKRRAVDSALGLHNYGVECDETKNWIIEKIKVVESIQDLGS 983

  Fly   984 DLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048
            ||..||::||:|.|::||||||:|||.:|:.:|..:.::||::|:.|.:|:..|...||:|.:.|
 Frog   984 DLASVMSIQRKLYGIERDLAAIEAKLINLQGDAQKLANDHPDQAQNILDRLIDINKKWEELQKAL 1048

  Fly  1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113
            :.::..|.|:..:.:||.||..|:|||.:.|...||||.||||||||||...|.|::::|:.:..
 Frog  1049 QNQEESLGESSKVQKFLVDLFDFETWLYRAQQATASEDIPTSLPEAEKLYANHLSLKDDIERHEP 1113

  Fly  1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDA 1178
            |:.::::.|.::|| |.|  ||||..|.:|.|.:|:||.:||:||:||:..|||.|:.|.|.:||
 Frog  1114 DFCDVVDTGNKVTS-GQT--DPQYEQLDQRGNDIKEGWNDLHKMWDNREKSLSQCLEFQKFLKDA 1175

  Fly  1179 RQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDA 1243
            :|:|.:||.||:..:..:.|..|:.::.:||:||.||.|||.||:||...:.....|.|..:..|
 Frog  1176 KQSEAILSNQEYTFAHIEVPTTLQASQTRLKKHEDFLATMENNDEKIVGTINHGKKLDEDKNVFA 1240

  Fly  1244 DKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKT 1308
            ||...:...|..|...|..:|.:....||:...|..||::.|||..|:.||..|:||.||..|:.
 Frog  1241 DKALGKISFIEERYAKNLNKAKEVSILLKDNCDLQNFLENCEELNIWINEKMLTAQDTSYDGARN 1305

  Fly  1309 IHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKG 1373
            :||||.:||||:||:.:|||||...:|..::|::||.:|..:|..||.||.:.:|:||..|.:|.
 Frog  1306 LHSKWLKHQAFKAELDSNKERLENLDKEGKQLAQEKEQFAPIISEKLSELHRLWDELETTTLQKE 1370

  Fly  1374 AMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEE 1438
            ..||||:|..|.:|...|::.:|.|:|:|:.|.|...||||||||:.|.:.|:.|:..|..::::
 Frog  1371 QSLFDAHRTELYEQRYADLNKWIKDMEQQVKSDDCGTDLTSVNILLNKHKRIEDQIQQKTIEMDQ 1435

  Fly  1439 IDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWI 1503
            :..|...|.|. |:||...|.|       ||.:::..:.||::.|...|:..|..||:|||.|||
 Frog  1436 VLPQASALGKE-PDEKEPEINV-------RFLQLEPLMQERKRKLLSSKQVHQLHRDLEDEILWI 1492

  Fly  1504 DEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALI 1568
            .|:||:|.|.||||:|..|.:|.||||:|..||..|.|||..:....:.:..:...|.:..|...
 Frog  1493 QERLPLAESQDYGNNLQTVQMLMKKNQTLQKEIAGHSPRIEDVLMRAKHIEHDADIDDQPIEKKR 1557

  Fly  1569 SDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMK 1633
            ..|.:.|..|:..|..|.||||::.:...|:.||.|||:|:.||:||::.:::.|||.|...::|
 Frog  1558 KSLEESWDNLQKQIAEREKHLLQALEAHHYYMDAGEAEAWIDEQQLYLIGDEQPKDEESVVAMLK 1622

  Fly  1634 KHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEA 1698
            ||.||:.:||.|...|:.|.:.|::....:....:.:...|..::|.||.|:|:|.|:|.:|:..
 Frog  1623 KHLNLQHAVEHYGKNIKDLADQAQKLLALEHPDSERITRHQGNIEKQYAALRDMADEKRQKLDNI 1687

  Fly  1699 LQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIA 1763
            ..:|.|.|||:||||||.:|:|.|.|||:|||.|||::|.::|.:|||:|..:|.||:..||.:.
 Frog  1688 YHMFQLRREVEDLEQWIAERDVKASSQEMGQDLDHVSILRDKFRDFARETGVIGQERIDNVNILI 1752

  Fly  1764 DNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828
            :.||.|||:|:|.||||||||||||.||||||:||.|:|:||.||||||:|..::|..|.||...
 Frog  1753 EQLIDAGHADAAMIAEWKDNLNESWADLLELIDTRVQLLSASYELHKFFYDGTEILSMIEEKHKE 1817

  Fly  1829 VSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHA 1893
            :.::||.|..:..:|.|.|..|.:|:..:.||||..|:.:|:|..||||.:|.:|..:||||:.|
 Frog  1818 LPEDLGGDVHTAQSLHRVHTAFERDIHFIGSQVQHFQDTAARLYAAYAGTQAVDIQKKEQEVVEA 1882

  Fly  1894 WDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLK 1958
            |..|...||.|:.:|....:.||||:|||.||:|||:::||:.|.|||||:|.||.|:..||.||
 Frog  1883 WKGLLDACDGRRTELISAAEKFRFFSMVRDLMLWMENMIRQIETQEKPRDISSVEYLIKYHQELK 1947

  Fly  1959 AEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQF 2023
            |||:.|...:.||:.||..||.|||.||.:||::|:.|...|..::.:|.:||:.|.::|||.||
 Frog  1948 AEIEARNVTYTACVDLGNTLLARNHPASEEIKEKLVQLEERREEMMEKWHKRWDWLSILLEVCQF 2012

  Fly  2024 ARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEM 2088
            ||||::||:|||::||||.|:.:|:::|:||.||::||:||||....||||||||||||.||.|:
 Frog  2013 ARDASMAESWLISKEPYLYSTYVGNSVDDVEKLIRRHESFEKSTLTWEERFSALERLTTLELLEV 2077

  Fly  2089 KRRQE-------LAEEAERQRI--KEEQ---------EAKAASEAA------EQAK--------- 2120
            ::.||       :|.|:|.:..  ||:|         |.||...||      |:.|         
 Frog  2078 RKYQEAKRHEMLMAAESEMKETAQKEQQFQTHEEKEHEVKAIIHAAPDSPVLEELKPRLPSITEV 2142

  Fly  2121 ----REAERRDDVDVGASHDDSAAK------DTAVEFERVVEIQTERGGTPGAGEGHEGYVTRKH 2175
                :|.|.........:|.:|..:      |..........:.|:.|.:  :...|:||:.|||
 Frog  2143 TEETKEKEEEKITQEEYTHTESMEQTEYSILDPETRQIEATTLPTDSGSS--SSIQHQGYLNRKH 2205

  Fly  2176 EWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKK 2240
            :.|.|.|||:||||:.||...|...:.||||.|.:..|.  .|:||....|:||:.||.:||.||
 Frog  2206 DLDGTLKKAANRSWNNVYCVLKNHDLYFYKDAKCFALNE--AFQGEGPLPLRNASCEIVADYKKK 2268

  Fly  2241 KHVLRVKLANGALFLLQAHDDTEMSQWV----TSLKAQSDSTAVAASRSQTLPATSQKD-----E 2296
            |||.|::|.:|..:|.||.|:.::..||    |::...:|..  ..|:|..||:||..:     :
 Frog  2269 KHVFRLRLGDGNEWLFQAKDEADLQTWVPILATTITEATDHK--PKSKSLPLPSTSASEGKPEKK 2331

  Fly  2297 PKRRSFFTLKK 2307
            .||.:||:.||
 Frog  2332 DKRFTFFSSKK 2342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 78/97 (80%)
CH 170..269 CDD:278723 75/98 (77%)
Spectrin 298..408 CDD:278843 74/109 (68%)
SPEC 422..521 CDD:197544 72/98 (73%)
SPEC 525..740 CDD:238103 95/214 (44%)
SPEC 639..846 CDD:238103 68/206 (33%)
SPEC 848..1058 CDD:238103 72/209 (34%)
SPEC 955..1169 CDD:238103 90/213 (42%)
SPEC 1170..1380 CDD:238103 84/209 (40%)
SPEC 1386..1484 CDD:197544 32/97 (33%)
SPEC 1488..1699 CDD:238103 79/210 (38%)
SPEC 1594..1806 CDD:238103 100/211 (47%)
SPEC 1807..2015 CDD:238103 94/207 (45%)
Spectrin 2018..>2078 CDD:278843 37/59 (63%)
PH 2167..2275 CDD:278594 49/111 (44%)
PH_beta_spectrin 2167..2274 CDD:269975 49/110 (45%)
sptbXP_002936942.2 SAC6 47..>394 CDD:227401 252/347 (73%)
SPEC 421..635 CDD:238103 133/215 (62%)
SPEC 639..846 CDD:238103 68/206 (33%)
SPEC 743..952 CDD:238103 70/208 (34%)
SPEC 954..1166 CDD:238103 90/214 (42%)
SPEC 1169..1269 CDD:197544 34/99 (34%)
SPEC 1273..1475 CDD:238103 84/209 (40%)
SPEC 1477..1688 CDD:238103 79/210 (38%)
SPEC 1583..1795 CDD:238103 100/211 (47%)
SPEC 1796..2018 CDD:238103 104/221 (47%)
SPEC 2011..>2065 CDD:197544 32/53 (60%)
PH_beta_spectrin 2197..2296 CDD:269975 46/100 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 167 1.000 Domainoid score I3803
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2508 1.000 Inparanoid score I32
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 1 1.000 - - otm48383
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1255
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.060

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