DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and clmn

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	XP_002936114.3	Gene:	clmn / 100488669	XenbaseID:	XB-GENE-987920	Length:	890	Species:	Xenopus tropicalis

Alignment Length:	1141	Identity:	251/1141 - (21%)
Similarity:	400/1141 - (35%)	Gaps:	399/1141 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RIKALAEERESVQKKTFTKWVNSHLCRVN--CRIADLYVDMRDGKHLIKLLEVLSGERLPKPTK- 101
            |::.|..|||:|||:|||:|:|.||.:.|  ..:.||:||::|||.|:.|||||:|:.|.:..|
Frog    22 RVQNLQVERENVQKRTFTRWINLHLEKRNPPIEVKDLFVDIQDGKILMSLLEVLTGQSLLQEYKP 86

  Fly   102 GKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIE----- 161
            ...||..|.|:.|||:||.:..|.|.:|.:.:|.|||.||.|||||.|||..||:::|..
Frog    87 SSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFLQIKELTGNLNRMS 151

  Fly   162 ----------------------------EVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSW 198
                                        .|..|:.:.|..|||.|.|.:|..| .|.|::|.:||
Frog   152 SSSSLSSLPSGPDSDSSHSSTPSTEKSLSVSIKDQRKAIKALLNWVQQRTRKY-GVAVQDFASSW 215

  Fly   199 RDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSII 263
            :.||||.|:|......||..::.....|..||.:||.:|:::|.:.:||:.|||.|..|||:||:
Frog   216 KSGLAFLALIKAIDSRLVDIKQALVKTARENLEDAFRIAQEELSVPRLLEPEDVMVNSPDEQSIM 280

  Fly   264 TYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKW--IETTIQSL--GER 324
            |||..:..:|.:|                         |.|:| ||.|.:  :|:|....  |..
Frog   281 TYVTQFLEHFPEL-------------------------DAEDF-SDHLDYLPLESTFVHYKDGPA 319

  Fly   325 EFENSL------AGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGK 383
            |.|:.:      ..|||.:     :.....|.::.....|....|...|..:.|:
Frog   320 EEESKIITLSKEPDVQGDI-----HSPATHPERYHYPEELIAEYFHSDSHSKIND---------- 369

  Fly   384 MISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGF 448
                    |.: .::||.:.                    .:..|.:|.:....|.::..|:..
Frog   370 --------WSQ-SRSEHNQS--------------------PKGNSTKEIYSILGQEVIPSDHSD- 404

  Fly   449 DLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELL 513
              :::|:.|::...|                  ||...:|
Frog   405 --SSMESPAEEFGGI------------------DETTEDR------------------------- 424

  Fly   514 RARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQK---HSLVEADINI 575
                   |..:|..        ::.|....|..:.:|:  ...:...|.|.|   ||
Frog   425 -------ETLIQPS--------VVFNGSHAKNCISSDE--NRPVSASDKLYKSTTHS-------- 464

  Fly   576 LGERVKVVVQNSQKFLSDDPES----YKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRK 636
                      |.:|....||.|    |...|.| ..|..::..:.|:|.|
Frog   465 ----------NLKKINDIDPFSSIDVYTATDKE-PTSVSKESTNTYSETV--------------- 503

  Fly   637 LWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSEL 701
                                                     |:||.      ..::..:.:....
Frog   504 -----------------------------------------KSLEK------GPVEGTSFINGNG 521

  Fly   702 ITEGHFGADRIKDRLKEI-----LNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTL 761
            ::.||  .|.:.|..|.|     ....||...||.::..|.....|..:...:...||:
Frog   522 LSPGH--NDNVDDACKYIPHHANATGSDHAKQLTVFQPYRASAVKEKCKSINEGHSVDS------ 578

  Fly   762 RIVSSEDVGRDEANVQSLLKKHKDVADELKN------------------YA-EVIDALHKQAES- 806
              ||       :.|||.|..|..|..|.:.|                  |: .:.|.||..||:
Frog   579 --VS-------DTNVQILPPKKSDAIDTIDNADLPLISVIPHNLFYYPHYSVPIADVLHAFAENS 634

  Fly   807 ----LKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLY-KLMSEADGVEQWIKEKT 866
                :..|.|.....:|..:.|:: |.:             |.:..| |.|::.:...|::.|..
Frog   635 PGAPISSNMASSFPQEKDHDVIES-YNQ-------------DCMQTYNKEMADKELNTQFVDEAQ 685

  Fly   867 KMLDTMTPGKDIEDVEIMKH---RFEGFDKEMNANASRVAVVNQLARQLLHVEHPNS---DEILE 925
            ....:..|      .|::|.   |        .||.|              .::|.|   |.::|
Frog   686 DFSHSDNP------PELLKSPCLR--------TANGS--------------TQNPASQTKDSVVE 722

  Fly   926 RQNHLNQEWSTLREKAEAKMD-DLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVM 989
            ..:..|.:.|.::|......| |.|::..:.....|.:|.....|||   |.:|
Frog   723 PTHSDNTQISEIQEGQRMAADKDFKNSKKLSFQKAEPKEDFLLTEDK---LHDT----------- 773

  Fly   990 TLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSK 1054
            .|:|:  |...::.::.:..|.:||:.:            :|.|.....|   ....:|.....|
Frog   774 ALERK--GESHNVLSLPSTCSEIERDTS------------VRHRRKDCVL---DTKNVLDPNTKK 821

  Fly  1055 LEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTS 1090
            ..|..|...|.:..|   |.|.:..| ...||.|:|
Frog   822 NNEQHDHISFKKIAD---TCLAEKVT-TQPEDAPSS 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	50/100 (50%)
		CH	170..269	CDD:278723	42/98 (43%)
		Spectrin	298..408	CDD:278843	22/119 (18%)
		SPEC	422..521	CDD:197544	10/98 (10%)
		SPEC	525..740	CDD:238103	35/226 (15%)
		SPEC	639..846	CDD:238103	39/235 (17%)
		SPEC	848..1058	CDD:238103	40/217 (18%)
		SPEC	955..1169	CDD:238103	29/136 (21%)
		SPEC	1170..1380	CDD:238103
		SPEC	1386..1484	CDD:197544
		SPEC	1488..1699	CDD:238103
		SPEC	1594..1806	CDD:238103
		SPEC	1807..2015	CDD:238103
		Spectrin	2018..>2078	CDD:278843
		PH	2167..2275	CDD:278594
		PH_beta_spectrin	2167..2274	CDD:269975
clmn	XP_002936114.3	CH_CLMN_rpt1	29..142	CDD:409040	58/112 (52%)
clmn	XP_002936114.3	CH_CLMN_rpt2	186..291	CDD:409094	42/105 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920