Protein Alignment beta-Spec and sptbn4

DIOPT Version :10

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: XP_002938861.2
• Gene: sptbn4 / 100488521
• XenbaseID: XB-GENE-1013360
• Length: 2545
• Species: Xenopus tropicalis
• Alignment Length: 2526
• Identity: 1057/2526 - (41%)
• Similarity: 1485/2526 - (58%)
• Gaps: 258/2526 - (10%)

  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            ||:..:.|         :|...::.:|||.|||||||:||::|||||||||:||||.:|..|:.|
 Frog    22 RWEQKEHP---------WDEPAATGKLFECSRIKALADERDAVQKKTFTKWINSHLSKVPLRVND 77

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||.|:|||..:.|||||||||:|||||:|:||||.|||||||||||:||||||||:|||||||||
 Frog    78 LYTDLRDGYIITKLLEVLSGEQLPKPTRGRMRIHYLENVDKALQFLKEQRVHLENVGSHDIVDGN 142

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.||||||||||||||.|.||..|::||:||||||||||||||:||..||::|||||||||||
 Frog   143 HRLTLGLIWTIILRFQIQVIRIETEDSRETRSAKDALLLWCQMKTSGYPEVNIQNFTTSWRDGLA 207

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            |:|:||:||||::.|.||:|:||.:||.:||:.||.:|||.||||.|||.:|||||||||||||:
 Frog   208 FSALIHRHRPDVIDFNKLTKSNATYNLQHAFNTAEQQLGLTKLLDPEDVNMEHPDEKSIITYVVS 272

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            :||||||:|...|:|||||||:..|:|.:|.:..||...|:||:|||.||..:..::|.|||.||
 Frog   273 FYHYFSKMKALAVEGKRIGKVLDKAIETEKDIVKYEVLASELLEWIERTIAIITNQKFANSLLGV 337

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..|:.|.|.|||.||.||||||||||::|||||....|.|.|.|||.||||||||..||||
 Frog   338 QQQLQVFTTYCTTEKPCKFQEKGNLEVLLFSIQSKMREEKCKLYVPSEGKNISDINKAWACLEKA 402

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            |||||:|||.|||||||||.|:.|||:||:|||.|||||||||||||||:||.|||||.||||||
 Frog   403 EHEREVALRNELIRQEKLELLSQRFDQKAAMREAWLSENQRLVSQDNFGYDLPAVEAAMKKHEAI 467

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            |.||.:||||:|.|..:..|||:|.|:|:.||..:|||::|.|..|.::|.:||.|||.:|.||:
 Frog   468 EADISSYEERIQVVADLAQELEAEGYYDICRISAQKDNILRQWNLLKDMLSSRRARLEQNLSLQK 532

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKF--L 591
            .||||:|::|.|:|::..|.:.|:||||:.||||||||.|:||||....|||..:.|.:.||  :
 Frog   533 IFQEMVYMIDWMDEMQVPLSSKDFGKHLLEVEDLLQKHCLLEADIAAQTERVNSLNQAALKFTQM 597

  Fly   592 SDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQ 656
            :|    |:||||::|.:||:.:......|.:||.:||..|||||:||.|..:..:.|.||:||||
 Frog   598 TD----YQPCDPQVICNRVEHVRSCLEGLRQLAEKRRGELEESRRLWCFLQEVEEAEGWIREKEQ 658

  Fly   657 IVSTDE-VGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEIL 720
            |:|..: .|.||::|..:|||||.|..|:......||...:.|.:::.:...|...::.|::::.
 Frog   659 ILSAPQSYGKDLSSVLRLLSKHKILVGELRGRHAMLQQTLQKGEQVLAKRRKGMSGLRQRMEQVR 723

  Fly   721 NKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKD 785
            .||::|.......:|:|:.|..::|..||..::..|:.||.|:|||:|.|.||.:.|||:|||:.
 Frog   724 LKWENLQKACDNHQQKLQEASSFYQFSADTMELAGWLQDTYRLVSSDDFGHDEYSTQSLVKKHRA 788

  Fly   786 VADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYK 850
            ...|::.:...:..|.:|...|.....::.:|...:..::..|.|:.|::.||.|.|.|||.:||
 Frog   789 ETVEIEKHKVAVLGLRQQLSELGAEYRDQVDVQITIVEVEQLYGEVVEVSALRSQWLQDALDVYK 853

  Fly   851 LMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHV 915
            :..|.:..|.||.||.:.|..|...:.:|:||:::||||..|:|||:...||..|||:.:|||..
 Frog   854 MFGEVNSCEVWIDEKEQWLMKMEIPQRLEEVEVVQHRFESLDQEMNSLMGRVLDVNQIVQQLLEG 918

  Fly   916 EHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDS 980
            .||:|.|:...|:|||..|:.:.|..|.:.:.|.|...:|.:::||.|..|.|.:|:|.:.....
 Frog   919 GHPSSSEVRACQDHLNSRWNRIVELVEQRKEQLSSVLRLQNYFLECNEVKSQIREKRRTMETPQC 983

  Fly   981 LEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLT 1045
            ...:|.||::|||:||.|:..|.|::.||..|:::|..:...||.:|..:.....:|...|:.|.
 Frog   984 GSGELGGVLSLQRKLSSMEAALLALEPKLVQLQQDAEILATSHPSQAMEVLVHFEEISGEWDALK 1048

  Fly  1046 QMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDN 1110
            :.|:..:..|..|..|.:|::|||:|.|||.||||.||:|:.|::|.|||:||..|.|::|||..
 Frog  1049 RTLQGCEDSLTVANKLQQFIQDLDNFLTWLVKTQTAVAAEELPSNLAEAERLLGLHGSLKEEISR 1113

  Fly  1111 YTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFN 1175
            |.|:|..:....:.|:.|.:   |..|:.|::.|..|:.||.:|.||||||:.:|.|:....||.
 Frog  1114 YEEEYNKIQAVNDLLSLEEA---DLPYLSLQQWLQKLEVGWNKLLQMWENRREVLVQAHIFHLFL 1175

  Fly  1176 RDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDH 1240
            ||.:|.|..|:.||..|:..:.|..:|..|..:|:|:.|:||||.|..|::..::..::|:...:
 Frog  1176 RDFKQAEACLNTQESTLAHVELPNTVEGVEAAIKKHKDFVTTMELNVQKVSVAVEAGESLIRLGN 1240

  Fly  1241 FDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRS 1305
            ..||.:.:|...|..|...|...|....::|::.::|..|||:..||..||.||...::|.|...
 Frog  1241 VFADHVQERISAIQKRSQRNTALAQKWLQRLRDHLQLQHFLQNCNELDAWVHEKTLMARDSSRDL 1305

  Fly  1306 AKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTK 1370
            ::..|.||.:||||.||::.||..|.:.||..|:|.:||||...|::.||:|:.:.:.:||..|:
 Frog  1306 SQKPHKKWLKHQAFMAELSQNKGWLEKIEKEGQQLIQEKPELAGVVKKKLEEIRQCWVELESSTQ 1370

  Fly  1371 EKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQ 1435
            .|...||.|.:...|.|...::...:..|::|:...|...|::|||..:::.:.:::||....::
 Frog  1371 AKAQQLFQATKADQVVQNYSELGKRLYHLKEQLQPVDPVPDVSSVNTQLKRLETMESQMEEWYKE 1435

  Fly  1436 VEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEK 1500
            |.|:..|...|...|..:|  .:..|:..|.....::..||.||::.|...||..|..||:|||.
 Frog  1436 VGELQAQIASLPLEVASQK--ALEEKQNEVGTTIVRLIEPLKERRRILLASKEVHQVTRDLEDEI 1498

  Fly  1501 LWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFE 1565
            .|:.|:||:|.|.::|::|..|..|.||||:|..||..|.||::.|......:......:|:...
 Frog  1499 FWVQERLPLATSKEHGSNLQIVQQLIKKNQNLRREIQVHSPRVDDILERAGAIASIRTPEAEGVR 1563

  Fly  1566 ALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQN 1630
            .....|.:.|..|:|..|.|::.|..:.:||||:||..|.|:|:|||||.||.:::||||.|...
 Frog  1564 LGYESLGEMWNMLRDETERRQQLLDITYQVQQYYFDVGEVETWLSEQELLMMNDEKGKDEQSTLQ 1628

  Fly  1631 LMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARL 1695
            |:|||..|||::|:|..||.||....|..........:.::.:|||:|:||..||||..||:.||
 Frog  1629 LLKKHLMLEQTIENYEETIAQLSRQCRTLLDLGHPDSEQISKRQSQIDRLYVSLKDLVDERKGRL 1693

  Fly  1696 NEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVN 1760
            .:...||.||||||:|||||.::||||||.|||||::|||||.|:|.|||.:|.:||.||::.||
 Frog  1694 EQQYWLFQLSREVDELEQWIAEKEVVAGSPELGQDYEHVTLLQEKFTEFATETGSVGQERISAVN 1758

  Fly  1761 GIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEK 1825
            .:.|.||..||||:|.||||||.:||:|.|||||:|||:||||||.||:|||:|||:||.::.||
 Frog  1759 QMVDELIDFGHSDAAIIAEWKDGVNEAWADLLELMETRSQMLAASHELYKFFNDCKEVLSQVEEK 1823

  Fly  1826 QHGVSDELGRDAG-SVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQE 1889
            :..:.:...::|. |..:|||...:|..|:..|.:||:|:||.:|:|:..|||:.|..|...|||
 Frog  1824 KQRLPEVKAQEAKLSAGSLQRILSSFEHDIQVLVTQVRQLQENAAQLRTVYAGENAAAIVTSEQE 1888

  Fly  1890 VLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNH 1954
            |:.||..|...|:..:.::..|.|..:|.|:||.|:.|||.:..|:...|||||||.||:||:.|
 Frog  1889 VMRAWKELLTSCEDCRLQITSTTDRIKFLNLVRDLISWMESITCQIGAEEKPRDVSSVEVLMSYH 1953

  Fly  1955 QSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILE 2019
            |.||:||::|......|:.|||.|:.....:|.:||..|..|...:..:|.:|.:.||.||.:||
 Frog  1954 QGLKSEIESRNKRIADCVELGKTLVLNKRPSSDEIKQSLDRLMAKKKEMLEKWNKHWEWLQQMLE 2018

  Fly  2020 VYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFE 2084
            |:|||::|.||:|||.||||.:.|.|||:::||||.||::||||.|:||..|||||:|.||||.|
 Frog  2019 VHQFAQEAGVADAWLTAQEPIVKSPELGNSVDEVEQLIRRHEAFRKTAAVWEERFSSLRRLTTLE 2083

  Fly  2085 -LK---------------------------------------------------------EMKR- 2090
             ||                                                         |::|
 Frog  2084 KLKAEQSKQPATPLLGRKVFPDTTDYSARPSPLSRQTVYENSETKLDQKEALSIPDGGQQEIRRA 2148

  Fly  2091 ------------RQEL-------------------------AEEAERQRIK----------EEQE 2108
                        ||::                         .|.||:..||          |:.|
 Frog  2149 RAEKGETRVGYVRQDIKPERLQPKMDHVETKVADKPLAAQEVERAEKTEIKFAQGMANLTVEKPE 2213

  Fly  2109 AKAA----------------SEAAEQA-------------------------------------- 2119
            .|.:                .|::||.
 Frog  2214 IKGSRHTERKRDRHERRLERQESSEQETPKQEPPERRRDRHEKRLERQGSSEQETPKQEQSERRR 2278

  Fly  2120 ---KREAERRDDVDVG--------------------------ASHDDSAAKDTAVEFERVVEIQT 2155
               :|..||:|.::..                          |..:.|..:|:.......|:...
 Frog  2279 DRHERRTERQDTIEQDKPRTEPEKQAGKATLADIVEQLQEKEAFQNSSGGQDSPARVPNGVDKLP 2343

  Fly  2156 ERGGTPG----------------------AGEG-----------------------HEGYVTRKH 2175
            ||...|.                      .||.                       .|||:.|||
 Frog  2344 ERTTRPDRPRARDRPKPRRRPRPKDPNQPPGEARRSRSAPAQSSAPPPPPPTHTIQQEGYLFRKH 2408

  Fly  2176 EWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKK 2240
            |.|..:||||||||..:|.....|.:..|||.|...|.  .|..|||..:|..|:.|:||:|.||
 Frog  2409 ELDGPSKKASNRSWINLYCVLNKGDLGVYKDAKSQSSG--ATHGGEPLLNLLGASCEVASEYKKK 2471

  Fly  2241 KHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRSQTLPATSQKDE 2296
            |.|.:::..:|..||.||.|:.||..|:|::.......|..|..||:|..||..||
 Frog  2472 KFVFKLRSTDGREFLFQAKDEEEMKNWITAITTCVSQHAEIARWSQSLLTTSSTDE 2527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	89/115 (77%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	74/103 (72%)
		Spectrin	298..408	CDD:395348	68/109 (62%)
		SPEC	422..521	CDD:197544	63/98 (64%)
		SPEC	525..740	CDD:238103	87/217 (40%)
		SPEC	639..846	CDD:238103	65/207 (31%)
		SPEC	848..1058	CDD:238103	73/209 (35%)
		SPEC	955..1169	CDD:238103	81/213 (38%)
		SPEC	1170..1380	CDD:238103	73/209 (35%)
		SPEC	1386..1484	CDD:197544	22/97 (23%)
		SPEC	1488..1699	CDD:238103	85/210 (40%)
		SPEC	1594..1806	CDD:238103	120/211 (57%)
		SPEC	1807..2015	CDD:238103	83/208 (40%)
		Spectrin	2018..>2078	CDD:395348	38/59 (64%)
		PH_beta_spectrin	2167..2274	CDD:269975	47/106 (44%)
sptbn4	XP_002938861.2	CH_SPTBN4_rpt1	18..156	CDD:409167	94/142 (66%)
		CH_SF	158..287	CDD:469584	89/128 (70%)
		SPEC	302..412	CDD:413338	68/109 (62%)
		SPEC	425..637	CDD:238103	118/215 (55%)
		SPEC	642..849	CDD:238103	65/206 (32%)
		SPEC	746..955	CDD:238103	77/208 (37%)
		SPEC	956..1169	CDD:238103	81/215 (38%)
		SPEC	1171..1379	CDD:238103	73/207 (35%)
		SPEC	1276..1484	CDD:238103	67/209 (32%)
		SPEC	1488..1588	CDD:197544	34/99 (34%)
		SPEC	1592..1804	CDD:238103	120/211 (57%)
		SPEC	1804..1906	CDD:413338	40/101 (40%)
		SPEC	1915..>2079	CDD:238103	82/163 (50%)
		PTZ00121	<1985..2345	CDD:173412	80/359 (22%)
		PH_beta_spectrin	2401..2505	CDD:269975	47/105 (45%)