DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and sptbn4

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_002938861.2 Gene:sptbn4 / 100488521 XenbaseID:XB-GENE-1013360 Length:2545 Species:Xenopus tropicalis


Alignment Length:2526 Identity:1057/2526 - (41%)
Similarity:1485/2526 - (58%) Gaps:258/2526 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            ||:..:.|         :|...::.:|||.|||||||:||::|||||||||:||||.:|..|:.|
 Frog    22 RWEQKEHP---------WDEPAATGKLFECSRIKALADERDAVQKKTFTKWINSHLSKVPLRVND 77

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||.|:|||..:.|||||||||:|||||:|:||||.|||||||||||:||||||||:|||||||||
 Frog    78 LYTDLRDGYIITKLLEVLSGEQLPKPTRGRMRIHYLENVDKALQFLKEQRVHLENVGSHDIVDGN 142

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.||||||||||||||.|.||..|::||:||||||||||||||:||..||::|||||||||||
 Frog   143 HRLTLGLIWTIILRFQIQVIRIETEDSRETRSAKDALLLWCQMKTSGYPEVNIQNFTTSWRDGLA 207

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            |:|:||:||||::.|.||:|:||.:||.:||:.||.:|||.||||.|||.:|||||||||||||:
 Frog   208 FSALIHRHRPDVIDFNKLTKSNATYNLQHAFNTAEQQLGLTKLLDPEDVNMEHPDEKSIITYVVS 272

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            :||||||:|...|:|||||||:..|:|.:|.:..||...|:||:|||.||..:..::|.|||.||
 Frog   273 FYHYFSKMKALAVEGKRIGKVLDKAIETEKDIVKYEVLASELLEWIERTIAIITNQKFANSLLGV 337

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..|:.|.|.|||.||.||||||||||::|||||....|.|.|.|||.||||||||..||||
 Frog   338 QQQLQVFTTYCTTEKPCKFQEKGNLEVLLFSIQSKMREEKCKLYVPSEGKNISDINKAWACLEKA 402

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            |||||:|||.|||||||||.|:.|||:||:|||.|||||||||||||||:||.|||||.||||||
 Frog   403 EHEREVALRNELIRQEKLELLSQRFDQKAAMREAWLSENQRLVSQDNFGYDLPAVEAAMKKHEAI 467

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            |.||.:||||:|.|..:..|||:|.|:|:.||..:|||::|.|..|.::|.:||.|||.:|.||:
 Frog   468 EADISSYEERIQVVADLAQELEAEGYYDICRISAQKDNILRQWNLLKDMLSSRRARLEQNLSLQK 532

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKF--L 591
            .||||:|::|.|:|::..|.:.|:||||:.||||||||.|:||||....|||..:.|.:.||  :
 Frog   533 IFQEMVYMIDWMDEMQVPLSSKDFGKHLLEVEDLLQKHCLLEADIAAQTERVNSLNQAALKFTQM 597

  Fly   592 SDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQ 656
            :|    |:||||::|.:||:.:......|.:||.:||..|||||:||.|..:..:.|.||:||||
 Frog   598 TD----YQPCDPQVICNRVEHVRSCLEGLRQLAEKRRGELEESRRLWCFLQEVEEAEGWIREKEQ 658

  Fly   657 IVSTDE-VGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEIL 720
            |:|..: .|.||::|..:|||||.|..|:......||...:.|.:::.:...|...::.|::::.
 Frog   659 ILSAPQSYGKDLSSVLRLLSKHKILVGELRGRHAMLQQTLQKGEQVLAKRRKGMSGLRQRMEQVR 723

  Fly   721 NKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKD 785
            .||::|.......:|:|:.|..::|..||..::..|:.||.|:|||:|.|.||.:.|||:|||:.
 Frog   724 LKWENLQKACDNHQQKLQEASSFYQFSADTMELAGWLQDTYRLVSSDDFGHDEYSTQSLVKKHRA 788

  Fly   786 VADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYK 850
            ...|::.:...:..|.:|...|.....::.:|...:..::..|.|:.|::.||.|.|.|||.:||
 Frog   789 ETVEIEKHKVAVLGLRQQLSELGAEYRDQVDVQITIVEVEQLYGEVVEVSALRSQWLQDALDVYK 853

  Fly   851 LMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHV 915
            :..|.:..|.||.||.:.|..|...:.:|:||:::||||..|:|||:...||..|||:.:|||..
 Frog   854 MFGEVNSCEVWIDEKEQWLMKMEIPQRLEEVEVVQHRFESLDQEMNSLMGRVLDVNQIVQQLLEG 918

  Fly   916 EHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDS 980
            .||:|.|:...|:|||..|:.:.|..|.:.:.|.|...:|.:::||.|..|.|.:|:|.:.....
 Frog   919 GHPSSSEVRACQDHLNSRWNRIVELVEQRKEQLSSVLRLQNYFLECNEVKSQIREKRRTMETPQC 983

  Fly   981 LEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLT 1045
            ...:|.||::|||:||.|:..|.|::.||..|:::|..:...||.:|..:.....:|...|:.|.
 Frog   984 GSGELGGVLSLQRKLSSMEAALLALEPKLVQLQQDAEILATSHPSQAMEVLVHFEEISGEWDALK 1048

  Fly  1046 QMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDN 1110
            :.|:..:..|..|..|.:|::|||:|.|||.||||.||:|:.|::|.|||:||..|.|::|||..
 Frog  1049 RTLQGCEDSLTVANKLQQFIQDLDNFLTWLVKTQTAVAAEELPSNLAEAERLLGLHGSLKEEISR 1113

  Fly  1111 YTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFN 1175
            |.|:|..:....:.|:.|.:   |..|:.|::.|..|:.||.:|.||||||:.:|.|:....||.
 Frog  1114 YEEEYNKIQAVNDLLSLEEA---DLPYLSLQQWLQKLEVGWNKLLQMWENRREVLVQAHIFHLFL 1175

  Fly  1176 RDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDH 1240
            ||.:|.|..|:.||..|:..:.|..:|..|..:|:|:.|:||||.|..|::..::..::|:...:
 Frog  1176 RDFKQAEACLNTQESTLAHVELPNTVEGVEAAIKKHKDFVTTMELNVQKVSVAVEAGESLIRLGN 1240

  Fly  1241 FDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRS 1305
            ..||.:.:|...|..|...|...|....::|::.::|..|||:..||..||.||...::|.|...
 Frog  1241 VFADHVQERISAIQKRSQRNTALAQKWLQRLRDHLQLQHFLQNCNELDAWVHEKTLMARDSSRDL 1305

  Fly  1306 AKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTK 1370
            ::..|.||.:||||.||::.||..|.:.||..|:|.:||||...|::.||:|:.:.:.:||..|:
 Frog  1306 SQKPHKKWLKHQAFMAELSQNKGWLEKIEKEGQQLIQEKPELAGVVKKKLEEIRQCWVELESSTQ 1370

  Fly  1371 EKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQ 1435
            .|...||.|.:...|.|...::...:..|::|:...|...|::|||..:::.:.:::||....::
 Frog  1371 AKAQQLFQATKADQVVQNYSELGKRLYHLKEQLQPVDPVPDVSSVNTQLKRLETMESQMEEWYKE 1435

  Fly  1436 VEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEK 1500
            |.|:..|...|...|..:|  .:..|:..|.....::..||.||::.|...||..|..||:|||.
 Frog  1436 VGELQAQIASLPLEVASQK--ALEEKQNEVGTTIVRLIEPLKERRRILLASKEVHQVTRDLEDEI 1498

  Fly  1501 LWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFE 1565
            .|:.|:||:|.|.::|::|..|..|.||||:|..||..|.||::.|......:......:|:...
 Frog  1499 FWVQERLPLATSKEHGSNLQIVQQLIKKNQNLRREIQVHSPRVDDILERAGAIASIRTPEAEGVR 1563

  Fly  1566 ALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQN 1630
            .....|.:.|..|:|..|.|::.|..:.:||||:||..|.|:|:|||||.||.:::||||.|...
 Frog  1564 LGYESLGEMWNMLRDETERRQQLLDITYQVQQYYFDVGEVETWLSEQELLMMNDEKGKDEQSTLQ 1628

  Fly  1631 LMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARL 1695
            |:|||..|||::|:|..||.||....|..........:.::.:|||:|:||..||||..||:.||
 Frog  1629 LLKKHLMLEQTIENYEETIAQLSRQCRTLLDLGHPDSEQISKRQSQIDRLYVSLKDLVDERKGRL 1693

  Fly  1696 NEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVN 1760
            .:...||.||||||:|||||.::||||||.|||||::|||||.|:|.|||.:|.:||.||::.||
 Frog  1694 EQQYWLFQLSREVDELEQWIAEKEVVAGSPELGQDYEHVTLLQEKFTEFATETGSVGQERISAVN 1758

  Fly  1761 GIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEK 1825
            .:.|.||..||||:|.||||||.:||:|.|||||:|||:||||||.||:|||:|||:||.::.||
 Frog  1759 QMVDELIDFGHSDAAIIAEWKDGVNEAWADLLELMETRSQMLAASHELYKFFNDCKEVLSQVEEK 1823

  Fly  1826 QHGVSDELGRDAG-SVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQE 1889
            :..:.:...::|. |..:|||...:|..|:..|.:||:|:||.:|:|:..|||:.|..|...|||
 Frog  1824 KQRLPEVKAQEAKLSAGSLQRILSSFEHDIQVLVTQVRQLQENAAQLRTVYAGENAAAIVTSEQE 1888

  Fly  1890 VLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNH 1954
            |:.||..|...|:..:.::..|.|..:|.|:||.|:.|||.:..|:...|||||||.||:||:.|
 Frog  1889 VMRAWKELLTSCEDCRLQITSTTDRIKFLNLVRDLISWMESITCQIGAEEKPRDVSSVEVLMSYH 1953

  Fly  1955 QSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILE 2019
            |.||:||::|......|:.|||.|:.....:|.:||..|..|...:..:|.:|.:.||.||.:||
 Frog  1954 QGLKSEIESRNKRIADCVELGKTLVLNKRPSSDEIKQSLDRLMAKKKEMLEKWNKHWEWLQQMLE 2018

  Fly  2020 VYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFE 2084
            |:|||::|.||:|||.||||.:.|.|||:::||||.||::||||.|:||..|||||:|.||||.|
 Frog  2019 VHQFAQEAGVADAWLTAQEPIVKSPELGNSVDEVEQLIRRHEAFRKTAAVWEERFSSLRRLTTLE 2083

  Fly  2085 -LK---------------------------------------------------------EMKR- 2090
             ||                                                         |::| 
 Frog  2084 KLKAEQSKQPATPLLGRKVFPDTTDYSARPSPLSRQTVYENSETKLDQKEALSIPDGGQQEIRRA 2148

  Fly  2091 ------------RQEL-------------------------AEEAERQRIK----------EEQE 2108
                        ||::                         .|.||:..||          |:.|
 Frog  2149 RAEKGETRVGYVRQDIKPERLQPKMDHVETKVADKPLAAQEVERAEKTEIKFAQGMANLTVEKPE 2213

  Fly  2109 AKAA----------------SEAAEQA-------------------------------------- 2119
            .|.:                .|::||.                                      
 Frog  2214 IKGSRHTERKRDRHERRLERQESSEQETPKQEPPERRRDRHEKRLERQGSSEQETPKQEQSERRR 2278

  Fly  2120 ---KREAERRDDVDVG--------------------------ASHDDSAAKDTAVEFERVVEIQT 2155
               :|..||:|.::..                          |..:.|..:|:.......|:...
 Frog  2279 DRHERRTERQDTIEQDKPRTEPEKQAGKATLADIVEQLQEKEAFQNSSGGQDSPARVPNGVDKLP 2343

  Fly  2156 ERGGTPG----------------------AGEG-----------------------HEGYVTRKH 2175
            ||...|.                      .||.                       .|||:.|||
 Frog  2344 ERTTRPDRPRARDRPKPRRRPRPKDPNQPPGEARRSRSAPAQSSAPPPPPPTHTIQQEGYLFRKH 2408

  Fly  2176 EWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKK 2240
            |.|..:||||||||..:|.....|.:..|||.|...|.  .|..|||..:|..|:.|:||:|.||
 Frog  2409 ELDGPSKKASNRSWINLYCVLNKGDLGVYKDAKSQSSG--ATHGGEPLLNLLGASCEVASEYKKK 2471

  Fly  2241 KHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRSQTLPATSQKDE 2296
            |.|.:::..:|..||.||.|:.||..|:|::.......|..|..||:|..||..||
 Frog  2472 KFVFKLRSTDGREFLFQAKDEEEMKNWITAITTCVSQHAEIARWSQSLLTTSSTDE 2527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 75/97 (77%)
CH 170..269 CDD:278723 72/98 (73%)
Spectrin 298..408 CDD:278843 68/109 (62%)
SPEC 422..521 CDD:197544 63/98 (64%)
SPEC 525..740 CDD:238103 87/217 (40%)
SPEC 639..846 CDD:238103 65/207 (31%)
SPEC 848..1058 CDD:238103 73/209 (35%)
SPEC 955..1169 CDD:238103 81/213 (38%)
SPEC 1170..1380 CDD:238103 73/209 (35%)
SPEC 1386..1484 CDD:197544 22/97 (23%)
SPEC 1488..1699 CDD:238103 85/210 (40%)
SPEC 1594..1806 CDD:238103 120/211 (57%)
SPEC 1807..2015 CDD:238103 83/208 (40%)
Spectrin 2018..>2078 CDD:278843 38/59 (64%)
PH 2167..2275 CDD:278594 47/107 (44%)
PH_beta_spectrin 2167..2274 CDD:269975 47/106 (44%)
sptbn4XP_002938861.2 SAC6 48..>454 CDD:227401 285/405 (70%)
SPEC 425..637 CDD:238103 118/215 (55%)
SPEC 642..849 CDD:238103 65/206 (32%)
SPEC 746..955 CDD:238103 77/208 (37%)
SPEC 956..1169 CDD:238103 81/215 (38%)
SPEC 1171..1379 CDD:238103 73/207 (35%)
SPEC 1276..1484 CDD:238103 67/209 (32%)
SPEC 1488..1588 CDD:197544 34/99 (34%)
SPEC 1592..1804 CDD:238103 120/211 (57%)
SPEC 1804..1906 CDD:351773 40/101 (40%)
SPEC 1915..>2079 CDD:238103 82/163 (50%)
PTZ00121 <1985..2345 CDD:173412 80/359 (22%)
PH_beta_spectrin 2401..2505 CDD:269975 47/105 (45%)
DUF5069 <2473..2540 CDD:374811 20/55 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 183 1.000 Domainoid score I3368
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52262
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.030

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