DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and sptbn2

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_012817859.1 Gene:sptbn2 / 100486199 XenbaseID:XB-GENE-1008690 Length:2437 Species:Xenopus tropicalis


Alignment Length:2438 Identity:1204/2438 - (49%)
Similarity:1606/2438 - (65%) Gaps:163/2438 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAE--------------------------- 46
            |||         :.:.::|..|||:|||||||||||||                           
 Frog    25 RWD---------LTDDDWDNENSSARLFERSRIKALAEMDFVPRSGSPLLSPAAFVNAVQYANVL 80

  Fly    47 ---------ERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKG 102
                     |||:||||||||||||||.||.|||:|||.|:|||:.||:||||||||:|||||||
 Frog    81 EGRFKQLQDEREAVQKKTFTKWVNSHLARVTCRISDLYNDLRDGRMLIRLLEVLSGEQLPKPTKG 145

  Fly   103 KMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKE 167
            :||||||||||||||||:||:|||||:|||||||||..|.||||||||||||||||::|..||||
 Frog   146 RMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKE 210

  Fly   168 TKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNN 232
            .||||||||||||||||||.||||.|||||||||||||||:||||||::.|:.|.|:||.|||.|
 Frog   211 KKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDIIDFDTLKKSNAHHNLQN 275

  Fly   233 AFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMEND 297
            ||:|||.:|||.||||.|||.|:.||||||||||.|:||||||:|...|:|||||||:..|:|.|
 Frog   276 AFNVAERELGLTKLLDPEDVNVDQPDEKSIITYVATFYHYFSKMKALAVEGKRIGKVLDQAIEAD 340

  Fly   298 KMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLL 362
            :::.:||...|:||:|||..|.:|.:|:..|||:|||.||..|:.|||:||||||.|||||||||
 Frog   341 QLIENYEGLASELLQWIEQMIITLNDRKLANSLSGVQNQLQAFNTYRTVEKPPKFTEKGNLEVLL 405

  Fly   363 FTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKA 427
            ||:||||||||||.|||:|||:|||||||||||||||||||||||.|||||||||||||||||||
 Frog   406 FTIQSKMRANNQKVYTPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAARFDRKA 470

  Fly   428 SMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDV 492
            :|||||||||||||:|||||.||.|||||.:|||||||||.||.||||||.||.||||:|.||||
 Frog   471 AMRETWLSENQRLVAQDNFGVDLTAVEAALRKHEAIETDILAYSERVQAVNAVADELEAENYHDV 535

  Fly   493 KRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLM 557
            :|||.||.||:||..||.||:.|||.||.::|:||:.||::.|::|..|::|..|.::||||||.
 Frog   536 RRILARKCNVIRLSDYLRELVTARRQRLHMNLELQRMFQDLHYLMDWTEDMKGRLQSEDYGKHLH 600

  Fly   558 GVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVR 622
            |||||||.|:||||||.:..||||.|...:|||:::| |.|||||||::.:||..||..||||..
 Frog   601 GVEDLLQTHTLVEADIAVQAERVKSVTAVAQKFMTED-EGYKPCDPELVRNRVHLLEQRYAELCN 664

  Fly   623 LAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSH 687
            |:..|||:|||||:||:|:||..:||.||:|:.:::.:|:.|.|||:...::|||.|...|::.|
 Frog   665 LSAARRSKLEESRRLWKFFWDMGEEEAWIREQSRLLLSDDYGKDLTSSLRLISKHNAFRGEMSGH 729

  Fly   688 DPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADD 752
            ...||.....|.|||::|||||..|::|:||:..:|..:..|.:.|.:||..|..|:|..|||:|
 Frog   730 RGPLQQTVAEGEELISKGHFGAGEIEERIKEVKGQWTEMEALAEDRERRLREAYSYYQFQADAND 794

  Fly   753 VDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANV 817
            .:.|:|||||:||:.:||.||.:.|:|:||||::.:|:.::...|||||:||..|....:....|
 Frog   795 AEAWILDTLRLVSTSEVGHDEYSTQTLVKKHKEIEEEILSHRPAIDALHEQARGLPPAYSHSPEV 859

  Fly   818 DKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVE 882
            |.||.|::.||:||..||..|||.|.|:|:|:|:.||||....||.||.:.|:.....:.:||:|
 Frog   860 DGRLPALEQRYEELVALAAHRKQALQDSLALHKMFSEADACLLWIDEKEQWLNVTEIPEKLEDLE 924

  Fly   883 IMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDD 947
            :::.|||..:.|||..|||:|.||::|.|||..:..|.:.|.:.|:.||..|:..|:..:.|...
 Frog   925 VVQQRFETLEAEMNNLASRIASVNEVAGQLLTTDQRNENSIRDMQDQLNSRWNEFRKLVDQKKGA 989

  Fly   948 LKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSL 1012
            |.||..:|.:::||.||:.|:.:|.:::..|.||..||.||..|||:|:||:|||.|||.|:..|
 Frog   990 LDSALDIQNYHLECNETVCWMREKTKVIESTQSLGNDLAGVTALQRKLTGMERDLKAIQGKVGDL 1054

  Fly  1013 EREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTK 1077
            ..||..:.|.||::|..|..|::.|:..|.:|...:|.|:..|.||..|..||||||.||:||::
 Frog  1055 RSEAEKLADGHPQKAPAIIGRLSDIDETWGELKDTMKRREETLGEASKLQGFLRDLDDFQSWLSR 1119

  Fly  1078 TQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRE 1142
            .||.|||||.|..|.|||:||.||:.|:.|||:|..||..:.:.||.:| .|.|  |.|||||::
 Frog  1120 AQTAVASEDVPADLAEAERLLAQHEGIKNEIDHYGADYHRVRDVGEEVT-RGQT--DAQYMFLQQ 1181

  Fly  1143 RLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQ 1207
            ||.||..||.||.||||||..||||....|.|.:|.:|.|..|:.||:.||..:.|..|:.||..
 Frog  1182 RLKALDTGWNELGQMWENRHQLLSQGHSFQQFLKDTKQVEGFLNNQEYVLSHTEMPSTLQAAEAA 1246

  Fly  1208 LKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLK 1272
            :||||.|||||:||::||..|::....|:|:.:.:::||.::..:|..|...|::.|.:...:||
 Frog  1247 IKRHEDFLTTMDANEEKIQGLVESGRKLIEEQNVNSEKIQEKVTSIDERHKKNQKTASEVLTRLK 1311

  Fly  1273 NQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSA 1337
            :...|..||||.:||..|:.||..|:||.||..|:.:||||.:||||.||:|:||:.|.:.:|..
 Frog  1312 DNRDLQHFLQDCQELTLWINEKMLTAQDVSYDEARNLHSKWQKHQAFMAELASNKDWLDKIDKEG 1376

  Fly  1338 QELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQ 1402
            |:|..||||.:.|:..||..|.|.::|||..|:.|...||||||..|..|:|..::|::.:||.|
 Frog  1377 QQLMSEKPELEPVVREKLDTLHKLWNDLESTTQSKAQCLFDANRAELFTQSCSALESWLQNLESQ 1441

  Fly  1403 IVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLE 1467
            :.|.....||||||||:.|||:::.||.|:.:::|.|..|.:.|.:  .:..|..:..|...|.:
 Frog  1442 LQSDHYGKDLTSVNILLNKQQMLENQMEVREKELEAIQSQAQALGQ--EDANIVEVDSKHKDVAD 1504

  Fly  1468 RFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSL 1532
            :|.|::|||.:|:|.|...||..||.||:|||.||:.||:|:|.|.|:|..|..|.:|.||||:|
 Frog  1505 KFSKLRAPLNKRRKLLLASKEGHQFNRDLEDEILWVKEKMPMAISTDHGKDLPTVQLLIKKNQTL 1569

  Fly  1533 ATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKH--LLESEKV 1595
            ..||..|:|||:.|...|:.:|.:...|.::.|..:..|...|:||  |.|..::|  |.||...
 Frog  1570 QKEILGHQPRIDDILERGKSMIQDSSLDPQEIEERLGLLKSTWEEL--AAEGGKRHARLEESLAA 1632

  Fly  1596 QQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFS 1660
            ||::.||.|||:||.||||:||.|::.||||.||.::|||..:||:::|||:.|.||...:|   
 Frog  1633 QQFYADAAEAEAWMGEQELHMMSEEKAKDEIGAQAMLKKHLVMEQALDDYADNIHQLANSSR--- 1694

  Fly  1661 GDDISSG----DAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVV 1721
             |.:|.|    |.:.::|.|:|||||.|||||.||:.:|.|..:|..|.|:|:|||.||::||||
 Frog  1695 -DMVSRGHPESDRITLRQGQVDKLYASLKDLAEERQGKLQEHHRLCQLKRDVEDLEHWISEREVV 1758

  Fly  1722 AGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNE 1786
            |.|.|||||::|||:|.::|.||:|||..:|.|||..||.:||:||.:|||::||:|:|||.|||
 Frog  1759 AASHELGQDYEHVTMLRDKFREFSRDTSNIGQERVDAVNLMADDLISSGHSENATVADWKDQLNE 1823

  Fly  1787 SWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFL 1851
            :|.||||:|:||:||||||.|||:|:.|.|:.||:|.:||..:.:|.|||..:...:||.|..|.
 Frog  1824 AWADLLEMIDTRSQMLAASYELHRFYQDAKETLGQIQDKQKQIPEETGRDLNTAEAMQRMHTAFE 1888

  Fly  1852 QDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFR 1916
            .|:..|.:||:|:||::::||.||||:||.:|...||.|..||..||....||:|.|.||.:.||
 Frog  1889 HDIQALSAQVKQVQEDASRLQKAYAGEKAADIHRHEQAVSEAWGELQNASGARRQLLLDTVEKFR 1953

  Fly  1917 FFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTR 1981
            ||.|||.||:||:|:...::..|||||||..:|::.||..:|||:|.|.|:|..||.||..||.:
 Frog  1954 FFRMVRDLMLWMDDINLLIDAQEKPRDVSSADLVIQNHLGIKAEVDARADSFTTCIDLGNSLLEK 2018

  Fly  1982 NHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSEL 2046
            |||||..|.::|..|...|.....:|:::...|:::.||..|.|||:||||||.:|||.:.||||
 Frog  2019 NHYASDKISEKLEQLQERRQETENKWKDKMAWLRVVHEVLMFGRDASVAEAWLASQEPIVRSSEL 2083

  Fly  2047 GHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQE------------LAEEAE 2099
            |..:||||:|||:||||:|:.:..:|||..||:|||.|..||:|::|            |..|..
 Frog  2084 GGNVDEVESLIKRHEAFQKAVSTWDERFVLLEKLTTLEEIEMRRKREEEERKKRPPTPPLPVEEP 2148

  Fly  2100 RQRIKEEQEAKAASEAAEQAKREAER--------RDDVDVGASHDDSAAKDTAVEFERV------ 2150
            |:.:.:.|.::......:.|....||        ::.|.|.....:|.:...:.:.:|:      
 Frog  2149 REEVVKTQVSQTIEGQTDPANILQERINGMQNSFQEQVSVNGLCTESDSPQPSSDTQRLEDSISE 2213

  Fly  2151 --------------VEIQTERGG-TPG---------------------------AGEGHEGYVTR 2173
                          .|:.|:.|. ||.                           |.|..||.:.|
 Frog  2214 NQGPEQSDVTNGARTEVITKDGSPTPSPQLVARPTFSPINLQYSTLPSSPTEPLASEQMEGMLHR 2278

  Fly  2174 KHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYT 2238
            |.|.||..|||:||||..||.|.|.|.:.||||.|...|.  :::..|||..|..|...:|.||.
 Frog  2279 KQEMDSHNKKAANRSWQNVYCALKRGSLGFYKDAKSAASG--VSYHSEPSVQLNGAQCSVAHDYK 2341

  Fly  2239 KKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKA-----------QSDSTAVAASRSQTLPATS 2292
            |:|:|.::.|.:|..:|.||.|:.|||.|:..:.|           .|.......:|:.|:|..|
 Frog  2342 KRKNVFKLSLLDGKEYLFQAKDEAEMSSWMRVINASLTSSPGDPSDHSPGIMKGMTRAMTMPPVS 2406

  Fly  2293 -----------------QKDEPKRRSFFTLKKK 2308
                             :||..||.|||  |||
 Frog  2407 PNSGTEGSVTLRNKDGKEKDREKRFSFF--KKK 2437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 81/97 (84%)
CH 170..269 CDD:278723 77/98 (79%)
Spectrin 298..408 CDD:278843 78/109 (72%)
SPEC 422..521 CDD:197544 76/98 (78%)
SPEC 525..740 CDD:238103 104/214 (49%)
SPEC 639..846 CDD:238103 89/206 (43%)
SPEC 848..1058 CDD:238103 83/209 (40%)
SPEC 955..1169 CDD:238103 107/213 (50%)
SPEC 1170..1380 CDD:238103 88/209 (42%)
SPEC 1386..1484 CDD:197544 35/97 (36%)
SPEC 1488..1699 CDD:238103 100/216 (46%)
SPEC 1594..1806 CDD:238103 119/215 (55%)
SPEC 1807..2015 CDD:238103 93/207 (45%)
Spectrin 2018..>2078 CDD:278843 35/59 (59%)
PH 2167..2275 CDD:278594 47/118 (40%)
PH_beta_spectrin 2167..2274 CDD:269975 47/117 (40%)
sptbn2XP_012817859.1 CH 94..197 CDD:237981 86/102 (84%)
CH 213..316 CDD:237981 80/102 (78%)
Spectrin 341..451 CDD:278843 78/109 (72%)
SPEC 465..563 CDD:197544 75/97 (77%)
SPEC 568..783 CDD:238103 104/215 (48%)
SPEC 681..888 CDD:238103 89/206 (43%)
SPEC 785..994 CDD:238103 90/208 (43%)
SPEC 997..1206 CDD:238103 105/211 (50%)
SPEC 1210..1419 CDD:238103 88/208 (42%)
SPEC 1420..1630 CDD:238103 84/213 (39%)
SPEC 1527..1734 CDD:238103 98/212 (46%)
SPEC 1632..1843 CDD:238103 119/214 (56%)
SPEC 1844..2051 CDD:238103 93/206 (45%)
SPEC 2060..>2117 CDD:197544 35/56 (63%)
PH 2272..2378 CDD:278594 47/107 (44%)
PH_beta_spectrin 2272..2377 CDD:269975 46/106 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I3182
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2508 1.000 Inparanoid score I32
OMA 1 1.010 - - QHG52262
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 1 1.000 - - otm48383
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1255
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.080

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