DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and sptbn5

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_031747272.1 Gene:sptbn5 / 100485263 XenbaseID:XB-GENE-6043625 Length:3867 Species:Xenopus tropicalis


Alignment Length:2264 Identity:716/2264 - (31%)
Similarity:1205/2264 - (53%) Gaps:121/2264 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 FERSRIKALAEERESVQKKTFTKWVNSHLCRVNCR-IADLYVDMRDGKHLIKLLEVLSGERLPKP 99
            :|:..||.|.|:|..:||||||.|:|:.....:|. |.|:|.:::||.:|:.|||::|||:||:|
 Frog     8 YEQGHIKKLQEQRMVMQKKTFTNWMNNIYRENDCNIITDIYTELQDGLYLLLLLELISGEQLPRP 72

  Fly   100 TKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVD 164
            .:||||:|.|||..|||.||: .:|.::.||..:||||:.:|.|||:|.|||||||.:||:::.:
 Frog    73 ARGKMRVHFLENNSKALTFLK-SKVPVKLIGPENIVDGDRTLILGLLWIIILRFQISNITLDKDE 136

  Fly   165 ---NKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNA 226
               :....|||:|||:|||.|||||.||:|::|:.||||||||||:||.|||||:.::.|::|..
 Frog   137 FGASAAVLSAKEALLVWCQRKTAGYSNVDVQDFSGSWRDGLAFNALIHAHRPDLINYDSLTRTKP 201

  Fly   227 IHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQ-ETVQGKRIGKVV 290
            ::||||||||||.|||::||||||||.|.||||:||:||:..|||||||::| :||| ||:..::
 Frog   202 LYNLNNAFDVAETKLGISKLLDAEDVAVPHPDERSIMTYISLYYHYFSKMRQGQTVQ-KRMNNMM 265

  Fly   291 GIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEK 355
            .:.:|.:.:...||...|||::||:..:..:.:|.|.||:.|::..:..|..:||:|||||:.|:
 Frog   266 SLILEIENLKKQYEAMVSDLIQWIQQKVVQMNDRHFPNSITGMRQLMTDFKTFRTVEKPPKYQER 330

  Fly   356 GNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLA 420
            |.:|...|.:::.:..||.:||.|.:||.:.|:.|.|..|||||:|||.||:.|::|.|:||.:|
 Frog   331 GLIEAHFFKIRTILHGNNLRPYFPPDGKSLIDVEKYWAILEKAEYEREKALQAEMLRLERLELVA 395

  Fly   421 ARFDRKASMRETWLSENQRLVSQDNF-GFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDEL 484
            ..|::|||:|.|:|.:.::::.|.:| ..::|.||||.||.||||.|:...|:|.:.:..:...|
 Frog   396 QMFNKKASLRGTYLHDMKQVIEQGDFRPNNIAQVEAATKKLEAIEADVLPREQRFRTLADMAAVL 460

  Fly   485 ESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMT 549
            |.|.||....|:.::..:...|..|:||||.:::.||....:....:::..:::.::.:::||.:
 Frog   461 EKENYHRKPEIVQKQQELSSGWNGLIELLRKQKVLLEEKRHVLTLLRDIDSVVEELKSMQELLGS 525

  Fly   550 DDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLE 614
            .|:||.|..||||||||||.|:.|...|||||..:..::|.    |.| |....:::.::|..|:
 Frog   526 KDFGKQLPEVEDLLQKHSLYESQIVSYGERVKQNLMRAEKI----PVS-KATSVDVLQTKVLNLQ 585

  Fly   615 DAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKA 679
            ..|..|:.|:..|||||||:.||::|:.|..:.|.||.||.|::.......|::.:...:.|.||
 Frog   586 QLYQSLLSLSKSRRSRLEETLKLYEFFRDCGEVEAWINEKWQVLGLASPERDISHITASIQKQKA 650

  Fly   680 LESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYF 744
            ||:||.|..|.|..|.:.|.||..:.|.....|:.|:..:..:|.||.|..|..:.|||.|....
 Frog   651 LEAEIYSRQPILAKVVRNGKELCQQSHTDQGEIQKRMDNLQTQWHHLQDEVKTSKFRLEVAALIK 715

  Fly   745 QLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAES--- 806
            |.|||||:.|:|:.:.|.::|:||.|:||::.:::|::|..:..|:..||..:..|..||:|   
 Frog   716 QYFADADEADSWLRERLPLLSNEDYGKDESSAEAMLQRHLRLEKEIAAYAMEMRRLGDQAQSVAS 780

  Fly   807 -----------------------LKLNEAEKANV-------DKRL---------EAIDNRYKELT 832
                                   ||.:.|.:.|:       |..:         ..:::.|:.|.
 Frog   781 KAPLIQQKKKPVIVIMTQEASRPLKRSYAPQINIQTEDPKHDPHMGQEEILASQTKLESSYENLQ 845

  Fly   833 ELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNA 897
            .|||.|::.|.:.:.||:..|.....:.||.:|.|:..|..|..  |::|:|:.::|....::.|
 Frog   846 ALAKKRRKALEEMVRLYQFYSSCGDFQSWIDDKEKLFQTFQPNP--ENLEVMQQKYENLLTDLAA 908

  Fly   898 NASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECR 962
            ..:|...:|.||..|:.:......||...|..::..|:.|....|.|..||.....|::....|:
 Frog   909 GKARHDEINDLAEDLIKIAPNRKKEIQAHQKDIDNSWNHLEILKEQKGADLIGLADVKSLLQNCQ 973

  Fly   963 ETISWIEDKKRILTETDSLEMDLTGVM-TLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEE 1026
            .|.:.|::|.:.|..::  .::.||.: |.:|:|..::||:..::.|:..|:....||.|.:|:|
 Frog   974 NTEALIQEKFKELEGSE--PVNATGNLDTEERKLKNLERDIQILERKIEYLKNVEQSIRDTNPQE 1036

  Fly  1027 AKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSL 1091
            ::.||:::|::|...|:|....:|:...|::|.|...||:|......|:...:..:.:|:..:.:
 Frog  1037 SEAIRKQVAEMENQLEKLKHQAEEKRMSLKKAKDQKIFLQDSRRQLLWVQDMKDKLTNEEMGSDV 1101

  Fly  1092 PEAEKLLNQHQSIREEIDNYTEDYKNMMEYGE-RLTSEGSTSDDPQYMFLRERLNALKDGWEELH 1155
            ..||:||..||.:..||....:....:.:.|: .|..|.|::.:     :|:.|..|...:..|.
 Frog  1102 ASAEQLLRDHQYLLIEIQREKDRIIELQQMGQAALQYESSSTPE-----VRDALITLSKEYNALG 1161

  Fly  1156 QMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEA 1220
            .:|..|...|.|.|:.|.||::|......||..|.||..:|....|:..::.|.||:.|...:..
 Frog  1162 DLWVERNKRLQQGLELQQFNKEADSINAALSSHEAFLRVNDLGDQLDTVQSLLHRHDQFEKLLAT 1226

  Fly  1221 NDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLE 1285
            ...::::.....:||.:..||.:|.|.:|..:...|..:...::.::.:.|.:.::|.||.:|..
 Frog  1227 LKKRVDSFAVNGETLEQNQHFASDLIKQRVSDTKDRLKNVNHKSEERKKSLIDSLRLQEFNRDAT 1291

  Fly  1286 ELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDV 1350
            ||..|::|||..:.|||||....|..|...|:|.|.|:.||:.......|...:|..|....|:.
 Frog  1292 ELLVWMEEKYKIALDESYRDPTNILRKLKWHEAAEKEMEANRVCYEGLLKVGHQLVGEDHYAKES 1356

  Fly  1351 IEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSV 1415
            |:.|:.|:.::::||.....|:|..|..|.::..:.:...|....|..:||.:.:.::::||.|.
 Frog  1357 IKSKMLEVTRRWEDLNNKMSERGNKLRQAGQQEQLMELLQDAKVKIEKIEKVLQAPESSHDLRSS 1421

  Fly  1416 NILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEE-KIEPIVVKKTAVLERFEKIKAPLLER 1479
            ..|::..:.::.:....|.::..|   ..:.||..... ..:.|:.:....|.|||.::.||.:|
 Frog  1422 RDLLKAHRQLENESQELADKMNSI---VSHAQKMASNHFNSQGIMDETMKYLRRFESLQEPLAKR 1483

  Fly  1480 QKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRIN 1544
            ::.|:.|...::|....:.|..||.||:|.|:|.:||.||.......:|::.|..|::.|..::.
 Frog  1484 REFLQAKVNQYEFYHYYDLEMKWISEKMPSASSTNYGKSLDAAQSSFQKHKELQAEVNAHIQQLQ 1548

  Fly  1545 AICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWM 1609
            .:.:.|:.||...|.::........:|...|.||:.|.|.|.|:|.:|...||:..|..:.|:|:
 Frog  1549 RVLDMGKLLITSNHPESCNIAEKNKELQHSWSELERACEERMKNLQKSVSFQQFLLDVSDMENWI 1613

  Fly  1610 SEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQ 1674
            .|:...:..:|.||:|.:...|:|||::|:|.:|.|.|....|....:..|.......|.|....
 Frog  1614 VEKLPLVNSKDFGKEEDATLKLIKKHKDLQQEIELYGNLASDLERTGQSLSLPSSVRYDEVDAPV 1678

  Fly  1675 SQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSE 1739
            .:::.....||:.|..|..:|.|:|.|:...||..||:.||..:..:|.|::.|.|::.|..|..
 Frog  1679 GKINVQMRDLKERASVRWGKLEESLALYEYLRESADLQDWINQQRQLASSEDCGNDYEQVLHLQA 1743

  Fly  1740 RFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAA 1804
            :||.|....|. ...|::....|||:|:..||::|..|.:.:..|..||::|.:|...|.:.|..
 Frog  1744 KFNTFQHQMEP-ASLRMSACQRIADSLLDRGHAESMLIVQKQKELRASWEELQQLTRERGKHLQD 1807

  Fly  1805 SRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESA 1869
            :..:||.|.|.|:.|.:|.||...|.|::.:|...|.:..||......:|.....|:|::.:.:.
 Frog  1808 AEAVHKSFWDLKEALAQIKEKSKSVPDDIAKDLSGVQSQLRKQEALEHELSGNEHQLQEVIDAAD 1872

  Fly  1870 KLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQ 1934
            :.......::...:..::|||:..|:.|:...:.|:..|.....|:.|..|||....|:..:.|:
 Frog  1873 EALPRCTTNQRVPLQQKQQEVVEKWELLKTKVEKRRTDLEQACKLYFFLTMVRDYFSWVAGISRE 1937

  Fly  1935 MNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNS 1999
            |...|..|.|......:..||.||.:||..::.:...::||:.||......:|.|.::|..|...
 Frog  1938 MMAEETIRGVLASTENLKGHQDLKQQIDAHQETYNRAVTLGQSLLQERKAPAAQINEKLQALVEE 2002

  Fly  2000 RNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFE 2064
            ...|.::||::.:.|:.:.:...|.||....|..|.:||..|.||:||.:..|:|.|||||||||
 Frog  2003 NKKLYKQWEQKRKLLEQVHQEQVFYRDVDHLEKILNSQEVSLKSSDLGTSSGEIEQLIKKHEAFE 2067

  Fly  2065 KSAAAQEERFSALERLTTFELKEMKR-------RQELAEEAERQR-IKEEQEAKA---------- 2111
            |..|:|||:..:|:.... :|::..:       :|:|....||:| :|:...|:.          
 Frog  2068 KLFASQEEKVVSLQDQAN-KLQDSSKWPEREQIQQKLRSVLERRRKVKDLSRARKDELNTALLLA 2131

  Fly  2112 -----ASEAAEQAKREAERRDDVDVGASHDDSAAKDTAVEFERVVEIQ-----------TERGGT 2160
                 .:||........::.||........|..:|...::..:|.|.:           ||:|.:
 Frog  2132 LFYQNLTEAQYWINERMQKLDDNTHQQGPMDLQSKLKVLQKHQVFEAEILAHEKNIQDVTEKGNS 2196

  Fly  2161 PGAGEGHEGYVTRKHEWDST----TKKASNRSWDKVYMAAKAGRISFYKDQKGY 2210
                      :..:|...||    ..:|.:..|:|:..|. |.|....:|.:.:
 Frog  2197 ----------LLSQHHPKSTEIRQKSRALHEEWEKLKRAV-AARGKMLEDNRDF 2239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 49/98 (50%)
CH 170..269 CDD:278723 67/98 (68%)
Spectrin 298..408 CDD:278843 44/109 (40%)
SPEC 422..521 CDD:197544 35/99 (35%)
SPEC 525..740 CDD:238103 75/214 (35%)
SPEC 639..846 CDD:238103 71/248 (29%)
SPEC 848..1058 CDD:238103 56/210 (27%)
SPEC 955..1169 CDD:238103 54/215 (25%)
SPEC 1170..1380 CDD:238103 59/209 (28%)
SPEC 1386..1484 CDD:197544 20/98 (20%)
SPEC 1488..1699 CDD:238103 60/210 (29%)
SPEC 1594..1806 CDD:238103 63/211 (30%)
SPEC 1807..2015 CDD:238103 53/207 (26%)
Spectrin 2018..>2078 CDD:278843 28/59 (47%)
PH 2167..2275 CDD:278594 10/48 (21%)
PH_beta_spectrin 2167..2274 CDD:269975 10/48 (21%)
sptbn5XP_031747272.1 CH_SF 4..127 CDD:412120 60/119 (50%)
SAC6 13..>499 CDD:227401 231/487 (47%)
CH_SPTBN5_rpt2 142..250 CDD:409098 72/107 (67%)
SPEC 395..606 CDD:238103 77/215 (36%)
SPEC 607..783 CDD:238103 61/175 (35%)
SPEC 716..959 CDD:238103 62/244 (25%)
SPEC 968..1173 CDD:238103 53/211 (25%)
SPEC 1176..1385 CDD:238103 59/208 (28%)
SPEC 1387..1596 CDD:238103 52/211 (25%)
SPEC 1494..1703 CDD:238103 60/208 (29%)
SPEC 1705..1914 CDD:238103 58/209 (28%)
SPEC 1812..2021 CDD:238103 54/208 (26%)
SPEC 2022..2235 CDD:238103 57/224 (25%)
SPEC 2238..2453 CDD:238103 0/2 (0%)
SPEC 2454..2665 CDD:238103
SPEC 2666..2870 CDD:238103
SPEC 2873..3085 CDD:238103
SPEC 3086..3297 CDD:238103
SPEC 3299..3487 CDD:238103
PH-like 3693..3780 CDD:418428
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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