DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and dst

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_021336603.1 Gene:dst / 100333215 ZFINID:ZDB-GENE-030131-3399 Length:8085 Species:Danio rerio


Alignment Length:2796 Identity:629/2796 - (22%)
Similarity:1042/2796 - (37%) Gaps:809/2796 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PSQGPGN-----------EYIDEYEYD--GGNSSSR----------LFERSRIK----------- 42
            ||.|.||           ::.|:.||.  .|:.|..          ..|||:.|           
Zfish   131 PSSGSGNASLRCSMSSSADFSDDEEYSVKSGSVSPAPGDTLPWNLPRHERSKRKIQGGSVLDPAE 195

  Fly    43 ----ALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKP---- 99
                .:|:||:.|||||||||:|.||.:|...:.|||.|:|||.:||.||||||||.||:.    
Zfish   196 RAVLRIADERDRVQKKTFTKWINQHLLKVRKHVNDLYEDLRDGHNLISLLEVLSGETLPRERDLL 260

  Fly   100 -------TKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQD 157
                   .||:||.|.|:||..||.:|:.::|.|.||.:.||.|||..|.|||||||||.|||.:
Zfish   261 KTLRLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISE 325

  Fly   158 ITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLS 222
            |.:  ....|..:||:.||||.:..|.||..|...|||||||||..|||||||:|||||...::|
Zfish   326 IHV--TGESEDMTAKERLLLWSKQMTEGYVGVRCDNFTTSWRDGRLFNAIIHKYRPDLVDMSRVS 388

  Fly   223 KTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIG 287
            ...:..||..||.||| :||:|:|||.|||.|..|||||:||||.|.|..|.|:.:   .|..|.
Zfish   389 AQTSRSNLEQAFGVAE-QLGVARLLDPEDVDVSSPDEKSVITYVSTLYDVFPKVPE---GGDGIN 449

  Fly   288 KVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKF 352
                 |.:.|....:|:|..:.|.:||:..:..:.:|.|.:|...::....|:.:::..|.|||.
Zfish   450 -----ANDVDVKWVEYQNMVNYLSQWIKHNVTVMSDRHFPSSPVELKALYTQYLHFKENEIPPKE 509

  Fly   353 VEKGNLEVLLFTLQSKMRANN-QKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKL 416
            .||..::.|...|:..:.... |.|    .|...:|:.|.|.:|..|..|||.:||.|:.|.|.|
Zfish   510 NEKSKIKHLYKMLEIWIEFGRVQLP----PGFHPNDVEKEWGKLIVAMLEREKSLRPEVDRLEML 570

  Fly   417 EQLAARF--------DRKASMRETWLSENQRLVSQDNF-------GFDLAAVEAAAKK-----HE 461
            :|:|.|.        |:.|..|.:..|:.:||.|...|       || |...|...::     .:
Zfish   571 QQIANRVQRDCAAGEDKLALARTSLQSDVKRLESGIQFQNEAEIAGF-LLECETLLRQQVVDIQQ 634

  Fly   462 AIETDIFAYEERVQAVVAVCDEL-----ESERYHDVKRILLRKDNVMRLWTY------------- 508
            .::...:..::.||.|..:.|:|     |....:...|.|..:...|.:...             
Zfish   635 LLDGKFYLADQLVQRVSKLRDDLLSLRSECSSVYSKGRTLTSEQTKMMISGITQSLNSGFSAGLL 699

  Fly   509 --------------------------------LLELLRARRMRLEI--SLQLQQNFQE----MLY 535
                                            :||.|:...:|..:  |..|..|..|    |.:
Zfish   700 SSAGAPVISNPSMHQQSVVGTVSAFSNPGAGGVLEHLKHTHIRKPMLKSSFLDPNLSEDEANMKF 764

  Fly   536 ILDNM---EEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPES 597
            :.|.:   ||::..|...::|..|:.||..|.||......|...............:......:|
Zfish   765 VQDLLSWVEEMQVQLDQAEWGSDLLSVESNLGKHKDFHKAIEEFQMSXXXXXXXQMQMTQPLKQS 829

  Fly   598 YKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDE 662
            |.        .::.:||..|:.|::.:.||:..|:   .|..|......|..|:.|||:    :|
Zfish   830 YS--------EKINKLETLYSRLLKSSSERQRNLD---SLHDFVSRATQELIWLNEKEE----EE 879

  Fly   663 VGHDLTTVNLMLSK----HKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723
            |..|.:..|..:|:    |..|..|:...:..:::|.:....|:.|.|.....|:.....:..:|
Zfish   880 VAFDWSERNTSVSRKRDYHSDLMRELDDREEVIRSVQEKAENLLLENHPARLTIEAYRAAMQTQW 944

  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVS-------SEDVGRDEANVQSLLK 781
            ..:|.|.....|.|::...||..|:||.:    .||.|:.:.       |.|.......::.|::
Zfish   945 SWILQLCHCVEQHLKDNTVYFDFFSDAKE----SLDYLKSLQDAIHRKYSCDRSSSLHRLEDLIQ 1005

  Fly   782 KHKDVADELKNYAEVIDALHKQAES---LKLNEAE---------KANVD-KRLE----------A 823
            :..|..::|..|:..:..|..:|::   ||....|         ||..| :::|          .
Zfish  1006 ESMDEKEQLLKYSSTVGGLVGRAKAIVQLKARNPENPIRTSIPVKAICDYRQIEITIGKEDECVL 1070

  Fly   824 IDNRY---------------------------KELTELAKLRKQRLLDALSLYK----------- 850
            :.|.:                           ||.||:|...:|...:.|:|:.           
Zfish  1071 VSNSHRAKWKVISTSGNEAMVPSVCFSVPPPNKEATEMASRIEQLYQNVLALWHHSHINMKSVVS 1135

  Fly   851 ---LMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMN-ANASRVAVVNQLARQ 911
               ||::...:.   |.....:.|:.||...:.:..::..|:.|.::.: :....:|...||.::
Zfish  1136 WHYLMTDIRAIR---KSTVASIKTLLPGDHEQVLSDLQAHFQDFLRDSDESEVFTMADCAQLEKE 1197

  Fly   912 LLHVEHPNSDEIL---ERQNH-------LNQEWSTLREKAEA-------------KMDDLKSAHG 953
            :|..:. ..:|:|   ||:.|       ...|....|.:.|.             ..|||:    
Zfish  1198 VLACKE-YYEELLKSAEREEHEESVYNLFISEVRNFRMRVEGHEEQLIRKIRTPLDRDDLQ---- 1257

  Fly   954 VQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAA------IQAKLSSL 1012
                  ||...|:..|.||   .|.|.|:.:|.   ||:.:.....|..:|      :.::||.|
Zfish  1258 ------ECLLRITEQEKKK---VELDRLKDELE---TLREKCEVFLRQASASPSVPTLSSELSVL 1310

  Fly  1013 EREANSIEDEHPEEAKIIRERIAQIELI---WEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTW 1074
            .:.::.:.    ....|..|::..:.|:   .:....::|..::||.|...::..::.:|...:.
Zfish  1311 TQSSSQVY----SMCCIYLEKLKTVSLVVKHSQSAEALVKLYEAKLSEEDSVNANIKSIDGVVST 1371

  Fly  1075 LTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSD-DPQYM 1138
            |.:.::::..:                   ||...:..::.:......||:....:..| |..:.
Zfish  1372 LKQWRSEIDEK-------------------REVFHDLEDELQKARVVSERMFKTHNERDFDLDWH 1417

  Fly  1139 FLRERLNALKDGWEELHQMWENRQVL----------------------------LSQSLDQQLFN 1175
              :|:.:.||:.|:.:|...|||.:|                            .|..:.|:..:
Zfish  1418 --KEKADQLKERWQNIHSQIENRSLLEYELQLMTYRAMVDSQHKSPVKRRKMQSSSDVIQQEFMD 1480

  Fly  1176 RDARQTEVLLSQQEHFLSKDDTPVNLEQ----AENQLKRHEAFLTTMEANDDKINTLLQVADTL- 1235
            ...|.|.::....::.....:|....|:    .|::.|.|          .||:|.||....:: 
Zfish  1481 LRTRYTALVTLMTQYVKFAGETLKRAEEDERSVEDEKKEH----------GDKVNKLLNWMSSMK 1535

  Fly  1236 --VEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATS 1298
              :.||. .|...||.:...|.                |.|:.:.|.:...|::.|.::    |:
Zfish  1536 TNLSKDG-KAQSDGKASTESTS----------------KAQMSMEEMVTKKEQIGEALR----TT 1579

  Fly  1299 QDESYRSAKTIHS-KWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQF 1362
            |     ...|.|| |.|..:..||     ||:|....::..|:|::..:.....:..||.:....
Zfish  1580 Q-----LMLTKHSDKMTEEEKKEA-----KEQLASLHQAYSEISQQCADVTSSADQALKVIQGIL 1634

  Fly  1363 DDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITD-------LEKQIVSGDTANDLTSVNILMQ 1420
            |      .|.||          |...|..::..|.|       ||.|::        ||..|..:
Zfish  1635 D------VESGA----------VMSVCCSVNHGIIDQITGLSLLEAQLI--------TSGLIWPE 1675

  Fly  1421 KQQVIQTQMAVKA--------RQVEEIDKQTEYLQKTVPEEKIEPI----------VVKKTAVLE 1467
            :|..:..:.|.|:        ||:::::...:.:|.  |....||:          :.::||:  
Zfish  1676 RQLCMDLEDAFKSQLVDDAMFRQLQDLNDAKKCVQD--PRFASEPLPFIAALESGSISERTAI-- 1736

  Fly  1468 RFEKIKAPL--------------LERQKALEKKKEAFQ--------FCRDVEDEKLW---IDEKL 1507
               ||...|              |||         |||        |.:.:|.:..|   ||   
Zfish  1737 ---KIIEVLVATGGLRLAGDILHLER---------AFQLGLIPHSLFIQILEMKDAWKNLID--- 1786

  Fly  1508 PVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEP-RI-----------NAICNNGRKL-----ID 1555
                 |:.|.        |.....|....:.||| |:           |....:|:::     :.
Zfish  1787 -----PNSGE--------KVTLSQLVQRSEMHEPTRLCLLPVKRRKVGNISLTSGKEINIIQAMH 1838

  Fly  1556 EGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLE-SEKVQQYFFDAQEAESWMSEQELYMMVE 1619
            ||..|......|:|  .|.:  ....::.|..|:|. .|.:.:...|...|...:|.|       
Zfish  1839 EGVIDRDTMSRLLS--AQLF--AGGIVDPRNGHMLTVEEALSEGLIDQDTASEILSHQ------- 1892

  Fly  1620 DRGKDEISAQN--LMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQ------ 1676
                    |||  ::..|.....:|::....             |.|||..|:.|.:.|      
Zfish  1893 --------AQNGGIVNPHNKARLTVDEAVQC-------------DLISSSSALLVLERQKAFMGL 1936

  Fly  1677 --------------------LDKLYAGL--------------------KDLAGERR------ARL 1695
                                .|||.:.|                    .|.|.|:.      ..|
Zfish  1937 LWPNVGEILSFSTSLQQNIITDKLASDLFLNRQKITGLYIPETSEVVDVDFASEKHLIETFTKEL 2001

  Fly  1696 NEALQLFMLSREVDDL----EQWITDREV-VAGSQELGQDF--DHVTLL---SERFNEFA----- 1745
            .:.:::..:..:||:|    ..|:..:|: :.||...|...  :|.|..   ||....||     
Zfish  2002 LKTIEIPDVIPDVDELSNRFSSWLVMQELQIKGSCTSGGKISEEHGTNAPSPSEAKQLFASYLMM 2066

  Fly  1746 ---RDTEAVGGERV----AKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLA 1803
               .|.|:  |:|:    .::|.:|:.|.:...|:|:......|...||   .|.:::|....|.
Zfish  2067 NSYMDPES--GQRLLIFDLQLNKMAEILFECLQSESSDEISMDDISEES---PLSIVDTDNDCLE 2126

  Fly  1804 ASRELHKFFHDCKDVLG--RILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLIT---------- 1856
            |     |:   |  .||  :|.|.....::|......:|    |:||..|..|.|          
Zfish  2127 A-----KY---C--ALGELQICEPLESRTEECEAMDANV----RQHYLALNTLPTDQKCGISLGS 2177

  Fly  1857 ----LYSQVQQIQEESA-KLQDAYAGD------KAKEITNRE-QEVLHAWDNLQAMCDARKQKLA 1909
                ..|:..::|::|| .:.|.|..|      ||....|.| ::|:...:: .::..:......
Zfish  2178 NDHVTVSEADELQKDSACSIIDEYQADTNVPLSKAMHTVNPECKDVIQDQES-SSIFPSEAISYT 2241

  Fly  1910 DTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEID-------TREDN 1967
            :....|.|..:|     |.:.|.|..          .:.|       |||:::       |....
Zfish  2242 EMPSEFTFTEVV-----WDDKLERDY----------AIHL-------LKAQVEEGGILDVTSGKR 2284

  Fly  1968 FGACISLGKELL----------TRNHYASADIKDR--LMTLSNSRNALLRRWEERWENLQLILE- 2019
            :....:|||.|:          .|.:..|...|:|  |..|:.|.|   :.|......||:::: 
Zfish  2285 YDLEAALGKGLIDEETVLEVLALRLNEDSFKDKERAALSVLNTSAN---KGWISNKVALQIMVKQ 2346

  Fly  2020 -----VYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEER----FS 2075
                 .|    ||||.:...|.:     :.|.|...|::...:...|...|:....|::    .:
Zfish  2347 NLLGGFY----DAAVGKTVSICE-----ALETGLITDDISRSVLCSEPITKAIIDPEKKCILSVN 2402

  Fly  2076 ALERLTTFELKEMKR-----RQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVDVGASH 2135
            ...||...:.:|.:|     :.|:.:.|    :....|....|..:::|.:.:  .|...|.:|.
Zfish  2403 DASRLGMLDDEEAERLLHSQQDEIVDTA----VFHPSETVLISTTSDEATQVS--TDTKAVSSSQ 2461

  Fly  2136 D------------DSAAKDTAVEFERVVEIQTERGGTPGAGEGHEGYVTRKHEWDST-------- 2180
            |            .:::||  ..|.:|.:|..|...........|| |:...|...|        
Zfish  2462 DLHLPSVCGIPFKATSSKD--YSFAKVSKIDKESDEALHISTNPEG-VSCHQELSLTVISDIQPQ 2523

  Fly  2181 ---TKKASNRSWDKVYMAA----KAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYT 2238
               ||   :..:|||...:    ||.::|  .|.....|:.||             .:.|.||..
Zfish  2524 AISTK---DNVFDKVSKTSQGSDKAMQVS--SDVGSLSSSSEL-------------PLTIISDIQ 2570

  Fly  2239 KKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRSQTLP--------ATSQKD 2295
            .|....:..:.:......|..|:        :::..:|:.||..|:...||        |.|.||
Zfish  2571 PKAISTQANVFDDVSKTRQGSDE--------AIEVSTDTEAVRGSQDLYLPSICDIQPEAISTKD 2627

  Fly  2296 E 2296
            :
Zfish  2628 K 2628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 58/108 (54%)
CH 170..269 CDD:278723 58/98 (59%)
Spectrin 298..408 CDD:278843 29/110 (26%)
SPEC 422..521 CDD:197544 26/168 (15%)
SPEC 525..740 CDD:238103 50/225 (22%)
SPEC 639..846 CDD:238103 54/267 (20%)
SPEC 848..1058 CDD:238103 47/256 (18%)
SPEC 955..1169 CDD:238103 42/251 (17%)
SPEC 1170..1380 CDD:238103 44/217 (20%)
SPEC 1386..1484 CDD:197544 26/136 (19%)
SPEC 1488..1699 CDD:238103 52/293 (18%)
SPEC 1594..1806 CDD:238103 54/287 (19%)
SPEC 1807..2015 CDD:238103 50/250 (20%)
Spectrin 2018..>2078 CDD:278843 12/69 (17%)
PH 2167..2275 CDD:278594 23/122 (19%)
PH_beta_spectrin 2167..2274 CDD:269975 23/121 (19%)
dstXP_021336603.1 SAC6 202..>438 CDD:227401 130/238 (55%)
SPEC 765..960 CDD:238103 46/209 (22%)
SMC_N <1254..1633 CDD:330553 85/460 (18%)
Plectin 1661..1700 CDD:307019 11/46 (24%)
Plectin 1849..1889 CDD:307019 9/43 (21%)
Plectin 1888..1927 CDD:307019 12/66 (18%)
Plectin 2266..2305 CDD:307019 9/45 (20%)
SMC_N <3937..4311 CDD:330553
SMC_N 4143..>4925 CDD:330553
SPEC 5022..5242 CDD:238103
SMC_N 5187..5823 CDD:330553
SPEC 5356..5566 CDD:238103
SPEC 5788..6004 CDD:238103
SPEC 5902..6115 CDD:238103
SPEC 6009..6224 CDD:238103
SPEC 6335..6550 CDD:238103
SPEC 6444..6663 CDD:238103
SPEC 6555..6772 CDD:238103
SPEC 6665..6882 CDD:238103
SPEC 6885..7100 CDD:238103
SPEC 6993..7209 CDD:238103
SPEC 7211..7427 CDD:238103
SPEC 7324..7536 CDD:238103
SPEC 7546..>7602 CDD:197544
EF-hand_7 7706..7769 CDD:316058
GAS2 7783..7861 CDD:128539
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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