DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and sptan1

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_031762662.1 Gene:sptan1 / 100036647 XenbaseID:XB-GENE-986854 Length:2497 Species:Xenopus tropicalis


Alignment Length:1869 Identity:523/1869 - (27%)
Similarity:865/1869 - (46%) Gaps:346/1869 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   604 EIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADE-ENWIKEKEQIVSTDEVGHDL 667
            |.|..|.||:.|.|.....|:|.||.:||:|.: :||:...||| |.||:||.||.| ||...|.
 Frog    13 EDIQERRQQVLDRYLRFKELSVLRRQKLEDSYR-FQFFQRDADELEKWIQEKLQIAS-DENYKDP 75

  Fly   668 TTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKY 732
            |.:...|.||:|.|:|:.::...:..:.:.|:.:|:||||.::.|:.||.|:...|:.||     
 Frog    76 TNLQGKLQKHQAFEAEVQANAGAIVKLDETGNLMISEGHFSSETIRTRLVELHRLWELLL----- 135

  Fly   733 RRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVI 797
                                                                             
 Frog   136 ----------------------------------------------------------------- 135

  Fly   798 DALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWI 862
              |..|.:.:||.:|:|                                 |.:.:.|.:.|..||
 Frog   136 --LKMQEKGVKLQQAQK---------------------------------LVQYLRECEDVLDWI 165

  Fly   863 KEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQ 927
            .:|..::.:...|:|:|.||:::.:||.|..::.|:..||..|||.|.:|...|||..:.|..:|
 Frog   166 NDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFASKLAQEEHPELELIKTKQ 230

  Fly   928 NHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQ 992
            :.:|..|..|:..|..:...|..|..||.|..:..|||.||.:|::::. :|....||..|..|.
 Frog   231 DEVNASWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIREKEQLMA-SDDFGRDLASVQALL 294

  Fly   993 RRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEE 1057
            |:..|::|||||::.|:.:|..|::.::..||..|..|:.:..::...|||:..:..||.::|.:
 Frog   295 RKHEGLERDLAALEEKVKALCAESDRLQQSHPMNAPQIQVKGEELITNWEQIRTLAAERHARLND 359

  Fly  1058 AGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYG 1122
            :..|.|||.|.....:|:|:.:..:.:::....:..||.||::||..:.|||.:.:.:|.....|
 Frog   360 SYKLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKAADAAG 424

  Fly  1123 ERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQ 1187
            :.|.:.|..:.|.    :||:|..|.:....|.::||.|:....|.:|.|||.||..|.:..:|:
 Frog   425 QALLNGGHYASDE----VREKLTILAEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485

  Fly  1188 QEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAEN 1252
            ||.||..:|...:|:..|..||:||.|..::.|.::||..|.:.|..|::.:|:..:.:..|.:.
 Frog   486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAKEDVATRRDA 550

  Fly  1253 ITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQ 1317
            :..||:...:|||.:..:|.:...|.:|.:|.:||..|:.||..|:.||:|:....:..|..:||
 Frog   551 LLSRRNALHERALYRRTQLADSFHLQQFFRDSDELKSWINEKMKTATDEAYKDPSNLQGKVQKHQ 615

  Fly  1318 AFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANRE 1382
            |||||::||:.|:...|.|.|:|........|.:..::.|:...:..|...|:.||..|.:||::
 Frog   616 AFEAELSANQSRIDALENSGQKLIDVNHYASDEVAARMSEVITLWKKLLEATELKGIKLREANQQ 680

  Fly  1383 VLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQ 1447
            ....:..:||:.::.::|..:.|.|...|||:|..|.:|..:::..:|....:::.|..|....|
 Frog   681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745

  Fly  1448 KTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANS 1512
            : ......:.|..|:.|::.|:|.:|.|::.|::.|.......|..||||||:.||.||.|:|.|
 Frog   746 E-AGHFDADNIRKKQEALVNRYEALKEPMVARKQKLSDSLRLQQLFRDVEDEETWIREKEPIAAS 809

  Fly  1513 PDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQE 1577
            .:.|..|..|..|.||:|:|..||..|||||.|:...|..:|.|||..:.:.:..:.:|..||..
 Frog   810 TNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGESMISEGHFASDEVKGKLRELNDKWAT 874

  Fly  1578 LKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSV 1642
            ||:....||:.|.:|.:.||||.||.||||||.|:|..:...|.||||.||:.|:||||.|...:
 Frog   875 LKNKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDL 939

  Fly  1643 EDYANTIRQLGEVA----RQFSGDD-----------------------ISSGD------------ 1668
            ..|.::|:.|.|.|    :|.:..|                       :..||            
 Frog   940 RAYGSSIQGLREQAQACRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW 1004

  Fly  1669 ------------------------------------AVAVKQSQLD------------------- 1678
                                                ::|::|.|:|                   
 Frog  1005 WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDGQAHMSKEAGSVSLRMNQV 1069

  Fly  1679 -KLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFN 1742
             :||..:.::..:|:..|.::.:.|||.||.::|:|||.::|....::|:|.|.:.|.:|.::|:
 Frog  1070 EELYHNILEMGEKRKDMLEKSCKKFMLFREANELQQWINEKEASLTNEEVGADLEQVEVLQKKFD 1134

  Fly  1743 EFARDTEAVGGERVAKVNGIADNL--------------------IQAGHSDSATIAEWKD----- 1782
            :|.:|.:| ...|:..:|.:||.|                    :|...:||.:.:.||.     
 Frog  1135 DFQKDLKA-NESRLKDINKVADELESEGLITEEVQPVQHQEVYGMQRDEADSKSASPWKSVRTAV 1198

  Fly  1783 ----------NLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGV-SDELGRD 1836
                      :|||.|:.|.:|.|.|:|:|.::.|:.:|..|..:....|.||...: :|..|.|
 Frog  1199 LAVATFNSIKDLNERWKSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDSYGHD 1263

  Fly  1837 AGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMC 1901
            ..||..|||||..|.:||..|..:|..:.|.:.:|..::. :.|.:|..:..|:..||::|....
 Frog  1264 LASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESADDIQEKCTELNQAWNSLGTRA 1327

  Fly  1902 DARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTRED 1966
            :.||:||.|:.||.||.:..|.||.|:..:...:::.|..|||:|.|.|:..||..:.|||.|..
 Frog  1328 NQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELARDVTGAEALLERHQEHRTEIDARAG 1392

  Fly  1967 NFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAE 2031
            .|.|....|::||.|.||.|.:||::|..|...|.:|.:.|.||...|...||:..|.||...||
 Frog  1393 TFQAFEQFGQQLLARGHYDSPEIKEKLDILEQERASLEKAWVERRMMLDQCLELQLFNRDCEQAE 1457

  Fly  2032 AWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEM-------- 2088
            .|:.|:|.:|.|.:.|.::|.||.||||||.|:|:...|||:.:||:...    :::        
 Frog  1458 NWMAAREAFLNSEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA----EQLIIADHYAK 1518

  Fly  2089 ----KRRQELAEEAERQRIK--EEQEAKAASEAAEQAKREAERRDDVDVGASH------DDSAAK 2141
                .||.|:.:...|.:.:  |::.....|:..:|..|:.   |:::...|.      |:|...
 Frog  1519 GDIASRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV---DEIEAWISEKLQTASDESYKD 1580

  Fly  2142 DTAVEFER------------------------VVEIQT---ERGGTPGAGEGHEGYVTR-KHEWD 2178
            .|.::..:                        ||::..   |||...|:.:..:..::. ..:|.
 Frog  1581 PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVVDMGNSLIERGACAGSEDAVKARLSALADQWQ 1645

  Fly  2179 STTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFR-GEPSYDLQNAAIE--IAS-DYTK 2239
            ....|::.:|                  ||..::|.:..|. |...:|.....:|  :|| ||.|
 Frog  1646 FLVSKSAEKS------------------QKLKEANKQQNFNTGIKDFDFWLTEVEALLASEDYGK 1692

  Fly  2240 ---------KKHVL----------RVKLANG---ALFLLQAHDDTEMSQ 2266
                     |||.|          |:|..||   :|....|.|.|::.:
 Frog  1693 DLASVNNLLKKHQLLEADISAHEDRLKDLNGQADSLMTSSAFDTTQVKE 1741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723
CH 170..269 CDD:278723
Spectrin 298..408 CDD:278843
SPEC 422..521 CDD:197544
SPEC 525..740 CDD:238103 50/136 (37%)
SPEC 639..846 CDD:238103 42/207 (20%)
SPEC 848..1058 CDD:238103 67/209 (32%)
SPEC 955..1169 CDD:238103 63/213 (30%)
SPEC 1170..1380 CDD:238103 68/209 (33%)
SPEC 1386..1484 CDD:197544 23/97 (24%)
SPEC 1488..1699 CDD:238103 88/305 (29%)
SPEC 1594..1806 CDD:238103 83/341 (24%)
SPEC 1807..2015 CDD:238103 73/208 (35%)
Spectrin 2018..>2078 CDD:278843 28/59 (47%)
PH 2167..2275 CDD:278594 27/127 (21%)
PH_beta_spectrin 2167..2274 CDD:269975 27/127 (21%)
sptan1XP_031762662.1 Spectrin 44..147 CDD:395348 40/176 (23%)
SPEC 150..361 CDD:238103 68/244 (28%)
SPEC 362..572 CDD:238103 64/213 (30%)
SPEC 468..678 CDD:238103 68/209 (33%)
SPEC 679..890 CDD:238103 67/211 (32%)
SPEC 891..1161 CDD:238103 68/270 (25%)
SH3_Alpha_Spectrin 971..1023 CDD:212742 2/51 (4%)
SPEC 1092..1338 CDD:238103 73/247 (30%)
SPEC 1233..1444 CDD:238103 74/211 (35%)
SPEC 1445..1662 CDD:238103 52/241 (22%)
Spectrin 1662..1766 CDD:395348 22/80 (28%)
SPEC 1769..1978 CDD:238103
SPEC 1875..2086 CDD:238103
SPEC 1982..2200 CDD:238103
SPEC 2100..2337 CDD:238103
EFh 2352..2420 CDD:238008
EFhand_Ca_insen 2427..2495 CDD:400872
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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