DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and utrn

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_021325542.1 Gene:utrn / 100034367 ZFINID:ZDB-GENE-070228-6 Length:3523 Species:Danio rerio


Alignment Length:2966 Identity:591/2966 - (19%)
Similarity:1089/2966 - (36%) Gaps:899/2966 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRV-NCRIADLYVDM 78
            |..||:.|                 .||..::|.::|||||||||:|:...:. ...|.|::.|:
Zfish    14 GDNNEFTD-----------------IIKWRSDEHDAVQKKTFTKWINAQFSKTGKAAIKDMFTDL 61

  Fly    79 RDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNL 143
            |||:.|:.|||.|:...|.| .:|..|:|.|.||::.||.|.:..|.|.|||..||||||..|.|
Zfish    62 RDGRKLLDLLEGLTANTLIK-ERGSTRVHSLNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTL 125

  Fly   144 GLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAII 208
            ||||:|||.:|::|:..:.:.:.:..:::..||.|.:..|..|::|||.|||:||.||||||||:
Zfish   126 GLIWSIILHWQVKDVMKDVMSSLQQTNSEKILLSWVRNCTRSYNSVNVLNFTSSWADGLAFNAIL 190

  Fly   209 HKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYF 273
            |..||....:||:.....:..|.:||..|:|:|.:.||||.|||.|:.||:||||.||.:.:...
Zfish   191 HHFRPHGFSWEKVVSLTPVERLEHAFTFAKDQLNIEKLLDPEDVAVQLPDKKSIIMYVTSLFAVL 255

  Fly   274 ----------------SKLKQETVQG-----------------KRIGKVVGIAMENDKMVHDYEN 305
                            .:.|.||.:|                 .|...:..:.||.:  :..|:.
Zfish   256 PNDITMDDIREVETLPRRYKVETDEGHPGFAGEVEVDSSSSSSTRAETLAELQMEVN--LDSYQI 318

  Fly   306 FTSDLLKWIETTIQSLGERE------------------FENSLAGVQ---GQLAQFSNYRTIEKP 349
            ...::|.|:.:...:|..:|                  |...|...|   |.:.|..|       
Zfish   319 TLEEVLTWLLSAEDTLHMQEDVSEDVEEVKDQFHTHEAFMMELTAHQSSVGNVLQAGN------- 376

  Fly   350 PKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISD----INKAWERLEKAEHERELALREEL 410
             :.:.:|||                   :.:|.:.|.:    :|..||.|..|..:|:..|.|.|
Zfish   377 -QLIAQGNL-------------------SEEEEEEIREQMTLLNSRWENLRVASMDRQSRLHEVL 421

  Fly   411 --IRQEKLEQLAARFDRKASMRETWLSENQ---RLVSQDNFGFDLAAVEAAAKKHEAIETDIFAY 470
              ::|::|:||:           .||::.:   |.:..:....|:.......::|:|::.|:.|.
Zfish   422 MDLQQQQLQQLS-----------DWLTQTEGRIRKMEIEPIAGDIQGYLTQIEQHKALQNDLEAE 475

  Fly   471 EERVQA---VVAVCDE-------------LES--ERYHDVKRILLRK----DNVMRLWTYLLE-- 511
            :.:|.:   :|.|.||             |:|  ||:..|.|....:    |....:|..||:  
Zfish   476 QVKVNSLTHMVVVVDENSGESATAALEEQLQSLGERWAAVCRWTEERWNKLDETQLVWQRLLDDQ 540

  Fly   512 ------LLRARRMRLEISL-------QLQQNFQEMLYILDNMEEIKQLLMT-DDYGKHLMGV--- 559
                  |....:...|:..       .:..:.:.:..:.::|.:.::.|.. .|.|:.:|.:   
Zfish   541 SLFGSWLTEKEKALGEVQTCDFKDPSDINASVRRLASLKEDMAQKRRTLSALSDAGQDVMVLLNS 605

  Fly   560 ------------------EDLLQK----HSLVEADINILG-----ERV--------KVVVQNSQK 589
                              ::|:||    .|.|...:::.|     |:|        .|..:..|.
Zfish   606 PAAAQRIESDTELLTQRWDNLVQKLEDCSSQVTEAVSVTGMPQVQEKVLMETLTVTTVTTRMEQT 670

  Fly   590 FLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEK 654
            :.|.|.|...|..|:      ::..|...||.|||.....:|......|:....||.:.:.:||.
Zfish   671 YSSSDRELPPPAPPK------RRHLDTDGELRRLAETDVPKLLSGLAAWRSSAQTAGDSSSLKES 729

  Fly   655 EQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEI 719
            .|::..|            |::.:....|:|      |...|:..:|..|| ..::..:..|:.:
Zfish   730 LQVLEVD------------LAESEGSVKELT------QKAEKMIEQLEKEG-LSSEEARSGLESV 775

  Fly   720 LNKWDHLLDLTKYRRQR---LENAVEYFQLFADADDV----DNWMLDTLRIVSSEDVGRDEANVQ 777
            ..:|:....|.:..|.|   ||...|........|:.    .|||.:|...       |::.|:|
Zfish   776 CKEWESCQTLIQELRSRAGLLERLAEVESGLKAVDEALQEQKNWMNNTNEF-------REKENLQ 833

  Fly   778 SLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELA------- 835
            .|    :.:.|:.:.....::.|..|.|.|: .::|:.|.    |:.|:....:||||       
Zfish   834 EL----QTLKDDCEARITELEKLQPQMEDLR-TQSERLNP----ESADSLRSSVTELATNYSSTV 889

  Fly   836 -KLR-KQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDV---EIMKHRFEGFDKEM 895
             :|| :||.:.|: |.||:.     .:.:::....|:::  |.:|.||   |...::.:.|..|:
Zfish   890 QELRSRQRDITAV-LSKLVG-----SRALQQMESRLNSI--GAEIRDVTTAEQAINKAQAFSVEL 946

  Fly   896 NANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHG-VQTFYI 959
              ...|.:|::.:.:|.                     |:.|...|:.::..|:...| ::...:
Zfish   947 --EQQRGSVLDSVDQQC---------------------WTDLSTAAQDQLSMLQCILGSMKDSQV 988

  Fly   960 ECRETISWIEDKKRILT-------ETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREA- 1016
            :..|...|:...:.:|:       .||.|:.:......|...:..:|..|..::..::::::.: 
Zfish   989 KSAEVQRWLNAVEELLSRDAGSFRNTDKLQEEFKQCKELLAEMESVDSCLKQMKENVTAVQQSSV 1053

  Fly  1017 --------NSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGD-LHRFLRDLDHFQ 1072
                    ..:||....               |:.|::.|..||..:.|..: :....:|:...:
Zfish  1054 PGLVVWGQKELEDSQRR---------------WDLLSKQLLRRDECVSEGQEKVSNLKKDVAEMR 1103

  Fly  1073 TWLTKTQTDVASEDTPTSLP-EAEKLLNQHQSIREEI-----------DN--------------- 1110
            .|:.:...:....|.....| |.|:.|.:.:..:|::           ||               
Zfish  1104 EWMIQVDEEFLMRDFEYKSPEELEEALQEMKRAKEDVLQKEVRVKILKDNINVLISKTPPGGPDL 1168

  Fly  1111 ---YTEDYKNMMEYGERLTSEGSTSDDP--------QYMFLRER-LNALKDGWEELHQMWENRQV 1163
               ..|...|..:..:|..|:..|.::.        ||:.:... ||.|::..::...:.||.|.
Zfish  1169 TPELNEVLHNYQKLCDRFKSKCHTLEEVWSCWIELLQYLDVESAWLNTLEEKVQQTENIPENTQA 1233

  Fly  1164 LLSQSL-----------DQQLFNRDARQT--------EVLLSQQEHFLSKDD--------TPVNL 1201
             :|::|           |.:...|:..||        |::..:.|:|.::.|        ..::|
Zfish  1234 -ISEALESVECVVRHPSDNRTQIRELAQTLIDGGILDELISDKLENFNTRYDQLTHTAAERQMSL 1297

  Fly  1202 EQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENI-------TGRRDD 1259
            ||..:.|:..|..|.|::.:    .|||....|....|..||.::.:.|:.|       ....:|
Zfish  1298 EQQLSTLRESETALHTLQTS----LTLLDQTLTSYLTDRIDAFQLPQEAQTIQVEIAAHEATMED 1358

  Fly  1260 NRQR-------------------ALDQHEK----------------------------------- 1270
            .|:|                   .|||.::                                   
Zfish  1359 LRRRNVGNVPLTASEGKPVRGGTQLDQIQRKLREISTKFQLFQKPANFEQRMLDCRRILESAKAE 1423

  Fly  1271 -----LKNQ------------VKLHEFLQDLE-----------ELAEWVQEKYATSQDESYRSAK 1307
                 |||.            :||::.|.:::           ::.:..|.:.....||...:.|
Zfish  1424 LHILDLKNTQPDEIQTHLSGCMKLYKILSEVKLEVETVIKTGRQIVQKQQTENPKEMDEQLTALK 1488

  Fly  1308 TIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKE-----------KPEFKDVIEPK------- 1354
            .::::      ..|::...|:.|.:|...:|.:.||           :.|.|:.:...       
Zfish  1489 LLYNE------LGAQVTEGKQDLEKALSLSQRVQKESAALQVWMKNSETELKEKLSTADMPADID 1547

  Fly  1355 ---------LKELAKQFDDLEVHTKEKGAM--------------LFDAN---------------- 1380
                     |||..::..||.|..::..|:              ||:.|                
Zfish  1548 SEISWANGVLKESERRKSDLSVLMEDSAALQALVEGSEAQLEDRLFELNEDWERVHTLIEDWLSA 1612

  Fly  1381 -----REV------------LVQQT---CDD------------IDSYITDLEKQIVSGDTAND-- 1411
                 |||            .:.||   .|:            |.:.:.:|.:..|..|:|.|  
Zfish  1613 VLNHRREVEMFDENLAHISTWLYQTEIRLDEMEKKPAADRQRIIQAVLCELVEMTVRVDSARDQA 1677

  Fly  1412 ------------------LTSVNILMQK----------------QQVI----------QTQMAVK 1432
                              |..:|...||                ||.:          .:|:.:.
Zfish  1678 VILMTSRGPSCRELVEPKLEDLNRNFQKVAQHISSAQESAGLKVQQEVTDRRSAALLSSSQLQLF 1742

  Fly  1433 ARQVEEIDKQTEYLQKT--------VPEEK--IEPIVVKKTAVL------ERFEKIKAPLL---E 1478
            ..::::..:..|..|||        :.|||  :|.::.:...:|      :|.|.|::.||   .
Zfish  1743 ESELQDAIRALEQQQKTHTADQHRQLDEEKADVEELLRRGEELLPSVCDEDRRENIRSTLLLLHT 1807

  Fly  1479 RQKALE------KKKEAFQF------------------------------CRDVEDEKLWIDEKL 1507
            |.|.|:      ..:.|.:|                              |....|..|.|::.|
Zfish  1808 RYKDLDISRAPAVSESALEFSSVPLQRSESSVSPQDQRSVCVSPSEHRSVCASPSDYLLDINKVL 1872

  Fly  1508 -------PVANSPDYGNSLF--------NVHVLKKKNQSLATEID-NHEPRINAICNNGRKLIDE 1556
                   .:.||.:....||        .:..:|:....|..::. .||.:.:.|       ::.
Zfish  1873 LAMADNELLLNSSELSGGLFEDFSSQEDTLRSIKQSLDCLGEQVQLIHELQPDVI-------LEA 1930

  Fly  1557 GHEDAKKFEALISDLTQKWQELKDAIENRRKHLLES--EKVQQYFFDAQEAESWMSEQELYMMVE 1619
            ..::..:....::.|..:|..: :.:.::||...:.  |:.:::..|..|...|:|:      .|
Zfish  1931 SRQETTQIADALTQLNSEWDRV-NRMYSQRKGSFDGALEEWRRFHCDLTELSQWLSD------TE 1988

  Fly  1620 DRGKD-EISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKL--- 1680
            .|..| |:.|::...:.::|||.|....:.:..|.. :.|.....:||.|. |:.|.:||.|   
Zfish  1989 QRLTDGELDAEHTHTQQQDLEQGVSSQESVLLDLSR-SGQHIISQVSSADG-ALLQEKLDTLRRR 2051

  Fly  1681 YAGLKDLAGERRARLN-------EALQLFMLSREVDDLEQWI--TDREVVAGSQELGQDFDHVTL 1736
            :..::....||:.||.       |.||      ..|.|.||:  |:|.|                
Zfish  2052 FTHVQRAVSERQRRLAGGDPAVVEVLQ------RTDALAQWLQHTERAV---------------- 2094

  Fly  1737 LSERFNEFARDT---------EAVGG--ERVAKVNGIADNLIQAGHSDSATIAEWKD-------N 1783
              |.....|.||         |.:.|  |.::.:|.....::    |:.:..|:.:|       .
Zfish  2095 --ETLTVSATDTNLRELKCLMEQMDGQNESLSWLNKSGSQIL----SNCSLSAQDRDAHVSKIRQ 2153

  Fly  1784 LNESWQDL-LELIE----------TRTQMLAASRELHKFFHDCKDVLGR-ILEKQHGVSDEL--G 1834
            :|..|..: :||::          |.|..|......:..|.:..:.||. :......:||:.  .
Zfish  2154 INMRWSKVSVELLDKVREVEAGLPTHTPPLQDESRSYGQFQERINTLGDWVYTSSRSLSDDTHSD 2218

  Fly  1835 RDAGSVSTLQRKHYNFLQDLITLYSQVQQIQ----EESAKLQDAYAGDKAKEITNRE--QEVLHA 1893
            |.|..:|.|::|..  |:||::...::|:.|    :|.:|::...|..||.::..:|  |..:..
Zfish  2219 RQAVEMSMLEQKCE--LEDLLSYSIELQRKQLLLPQEKSKIEKLAADWKALDVRQKETQQPAVSP 2281

  Fly  1894 WDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDV--SGVEL---LMNN 1953
            |.:.|    ...|..|.:..     :.|.::.:..|:..|.......|.::  :..||   |:..
Zfish  2282 WVSQQ----VSPQTFAASVP-----SAVHMVSLRSEERRRSPELMMGPSELHQTATELADWLLLI 2337

  Fly  1954 HQSLKAEIDTREDNFGACISLGKELLTR-----NHYASADIKDRLMTLSNSRNAL---------L 2004
            ||.||:.|.|..|......::|:..:|:     .|....||......:.|..:.|         |
Zfish  2338 HQMLKSNIVTLGDKDEIRTTIGRLQVTKGDLEQRHPQLEDIITLAQNIKNKTSNLDVRTSISEKL 2402

  Fly  2005 RRWEERWENLQLILEVYQFARDAAV--AEAW---------LIAQEPYLLSSELGHTIDEVENLIK 2058
            .:...:|::.|..:|......|..:  ::.|         ||.|....|::.|..:.:.:...|.
Zfish  2403 EKVRSQWDSTQHGVETRLLQLDHMIGHSDQWEEQRRKVKALIGQNELRLNNLLQQSREPLTKQIS 2467

  Fly  2059 KHEAFEKSAAAQEERFSALERLT-----------TFELKEMKRRQELAEEAERQRIKEEQEA--- 2109
            .::||.:..:..:|..||...|:           |.::||:......:..:...|..:.|.|   
Zfish  2468 DNKAFLQELSRGQESVSAFNELSNQLLQDYANDDTRKVKEVMDTHNNSWNSINNRASDRQAALDL 2532

  Fly  2110 --KAA----------------SEAAEQAKREAERRDDVDVGASHD---DSAAKDTAVEFERVVEI 2153
              |:.                ||.......:|.:|:.:...::|:   .|..:|...|.|...::
Zfish  2533 DLKSVQTSLRELELFLKWLHESETTVNVLSDAAQREGLSQDSAHNKQLKSQLEDIQAEIEAHNDV 2597

  Fly  2154 QTERGG-----TPGAGEGHEGYVTRK------HEWDSTTKKASNRSWDKVYMAAKAGR----ISF 2203
            .....|     ....|...|....::      ..|.....|::|   .:.::.|.|.|    :|.
Zfish  2598 FRSVEGNKLKMVKALGSSEEAVFLQQRLDDMNQRWSDLKAKSAN---IRAHLEASAERWNRLLSV 2659

  Fly  2204 YKD------QKGYKSNPELTFRGEPSYDLQNA--AIEIASDYTKKKHVLRVKLANGALFLLQ--- 2257
            .:|      .|..:.|.::...|:....||..  .:.:.::..:::||:...|....:||.:   
Zfish  2660 LEDLSRWIGLKDEELNKQMPIGGDVPTLLQQQTHGMALRAELKEREHVVLSTLDQARMFLAEQPI 2724

  Fly  2258 --AHDDTEMSQWVTSLKAQSDSTAVA-ASRSQTLPATSQKD 2295
              ..:..:..|..|.|..:..:..|| |.|.||.....:.|
Zfish  2725 EGPEEPRKNLQPKTELTPEEKAQRVAKAIRKQTAEVCERWD 2765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 49/98 (50%)
CH 170..269 CDD:278723 48/98 (49%)
Spectrin 298..408 CDD:278843 23/134 (17%)
SPEC 422..521 CDD:197544 24/131 (18%)
SPEC 525..740 CDD:238103 49/256 (19%)
SPEC 639..846 CDD:238103 48/222 (22%)
SPEC 848..1058 CDD:238103 35/229 (15%)
SPEC 955..1169 CDD:238103 41/269 (15%)
SPEC 1170..1380 CDD:238103 58/355 (16%)
SPEC 1386..1484 CDD:197544 32/177 (18%)
SPEC 1488..1699 CDD:238103 49/269 (18%)
SPEC 1594..1806 CDD:238103 55/253 (22%)
SPEC 1807..2015 CDD:238103 49/235 (21%)
Spectrin 2018..>2078 CDD:278843 14/70 (20%)
PH 2167..2275 CDD:278594 22/130 (17%)
PH_beta_spectrin 2167..2274 CDD:269975 22/129 (17%)
utrnXP_021325542.1 SAC6 22..>248 CDD:227401 103/226 (46%)
SPEC 316..528 CDD:238103 48/249 (19%)
SPEC 434..640 CDD:238103 35/205 (17%)
SMC_N <714..1373 CDD:330553 137/744 (18%)
SMC_N 1383..>2153 CDD:330553 137/819 (17%)
SPEC 1863..2066 CDD:238103 43/218 (20%)
SPEC 1969..2174 CDD:238103 52/240 (22%)
SPEC 2322..2531 CDD:238103 41/208 (20%)
SPEC 2541..2782 CDD:238103 40/228 (18%)
SPEC 2784..>2900 CDD:238103
WW 2909..2937 CDD:238122
EFh_DMD_DYTN_DTN 2974..3135 CDD:324054
EF-hand-like motif 2974..3012 CDD:319999
EF-hand-like motif 3020..3054 CDD:319999
EF-hand-like motif 3060..3096 CDD:319999
EF-hand-like motif 3109..3135 CDD:319999
ZZ_dystrophin 3160..3208 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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