Protein Alignment IntS2 and ints2

DIOPT Version :10

• Sequence 1: NP_573232.1
• Gene: IntS2 / 32745
• FlyBaseID: FBgn0030858
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: NP_001025696.1
• Gene: ints2 / 595088
• XenbaseID: XB-GENE-5787298
• Length: 1180
• Species: Xenopus tropicalis
• Alignment Length: 1144
• Identity: 427/1144 - (37%)
• Similarity: 653/1144 - (57%)
• Gaps: 102/1144 - (8%)

  Fly     8 VSPRVFCAMQNLDITLLASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVN 72
            |||..|.|||.:|:..||:..:.|:|.:||.||||:|.:|.|.::...:.:|.:|.:|.|:|.||
 Frog    10 VSPYAFEAMQKVDVVRLAALSDPELRLLLPCLVRMALCAPADQSQKWAQDKKLLLRLLSGVEAVN 74

  Fly    73 SIVSYLQVNYHELENELKKELQARQKSAFFEGQQHEYG-LQSGIALGFERADVARKVRVVLSEIF 136
            |||:.|.|::|.||.:..||.|.|.|.....|:..... ||.|:.|.||.:|..|::|:||||:.
 Frog    75 SIVALLSVDFHALEQDANKEQQLRHKLGGGSGESILVSQLQHGLTLEFEHSDSPRRLRLVLSELL 139

  Fly   137 NLQQQVSEQKP---AAHSEMLDDGIYLEEVVDILCIALAELPSLLNILELTDALVHVPNGHRIIC 198
            .:..:|::...   ...||:.:..:::||..|:|||..|||.:||.|.::.:||:||.||...:|
 Frog   140 AIINKVADSSGEFFLKSSELFESPVHMEEAADVLCILQAELHTLLPINDMAEALLHVRNGAWFLC 204

  Fly   199 ALVANFPDCYRDVVSHVIAN---CDEDGSDGKHRLMLLMGLSEMNPSQALANRSMCVDMLKVPSF 260
            .||||.||.:.:|...:|.|   .||:...|:.|...|..|.:|||||||..|||.|:...:|..
 Frog   205 LLVANVPDSFSEVCRSLIKNGERQDEESIGGRRRTEALRQLCKMNPSQALKVRSMVVEECHLPGL 269

  Fly   261 MLKLTLKHPE---------DLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRK----GDALNLVRVE 312
            .:.|||.|.:         :::.|::|||||.:..:|:||..:||:.|.|:    ...|..:|.:
 Frog   270 GVALTLDHTKNEVGEDGVSNMVCFVSGLLLGTNTKVRTWFGTFIRNGQLRRRENSSSVLWQMRRQ 334

  Fly   313 LLQKVIQTTTNAAEL---------------------RDFNLQGAVLLRLYCALRGIGGLKFNDDE 356
            ||.:::.....|..:                     .:..::.:.||||||||.||.|||..|:|
 Frog   335 LLSELMGILPAAKSISVADEAEKSQEPGVSVHPGLKEEHVVKASALLRLYCALMGIAGLKPTDEE 399

  Fly   357 INALSQLVTSCPQATPSGVRFVTLALCMLIACPSLVSTIPLENKAVEWLQWLIREDAFFCKRPGT 421
            ...:.||:||.|.|||:|||||:|:.|||:|..::|||...|...:.||.|:|:|:|:|....|.
 Frog   400 AEQVLQLMTSRPPATPAGVRFVSLSFCMLLAFSTVVSTPEQEQLMLMWLSWMIKEEAYFESTAGV 464

  Fly   422 STSLGEMLLLLAIHFHSNQISAISEMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVVALHAVR 486
            |.|.||||||:|::|||||:|||.::|||||.|||.|:|:|.:|:|.:|||::||||||..||||
 Frog   465 SASFGEMLLLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVR 529

  Fly   487 VPVTPNLNGTILCYLPVHCIQQLLKSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNT 551
            ||||.||:..|..:||:|||.|||:||.|.||||.||.||:.|||.:..|:|..:..|::|::|:
 Frog   530 VPVTSNLSANISGFLPIHCIYQLLRSRAFTKHKVSIKDWIYTQICETTTPLHQQLLPLIDVYINS 594

  Fly   552 LIIPNPTGKVNIDHMHRPFTEAEILHVFRTSKLTFFAEELPPMAESQELNQIEVTCPLTAQLLMI 616
            :|  .|..|.:.:..::|.||.|||.||.  .||.......|..             :|.||||:
 Frog   595 II--TPASKSSPEATNKPVTEQEILKVFH--GLTGENSRAKPHT-------------ITTQLLML 642

  Fly   617 YYLMLYEDTRLMNLSALG--GRKQKEYSNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISN 679
            ||::.||:..|.|..:|.  .||.|.||:..:..:|:|||:::|.....:...|...||||:.:|
 Frog   643 YYVLSYEEALLANSKSLAVMQRKPKSYSSAMMDQIPIKYLIRQAQGLQQELGGLHSALLRLLSTN 707

  Fly   680 YPHLSMVDDWLEEHNLAQGNS-------TVVVSKHELKPETLDRALAAIQTKPHLAIRVFKQLLQ 737
            ||||.:||||:.|..:...::       |.....|  .|:.|..|...:|:.....:::.:.|..
 Frog   708 YPHLCIVDDWICEEEITGTDALLRRMLLTSSAKSH--SPKQLQEAFQLLQSNHTHVMQILEHLTL 770

  Fly   738 MPPETQAQYGQQLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDTMDR 802
            :.......|.:.:..::..:....|||.:....|.:|:.||.|:|..||:|::.|:.........
 Frog   771 LSASDLIPYAEVITANMIQLLNVGVPRRILQTVNKLWMTLNTVMPRRLWVMTVNALQPPLKLARH 835

  Fly   803 RTFA-NESLLEPMEVLSC-PRFVFCSPYLLMILLRILKGSLAASKTYLNVHMQMQQKQVLDKN-- 863
            ..:. |:.:::|:.||.| ||...|.| ::.|.|.:|.|.|.|||.|||.::    |:..|::
 Frog   836 HKYTQNDLMIDPLIVLRCDPRIQRCPP-IMDITLHMLNGYLLASKAYLNSYL----KETADQDMK 895

  Fly   864 ----------GMMQT-DAIWEDLRTTLIASQESAAVHILLEVLDYIASKATDR---VSHL----- 909
                      |.::. :...|:|:..|:|:|:||||.||||:. ..|.:..|:   .|.|
 Frog   896 PSPNNTAALAGQVEAMEVTREELKNALLAAQDSAAVQILLEIC-LSAEEGKDQNPACSQLLEGEE 959

  Fly   910 ----ELREIQGIIGTYVHQAFISEPSLAKLVHFQTYPKSVIPMMVASVPSMHICIDFVHEFLNVT 970
                .|||:|.:|...:||.||::|::|||||||.||..::|:.||.:||||||:||:.|.:...
 Frog   960 SLLCNLREVQCLICCLLHQMFIADPNIAKLVHFQGYPCQLLPLTVAGIPSMHICLDFIPELIAQP 1024

  Fly   971 EMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQTTLSMLTASTKCRFLRNVMPAMVRFVETF 1035
            |:|||||.|.|.|||.:.|::||||.:::..:||:.|.|::||.:.:..|....:|.:|.|.:.|
 Frog  1025 ELEKQIFAIQLLSHLCIQYALPKSLSMARLAINVMGTLLTVLTQAKRFLFFMPTLPCLVSFCQAF 1089

  Fly  1036 PILADDCVNILMTTGRILHSQSSLGMTTMEMPLTDSDKL 1074
            |.|.:|.:::|:..|::..|..:.....::..:|...||
 Frog  1090 PPLYEDIMSLLIQIGQVCASNVTTQTRDVDPVITRLQKL 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS2	NP_573232.1	INTS2	24..1058	CDD:464296	416/1110 (37%)
ints2	NP_001025696.1	INTS2	26..1109	CDD:464296	415/1107 (37%)