Protein Alignment IntS2 and Ints2

DIOPT Version :10

• Sequence 1: NP_573232.1
• Gene: IntS2 / 32745
• FlyBaseID: FBgn0030858
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_008766294.1
• Gene: Ints2 / 360589
• RGDID: 1305547
• Length: 1199
• Species: Rattus norvegicus
• Alignment Length: 1136
• Identity: 447/1136 - (39%)
• Similarity: 666/1136 - (58%)
• Gaps: 105/1136 - (9%)

  Fly     8 VSPRVFCAMQNLDITLLASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVN 72
            |||..|.|||.:|:..|||..:.|:|.:||.||||:|.:|.|.::|..:.:|.||.:|.|:|.||
  Rat    11 VSPCAFEAMQKVDVVRLASLSDPELRLLLPCLVRMALCAPADQSQSWAQDKKLILRLLSGVEAVN 75

  Fly    73 SIVSYLQVNYHELENELKKELQARQKSAFFEGQQHEYG-LQSGIALGFERADVARKVRVVLSEIF 136
            |||:.|.|::|.||.:..||.|.|.|.....|:..... ||.|:.|.||.:|..|::|:||||:.
  Rat    76 SIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVSQLQHGLTLEFEHSDSPRRLRLVLSELL 140

  Fly   137 NLQQQVSEQKPA---AHSEMLDDGIYLEEVVDILCIALAELPSLLNILELTDALVHVPNGHRIIC 198
            .:..:|||....   ..||:.:..:||||..|:|||..|||||||.|:::.:||:||.||...:|
  Rat   141 AIMNKVSECSGEFFFKSSELFESAVYLEEAADVLCILQAELPSLLPIVDVAEALLHVRNGAWFLC 205

  Fly   199 ALVANFPDCYRDVVSHVIAN---CDEDGSDGKHRLMLLMGLSEMNPSQALANRSMCVDMLKVPSF 260
            .||||.||.:.:|...:|.|   .||:...|:.|...|..|..|||||||..|.|.|:...:|..
  Rat   206 LLVANVPDSFNEVCRGLIKNGERQDEESLGGRRRTDALRFLCRMNPSQALKVRGMVVEECHLPGL 270

  Fly   261 MLKLTLKHPE---------DLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRK----GDALNLVRVE 312
            .:.|||.|.:         ||:.|::|||||.:..:|:||..:||:.|:|:    |..|..:|.:
  Rat   271 GVALTLDHTKTEACEDGVSDLVCFVSGLLLGTNAKVRTWFGTFIRNGQQRRRENSGSVLWQMRRQ 335

  Fly   313 LLQK---VIQT--TTNAAELRDFNLQGAV----------------LLRLYCALRGIGGLKFNDDE 356
            ||.:   ::.|  :|...|..|..::..|                ||||||||.||.|||..::|
  Rat   336 LLLELMGILPTVRSTRIVEEADVEMEPTVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEE 400

  Fly   357 INALSQLVTSCPQATPSGVRFVTLALCMLIACPSLVSTIPLENKAVEWLQWLIREDAFFCKRPGT 421
            ...|.||:||.|.|||:|||||:|:.|||:|..:||||...|...|.||.|:|:|:|:|....|.
  Rat   401 AEQLLQLMTSRPPATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGV 465

  Fly   422 STSLGEMLLLLAIHFHSNQISAISEMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVVALHAVR 486
            |.|.||||||:|::|||||:|||.::|||||.|||.|:|:|.:|:|.:|||::||||||..||||
  Rat   466 SASFGEMLLLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVR 530

  Fly   487 VPVTPNLNGTILCYLPVHCIQQLLKSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNT 551
            ||||.||:..|..:||:|||.|||:||:|.||||.||.||::|:|.:..|:||.:..|::|::|:
  Rat   531 VPVTSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYINS 595

  Fly   552 LIIPNPTGKVNIDHMHRPFTEAEILHVFRTSKLTFFAEELPPMAESQELNQIEVTCPLTAQLLMI 616
            ::  .|..|.|.:..::|.||.|||::|:        |.:.  .:|..|||   ...:|||||::
  Rat   596 IL--TPASKSNPEATNQPVTEQEILNIFQ--------EVIG--GDSVRLNQ---RFSITAQLLVL 645

  Fly   617 YYLMLYEDTRLMNLSALGG--RKQKEYSNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISN 679
            ||::.||:..|.|...|..  ||.|.||::.:..:|:|:|:::|.....:...|...||||:.:|
  Rat   646 YYILSYEEALLANTKTLASMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATN 710

  Fly   680 YPHLSMVDDWLEEHNLAQGNS-------TVVVSKHELKPETLDRALAAIQTKPHLAIRVFKQLLQ 737
            ||||.:||||:.|..:...::       |.....|  .|:.|..|.:|:.......:::.:.|..
  Rat   711 YPHLCIVDDWICEEEITGTDALLRRMLLTSNAKTH--SPKQLQEAFSAVPVSHTQVMQIMEHLTL 773

  Fly   738 MPPETQAQYGQQLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDTMDR 802
            :.......|.:.|..::..:....|||.:....|.:|:.||.|:|..||:|::.|:......:.:
  Rat   774 LSASELIPYAEVLTSNMNQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSIKFIRQ 838

  Fly   803 RTFA-NESLLEPMEVLSCPRFVFCSPYLLMILLRILKGSLAASKTYLNVHMQ--MQQKQVLDKN- 863
            :.:. |:.:::|:.||.|.|.|...|.|:.:.|.:|.|.|.|||.||:.|::  .:|.:....|
  Rat   839 QKYTQNDLMIDPLIVLRCDRRVHRCPPLMDVTLHMLNGYLLASKAYLSAHLKETAEQDRPSPNNT 903

  Fly   864 -GMM-QTDA---IWEDLRTTLIASQESAAVHILLEV-LDYIASKATDRVSHLELREIQGI--IGT 920
             |:: ||||   ..|:|:..|:|:|:||||.||||: |.....||....|.:.||..||:  |||
  Rat   904 VGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKAKAANSDISLRNTQGVITIGT 968

  Fly   921 -------------------------YVHQAFISEPSLAKLVHFQTYPKSVIPMMVASVPSMHICI 960
                                     .:||.:|::|::|||||||.||..::|:.||.:||||||:
  Rat   969 PNKDTEEGEDSLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGYPCELLPLTVAGIPSMHICL 1033

  Fly   961 DFVHEFLNVTEMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQTTL-SMLTASTKCRFLRNV 1024
            ||:.|.:...|:|||||.|.|.|||.:.|::||||.|::..:||:.|.| ::||.:.:..|....
  Rat  1034 DFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLAVNVMGTLLTAVLTQAKRHSFFMPT 1098

  Fly  1025 MPAMVRFVETFPILADDCVNILMTTGRILHS 1055
            :|::|.|...||.|.:|.:::|:..|::..|
  Rat  1099 LPSLVSFCRAFPPLYEDVMSLLVQIGQVCAS 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS2	NP_573232.1	INTS2	24..1058	CDD:464296	439/1120 (39%)
Ints2	XP_008766294.1	INTS2	27..1132	CDD:464296	439/1120 (39%)