Protein Alignment IntS2 and IntS2

DIOPT Version :10

• Sequence 1: NP_573232.1
• Gene: IntS2 / 32745
• FlyBaseID: FBgn0030858
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_563061.3
• Gene: IntS2 / 3290728
• VectorBaseID: AGAMI1_000423
• Length: 1149
• Species: Anopheles gambiae
• Alignment Length: 1145
• Identity: 535/1145 - (46%)
• Similarity: 765/1145 - (66%)
• Gaps: 56/1145 - (4%)

  Fly     8 VSPRVFCAMQNLDITLLASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVN 72
            |:.:.|.|||||||..||:..:.||||:||.|||||||||||||:...|:||:||::|:||||||
Mosquito     6 VTSKAFSAMQNLDIAQLATCSQQEIRPLLPCLVRMSLLSPLDNTKGWAEARKQILSLLVGIEVVN 70

  Fly    73 SIVSYLQVNYHELENELKKELQARQKSAFFEGQQHEY-GLQSGIALGFERADVARKVRVVLSEIF 136
            :|||.|||||||||.::|||.|.|||..:......:: .|.:||.:||||||...||||||||:|
Mosquito    71 NIVSLLQVNYHELEIDVKKEQQIRQKIGYTTQDSAQFHSLPNGIVMGFERADGTNKVRVVLSELF 135

  Fly   137 NLQQQVSE-------QKPAAH------SEMLDDGIYLEEVVDILCIALAELPSLLNILELTDALV 188
            .||.|::|       ||.:::      ||:.|:.|||||:.||:||||||||||||:.|:.:.|:
Mosquito   136 YLQAQINELATQASLQKSSSNELTIRPSELFDNEIYLEEIADIICIALAELPSLLNLQEVVETLL 200

  Fly   189 HVPNGHRIICALVANFPDCYRDVVSHVIANCDEDGSDGKHRLMLLMGLSEMNPSQALANRSMCVD 253
            :|.||.:|:|.:|||.|||:|:||:.:|.|.|||.:||:.:|..|..||||||||||:.|::||:
Mosquito   201 YVRNGSKIVCWIVANMPDCFREVVTALITNSDEDTTDGRVKLAALYELSEMNPSQALSMRTICVE 265

  Fly   254 MLKVPSFMLKLTLKHPEDLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRKGDALNLVRVELLQKVI 318
            .:|:||.|:||:|:.|::|:||::|||||||||:||.||.|||:|||||||.|:.:|.|||::::
Mosquito   266 TVKMPSLMIKLSLQDPQNLVAFVSGLLLGNDQNIRSSFALYIRTSQKRKGDVLHQLREELLKQLM 330

  Fly   319 ---QTTTNAAELRDFNLQGAVLLRLYCALRGIGGLKFNDDEINALSQLVTSCPQATPSGVRFVTL 380
               ..:.|.|...:..:|.|.::|||||||||.|:||.|:||..|.||:||.|..||:|:|||:|
Mosquito   331 NINMQSVNGALPEELVVQAAAIVRLYCALRGISGIKFFDEEIQLLMQLITSKPPPTPAGIRFVSL 395

  Fly   381 ALCMLIACPSLVSTIPLENKAVEWLQWLIREDAFFCKRPGTSTSLGEMLLLLAIHFHSNQISAIS 445
            .|||.||||||::....|.|.:||:||||:|:|:|......|.|.||||||:|||||.||::.|.
Mosquito   396 GLCMFIACPSLITHQSHEAKMIEWIQWLIKEEAYFESVSEVSASFGEMLLLMAIHFHGNQLAHIC 460

  Fly   446 EMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVVALHAVRVPVTPNLNGTILCYLPVHCIQQLL 510
            |:.||||.||..:|||:..|:|.:|||::|||||||.|||:||||.|||.:|..|||||||.|||
Mosquito   461 ELACSTLGMKFSLRPNTITRMKLIFTQEIFTEQVVAAHAVKVPVTLNLNASIPGYLPVHCIHQLL 525

  Fly   511 KSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNTLIIPNPTGKVNIDHMHRPFTEAEI 575
            |||.|.||||||||||::|||:||.|:|||:|||:||:|:::|:||..| :...|.|:..:|.||
Mosquito   526 KSRAFSKHKVPIKSWIYRQICNSVTPMHPVLPALIEVYVSSIILPNQKG-LQEQHTHKALSEQEI 589

  Fly   576 LHVFRTSKLTFFAEELP------------PMAESQELNQIEVTCP------LTAQLLMIYYLMLY 622
            ..||:.:...:..|:..            |..|......:||...      ||.|||::|||:||
Mosquito   590 AQVFQNAAGLWNKEQQSKLKTAGQTGVDRPTKEHVHQQPMEVDDSGNRQPNLTPQLLLLYYLLLY 654

  Fly   623 EDTRLMNLSAL--GGRKQKEYSNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISNYPHLSM 685
            ||.||.::..:  .||:.|.|||.|:..||:|||||:|....::|.:||.|||||:::::||||:
Mosquito   655 EDVRLSSMPQIITSGRQVKSYSNEFMSELPIKYLLQQAQKNQHEYSALFSPLLRLLVTHFPHLSL 719

  Fly   686 VDDWLEEHNLAQGNSTV--VVSKHELKPETLDRALAAIQTKPHLAIRVFKQLLQMPPETQAQYGQ 748
            ||||::|..:|..:|:.  .:|:|     ::..|...|:..|...|::.:::::..|........
Mosquito   720 VDDWIDEETIAFSDSSTGRSISEH-----SIVEAFEEIELNPARVIKLLRRMMRKSPTDLWPLAP 779

  Fly   749 QLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDTMDRRTFANESLL-E 812
            ..:::.......:||..:::||..:|:|||.:.|..||:||:.|:....:.....|...|.:| :
Mosquito   780 TFIRYFKHTLNPTVPSLLQELYRQVWMRLNTIFPRRLWVMSINALMPADNVTKNFTLTQEKILYD 844

  Fly   813 PMEVLSCPRFVFCSPYLLMILLRILKGSLAASKTYLNVHMQMQQKQVLDKNGMMQTDAIWEDLRT 877
            |::||.|.:.||.....|.::||||:..||||::.|:.|  |..|.::|....::||...|:|:.
Mosquito   845 PLQVLRCDKRVFRCSSALTVVLRILQAILAASRSQLSRH--MLDKPLIDIGNQVKTDNDREELKL 907

  Fly   878 TLIASQESAAVHILLEVLDYIASKATDRVSHLELREIQGIIGTYVHQAFISEPSLAKLVHFQTYP 942
            .|:|:|||.||.|:||......:..::......|||::|:|.:::||.||:|||||||||||.||
Mosquito   908 ALLATQESIAVQIILEACLENETDCSEPGRLWALREVRGVICSFIHQMFIAEPSLAKLVHFQGYP 972

  Fly   943 KSVIPMMVASVPSMHICIDFVHEFLNVTEMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQT 1007
            :.::.|.|..:||||||:||:.|.|::.|||||||.|||.|||.|.|::||||.::|.|:|.:.|
Mosquito   973 RELLAMTVRGIPSMHICLDFIPELLSMAEMEKQIFAIDLASHLSLQYALPKSLSIAKLCINTLTT 1037

  Fly  1008 TLSMLTASTKCRFLRNVMPAMVRFVETFPILADDCVNILMTTGRILHSQSSLGMTTMEMPLTDSD 1072
            .|.:|:..|:....|.|:|.:|||.|.||.|.|:|:..|:..|||:.||::||.:| .:|.....
Mosquito  1038 LLGVLSGDTRIEMFRAVLPCIVRFAEAFPPLLDECILYLLQLGRIVQSQTALGRST-SLPSLFVG 1101

  Fly  1073 KLCTYRD-------AQLHIIMIEDAFKALVTAVMKKSDLY 1105
            :.|..|.       |:..:..:.:.|..|:.|.:....:|
Mosquito  1102 QECKRRSQSGQLQHAESLVDEVRETFVKLLDAAVLSPKIY 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS2	NP_573232.1	INTS2	24..1058	CDD:464296	515/1073 (48%)
IntS2	XP_563061.3	INTS2	22..1088	CDD:464296	522/1112 (47%)