Protein Alignment RhoGAPp190 and arhgap5

DIOPT Version :9

• Sequence 1: NP_001259658.1
• Gene: RhoGAPp190 / 32743
• FlyBaseID: FBgn0026375
• Length: 1621
• Species: Drosophila melanogaster
• Sequence 2: XP_001336016.1
• Gene: arhgap5 / 795752
• ZFINID: ZDB-GENE-081014-1
• Length: 1502
• Species: Danio rerio
• Alignment Length: 1683
• Identity: 487/1683 - (28%)
• Similarity: 790/1683 - (46%)
• Gaps: 306/1683 - (18%)

  Fly     4 FNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGD 68
            :.:||:|||||||::|..||||||||||::||.||.|:::|.||||..||.||:||||||||||:
Zfish    11 YAVSVVGLSGTEKEKGNCGVGKSCLCNRYVRPSADCYYLEHTSVLSTIDFGGRVVNNDHFLYWGE 75

  Fly    69 VRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEK 133
            |....::|||.:..:||||||:||.||...:...:.||:||...||:.|||||||||.:|||:|:
Zfish    76 VLHRGDDGVECRIQVIEQTEFIDDQTFLPHRSTNLQPYTKRAANTKLQSAEKLMYICTDQLGLEQ 140

  Fly   134 EYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYEL 198
            :::||.||||:|:|||||:..|:|...||..:.|::||.::.:.|.|.|||:::..||.|:..|.
Zfish   141 DFDQKQMPDGKLNIDGFVLCIDISKGCNRKFDDQMKFVHSLYSQISKAKKPIIIAATKCDECVEQ 205

  Fly   199 YVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELL 263
            |:||.:.....   |..:.|:||||..|:|::|.|..|.|.|||.:.:.|||||.|:.||:::|:
Zfish   206 YLREVQTFVTG---KKNLMLVETSARASVNVELCFNALTQQIDKTRGKPKIISYLEAYKSQRQLV 267

  Fly   264 DTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNK 328
            .:.|:...:||...:.|||..|...|..|..:.::.|::|:.|.:..:..|.:|:::||.:|:.:
Zfish   268 ASVSDKFEKLIVQTVRDYHTSWKIVSNKLKSHPDYEEYINLEGTKKARNTFSKHIEQLRQEHIKR 332

  Fly   329 KLHQYLDKFALALEYLLPDIGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDEA 393
            :...||.........||.::..:   :..:|..|::.:::..||:..|.|.....|.|...:|:.
Zfish   333 RREDYLTSLPKIFNKLLNNLEEI---ETMSWTEAQSLMRSRHEFQYCFIELEHTPWYETDHLDKT 394

  Fly   394 EDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFMG 458
            :|. |:|||:|:|.:.|.:::|::..:..:|:::..|::||..||...|::||:...||....|.
Zfish   395 DDR-RVPFDILQTMQGERIYQNHVQHLISEKRRLEMKEKFKKTLERVHFISPGQPWEEVMCFVME 458

  Fly   459 RECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDVIQE 523
            .|.::.::|.|.:.:|..||.:|:|::|:.|.|:|.|||:.|.........:.:.:.:|..|:.|
Zfish   459 DEAYKYITESDRRDVYSRHQQEIVERAKEEFQEMLFEHAELFYDLDLNATPSYDKMSEIHAVLNE 523

  Fly   524 DSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSAS-NHKTPSGGGW 587
            :.||:.|.:|..:|..:|::|:.|::.|.::.|.....|:|..:|:||:::... :|    |...
Zfish   524 EPRYRALQKLATDRESLLLKHIGFVYHPTKETCLSGTACIDLKVEQVLANRLVQLDH----GRSN 584

  Fly   588 KSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGDMEAFKAIDV 652
            ....|.:...:||.:||.|.||.:|.|:|| ...:..||..:.:.|.|:          ...:||
Zfish   585 IYYNSANIEKVNLCLVGREGLAQELANEIR-AQSTDDEYTLDGKIYELD----------LLPVDV 638

  Fly   653 YSS--------------GLICVYSNQQSFETLKDNLERTLLCNLEL----EDKF-ENLPIVLVYQ 698
            .|.              |..||:|:.:|...:.|.:.|   ...|:    .|:: :.:|.:|:..
Zfish   639 NSGMLLNHSWISTFKPHGFFCVFSSIESLNYIGDRVSR---IRAEIAQSRRDRYSQPVPFILILA 700

  Fly   699 PQ-DLKENEVEYLRNEGMRLSEMLHCDFID------HTQNHQKYVYDILNIVILSLKLT-EMKSY 755
            .| |.....:..||::|.:|:..|.|.|:|      ..:.::..:...|..|:..||.. :|.|
Zfish   701 NQRDSVCKNMPILRHQGQQLANKLQCTFVDIPTGTFPRKFNESQIKQALRAVLEGLKHNFDMMS- 764

  Fly   756 EPYPS----NHTDLRILCCIFCGDQYDIENIVQPLVEESTLVKANE---HSIIVDVFIGDAKRRV 813
             |.||    :.|||||:.|..|||.:.::.|:.|.::..:......   :::|:|..||:.:||:
Zfish   765 -PMPSIKDLSETDLRIVMCAMCGDPFSVDLILSPFLDSHSCSAGQPGQCNTLILDKIIGNGRRRI 828

  Fly   814 EFILSSYHGTSQYR-DELIHGYIYFYSTKRRSSLANL-SILAAQNANIPLQIIAVTESGGVNAFF 876
            :..:.|||.:...| |||:||||..||.||:||:|.| :.||.....||:|::|:|:|..  .||
Zfish   829 QVTVLSYHSSIGIRKDELVHGYILVYSAKRKSSMAMLRAFLAEVQDVIPVQLVAITDSQA--DFF 891

  Fly   877 NSDICQFLITEGNAVADRFKGSFMT-FSADQYVK-FAFYNPFLKTAWDNKYEVENLHVEESITLD 939
            .::..:.|:|||..:|......|.. :|..||.: ...:.||.....:.|     .::|.|...|
Zfish   892 ENEAIKELMTEGEHIATEIAAKFTALYSLSQYHRQTEVFTPFFNEVLEKK-----SNIESSFMFD 951

  Fly   940 S---GEGTLENSVNQMPRP-PPRHESYMLSNTLGTDGSGSENY-------EMAPTRSLNSLNEER 993
            :   |.||.|:...|.|.. .|.::.|..|.   .||.|...|       ::.|..|      ||
Zfish   952 NSRDGTGTTEDVFPQSPHSHSPAYQYYPDSE---DDGEGPPPYSPIGDDVQLLPNPS------ER 1007

  Fly   994 DISLDEIYDDNEKPKHL-----HQRFQIFPPPTTP-----PEP--APPDHQLITCTYKSQFVSAS 1046
            ...:|  .:.||.|.|.     |:|....|||..|     |:|  ...|..|:      :.:.|.
Zfish  1008 KYRID--LEGNEYPIHSTPVGEHERNHKVPPPVKPKPNVLPKPNVKKLDPNLL------RTIEAG 1064

  Fly  1047 ESSLEEITSDVSGSKDSLATHD-----AEWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHID 1106
            ..:.......:.|..|.|...|     |:.|:.||.|            :|...:|..   ....
Zfish  1065 MRTSRWTRGPMMGHSDDLEASDNYAEPADTLQHKSKG------------YSDDIYAVP---EDAH 1114

  Fly  1107 SNLNKIRPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVA---KMNFTG 1168
            |...|.|.......:.|.|  .....:||.|.   ..::|.|...::..|.|...|   :::...
Zfish  1115 SRSGKTRNSFGGLVVHVDE--ENGFDSMSKSQ---GGRRPSKYKHRSKILFSKTKAYHRRVHSDV 1174

  Fly  1169 SGSGSGSGSGSGSTGLGLGLGSGSGCMGDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYE 1233
            |...||..:.....|.|     ..|...|..|.|||......|:..:..:.|..|
Zfish  1175 SDDESGPATQKKKKGRG-----NRGSEEDPLLSPVDPWKGGIDNPAITSDPEQDE---------- 1224

  Fly  1234 NEDCTESDSCASSTERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPL 1298
                                              :|.|||| |...:.|:.|...:
Zfish  1225 ----------------------------------RKTKKKK-APKTKEPKKPTRST--------- 1245

  Fly  1299 HYQRMAVGGSGPGEKKKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDF 1363
                           |..:|..|...::.:| .|..||
Zfish  1246 ---------------KTTKPLYPPTRRNWES-NYFGVP--------------------------- 1267

  Fly  1364 EKLEKRRIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLN 1428
                                             .||               ::|.:: .||:|:.
Zfish  1268 ---------------------------------LQN---------------LVTPDR-PIPLFVE 1283

  Fly  1429 KCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPP 1493
            |||::||:.|..:||:|||.|::...|.:.::|::|.:.::..:|:.|||||.|||.||:....|
Zfish  1284 KCVDYIERTGFTTEGLYRVCGNKTDQDNIQKQFDQDHSIDLIVMDVAVNAVAGALKAFFADLPDP 1348

  Fly  1494 LFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVS 1558
            |....:..||.|.|        |:     .|...||..||.:::|.||:|:.:.||:..|...||
Zfish  1349 LIPYSLHPELVEAA--------KI-----VDHYERLQVLKEIVRKFPPVNYEVFKYVITHLNRVS 1400

  Fly  1559 DNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLFCGKD 1616
            .:||...|.:.||:||:||||:..||.:.......: ..:.::::.|.|..|.|.|.|
Zfish  1401 QHSKTTLMTADNLSICFWPTLMRPDFENKDTLSTTK-LNQSVIESFIQQCQYFFYGGD 1457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAPp190	NP_001259658.1	P-loop_NTPase	<148..238	CDD:304359	34/89 (38%)
		RhoGAP-FF1	254..333	CDD:293121	21/78 (27%)
		RhoGAP_p190	1411..1611	CDD:239838	66/199 (33%)
arhgap5	XP_001336016.1	P-loop_NTPase	<153..244	CDD:304359	36/93 (39%)
		RhoGAP-FF1	258..337	CDD:293121	21/78 (27%)
		FF	428..480	CDD:128718	17/51 (33%)
		FF	483..532	CDD:128718	15/48 (31%)
		P-loop_NTPase	<621..728	CDD:304359	26/119 (22%)
		RhoGAP_p190	1264..1448	CDD:239838	69/273 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I629
OMA	1	1.010	-	-		QHG50036
OrthoDB	1	1.010	-	-		D110157at2759
OrthoFinder	1	1.000	-	-		FOG0003137
OrthoInspector	1	1.000	-	-		otm24424
orthoMCL	1	0.900	-	-		OOG6_105533
Panther	1	1.100	-	-	O	PTHR46005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4737
SonicParanoid	1	1.000	-	-		X2106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010