DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAPp190 and Syde1

DIOPT Version :9

Sequence 1:	NP_001259658.1	Gene:	RhoGAPp190 / 32743	FlyBaseID:	FBgn0026375	Length:	1621	Species:	Drosophila melanogaster
Sequence 2:	NP_082151.1	Gene:	Syde1 / 71709	MGIID:	1918959	Length:	737	Species:	Mus musculus

Alignment Length:	618	Identity:	135/618 - (21%)
Similarity:	215/618 - (34%)	Gaps:	140/618 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1018 PPPTTPPEPAPPDHQLITCTYKSQFVSASESSLEEITSDVSGS-KDSLATHDAEWL-------ED 1074
            |...:.|:|..|:.:::.   .||..:....|.|...|...|: ..||......|:       |:
Mouse    32 PAQRSEPKPPEPEPRVLE---GSQAGAEVPPSPETPRSPTRGAYLQSLEPSSRRWVLGGAKPPEE 93

  Fly  1075 KSDGRRNMNK----NLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTLKVGEAPSRNCPAMS 1135
            .|.|.|..:.    ..||.|..............:.|.|....|:||:..   |.||:      |
Mouse    94 ISLGPRTPSSGEPAGEIWYNPIPEEDPRPPAPEPLGSQLASSEPEGPNIQ---GAAPT------S 149

  Fly  1136 SSTFTLPTQQPG---KLNMKNFQLVS-DAVAKMNFTGSGSGSGSGSGSGSTGLGLGLGSGSGCMG 1196
            ..|.|..|:.||   :|:||..:|.. .....:..|.:|......:.:||......|.|..|..|
Mouse   150 PPTKTSRTKSPGPARRLSMKMKKLPELRRRLSLRSTRTGRDRERTAPAGSVISRYHLDSSVGTPG 214

  Fly  1197 DSFLEPVDKDGKRYDHAQL--DGEDEDSEELAEYEQIYENEDCTESDSCASSTERRVRQQNAYYK 1259
            .:.:    ..|.|......  ||:                           |.||
Mouse   215 QASV----AGGSRSPRGGYLSDGD---------------------------SPER---------- 238

  Fly  1260 ASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGG--SGPGEKKKPEPCV-- 1320
             ...|.:....:..:|....:||....:|      .:.||.  ..:||  ..||...:...|:
Mouse   239 -PGGPPSPTAFRPYEVGPSARTPPAALWG------RLSLHL--YGLGGLRPSPGATPRDLCCLLQ 294

  Fly  1321 ---------------PEFMKSDKSPEYSMVPELAGAGIFGAENL---PEYNMNQAKCLKD----- 1362
                           |:|::.|    ::...||..|.:..|..|   |....:: .|.:.
Mouse   295 VDGVARARTGPLRSGPDFLRLD----HTFHLELEAARLLRALVLAWDPGVRRHR-PCAQGTVLLP 354

  Fly  1363 --FEKLEKRRIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFG---KLMITSEQ-- 1420
              |...:.:::......|..|.       .||....:|.|....|  ...||   :|::..||
Mouse   355 TIFRGCQAQQLAVRLEPQGLLY-------AKLTLSEQQEAPATAE--PRVFGLPLQLLVEREQSP 410

  Fly  1421 GEIPIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDI--PVNAVATAL 1483
            |::|:.:.|||..||..||...|:||:.||.|....|...||:|:.....:.|:  .:|.:...|
Mouse   411 GQVPLIIRKCVGQIECRGLRVVGLYRLCGSAAVKKELRDAFEQDSAAVCLSEDVYPDINVITGIL 475

  Fly  1484 KDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILK 1548
            ||:..:...||.::.:.:.:.|.........:.|..|          ..:.||:.||.:..|.|.
Mouse   476 KDYLRELPTPLITQPLYQVVLEAMAQGHPSRASLGPE----------GTRGLLRCLPDVERATLT 530

  Fly  1549 YIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIP 1581
            .:..|...||.....|.|..:|||:|:.|.|:|
Mouse   531 LLLDHLRLVSSFHTHNRMTPQNLAVCFGPVLLP 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAPp190	NP_001259658.1	P-loop_NTPase	<148..238	CDD:304359
		RhoGAP-FF1	254..333	CDD:293121
		RhoGAP_p190	1411..1611	CDD:239838	52/178 (29%)
Syde1	NP_082151.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..255		55/276 (20%)
		CAC1F_C	73..>250	CDD:293490	44/227 (19%)
		RhoGAP	396..601	CDD:295372	52/178 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..654
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4271
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900