DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAPp190 and Arhgap5

DIOPT Version :9

Sequence 1:NP_001259658.1 Gene:RhoGAPp190 / 32743 FlyBaseID:FBgn0026375 Length:1621 Species:Drosophila melanogaster
Sequence 2:XP_008762878.1 Gene:Arhgap5 / 299012 RGDID:1308507 Length:1503 Species:Rattus norvegicus


Alignment Length:1682 Identity:483/1682 - (28%)
Similarity:794/1682 - (47%) Gaps:317/1682 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGD 68
            :.:||:||||||||:|..|||||||||||:|..||:|:.:|.||||..||.||:|||||||||||
  Rat    13 YTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGD 77

  Fly    69 VRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEK 133
            :.:..|:|||.:.::||||||:||.||...:...:.||.||..|:|:.|||||||||.:|||:|:
  Rat    78 ITQNGEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQ 142

  Fly   134 EYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYEL 198
            ::|||.||:|:|::|||::..|||...||..:.|::||.|:...:.|:|||:::..||.|:..:.
  Rat   143 DFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDH 207

  Fly   199 YVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELL 263
            |:||.:..:..   |..:.::||||..::||:..|..|.||:||.:.:.|||.|.::.|::::|:
  Rat   208 YLREVQAFASN---KKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLV 269

  Fly   264 DTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNK 328
            .|.::...:|::. :.|||..|...|..|..:.::.|::|:.|....:..|.:|:::|:.:|:.|
  Rat   270 VTATDKFEKLVQT-VRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRK 333

  Fly   329 KLHQYLDKFALALEYLLPD---IGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDM 390
            :..:|:.....|...||||   |..||      |..|...::...:|:..|....:..|.|...:
  Rat   334 RREEYISTLPRAFNTLLPDLEEIEHLN------WLEALKLMEKRADFQLCFVVLEKTPWDETDHI 392

  Fly   391 DEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVL 455
            |:..|. |||||:|.|.|||.|::|::..:..:|::|..|::||..||:..|::||:...||...
  Rat   393 DKINDR-RIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPWEEVMCF 456

  Fly   456 FMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDV 520
            .|..|.|:.::|.|.:::|..||.:|:||:|:.|.|:|.||::.|.........:.:.:.:|..|
  Rat   457 VMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTV 521

  Fly   521 IQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGG 585
            :.|:.|||.|.:|..:|..:|::|:.|::.|.::.|.....|.|..:|.:|::...  |...:..
  Rat   522 LSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDIKVENLLANSLL--HSDHNRS 584

  Fly   586 GWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGD------- 643
            ......:..|: :||.|:|.:.||.:|.|:|| ...:..||..:.:.|.|:.|..:..       
  Rat   585 RLYHDSTNIDK-VNLFILGKDGLAQELANEIR-TQSTDDEYALDGKIYELDLRPVDAKSPYILSQ 647

  Fly   644 --MEAFKAIDVYSSGLICVYSNQQSFETLKDNLE--RTLLCNLELEDKFENLPIVLVYQPQ-DLK 703
              ..|||     ..|..||:::.:|...:.:.:.  ||....:..:....|||..|:...| |..
  Rat   648 LWTAAFK-----PHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSI 707

  Fly   704 ENEVEYLRNEGMRLSEMLHCDFID------HTQNHQKYVYDILNIVILSLKLTEMKSYEPYPSN- 761
            ...:..||::|.:|:..|.|.|:|      ..:.::..:...|..|:.|:| ..:....|.|.| 
  Rat   708 SKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNESQIKQALRGVLESVK-HNLDVVSPVPINK 771

  Fly   762 ---HTDLRILCCIFCGDQYDIENIVQPLVEE---STLVKANEHSIIVDVFIGDAKRRVEFILSSY 820
               ..||||:.|..|||.:.::.|:.|.::.   |.......:|:::|..||:.:||::..:.||
  Rat   772 DVSEADLRIVMCAMCGDPFSVDIILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSY 836

  Fly   821 HGTSQYR-DELIHGYIYFYSTKRRSSLANL-SILAAQNANIPLQIIAVTESGGVNAFFNSDICQF 883
            |.:...| |||:||||..||.||::|:..| :.|:.....||:|::|||:|..  .||.::..:.
  Rat   837 HSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQA--DFFENEAIKE 899

  Fly   884 LITEGNAVADRFKGSFMT-FSADQY-----VKFAFYNPFL--KTAWDNKYEVEN----LHVEESI 936
            |:|||..:|......|.. :|..||     |...|::..|  |...:|.|..:|    .|..|.:
  Rat   900 LMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDV 964

  Fly   937 TLDSGE-----GTLENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDIS 996
            .|.|..     ....:|.:....|||       .:.:|.|      .::.||.|     :.....
  Rat   965 FLPSPRDCFPYNNYPDSDDDTEAPPP-------YSPIGDD------VQLLPTPS-----DRSRYR 1011

  Fly   997 LDEIYDDNEKPKHL------HQRFQIFPPPTTPPEPAPPDHQLITCTYKSQFVSASESSLEEITS 1055
            ||  .:.||.|.|.      |:|....||| ..|:|..|                          
  Rat  1012 LD--LEGNEYPVHSTPNCHDHERNHKVPPP-IKPKPVVP-------------------------- 1047

  Fly  1056 DVSGSKDSLATHDAEWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQT 1120
                                   :.|:.|                    :|.||.|....|    
  Rat  1048 -----------------------KTNVKK--------------------LDPNLLKTIEAG---- 1065

  Fly  1121 LKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLG 1185
              :|:.|.:       .|..:|...|..::                                   
  Rat  1066 --IGKNPRK-------QTSRVPLAHPEDMD----------------------------------- 1086

  Fly  1186 LGLGSGSGCMGDSFLEPVDKDGKRY---DHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASST 1247
                     ..|::.||:|...|:.   |...:..:|..:..:........|....|.:..:..|
  Rat  1087 ---------SSDNYAEPLDTIFKQKGYPDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRT 1142

  Fly  1248 -----ERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGG 1307
                 |||..:    ||...|.:.:|.:.                           :|:|.....
  Rat  1143 SKGHGERRPSK----YKYKSKTLFSKAKS---------------------------YYRRTHSDA 1176

  Fly  1308 SG----PGEKKKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEK 1368
            |.    |..|.|.:   .....|::.|..|.|....|    |.:| |....:|.   .|.:|::|
  Rat  1177 SDDEAFPTSKTKRK---GRHRGSEEDPLLSPVETWKG----GIDN-PAITSDQE---VDDKKIKK 1230

  Fly  1369 R--RIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCV 1431
            :  ::||:    :|.::|.|......:|..:.|..|:....       ::|:|: .||:|:.|||
  Rat  1231 KPHKVKED----KKQKKKTKTFNPPTRRNWESNYFGMPLQD-------LVTAEK-PIPLFVEKCV 1283

  Fly  1432 EFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFS 1496
            ||||..||.:||:|||.|::...|.:.::|::|.|..:.::::.|||||.|||.||:....||..
  Rat  1284 EFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLASMEVTVNAVAGALKAFFADLPDPLIP 1348

  Fly  1497 KDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNS 1561
            ..:..||.|.|        |:     .|::.||.|||.:::|..|:|:.:.:|:..|...||..:
  Rat  1349 YSLHPELLEAA--------KI-----PDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQN 1400

  Fly  1562 KLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYL------EDIVQTMIDQFPYLF 1612
            |:|.|.:.||:||:||||:..||.:       |.:|      :.:|:|.|.|..:.|
  Rat  1401 KINLMTADNLSICFWPTLMRPDFEN-------REFLSTTKIHQSVVETFIQQCQFFF 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAPp190NP_001259658.1 P-loop_NTPase <148..238 CDD:304359 31/89 (35%)
RhoGAP-FF1 254..333 CDD:293121 18/78 (23%)
RhoGAP_p190 1411..1611 CDD:239838 73/205 (36%)
Arhgap5XP_008762878.1 P-loop_NTPase 31..246 CDD:422963 107/217 (49%)
RhoGAP-FF1 260..338 CDD:406821 18/78 (23%)
FF 368..420 CDD:128718 18/52 (35%)
FF 428..481 CDD:128718 19/52 (37%)
FF 484..533 CDD:128718 16/48 (33%)
pseudoGTPaseD_p190RhoGAP-B 592..762 CDD:412065 43/177 (24%)
RhoGAP_p190 1261..1445 CDD:239838 73/211 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 203 1.000 Domainoid score I2868
eggNOG 1 0.900 - - E1_KOG4271
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 735 1.000 Inparanoid score I573
OMA 1 1.010 - - QHG50036
OrthoDB 1 1.010 - - D110157at2759
OrthoFinder 1 1.000 - - FOG0003137
OrthoInspector 1 1.000 - - otm45092
orthoMCL 1 0.900 - - OOG6_105533
Panther 1 1.100 - - O PTHR46005
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2106
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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