DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGAPp190 and rga-5

DIOPT Version :9

Sequence 1:NP_001259658.1 Gene:RhoGAPp190 / 32743 FlyBaseID:FBgn0026375 Length:1621 Species:Drosophila melanogaster
Sequence 2:NP_001023257.1 Gene:rga-5 / 178348 WormBaseID:WBGene00010374 Length:1341 Species:Caenorhabditis elegans


Alignment Length:1720 Identity:371/1720 - (21%)
Similarity:640/1720 - (37%) Gaps:545/1720 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MRQFNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGR-IVNNDHFL 64
            :::.|:.|:|:||:|..:|..|||||.|||||:||.||::..:|.|||||.||.|. ::|.||:|
 Worm    14 IKEINVIVVGVSGSEAVKGPSGVGKSLLCNRFVRPAADEFHREHSSVLSQIDFCGSPVINKDHWL 78

  Fly    65 YWGD-VRKTTEEGVEYQFNII----EQTEFMDDSTFQAFK-VGKMDPYSKRCTATKVFSAEKLMY 123
            |||. |....|....   ||:    |||||:||.||:... ..|.:.|.:||..|.:.|.:||||
 Worm    79 YWGSRVLSNPESSAS---NILIRVAEQTEFLDDETFETIAGCSKSENYCQRCCQTSLQSRDKLMY 140

  Fly   124 ICKNQLGIEKEYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLV 188
            |.|.|||:|.|:.|:::|:|:.::|||::..|:|. |. |.......|.|:...|.|.|||:::.
 Worm   141 IQKEQLGLESEFPQQLLPNGKFNVDGFILACDISK-PT-SAHLHSSHVLNIAKAISKTKKPVIIA 203

  Fly   189 TTKNDDAYE----LYVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRV-K 248
            .||.|:|.|    .|:.......:.|...|.|..:|||:.:::|::..|..||.:..|.:..| |
 Worm   204 FTKCDEASEECKKNYLNLFYSTKELKHIMSHVPPVETSSVKNVNVEYLFGTLANLCLKSQKIVKK 268

  Fly   249 IISYQESAKSRKELLDTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNE------------- 300
            .::|.|::.    .::.|:..|.......::....|.:...|.||    ||:             
 Worm   269 PLAYHEASL----FVEQRNLHVKCCFSTLLSQAVPLCTYPKKCLS----WNQVLADIDRHPDLMN 325

  Fly   301 FLNIFGHEAGQKLFRRHMKKLRD----DHLNKKLHQYLDKFALALEYLLPDIGALNISDDDAWEC 361
            |:.:||.....:::.|::.:.::    :.|...:.:..:.|.:.|:.:  |:..:.      |..
 Worm   326 FVTVFGSRVAFEMYERYVSEAKELWAINRLRTLVPRLFEIFQVFLDVV--DLAEME------WSQ 382

  Fly   362 ARNYLQNH------IEFEQYFFE--CPQASWTELVDMDEAEDEARIPFDVLETSEAETVFRNYLN 418
            ||::::.|      .|..:|..|  .|.:|:.:       ::::|:|.::|...||..||..:..
 Worm   383 ARDFMRCHPLFHVLFESNEYNLEMWSPPSSFNK-------DEKSRLPSEILLLPEAAKVFEQFRL 440

  Fly   419 SVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDIHQDDIIE 483
            |....:.|....|:|:.||.|...:.||..:.....||......:.|:......:||..|..::|
 Worm   441 STLNLRLKHQLGQEFEYLLNEIPQILPGCSMETAFPLFQNFNVIKKLTPDIVTTVYDRFQKKLME 505

  Fly   484 KSKQNFVELLLEHAQYFLQFKNVD------------------NITQEDVRQITDVIQEDSRYKML 530
            .:::...|.:|| ....:|.:|:.                  |...|.|:...:|   |.||:.:
 Worm   506 NARKQLEECILE-VSPGIQLQNLKIKSWKTPGLSHFDMSMDFNQKLETVKNFLEV---DDRYEWM 566

  Fly   531 DRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGGGWKSSGSGSD 595
            ..:..||..::|.||.||......:||....|:|                               
 Worm   567 RIMAGERDQIIVNHLPFIFDVSPVNCPSTDMCID------------------------------- 600

  Fly   596 RTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGDMEAFKAIDVYSSGLICV 660
                  :||     :.:|||          :..:|.|:                  ..|||.   
 Worm   601 ------LVG-----TSILND----------FSEQNSTF------------------CGSSGF--- 623

  Fly   661 YSNQQSFETLKDNLERTLLCNLELEDKFENLPIVLVYQPQDLKENEVEYLRNEGMRLSEMLHCDF 725
               .:.||..:.|             ..:|:|                                 
 Worm   624 ---SECFEATRKN-------------SGKNMP--------------------------------- 639

  Fly   726 IDHTQNHQKYVYDILNIVILSLKLTEMKSYEPYPSNHTDLRILCCIFCGDQYDIENIVQPLVEES 790
                                                    ||.....||||..|:::...|. .:
 Worm   640 ----------------------------------------RIQISAMCGDQLSIDSLAGALF-HN 663

  Fly   791 TLVK------ANEHSIIVDVFIGDAK--RRVEFILSSYHGTSQYRD-------ELIHGYIYFYST 840
            ||::      :|:.:..::|...:.:  ..:|..:.|||......|       :|..||::.|::
 Worm   664 TLIRPSNYNFSNDGATFIEVLDENTQIWNNIEINMCSYHSWFHKNDSNPSESIDLNDGYLFVYNS 728

  Fly   841 KRRSSL--ANLSI--LAAQNA-NIP-LQIIAVTESGG--------VNAFFNSDICQFLITEGNAV 891
            :|.||.  |..:|  ||..|: |.. :.::||.:.||        .|....:::|:.:....:|:
 Worm   729 QRASSFNYARCAIEKLAETNSVNFDCILLLAVVKGGGSDSMKLNLENLTEGAELCKSIGARFSAI 793

  Fly   892 ADRFKGSFMTFSADQYVKFAF------YNPFLKTAWDNKYEVENLHVEESITLDSGEGTL--ENS 948
            ..|.:.:.......|.::|..      ..|....|......:||  ...||...||...|  .:|
 Worm   794 DFRKRKTKSNGINHQMMEFLHDICDGQVQPITSNANSEIDSIEN--DRPSILSSSGIQLLAKPDS 856

  Fly   949 VNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDISLDEIYDDNEKPKH---- 1009
            .|:..||.|...|.:.:....||.....::...|...     :...::..|..|.:  |.:    
 Worm   857 SNRSRRPKPVVNSNLRNRVTRTDPLIMSHFYSQPIEI-----QPAPLATPEAVDFS--PAYSLVN 914

  Fly  1010 --LHQRFQI--FPPPTTPP-----EPAPPDHQLITCTYKSQFVSASESSLEEITSDVSGSKDSLA 1065
              :|...|:  ..|..:||     |.:.||.:..|.|     ||.|..:...:::||:       
 Worm   915 DAVHTVIQVNGSTPLKSPPTFHSYESSTPDSRSTTST-----VSGSSPAPRAVSADVT------- 967

  Fly  1066 THDAEWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTLKVGEAPSRN 1130
                         ||:...|:       |....:..|.|..|||.::||:.              
 Worm   968 -------------RRSRTSNV-------SLSTDSINRLHRTSNLFQLRPEA-------------- 998

  Fly  1131 CPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLGLGLGSGSGCM 1195
                     .|..:|      |...|..:::.|:                               
 Worm   999 ---------ALTAEQ------KRKSLSIESLTKV------------------------------- 1017

  Fly  1196 GDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASSTERRVRQQNAYYKA 1260
                  |..:.|.|:                                        ||:....::.
 Worm  1018 ------PEKEKGNRF----------------------------------------VRKVATSFRL 1036

  Fly  1261 SKKPV-------AAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGGSGPGEKKKPEP 1318
            .|..:       :.||:.|||.:            :..||.:|....::||...           
 Worm  1037 RKSLLDTTCDGESDKKENKKKTS------------TTTSPEQISSFLEKMATRS----------- 1078

  Fly  1319 CVPEFMKSD-KSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEKRRIKEETARQRKLQ 1382
             :|:..::| |:..||                   ::|...     ||:........:...:||.
 Worm  1079 -LPQSPRTDRKAKLYS-------------------SLNSTT-----EKVSNVLSWLPSKTSKKLM 1118

  Fly  1383 EKEKEQEKKLKRKL-----KQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCVEFIEKE-GLDS 1441
             |.|.....|...|     ..:.:|::.:.|..  :.:.:....:|||:|.||::|||:. |.:.
 Worm  1119 -KNKSATHDLSTSLINYPASTSTQGVIAANETL--ETLCSKSPSQIPIYLEKCIQFIEQNGGFEQ 1180

  Fly  1442 EGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFS----KRLPPLFS---KDI 1499
            ||:|||||::.|:..:.:||.:....::.:.|.||:..|||||.|||    ..:|..:.   |.|
 Worm  1181 EGLYRVPGNQTHLAEVEKRFLKYGEFDVSSFDTPVHVAATALKSFFSCLPESLIPTAYHLRWKQI 1245

  Fly  1500 IKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLN 1564
            :...::|.                    ::..::..|..||..|..:|:|:..|...||.:.| .
 Worm  1246 MMVSDDIK--------------------KIDGIRDALAILPVSNQKVLQYLVTHLTKVSCSPK-T 1289

  Fly  1565 SMDSKNLAICWWPTLI-PIDFTDMGHFEQL 1593
            .|:|.||:..|.|||. |:    ...:|:|
 Worm  1290 VMNSNNLSKVWTPTLFRPV----FASYEEL 1315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAPp190NP_001259658.1 P-loop_NTPase <148..238 CDD:304359 29/93 (31%)
RhoGAP-FF1 254..333 CDD:293121 14/95 (15%)
RhoGAP_p190 1411..1611 CDD:239838 56/192 (29%)
rga-5NP_001023257.1 Ras_like_GTPase <164..257 CDD:206648 29/94 (31%)
RhoGAP 1141..1332 CDD:383032 58/202 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 81 1.000 Domainoid score I5529
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 314 1.000 Inparanoid score I1538
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50036
OrthoDB 1 1.010 - - D110157at2759
OrthoFinder 1 1.000 - - FOG0003137
OrthoInspector 1 1.000 - - oto19019
orthoMCL 1 0.900 - - OOG6_105533
Panther 1 1.100 - - LDO PTHR46005
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4737
SonicParanoid 1 1.000 - - X2106
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1313.010

Return to query results.
Submit another query.