DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAPp190 and Arhgap5

DIOPT Version :9

Sequence 1:NP_001259658.1 Gene:RhoGAPp190 / 32743 FlyBaseID:FBgn0026375 Length:1621 Species:Drosophila melanogaster
Sequence 2:NP_033836.2 Gene:Arhgap5 / 11855 MGIID:1332637 Length:1503 Species:Mus musculus


Alignment Length:1698 Identity:483/1698 - (28%)
Similarity:794/1698 - (46%) Gaps:349/1698 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGD 68
            :.:||:||||||||:|..|||||||||||:|..||:|:.:|.||||..||.||:|||||||||||
Mouse    13 YTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGD 77

  Fly    69 VRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEK 133
            :.:..|:|||.:.::||||||:||.||...:...:.||.||..|:|:.|||||||||.:|||:|:
Mouse    78 ITQNGEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQ 142

  Fly   134 EYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYEL 198
            ::|||.||:|:|::|||::..|||...||..:.|::||.|:...:.|:|||:::..||.|:..:.
Mouse   143 DFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDH 207

  Fly   199 YVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELL 263
            |:||.:..:..   |..:.::||||..::||:..|..|.||:||.:.:.|||.|.::.|::::|:
Mouse   208 YLREVQAFASN---KKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLV 269

  Fly   264 DTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNK 328
            .|.::...:|::. :.|||..|...|..|..:.::.|::|:.|....:..|.:|:::|:.:|:.|
Mouse   270 VTATDKFEKLVQT-VRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRK 333

  Fly   329 KLHQYLDKFALALEYLLPD---IGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDM 390
            :..:|:.....|...||||   |..||      |..|...::...:|:..|....:..|.|...:
Mouse   334 RREEYISTLPRAFNTLLPDLEEIEHLN------WLEALKLMEKRADFQLCFVVLEKTPWDETDHI 392

  Fly   391 DEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVL 455
            |:..|. |||||:|.|.|||.|::|::..:..:|::|..|::||..||:..|::||:...||...
Mouse   393 DKINDR-RIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPWEEVMCF 456

  Fly   456 FMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDV 520
            .|..|.|:.::|.|.:::|..||.:|:||:|:.|.|:|.||::.|.........:.:.:.:|..|
Mouse   457 VMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTV 521

  Fly   521 IQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLS--------DKSAS 577
            :.|:.|||.|.:|..:|..:|::|:.|::.|.::.|.....|.|..:|.:|:        ::...
Mouse   522 LSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDIKVENLLATSLLEMDHNRVRL 586

  Fly   578 NHKTPSGGGWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANG 642
            .|          ..:..|: :||.|:|.:.||.:|.|:|| ...:..||..:.:.|.|:.|..:.
Mouse   587 YH----------DSTNIDK-VNLFILGKDGLAQELANEIR-TQSTDDEYALDGKIYELDLRPVDA 639

  Fly   643 D---------MEAFKAIDVYSSGLICVYSNQQSFETLKDNLE--RTLLCNLELEDKFENLPIVLV 696
            .         ..|||     ..|..||:::.:|...:.:.:.  ||....:..:....|||..|:
Mouse   640 KSPYILSQLWTAAFK-----PHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMTNLPFTLI 699

  Fly   697 YQPQ-DLKENEVEYLRNEGMRLSEMLHCDFID------HTQNHQKYVYDILNIVILSLKLTEMKS 754
            ...| |.....:..||::|.:|:..|.|.|:|      ..:.::..:...|..|:.|:| ..:..
Mouse   700 LANQRDSISKNLPILRHQGQQLANKLQCPFVDVPTGTYPRKFNESQIKQALRGVLESVK-HNLDV 763

  Fly   755 YEPYPSN----HTDLRILCCIFCGDQYDIENIVQPLVEE---STLVKANEHSIIVDVFIGDAKRR 812
            ..|.|.|    ..||||:.|..|||.:.::.|:.|.::.   |.......:|:::|..||:.:||
Mouse   764 VSPVPINKDVSEADLRIVMCAMCGDPFSVDLILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRR 828

  Fly   813 VEFILSSYHGTSQYR-DELIHGYIYFYSTKRRSSLANL-SILAAQNANIPLQIIAVTESGGVNAF 875
            ::..:.|||.:...| |||:||||..||.||::|:..| :.|:.....||:|::|||:|..  .|
Mouse   829 IQITILSYHSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQA--DF 891

  Fly   876 FNSDICQFLITEGNAVADRFKGSFMT-FSADQY-----VKFAFYNPFL--KTAWDNKYEVEN--- 929
            |.::..:.|:|||..:|......|.. :|..||     |...|::..|  |...:|.|..:|   
Mouse   892 FENEAIKELMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRE 956

  Fly   930 -LHVEESITLDSGE-----GTLENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNS 988
             .|..|.:.|.|..     ....:|.:....|||       .:.:|.|      .::.||.|   
Mouse   957 STHQSEDVFLPSPRDCFPYNNYPDSDDDTEAPPP-------YSPIGDD------VQLLPTPS--- 1005

  Fly   989 LNEERDISLDEIYDDNEKPKHL------HQRFQIFPPPTTPPEPAPPDHQLITCTYKSQFVSASE 1047
              :.....||  .:.||.|.|.      |:|....||| ..|:|..|                  
Mouse  1006 --DRSRYRLD--LEGNEYPVHSTPNCHDHERNHKVPPP-IKPKPVVP------------------ 1047

  Fly  1048 SSLEEITSDVSGSKDSLATHDAEWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKI 1112
                                           :.|:.|                    :|.||.|.
Mouse  1048 -------------------------------KTNVKK--------------------LDPNLLKT 1061

  Fly  1113 RPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGS 1177
            ...|      :|:.|.:       .|..:|...|..::                           
Mouse  1062 IEAG------IGKNPRK-------QTSRVPLAHPEDMD--------------------------- 1086

  Fly  1178 GSGSTGLGLGLGSGSGCMGDSFLEPVD---KDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTE 1239
                             ..|:::||:|   |.....|...:..:|..:..:........|....|
Mouse  1087 -----------------SSDNYVEPLDTIFKQKGYSDEIYVVPDDSQNRIIKIRNSFVNNTQGDE 1134

  Fly  1240 SDSCASST-----ERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLH 1299
            .:..:..|     |||..:    ||...|.:.:|.:.                            
Mouse  1135 ENGFSDRTSKGHGERRPSK----YKYKSKTLFSKAKS---------------------------- 1167

  Fly  1300 YQRMAVGGSGPGE-------KKKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQA 1357
            |.|.....:...|       |:|     .....|::.|..|.|....|    |.:| |....:| 
Mouse  1168 YYRRTHSDASDDEAFTTSKTKRK-----GRHRGSEEDPLLSPVETWKG----GIDN-PAITSDQ- 1221

  Fly  1358 KCLKDFEKLEKRRIKEETARQRKLQEKEKEQEKKLK-------RKLKQNAKGLVESAEAQFGKLM 1415
                   :::.::||::|   .|::| :|:|:||.|       |..:.|..|:....       :
Mouse  1222 -------EVDDKKIKKKT---HKVKE-DKKQKKKTKTFNPPTRRNWESNYFGMPLQD-------L 1268

  Fly  1416 ITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVA 1480
            :|:|: .||:|:.|||||||..||.:||:|||.|::...|.:.::|::|.|..:.::::.|||||
Mouse  1269 VTAEK-PIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLASMEVTVNAVA 1332

  Fly  1481 TALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFA 1545
            .|||.||:....||....:..||.|.|        |:     .|::.|..|||.:::|..|:|:.
Mouse  1333 GALKAFFADLPDPLIPYSLHPELLEAA--------KI-----PDKTERFHALKEIVKKFHPVNYD 1384

  Fly  1546 ILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYL------EDIVQTM 1604
            :.:|:..|...||..:|:|.|.:.||:||:||||:..||.:       |.:|      :.:|:|.
Mouse  1385 VFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFEN-------REFLSTTKIHQSVVETF 1442

  Fly  1605 IDQFPYLF 1612
            |.|..:.|
Mouse  1443 IQQCQFFF 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAPp190NP_001259658.1 P-loop_NTPase <148..238 CDD:304359 31/89 (35%)
RhoGAP-FF1 254..333 CDD:293121 18/78 (23%)
RhoGAP_p190 1411..1611 CDD:239838 72/205 (35%)
Arhgap5NP_033836.2 P-loop_NTPase 31..246 CDD:393306 107/217 (49%)
RhoGAP-FF1 260..338 CDD:374593 18/78 (23%)
FF 368..420 CDD:128718 18/52 (35%)
FF 428..481 CDD:128718 19/52 (37%)
FF 484..533 CDD:128718 16/48 (33%)
RhoGAP_p190 1261..1445 CDD:239838 72/211 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 203 1.000 Domainoid score I2954
eggNOG 1 0.900 - - E1_KOG4271
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 732 1.000 Inparanoid score I610
Isobase 1 0.950 - 0 Normalized mean entropy S5406
OMA 1 1.010 - - QHG50036
OrthoDB 1 1.010 - - D110157at2759
OrthoFinder 1 1.000 - - FOG0003137
OrthoInspector 1 1.000 - - otm43027
orthoMCL 1 0.900 - - OOG6_105533
Panther 1 1.100 - - O PTHR46005
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4737
SonicParanoid 1 1.000 - - X2106
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.820

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