DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAPp190 and arhgap5

DIOPT Version :9

Sequence 1:NP_001259658.1 Gene:RhoGAPp190 / 32743 FlyBaseID:FBgn0026375 Length:1621 Species:Drosophila melanogaster
Sequence 2:XP_004917331.1 Gene:arhgap5 / 100499209 XenbaseID:XB-GENE-982380 Length:1500 Species:Xenopus tropicalis


Alignment Length:1676 Identity:479/1676 - (28%)
Similarity:806/1676 - (48%) Gaps:310/1676 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGD 68
            :.|||:||||||||:|..||||||||||::|..|||::.:|.||||..||.||:|||||||||||
 Frog    13 YTISVVGLSGTEKDKGNCGVGKSCLCNRYVRRKADDFYSEHTSVLSTIDFGGRVVNNDHFLYWGD 77

  Fly    69 VRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEK 133
            |.:..|:||:.:.||||||||:||.||...:...:.||.||...||:.|||||||||.:|||:|:
 Frog    78 VTEVGEDGVDCKSNIIEQTEFIDDQTFLPHRSTNLQPYIKRAANTKLQSAEKLMYICTDQLGLEQ 142

  Fly   134 EYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYEL 198
            ::|||.||:|:|::||||:..|||...||..:.|::||.|:...:.|.|||:::..||.|:..:.
 Frog   143 DFEQKQMPEGKLTVDGFVLCIDVSQGCNRKFDDQLKFVNNLYTHVAKTKKPIIIAATKCDECVDH 207

  Fly   199 YVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELL 263
            |:||.:..:..   |..:.::||||..:||::..|..|.||:||.:::.|||.|.|:.|..::::
 Frog   208 YLREVQGFASN---KKNLLVVETSARNNINVETCFAALIQMLDKTRSKPKIIPYLEAFKIHRQIV 269

  Fly   264 DTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNK 328
            .:.|:...:||...:.|||.:|...|..|..:.::.:::|:.|....:|.|.:|:.:|:.:|:.|
 Frog   270 ISASDKFDKLIVQTVRDYHAVWKTVSNKLKNHSDYEDYINLEGTVKAKKTFSKHIDQLKQEHIRK 334

  Fly   329 KLHQYLDKFALALEYLLPDIGAL-NISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDE 392
            :..:||......|..|||.:..: |:|    |..|...|:...:|..:|.......|.:...:|:
 Frog   335 RKEEYLKTLPRTLNTLLPKLEDIENLS----WAEAIQVLEKRPDFSLWFVMLETVPWDQTDHIDK 395

  Fly   393 AEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFM 457
            ..|. |||||:|.|.|||.|:::::..:..:|:::..|::||..||....::||:...|:....:
 Frog   396 VTDR-RIPFDLLCTLEAEKVYQSHVQHLVSEKRRVEMKERFKKTLETIPIISPGQPWEELICFLL 459

  Fly   458 GRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDVIQ 522
            ..|.::.:||.|...:|..||.::|||:|:.|.|:|.||::.|.........:.:.:.:|..|:.
 Frog   460 DDEAYKFISESDRVDVYRKHQRELIEKAKEEFQEMLFEHSELFYDLDLNATPSTDKMSEINAVLG 524

  Fly   523 EDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGGGW 587
            |:.|||.|.:|..||..:|::|:.|::.|.::.|....:|:|..:|:||     :|....|..|.
 Frog   525 EEPRYKALQKLATERESLLLKHIGFVYHPTKETCLSGQSCMDIKVEQVL-----ANSLLQSNLGR 584

  Fly   588 KS---SGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGD----ME 645
            .:   ..:..|| :||||:|.:.||.::.|:|| ...:..|:..:.:.|.|:.:..:.:    :.
 Frog   585 MNLYQDSTNLDR-INLLILGKDGLAQEMTNEIR-TQSTDDEFALDGKIYELDLKTVDANSPYLLS 647

  Fly   646 AFKAIDVYSSGLICVYSNQQSFETLKDNLERTLLCNLEL--EDKFENLPIVLVYQPQ-DLKENEV 707
            ..:.......|..||:|:.:|...:.|.:.: :.|..::  |....:||..|:...| |.....:
 Frog   648 QLRTSGFKPHGCFCVFSSIESLNFIGDCIGK-IRCEAQIRREKDIASLPFALILANQRDSTSKNL 711

  Fly   708 EYLRNEGMRLSEMLHCDFID------HTQNHQKYVYDILNIVILSLK-LTEMKSYEPYPS----N 761
            ..||::|.:|:..|.|.|:|      ..:.::..:...|..|:.|:| .:::.|  |.|:    :
 Frog   712 PILRHQGQQLANKLQCPFVDIPAGTYPRKFNETQIKQALRGVLESVKHNSDIAS--PAPTIKELS 774

  Fly   762 HTDLRILCCIFCGDQYDIENIVQPLVEESTLVKANE---HSIIVDVFIGDAKRRVEFILSSYHGT 823
            ..||||:.|..|||.:.::.|:.|.:|..|...|..   :|:::|..|||.:||::..:.|||.:
 Frog   775 EADLRIVMCAMCGDPFSVDLILSPFLESRTCSAAQPGQINSLMLDKIIGDKRRRIQITILSYHSS 839

  Fly   824 SQYR-DELIHGYIYFYSTKRRSSLANL-SILAAQNANIPLQIIAVTESGGVNAFFNSDICQFLIT 886
            ...| |||:||||..||.:|::|:..| :.|:.....||:|::|||:|..  .||.::..:.|:|
 Frog   840 IGVRKDELVHGYILVYSARRKASMGMLRAFLSEVQDTIPVQLVAVTDSQA--DFFENEAIKELMT 902

  Fly   887 EGNAVADRFKGSFMT-FSADQYVK-FAFYNPFLKTAWDNKYEVENLHVEES----------ITLD 939
            ||..:|......|.. :|..||.: ...:.||.....:.|..:||.::.||          :...
 Frog   903 EGEHIATEISAKFTALYSLSQYHRQTEVFTPFFCDVLEKKTSIENSYLAESTREASQQCEDVFTH 967

  Fly   940 SGEGT------LENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDISLD 998
            |..|.      ..:|.:....|||       .:.:|.|      .::.|...|::          
 Frog   968 SSRGNSPAYICYPDSEDDTEAPPP-------YSPIGDD------VQLLPKCPLDN---------- 1009

  Fly   999 EIYDDNEKPKHL-------HQRFQIFPPPTTPPEPAPPDHQLITCTYKSQFVSASESSLEEITSD 1056
               :.||.|.|.       |:|....||| ..|:||.|..:          |:..:.:|.:....
 Frog  1010 ---EGNEYPIHSTPLNCHDHERNHKVPPP-IKPKPAVPKPR----------VNRLDPNLVKTIEA 1060

  Fly  1057 VSGS---KDSLATH-----DAEWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLN-KI 1112
            ..|.   |.:|.||     |.:..::.::....::|.   .:|...|:|.....::..|.|. ..
 Frog  1061 GMGKNPRKQALRTHLTHGEDLDASDNYAEPADTIHKP---KDFINDTYAIPDDSQNHSSRLRWFF 1122

  Fly  1113 RPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQ----PGKLNMKNFQLVSDAVAKMNFTGSGSGS 1173
            .|:|..:    ...|.|           :|..|    |.|...         ::|..|:.|.|  
 Frog  1123 TPQGDEE----NGIPDR-----------VPRGQVERRPSKYKY---------MSKTLFSKSKS-- 1161

  Fly  1174 GSGSGSGSTGLGLGLGSGSGCMGDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCT 1238
                                              .||..|..|..||::                
 Frog  1162 ----------------------------------YRYRRAHSDASDEEA---------------- 1176

  Fly  1239 ESDSCASSTERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRM 1303
                                      :..|::|:|                       |.|    
 Frog  1177 --------------------------LTGKERKRK-----------------------PKH---- 1188

  Fly  1304 AVGGSGPGEKKKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEK 1368
                 .|.|:   :|.:...:.|.|.               |.:| |....:|.:        |:
 Frog  1189 -----RPSEE---DPLLSPTVDSWKG---------------GIDN-PAITSDQEQ--------EE 1221

  Fly  1369 RRIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLM--ITSEQGEIPIFLNKCV 1431
            |:.|::..:.:  ::|:|::.|:|....::|.:      ...|||.:  :.|.:..||:|:.|||
 Frog  1222 RKTKKKATKVK--EDKKKKKTKQLNPPTRRNWE------SNYFGKPLHELVSPEKPIPVFVKKCV 1278

  Fly  1432 EFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFS 1496
            |:||:.||.:||:|||.|.:...|.:.::|::|.|..:.::::.|||||.|||.||:....||..
 Frog  1279 EYIEETGLSAEGLYRVSGYKTDQDNIQKQFDQDNNLNLASMEVTVNAVAGALKAFFADLPAPLIP 1343

  Fly  1497 KDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNS 1561
            .:...:|.|.        ||:..:|:     ||..||.:|:..||:|:.:|::|..|...||.:|
 Frog  1344 YNHHPDLLEA--------SKIPEKVE-----RLQVLKDILRSFPPVNYEVLRFIIAHLNRVSQHS 1395

  Fly  1562 KLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1612
            |.|.|.:.||:||:||||:..||.:...|...:.: :.:::|.|.|..:.|
 Frog  1396 KTNLMTADNLSICFWPTLMRPDFENKEFFSTTKNH-QSVIETFILQCQFFF 1445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAPp190NP_001259658.1 P-loop_NTPase <148..238 CDD:304359 32/89 (36%)
RhoGAP-FF1 254..333 CDD:293121 19/78 (24%)
RhoGAP_p190 1411..1611 CDD:239838 73/201 (36%)
arhgap5XP_004917331.1 P-loop_NTPase 28..244 CDD:393306 109/218 (50%)
RhoGAP-FF1 260..339 CDD:374593 19/78 (24%)
FF 430..482 CDD:128718 15/51 (29%)
FF 485..547 CDD:128718 20/61 (33%)
P-loop_NTPase <658..736 CDD:393306 21/78 (27%)
RhoGAP_p190 1256..1440 CDD:239838 72/197 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3117
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 721 1.000 Inparanoid score I621
OMA 1 1.010 - - QHG50036
OrthoDB 1 1.010 - - D110157at2759
OrthoFinder 1 1.000 - - FOG0003137
OrthoInspector 1 1.000 - - otm48150
Panther 1 1.100 - - O PTHR46005
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4737
SonicParanoid 1 1.000 - - X2106
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.110

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