Protein Alignment RhoGAPp190 and arhgap35

DIOPT Version :10

• Sequence 1: NP_001259658.1
• Gene: RhoGAPp190 / 32743
• FlyBaseID: FBgn0026375
• Length: 1621
• Species: Drosophila melanogaster
• Sequence 2: XP_004917008.1
• Gene: arhgap35 / 100498460
• XenbaseID: XB-GENE-999477
• Length: 1472
• Species: Xenopus tropicalis
• Alignment Length: 1670
• Identity: 500/1670 - (29%)
• Similarity: 800/1670 - (47%)
• Gaps: 319/1670 - (19%)

  Fly     4 FNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGD 68
            :::||:|||||||::||.|||||||||||:||.|||:.:||.||||.|||.||:||||||||||:
 Frog    14 YSVSVVGLSGTEKEKGQCGVGKSCLCNRFVRPSADDFHLDHTSVLSTSDFGGRVVNNDHFLYWGE 78

  Fly    69 VRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEK 133
            ..:..|:.|:::.:::|||||:||.|||..:...:.||.||..:.|:.|||||||.|.:|||:|:
 Frog    79 SGRMPEDCVDFKVHVVEQTEFIDDQTFQPHRSTALQPYIKRAASCKLASAEKLMYFCTDQLGLEQ 143

  Fly   134 EYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYEL 198
            ::|||.||:|:|.||||::..|||...||:.:.|::||.|:...:.|.|||:|||.||.|:..|.
 Frog   144 DFEQKQMPEGKLLIDGFLLCIDVSRGMNRNFDDQLKFVSNLYTQLAKTKKPIVLVLTKCDEGVER 208

  Fly   199 YVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELL 263
            |:|:|...:..   |..:|::||||..::|:||||..|.|:|||.:.:.|||.|.|:.|.:.:|:
 Frog   209 YIRDAHSFALN---KKNLQVVETSARSNVNVDLAFTTLVQLIDKSRGKSKIIPYFEALKQQSQLI 270

  Fly   264 DTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNK 328
            ....:....|:...:..::..|...|:.:....|:.:::::.|.:..:|||.:|:.:|:.:|:.:
 Frog   271 AAAKDKYEWLVSRVVKSHNETWINQSRRMQSNIEYQDYVHLEGTDKAKKLFHQHVLRLKQEHIER 335

  Fly   329 KLHQYLDKFALALEYLLPDIGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDEA 393
            :...||.....|||.|:||:..:   |..:|....|.|::..||.::|....:..|...:.:|..
 Frog   336 RRRNYLLALPRALESLVPDLDEI---DHLSWVKVSNLLESKAEFLKFFIVLEETPWDFTIHIDSI 397

  Fly   394 EDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVLFMG 458
            ::  |||:|:|||..||.|:..:|..::..:||...|:.||..|..|.|:||||...|.|...|.
 Frog   398 DE--RIPYDLLETVPAEEVYAAHLVKLRNARKKEEMKRSFKENLIASPFITPGKPWEEARSFIMS 460

  Fly   459 RECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDVIQE 523
            .|.::.|.|....:||..||.:||:|:|:.|.|||||:::.|.:.:.....::|.:..|.||:.|
 Frog   461 EEFYQWLEEPVYMEIYSRHQKEIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGE 525

  Fly   524 DSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSA----SNHKTPSG 584
            :.|:|.|.:|..||..::::|:.|::.|.:|.||....|||:.||.:||.:..    ..||.|:
 Frog   526 EQRFKALQKLQAERDALILKHIHFVYHPTKDTCPSNPYCVDTRIEHILSSRCTYPYDRLHKDPN- 589

  Fly   585 GGWKSSGSGSDRTLNLLIVGSEHLASDLLNDIR-ICTGSKGEYIYENQTYYLNYRIANGD----M 644
                     .|| :||:|:|.:.||.:|.|:|| :|| :..:|:.:.:.|.|:.|...|:    :
 Frog   590 ---------VDR-INLVILGKDGLARELANEIRALCT-NDDKYVIDGKMYELSLRPIEGNVRLPV 643

  Fly   645 EAFKAIDVYSSGLICVYSNQQSFETLKDNLERTLLCNL-ELEDKFENLP--IVLVYQPQDLKENE 706
            .:|:.......|.:|:|::::|...:.:::|::...:| ..|:...:||  ::||.:..|.....
 Frog   644 NSFQTSTFLPHGCLCLYNSKESLSYVVESIEKSRESSLGRKENHLIHLPLTLILVNRRGDTSSET 708

  Fly   707 VEYLRNEGMRLSEMLHCDFIDHTQN--------HQKYVYDILNIVILSLKLTEMKSYEPYPSNHT 763
            ...|..:|.:::..|.|.|:|....        ::|.:..||..::.|.:...:.|..|...:.|
 Frog   709 AHSLIQQGKQVASKLQCFFLDAASTGMGYGRNINEKQISLILRGLLESKRNLNLVSSTPSIKDLT 773

  Fly   764 D--LRILCCIFCGDQYDIENIVQPLVEESTLVKANEH---------SIIVDVFIGDAKRRVEFIL 817
            |  |||:.|:.|.|.::||:::..|       |.:.:         |:::|:.||..|||:|.:|
 Frog   774 DCELRIVMCLMCADIFNIEDVLNAL-------KPHTYRPSQCGLGGSVLLDLPIGSQKRRLELLL 831

  Fly   818 SSYHGTSQYR-DELIHGYIYFYSTKRRSSLANL-SILAAQNANIPLQIIAVTESGGVNAFFNSDI 880
            .|||.:...| ..|:|||:.||:.|||:|||.| :.|......:|:|::|:||  |...|.:. :
 Frog   832 LSYHASFNVRKTRLVHGYMIFYAAKRRASLAMLRAFLCEVQDIVPVQLVALTE--GPLTFLDY-V 893

  Fly   881 CQFLITEGNAVADRFKGSFMTFSADQ-YVKFAFYNPFLKTAWDNKYEVENLHV-----------E 933
            .:..:.||..:|...:|.|:.....| ..|...:.|:.|...:.|..:|..|:           |
 Frog   894 AREQLQEGEEIAQDIEGKFLILPQGQIQPKLDVFYPYFKDVLEKKVIIEASHMYDNTAEACSTTE 958

  Fly   934 ESITLDSGEGTLENS----VNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERD 994
            |..:.......|.||    ..:.|.|.|:|..:.           :|....||.:....|.|...
 Frog   959 EVFSSPRAGSPLCNSHLPDSEEDPEPSPQHILFQ-----------NEPNIAAPIKFTRELEETVM 1012

  Fly   995 ISLDEIYDDNEKPKHLHQRFQIFPPPTTPPEPAPPDHQLITCTYKSQFVSASESSLEEITSDVSG 1059
            .:|:...::.            .|||..|..|.|                      .|||
 Frog  1013 NTLESKLNNK------------VPPPLKPKPPIP----------------------YEIT----- 1038

  Fly  1060 SKDSLATHDAEWLEDKSDGRRNMNKNLIW---NNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTL 1121
             |..|:..|.    ...||.|....::.|   ..|..|.:|     ..:||   .::|:...:.:
 Frog  1039 -KPELSYLDT----GARDGHRKSLTSINWPPLEAFDPSDYA-----EPMDS---VVKPRNQEENI 1090

  Fly  1122 KVGEAPSRNCPAMSSSTFTLP---TQQPGK-LNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGST 1182
                             :::|   ||  || :.::|             |.....:|||:||
 Frog  1091 -----------------YSVPHDSTQ--GKIITIRN-------------TNKPQSNGSGNGS--- 1120

  Fly  1183 GLGLGLGSGSGCMGDSFLEPVDKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASST 1247
                                                                    :||...:|.
 Frog  1121 --------------------------------------------------------DSDMDTNSL 1129

  Fly  1248 ERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGGS---G 1309
            ||          |.|..:..     |.|....:..::..|.||.|         .::||..   |
 Frog  1130 ER----------ARKASIVT-----KPVLYRTKCAKLGKFSSYRS---------SLSVGSDDEPG 1170

  Fly  1310 PGEKKKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEKRRIKEE 1374
            |..:|:.|                       .|..|.:.....|..:|    |.|...||.|...
 Frog  1171 PIRRKEEE-----------------------TGTQGTKGDSTTNSYEA----DGEDPRKRNILRS 1208

  Fly  1375 TARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCVEFIEK--E 1437
            ..|..| :.|.|.:....|...:.|..|...|:       ::|||: .||:|:.||||:||.  |
 Frog  1209 LRRTTK-KVKPKPRPSLTKATWESNYFGFPLSS-------VVTSER-PIPVFIEKCVEYIEATGE 1264

  Fly  1438 GLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFSKDIIKE 1502
            |:.:||||||.|:::.::.|.::|::|.|.::...|..||.||.|||.|||:...||...::..|
 Frog  1265 GMTTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGALKSFFSELPDPLVPYNMQAE 1329

  Fly  1503 LEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMD 1567
            |.|.        .|:|     |...:|.|:|.||:|.|..|..|.||:..|...||.:..:|.|.
 Frog  1330 LVEA--------YKIN-----DLEHKLQAMKDLLKKFPKENHEIFKYVISHLNRVSQHHHINLMT 1381

  Fly  1568 SKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1612
            |:||:||:||||:..|||.|......|.| :.|::..|.|.|:.|
 Frog  1382 SENLSICFWPTLMRPDFTTMDALTATRTY-QTIIELFIQQCPFFF 1425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAPp190	NP_001259658.1	P-loop containing Nucleoside Triphosphate Hydrolases	<148..238	CDD:476819	38/89 (43%)
		RhoGAP-FF1	254..333	CDD:465153	14/78 (18%)
		pseudoGTPaseD_p190RhoGAP	598..748	CDD:412064	40/165 (24%)
		RhoGAP_p190	1411..1611	CDD:239838	79/201 (39%)
arhgap35	XP_004917008.1	P-loop containing Nucleoside Triphosphate Hydrolases	<158..247	CDD:476819	39/91 (43%)
		RhoGAP-FF1	261..340	CDD:465153	14/78 (18%)
		FF	429..>470	CDD:128718	15/40 (38%)
		FF	485..538	CDD:128718	18/52 (35%)
		RhoGAP_pG1_pG2	557..1238	CDD:466111	198/908 (22%)
		RhoGAP_p190	1234..1420	CDD:239838	79/207 (38%)