Protein Alignment CG5800 and DDX18

DIOPT Version :10

• Sequence 1: NP_573230.1
• Gene: CG5800 / 32742
• FlyBaseID: FBgn0030855
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_006764.3
• Gene: DDX18 / 8886
• HGNCID: 2741
• Length: 670
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 214/653 - (32%)
• Similarity: 322/653 - (49%)
• Gaps: 106/653 - (16%)

  Fly     3 RQKPKGPG----KPGSRFKPGSGTFKGAGGGRKS-----------GDNSQKRPRQEINKSRLAAT 52
            :|||...|    :.|...:...|..|.....:||           ..||:.:.:::..:..:...
Human    57 KQKPMNVGLSETQNGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQSSNSESKKKKKKKRKMVNDA 121

  Fly    53 EAEIQDLKT----KYAEIDATAIK----------------KFAQFPL------------------ 79
            |.:.:..||    |..|..|...|                :....||
Human   122 EPDTKKAKTENKGKSEEESAETTKETENNVEKPDNDEDESEVPSLPLGLTGAFEDTSFASLCNLV 186

  Fly    80 SKKTQKALAESKFVHPTQVQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLEHLFMNKWSRTDG 144
            ::.|.||:.|..|.:.|::|..||.|.|:|:|:|.||.||||||||||||.:|.:...::...:|
Human   187 NENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVELIVKLRFMPRNG 251

  Fly   145 VGAIIISPTRELAYQIFETLKKVGKHHDFSAGLIIGGKNLKFERTRM-DQCNILICTPGRLLQHM 208
            .|.:|:|||||||.|.|..||::..||..:.|||:||.|...|..:: :..||::.||||||.||
Human   252 TGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEAQKLGNGINIIVATPGRLLDHM 316

  Fly   209 DENPLFNTSTMEMLVLDEADRCLDMGFQKTLNSIIENFPPVRQTLLFSATQTNTVQDLARLNL-K 272
            ...|.|....::.||:|||||.||:||::.|..||:..|..|||:|||||||..|:||||::| |
Human   317 QNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVEDLARISLKK 381

  Fly   273 DPVYVGYGGATPREEPSASTKKTPNTAVLAVPELLQQSYVVLNLEDKITMLWSFIKNHLKQKIIV 337
            :|:|||.      ::..|:          |..:.|:|.|||...|.:..:|::|:|.:.|:|::|
Human   382 EPLYVGV------DDDKAN----------ATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKLMV 430

  Fly   338 FVASCKQAKYLYEIFCKLRPGSPLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTDVASRGLDFPA 402
            |.:||...||.||:...:  ..|:||::|...|::|...:..|.......:..||||:||||.|.
Human   431 FFSSCMSVKYHYELLNYI--DLPVLAIHGKQKQNKRTTTFFQFCNADSGTLLCTDVAARGLDIPE 493

  Fly   403 VNWVVQLDCPEDVSQYIHRAGRSARN-KTRGECLLVLTPSEEEYMISALKEQLNIDIRCVQIDPK 466
            |:|:||.|.|:|..:||||.||:||. ..||..||:|.| ||...:..|| |..:.:........
Human   494 VDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRP-EELGFLRYLK-QSKVPLSEFDFSWS 556

  Fly   467 KLFSPRVKIEAFLAQFPELRATAQRAFLSYIKSVFLMRNKRLFNVFSLDLDAFAQSLGLAVTPRV 531
            |:...:.::|..:.:...|..:||.|:.|||::......|::|||.:|:|...|.|.|..|.|.|
Human   557 KISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFV 621

  Fly   532 PFLEKFLWRQKQLQQQKEQGDNAKSINPLLSKLTKQQSFGGG-----DEDEENSDDEDFIKVKRK 591
                       .|.....:|              ||:..|||     .:.::....:.|..:.:|
Human   622 -----------DLNVNSNEG--------------KQKKRGGGGGFGYQKTKKVEKSKIFKHISKK 661

  Fly   592 DHD 594
            ..|
Human   662 SSD 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	SrmB	71..493	CDD:440279	171/458 (37%)
		DEADc_DDX10	83..279	CDD:350699	99/197 (50%)
		DUF4217	474..530	CDD:464056	18/55 (33%)
DDX18	NP_006764.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..169		19/111 (17%)
		Q motif	179..207		6/27 (22%)
		DEADc_DDX18	190..387	CDD:350700	98/196 (50%)
		DEAD box	333..336		2/2 (100%)
		SF2_C_DEAD	400..530	CDD:350174	54/131 (41%)
		DUF4217	562..619	CDD:464056	18/56 (32%)