Protein Alignment CG5800 and HCA4

DIOPT Version :10

• Sequence 1: NP_573230.1
• Gene: CG5800 / 32742
• FlyBaseID: FBgn0030855
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_012501.1
• Gene: HCA4 / 853419
• SGDID: S000003570
• Length: 770
• Species: Saccharomyces cerevisiae
• Alignment Length: 848
• Identity: 330/848 - (38%)
• Similarity: 463/848 - (54%)
• Gaps: 152/848 - (17%)

  Fly    46 KSRLAATEAE---------IQDLKTKYAEID--ATAIKKFAQFPLSKKTQKALAESKFVHPTQVQ 99
            |:||..|:.:         |::||||..|.|  .|..|.|...|:|..|.|.|.||.|:..|::|
Yeast     4 KNRLNTTQRKTLRQKEDEYIENLKTKIDEYDPKITKAKFFKDLPISDPTLKGLRESSFIKLTEIQ 68

  Fly   100 RDSIGPALQGKDVLGAAITGSGKTLAFLIPVLEHLFMNKWSRTDGVGAIIISPTRELAYQIFETL 164
            .|||..:|||.|||.||.||||||||||:||:|.|:..||:..||:||:|||||||||.||:|.|
Yeast    69 ADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEFDGLGALIISPTRELAMQIYEVL 133

  Fly   165 KKVGKHHDFSAGLIIGGKNLKFERTRMDQCNILICTPGRLLQHMDENPLFNTSTMEMLVLDEADR 229
            .|:|.|..|||||:||||::|||..|:.:.||||.||||:|||:|:....|||.::|||||||||
Yeast   134 TKIGSHTSFSAGLVIGGKDVKFELERISRINILIGTPGRILQHLDQAVGLNTSNLQMLVLDEADR 198

  Fly   230 CLDMGFQKTLNSIIENFPPVRQTLLFSATQTNTVQDLARLNLKDPVYVGYGGATPREEPSASTKK 294
            ||||||:|||::|:....|.||||||||||:.:|.|||||:|.|...||     ..:....|..|
Yeast   199 CLDMGFKKTLDAIVSTLSPSRQTLLFSATQSQSVADLARLSLTDYKTVG-----THDVMDGSVNK 258

  Fly   295 TPNTAVLAVPELLQQSYVVLNLEDKITMLWSFIKNHLKQKIIVFVASCKQAKYLYEIFCKLRPGS 359
            ..:|     ||.|||.|:.:.|.||:.:|:||||:|||.|:|||::|.||..::||.|.|::||.
Yeast   259 EAST-----PETLQQFYIEVPLADKLDILFSFIKSHLKCKMIVFLSSSKQVHFVYETFRKMQPGI 318

  Fly   360 PLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTDVASRGLDFPAVNWVVQLDCPEDVSQYIHRAGR 424
            .|:.|:|...|..|....:.|.|...|.:|:|||.:||:|||||:||||:||||||..||||.||
Yeast   319 SLMHLHGRQKQRARTETLDKFNRAQQVCLFATDVVARGIDFPAVDWVVQVDCPEDVDTYIHRVGR 383

  Fly   425 SARNKTRGECLLVLTPSEEEYMISALKEQLNIDIRCVQIDPKKL-------FSPRVKIEAFLAQF 482
            .||...:|:.|::|||.|:|..:..|..:        :|:|.||       .|.:.::::.|.:.
Yeast   384 CARYGKKGKSLIMLTPQEQEAFLKRLNAR--------KIEPGKLNIKQSKKKSIKPQLQSLLFKD 440

  Fly   483 PELRATAQRAFLSYIKSVFLMRNKRLFNVFSLDLDAFAQSLGLAVTPRVPFLEKFLWRQKQLQQQ 547
            |||:...|:||:||::|:::.::|::|....|..:.||.||||...|::.     :...|.::|.
Yeast   441 PELKYLGQKAFISYVRSIYVQKDKQVFKFDELPTEEFAYSLGLPGAPKIK-----MKGMKTIEQA 500

  Fly   548 KEQGDNA-------------------KSINP--------------LLSK----LTKQQSFGGGDE 575
            ||: .||                   ||..|              :||:    :||.|:    .|
Yeast   501 KER-KNAPRQLAFLSKANEDGEVIEDKSKQPRTKYDKMFERKNQTILSEHYLNITKAQA----QE 560

  Fly   576 DEENSDDEDFIKVKRKDHDVEGEPVKLDEEDDTENEAEAPLVVPKREKLVTKASLAKKALKKNLQ 640
            ||    |:|||.||||||::              ||||.|.:.....:...|.:|:|||...:..
Yeast   561 DE----DDDFISVKRKDHEI--------------NEAELPALTLPTSRRAQKKALSKKASLASKG 607

  Fly   641 VNSKLKFDDEGET-----MADDRSQMKALSAR-QRTVNQDDDDGGINLVLSKALLTEEDQYDKQR 699
            ..|||.||||||.     :.|:....|...|. |:|.         .|....|::.:.|..|||.
Yeast   608 NASKLIFDDEGEAHPVYELEDEEEFHKRGDAEVQKTE---------FLTKESAVMADIDNIDKQV 663

  Fly   700 FRELVKKRHKLQREKLRKKAE---EAKGSDDEEEQQ-----DDDNADDAGSESDHSVDLSWLPDP 756
            .:|..:::.:.:.|.:|::.|   |.:.|.||||.:     ...|..|..|:.|       :||.
Yeast   664 AKEKKQEKKRKRLEAMRREMEAAMEEEISGDEEEGKTVAYLGTGNLSDDMSDGD-------MPDS 721

  Fly   757 DKVYKNKPNASDRNESKSESSDASDDEKADDSDGDDDDVSDDEPAYKKSKLTNKMTLMDTEAIAA 821
            :...|.|....|.:...:.|:..           |||.:..:||          .||.|.|::.|
Yeast   722 EGHLKKKARTVDYSHGHNPSNSV-----------DDDIIEVEEP----------QTLEDLESLTA 765

  Fly   822 SLL 824
            .|:
Yeast   766 KLI 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	SrmB	71..493	CDD:440279	215/428 (50%)
		DEADc_DDX10	83..279	CDD:350699	122/195 (63%)
		DUF4217	474..530	CDD:464056	19/55 (35%)
HCA4	NP_012501.1	DEADc_DDX10	52..249	CDD:350699	123/201 (61%)
		SF2_C_DEAD	266..397	CDD:350174	67/130 (52%)
		DUF4217	431..488	CDD:464056	19/56 (34%)