Protein Alignment CG5800 and DDX49

DIOPT Version :10

• Sequence 1: NP_573230.1
• Gene: CG5800 / 32742
• FlyBaseID: FBgn0030855
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_061943.2
• Gene: DDX49 / 54555
• HGNCID: 18684
• Length: 483
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 154/525 - (29%)
• Similarity: 244/525 - (46%)
• Gaps: 94/525 - (17%)

  Fly    74 FAQFPLSKKTQKALAESKFVHPTQVQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLEHLFMNK 138
            ||:..||....:...:.....||.||...|...|:|:|.||.|.||||||.||::|:|:.|..:.
Human     4 FAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDP 68

  Fly   139 WSRTDGVGAIIISPTRELAYQIFETLKKVGKHHDFSAGLIIGGKNLKFERTRMD-QCNILICTPG 202
            :    |:..::::|||||||||.|..:.:||.......:|:||.::..:...:. :.:::|.|||
Human    69 Y----GIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPG 129

  Fly   203 RLLQHMDENPLFNTSTMEMLVLDEADRCLDMG---FQKTLNSIIENFPPVRQTLLFSATQTNTVQ 264
            ||..|:..:..|:...:..||:|||||.|:.|   |...|.:|:...|..|||||||||.|:|::
Human   130 RLADHLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPARRQTLLFSATLTDTLR 194

  Fly   265 DLARLNLKDPVYVGYGGATPREEPSASTKKTPNTAVLAVPELLQQSYVVLNLEDKITMLWSFIKN 329
            :|..|....|.:  :....|     .||.:..:...|.|||.::.:|:|       .::..|...
Human   195 ELQGLATNQPFF--WEAQAP-----VSTVEQLDQRYLLVPEKVKDAYLV-------HLIQRFQDE 245

  Fly   330 HLKQKIIVFVASCKQAKYLYEIFC-KLRPGS-PLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTD 392
            |....||:|..:||..    :|.| .||..| |.:||:..:.|..|.|....|....:.::.:||
Human   246 HEDWSIIIFTNTCKTC----QILCMMLRKFSFPTVALHSMMKQKERFAALAKFKSSIYRILIATD 306

  Fly   393 VASRGLDFPAVNWVVQLDCPEDVSQYIHRAGRSARNKTRGECLLVLTPSEEEYMISALKEQLNID 457
            |||||||.|.|..|:..:.|.....||||.||:||...:|:.:.::| ..:.:::.|::||:
Human   307 VASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVT-QYDIHLVHAIEEQI--- 367

  Fly   458 IRCVQIDPKKLFSPRVKIEAFLAQFPELRATAQRAFLSYIKSVFLMRNKRLFNVFSLDLDAFAQS 522
                    ||      |:|.|..:..|:        |..:..|.::|
Human   368 --------KK------KLEEFSVEEAEV--------LQILTQVNVVR------------------ 392

  Fly   523 LGLAVTPRVPFLEKFLWRQKQLQQQKEQGDNAKSINPLLSKLTKQQSFGGGDEDEENSDDEDFIK 587
                             |:.:::.:....|..|.||.     .||....|.|.|.|.....:..|
Human   393 -----------------RECEIKLEAAHFDEKKEINK-----RKQLILEGKDPDLEAKRKAELAK 435

  Fly   588 VKRKD 592
            :|:|:
Human   436 IKQKN 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	SrmB	71..493	CDD:440279	137/424 (32%)
		DEADc_DDX10	83..279	CDD:350699	73/199 (37%)
		DUF4217	474..530	CDD:464056	7/55 (13%)
DDX49	NP_061943.2	SrmB	1..441	CDD:440279	154/525 (29%)
		Q motif	2..30		7/25 (28%)
		DEAD box	152..155		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..483