DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5800 and Rs1

DIOPT Version :9

Sequence 1:	NP_573230.1	Gene:	CG5800 / 32742	FlyBaseID:	FBgn0030855	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	196/729 - (26%)
Similarity:	317/729 - (43%)	Gaps:	128/729 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DNSQKRPRQEINKSRLAATEAEIQD--LKTKYAE-IDAT-AIKKFAQFPLSKKTQKALAESKFVH 94
            ||.:.|.::|..|.:..|.|.:.:|  .|.::|: ::|. .|..|.|..||:...:|:....:::
  Fly   115 DNLRLREKKESKKKKKKAGEEDEEDEGEKMQFADTVEANEQITSFYQMNLSRPLMRAIGVLGYIY 179

  Fly    95 PTQVQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLEHLFMNKWSRTDGVGAIIISPTRELAYQ 159
            ||.:|..:|..||.|:|:.|.|.||:|||.|:::|.||.|.....:.......:::.|||||..|
  Fly   180 PTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQ 244

  Fly   160 IFETLKKVGKHHDFSAGLIIGGKNLKFERTRMDQ-CNILICTPGRLLQHMDENPLFNTSTMEMLV 223
            :::..|::.:......||.|||.::|.:...:.| .:|:|.|||||:.|:...|.|...::|:|:
  Fly   245 VYQVTKQLCQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLI 309

  Fly   224 LDEADRCLDMGFQKTLNSIIENFPPVRQTLLFSATQTNTVQDLARLNLKDPVYVGYGGATPREEP 288
            ||||||.||..|.:.:..||.:....|||:|||||.:..|:|||.::|..|:.|...
  Fly   310 LDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVN-------- 366

  Fly   289 SASTKKTPNTAVLAVPELLQQSYVVLNLE---DKITMLWSFIKNHLKQKIIVFVASCKQAKYLYE 350
                    |...:|..  |:|.::.:..:   |:..:|.|.|........:|||.:.|||..|:.
  Fly   367 --------NNQQVAFN--LRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTKKQAHRLHI 421

  Fly   351 IFCKL--RPGSPLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTDVASRGLDFPAVNWVVQLDCPE 413
            :...|  |.|.    |:|.|.|.:|:...:.|..:...|:.:||||:||||...|..|:....|.
  Fly   422 LLGLLGVRAGE----LHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPI 482

  Fly   414 DVSQYIHRAGRSARNKTRGECLLVLTPSEEEYMISALKEQLNIDIRCVQIDPKKLFSPRVKIEAF 478
            ....||||.||:|| ..|....:.|...:|..::..:.:.....|:      .::..|.: ||.:
  Fly   483 TTEHYIHRVGRTAR-AGRAGISVSLAGEKERKIVKDIIKNAESTIK------NRIIPPEI-IEKY 539

  Fly   479 LAQFPELRATAQRAFLSYIKSVFLMRNKRLFNVFSLDLDAFAQSLGLAVTPRVPFLEKFL-WRQK 542
                                     |||                    :|...|.::..| ..|.
  Fly   540 -------------------------RNK--------------------LTSLEPEIQNILDEEQA 559

  Fly   543 QLQQQKEQGDNAKSINPLLSKL--------TKQQ--------SFGGGDEDEEN---SDDEDFIKV 588
            :.|..|.:...:|:...||.:.        ||||        :...||||:.:   ...:...|.
  Fly   560 ERQLAKTEQQLSKTERKLLGQTNERRGWFQTKQQREAEKDRLALTTGDEDKASGGKGKGKTAGKR 624

  Fly   589 KRKDHDVEGE---PVKLDEEDDTENEAEAPLVVPKREKLVTKASLAKKALKKNLQVNSKLKFDDE 650
            ||.::..:||   |||..|....:.:.|.|     |:|  |...|||:...|.::..|.::
  Fly   625 KRPEYGGDGEDGPPVKDLEAKRNKKKKEEP-----RKK--TPEQLAKERAMKEIEKVSLVR---- 678

  Fly   651 GETMADDRSQMKALSARQRTVNQDDDD------GGINLVLSKALLTEEDQYDKQRFRELVKKRHK 709
             ..||..|.:...|.|..........|      ||.:...:.  ||:..:....|.|....:..|
  Fly   679 -AKMAKLRKRPGKLGAATEVHRSGASDGKPKRRGGQSAFTND--LTDVSRGGALRLRSEANRHKK 740

  Fly   710 LQREKLRKKAEEAK 723
            :.:...:|||...|
  Fly   741 MTKIAAKKKASSVK 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	PRK01297	2..471	CDD:234938	137/446 (31%)
		DEADc	74..277	CDD:238167	76/203 (37%)
		HELICc	311..437	CDD:238034	41/130 (32%)
		DUF4217	474..530	CDD:290667	6/55 (11%)
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	128/418 (31%)
		DEADc	159..364	CDD:238167	76/204 (37%)
		Helicase_C	393..498	CDD:278689	39/109 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940