DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5800 and ddx55

DIOPT Version :9

Sequence 1:	NP_573230.1	Gene:	CG5800 / 32742	FlyBaseID:	FBgn0030855	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_775336.2	Gene:	ddx55 / 286745	ZFINID:	ZDB-GENE-021212-1	Length:	593	Species:	Danio rerio

Alignment Length:	656	Identity:	199/656 - (30%)
Similarity:	310/656 - (47%)	Gaps:	120/656 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KFAQFP--LSKKTQKALAESKFVHPTQVQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLEHLF 135
            |:...|  |.....:.|.|..|.:.|.||...|...:..|||...|:|||||||||:||.||.|.
Zfish     8 KWGSLPVKLHDNILQTLKELGFTYMTPVQSACIPLFMSNKDVAAEAVTGSGKTLAFVIPALEILL 72

  Fly   136 MNKWS-RTDGVGAIIISPTRELAYQIFETLKK-VGKHHDFSAGLIIGGKN--LKFERTRMDQCNI 196
            ..:.. :...|||:||:||||||.||.|.:.: :.....|:..|:|||.|  ...|:.:....||
Zfish    73 KREEKLKKMQVGALIITPTRELAMQISEVMGRFLQGFPQFTQILLIGGSNPIEDVEKLKTQGANI 137

  Fly   197 LICTPGRLLQHMDENPLFN-----------TSTMEMLVLDEADRCLDMGFQKTLNSIIENFPPVR 250
            :|.|||||      ..:|.           ..::::||||||||.|||||:.:||:|:...|..|
Zfish   138 IIATPGRL------EDMFRRKADGLDLATAVKSLDVLVLDEADRLLDMGFEASLNTILGYLPKQR 196

  Fly   251 QTLLFSATQTNTVQDLARLNLKDPVYVGYGGATPREE--PSASTKKTPNTAVLAVPELLQQSYVV 313
            :|.|||||||..::.|.|..|::||.:     |.:|:  .::|.:||        |..|...|.:
Zfish   197 RTGLFSATQTQELEKLVRAGLRNPVRI-----TVKEKGVAASSVQKT--------PAKLSNYYTM 248

  Fly   314 LNLEDKITMLWSFIKNHLKQKIIVFVASCKQAKYLYEIFCKLRPGSPLLALYGTLHQDRRIAIYE 378
            ...|:|...|.:|::.|..:|.:||.::|...:|..:....|.....:..::|.: :.:|..|:.
Zfish   249 CRAEEKFNTLVAFLRQHKHEKQLVFFSTCACVEYFGKALEVLVKNVSIHCIHGKM-KHKRNKIFA 312

  Fly   379 DFLRKSHVVMFSTDVASRGLDFPAVNWVVQLDCPEDVSQYIHRAGRSARNKTRGECLLVLTPSEE 443
            ||......::..|||.:||:|.|.||||:|.|.|...|.::||.||:||...:|..|:.|.|.||
Zfish   313 DFRALKSGILVCTDVMARGIDIPEVNWVLQYDPPSSASSFVHRCGRTARIGNQGNALVFLLPMEE 377

  Fly   444 EYMISALKEQLNIDIRCVQIDPKKLFSPRVKIEAFLAQFPELRATA----------QRAFLSYIK 498
            .|:     ..|:|:.:|    |.:.||   .::..:...|:|:|.|          .|||:||::
Zfish   378 SYV-----NFLSINQKC----PLQSFS---SVKDVVDVLPKLKAMALGDRAMFEKGMRAFVSYVQ 430

  Fly   499 SVFLMRNKRLFNVFSLDLDAFAQSLGLAVTPRVPFLEKFLWRQKQLQQQKEQGDNAKSINPLLSK 563
            :........:|.:..||..|.|:...|...|::|.|     |.|.....|     |::|
Zfish   431 AYAKHECSLIFRIKDLDFAALARGFALVRLPKMPEL-----RGKTFPDFK-----AEAI------ 479

  Fly   564 LTKQQSFGGGDEDEENSDDEDFIKVKRKDHDVEGEPVKLDEEDDTENEAEAPLVVPKREKLVTKA 628
                              |.|.|:.|.|:.:.:.:. .|.|:.:.|        ||.|:..:...
Zfish   480 ------------------DTDTIRFKDKNREKQRQK-WLAEQKEKE--------VPLRKNFIKNK 517

  Fly   629 SLAKKALKKNLQVN--SKLKFDDEGETMADDRSQMKALSARQRTVNQDDDDGGINLVLSKALLTE 691
            :.:|:.:||:.:..  ||.|.|.:.:...:|             :|:..:|..:...|.|..:||
Zfish   518 AWSKQKIKKDRKKKRASKRKLDQDSDAAEED-------------LNELMNDTRLLKKLKKGKITE 569

  Fly   692 EDQYDK 697
            || :||
Zfish   570 ED-FDK 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	PRK01297	2..471	CDD:234938	146/416 (35%)
		DEADc	74..277	CDD:238167	88/219 (40%)
		HELICc	311..437	CDD:238034	40/125 (32%)
		DUF4217	474..530	CDD:290667	15/65 (23%)
ddx55	NP_775336.2	Q motif	9..37		7/27 (26%)
		SrmB	15..517	CDD:223587	179/576 (31%)
		DEADc	16..224	CDD:238167	87/218 (40%)
		DEAD box	171..174		2/2 (100%)
		Helicase_C	252..363	CDD:278689	37/111 (33%)
		DUF4217	403..462	CDD:290667	15/58 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..593		5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920