DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5800 and Ddx31

DIOPT Version :9

Sequence 1:	NP_573230.1	Gene:	CG5800 / 32742	FlyBaseID:	FBgn0030855	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001028466.2	Gene:	Ddx31 / 227674	MGIID:	2682639	Length:	687	Species:	Mus musculus

Alignment Length:	606	Identity:	185/606 - (30%)
Similarity:	287/606 - (47%)	Gaps:	127/606 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TFKGA--------------GGGRKSGDNSQKRPRQEINKSRLAATEAEIQDLKTKYAEIDATAIK 72
            ||||:              |.||:     :::|.  |..|.|.....||       .|:.:|.:|
Mouse    43 TFKGSTHKTFPPKKYLDSIGNGRQ-----EEKPC--IKTSSLFKNNPEI-------PELHSTVVK 93

  Fly    73 KFAQFPLSKKTQKALAESKFVHP---------------TQVQRDSIGPALQGKDVLGAAITGSGK 122
            :..:...|.:..:.|.    :||               |.||:.||...|:|:|.|..:.|||||
Mouse    94 QAREQVFSPEAFQELD----LHPHLISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGK 154

  Fly   123 TLAFLIPVLEHL--FMNKWSRTDGVGAIIISPTRELAYQIFETLKKVGKHHDFSA-GLIIGGKNL 184
            |||:.:||::.|  ..:|..|:||..|:::.||||||.|.|:|::|:.|...:.. |:::||:..
Mouse   155 TLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKR 219

  Fly   185 KFERTRMDQ-CNILICTPGRLLQHMDENPLFNTSTMEMLVLDEADRCLDMGFQKTLNSIIENFP- 247
            |.|:.|:.: .||||.|||||:.|:......:.:.:..|::|||||.||:||:|.:..|:....
Mouse   220 KSEKARLRKGINILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFEKDITVILNAVNA 284

  Fly   248 --PVRQTLLFSATQTNTVQDLARLNLKDPVYVGY-----GGATPREEPSASTKKTPNTAVLAVPE 305
              ..||.:|.|||.|..|..|..::|.:||.:..     ....|:|..|.....      .|:||
Mouse   285 ECQKRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNCNQPNPKEVASIQLNS------FAIPE 343

  Fly   306 LLQQSYVVLNLEDKITMLWSFIKNHLK----QKIIVFVASCKQAKYLYEIF-----CKLRPGSP- 360
            .|.|..|::..:.::..|.:||....|    ||:|||.:||:..::.|.:|     |  ..|:|
Mouse   344 SLDQHVVLVPSKLRLVCLAAFILQKCKFEKNQKMIVFFSSCELVEFHYSLFLHTLLC--HSGTPT 406

  Fly   361 ------------LLALYGTLHQDRRIAIYEDFLRKSHVVMFSTDVASRGLDFPAVNWVVQLDCPE 413
                        .|.|:|.:.|:.|.:::.:|......|:..|||||||||.|.|.|:||...|.
Mouse   407 SEHLPSASWPLKFLRLHGNMEQEERTSVFHEFSHSETGVLLCTDVASRGLDLPQVTWIVQYSAPS 471

  Fly   414 DVSQYIHRAGRSARNKTRGECLLVLTPSEEEYMISALKEQLNIDIRCVQIDPKKLFSPRVKIEAF 478
            ..::||||.||:||....|..||:|.|||.||:.|....::|:.    :|..:.:.:...|.:.|
Mouse   472 SPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASHKINVG----EIKMEDILAVLAKDDCF 532

  Fly   479 ----------LAQFPE---LRAT-------------------AQRAFLSYIK--SVFLMRNKRLF 509
                      .|..|:   .|||                   |::|..|:|:  :.:....|.:|
Mouse   533 KRRQRGAQKSRASGPQEIRERATVLQTVFEDYVHSSQRMVSWAKKALQSFIRAYATYPKELKSIF 597

  Fly   510 NVFSLDLDAFAQSLGLAVTPR 530
            :|.:|.|...|:|.||...||
Mouse   598 HVRALHLGHVAKSFGLRDAPR 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	PRK01297	2..471	CDD:234938	163/511 (32%)
		DEADc	74..277	CDD:238167	80/224 (36%)
		HELICc	311..437	CDD:238034	49/147 (33%)
		DUF4217	474..530	CDD:290667	20/89 (22%)
Ddx31	NP_001028466.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		4/19 (21%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	103..132		5/32 (16%)
		PRK04837	105..553	CDD:235314	150/463 (32%)
		P-loop_NTPase	105..317	CDD:304359	79/215 (37%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	261..264		2/2 (100%)
		HELICc	347..495	CDD:238034	50/149 (34%)
		DUF4217	557..618	CDD:290667	13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920