Protein Alignment CG5800 and DDX10

DIOPT Version :10

• Sequence 1: NP_573230.1
• Gene: CG5800 / 32742
• FlyBaseID: FBgn0030855
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_004389.2
• Gene: DDX10 / 1662
• HGNCID: 2735
• Length: 875
• Species: Homo sapiens
• Alignment Length: 920
• Identity: 383/920 - (41%)
• Similarity: 537/920 - (58%)
• Gaps: 151/920 - (16%)

  Fly    10 GKPGSRFKPGSG-------TFKGAGGGRKSGDNSQKRPRQEINKSRLAATEAEIQDLKTKYAEID 67
            ||..:  .||||       :|...........|.:|:.|:::.|.........|..|...|.:|:
Human     2 GKTAN--SPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKIN 64

  Fly    68 ATAIKKFAQFPLSKKTQKALAESKFVHPTQVQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLE 132
            ...|.:|:.|||||||.|.|.|:::...|::|:.:||.|||||||||||.||||||||||:||||
Human    65 VNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLE 129

  Fly   133 HLFMNKWSRTDGVGAIIISPTRELAYQIFETLKKVGKHHDFSAGLIIGGKNLKFERTRMDQCNIL 197
            .|:..:|:.|||:|.:|||||||||||.||.|:||||:||||||||||||:||.|..|::..|||
Human   130 ALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINIL 194

  Fly   198 ICTPGRLLQHMDENPLFNTSTMEMLVLDEADRCLDMGFQKTLNSIIENFPPVRQTLLFSATQTNT 262
            :||||||||||||...|:.:.::|||||||||.|||||..|:|::|||.|..|||||||||||.:
Human   195 VCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKS 259

  Fly   263 VQDLARLNLKDPVYVGYGGATPREEPSASTKKTPNTAVLAVPELLQQSYVVLNLEDKITMLWSFI 327
            |:|||||:||:|.||..     .|:...||           |..|:|:|:|..|:.||::|:||:
Human   260 VKDLARLSLKNPEYVWV-----HEKAKYST-----------PATLEQNYIVCELQQKISVLYSFL 308

  Fly   328 KNHLKQKIIVFVASCKQAKYLYEIFCKLRPGSPLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTD 392
            ::|||:|.|||.:|||:.:|||.:||:||||..:|||:|...|.||:.:|.:|:||...|:|:||
Human   309 RSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATD 373

  Fly   393 VASRGLDFPAVNWVVQLDCPEDVSQYIHRAGRSARNKTRGECLLVLTPSEEEYMISALKEQL--- 454
            :|:|||||||||||:|.|||||.:.|||||||:||.|..||.||:|.|||:     |:.:||
Human   374 IAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEK-----AMVQQLLQK 433

  Fly   455 NIDIRCVQIDPKKLFSPRVKIEAFLAQFPELRATAQRAFLSYIKSVFLMRNKRLFNVFSLDLDAF 519
            .:.::.::|:|:||...:.|:|:.|||..:|:..|||.|:||::||:||::|.:|:|..|.:..:
Human   434 KVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEY 498

  Fly   520 AQSLGLAVTPRVPFLEKFLWRQKQLQQQKEQGDNAKSINPLLSKLT------------------- 565
            |.||||||.|||.||:|.   |||..::..:....|.|.|....||
Human   499 ALSLGLAVAPRVRFLQKM---QKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQ 560

  Fly   566 -----------KQQSFGGGDEDEENSDDE------------------------------------ 583
                       :|.:..|.:|.||..|||
Human   561 KGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLD 625

  Fly   584 --------DFIKVKRKDHDVEGEPVKLDEEDDTENEAEAPLVVPKREKLVTKASLAKKALKKNLQ 640
                    ||:||||  |:|.|    ||.:|:...:.:.|.....::|: ||.:.|||.:|:|.:
Human   626 RDEEEEDADFLKVKR--HNVFG----LDLKDEKTLQKKEPSKSSIKKKM-TKVAEAKKVMKRNFK 683

  Fly   641 VNSKLKFDDEGETMAD-DRSQMKALSARQRTVNQDDDDGGINLVLSKALLTEEDQYDKQRFRELV 704
            ||.|:.|.||||.:.. .:.|..|:    :...:|||.|||||..:|..|.|||::||:.:|:.:
Human   684 VNKKITFTDEGELVQQWPQMQKSAI----KDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKI 744

  Fly   705 KKRHKLQREKLRKKAEE-----AKGSDDEE---EQQDDDNADDAGSESDHSVDLSWLPDPDKVYK 761
            |.:|:.:|.|.|:...|     ||..|:||   :..|||:.||.|      .|.|.|||||| |:
Human   745 KAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDG------FDPSTLPDPDK-YR 802

  Fly   762 NKPNASDRNESKSESSDASDDEKADD----SDGDDDDVSDDEPAYKKSK------LTNKMTLMDT 816
                :|:.::|:...:..||.:|...    |:.:.:||.......||::      |...::|.:.
Human   803 ----SSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAED 863

  Fly   817 EAIAASLLGS 826
            |.:...||.|
Human   864 EELVLHLLRS 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5800	NP_573230.1	SrmB	71..493	CDD:440279	239/424 (56%)
		DEADc_DDX10	83..279	CDD:350699	131/195 (67%)
		DUF4217	474..530	CDD:464056	27/55 (49%)
DDX10	NP_004389.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		10/42 (24%)
		SrmB	68..470	CDD:440279	237/422 (56%)
		Q motif	69..97		12/27 (44%)
		DEADc_DDX10	80..277	CDD:350699	131/201 (65%)
		DEAD box	222..225		2/2 (100%)
		DUF4217	451..509	CDD:464056	27/57 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..631		8/68 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	703..850		54/161 (34%)