DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8289 and CDYL

DIOPT Version :9

Sequence 1:	NP_573229.1	Gene:	CG8289 / 32741	FlyBaseID:	FBgn0030854	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001355054.1	Gene:	CDYL / 9425	HGNCID:	1811	Length:	598	Species:	Homo sapiens

Alignment Length:	207	Identity:	45/207 - (21%)
Similarity:	72/207 - (34%)	Gaps:	69/207 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TRRSVRGETEDSNELPSTSKASAHASSPIKKRKLSRASTSSVKNGKKVAEKDSESDVDAGTEDEK 190
            :.||..|::.         |.:.....|.:|..|.|         ..|:..|..||.......|:
Human     6 SHRSAWGKSR---------KKNWQYEGPTQKLFLKR---------NNVSAPDGPSDPSISVSSEQ 52

  Fly   191 SAQPQKVAAKSKSSPNAKKAKGRGRRNAGTKKADDSIDPEKQWEVEKILDHVATKEGDM-FKIRW 254
            |...|..|.                                  :||:|:|....|:|.. :.:||
Human    53 SGAQQPPAL----------------------------------QVERIVDKRKNKKGKTEYLVRW 83

  Fly   255 KKYGPKDDSWEPSKNLA-CDALIEKFMRK--QATQENVDVKELRESPKKTERLVDECYPRTNLHN 316
            |.|..:||:|||.::|. |:..|..|.|:  :..:|:...:..|.||             .|...
Human    84 KGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKESTLTRTNRTSP-------------NNARK 135

  Fly   317 RIERSSKRSSAK 328
            :|.||:..:.:|
Human   136 QISRSTNSNFSK 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8289	NP_573229.1	CHROMO	233..284	CDD:214605	20/54 (37%)
CDYL	NP_001355054.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		21/121 (17%)
		Interaction with EZH2. /evidence=ECO:0000269\|PubMed:22009739	61..309		29/134 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..149		9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..226
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	362..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810